Abstract：
:The effects of X-radiation on the Nembutal-induced redistribution of the cardiac output in two types of transplanted mouse tumours and some normal mouse tissues have been investigated, using rubidium-86 and 125I-human serum albumin. Irradiation causes an increase in 86Rb uptake (relative blood perfusion) by the tumours of anaesthetized mice, but has little or no effect in non-anaesthetized mice. The increase is dose- and time-dependent. Tumour plasma space is not significantly affected by radiation and Nembutal. Muscle blood perfusion is severely decreased in anaesthetized mice and is not affected by radiation, at least within the time limits of the experiments. This means that radiation-induced functional vascular changes in normal and neoplastic tissues follow different time courses. On the basis of the present results, and of the results of other authors, it is argued that irradiation damages the vasculature of tumours in such a way that it becomes more sensitive to changes in systemic blood pressure.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Zanelli GD,Lucas PBdoi
10.1038/bjc.1976.186subject
Has Abstractpub_date
1976-10-01 00:00:00pages
408-17issue
4eissn
0007-0920issn
1532-1827journal_volume
34pub_type
杂志文章abstract：:MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a major target of genetic and epigenetic alteration in these cance...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601776
更新日期：2004-05-17 00:00:00
abstract：:The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.173
更新日期：1994-05-01 00:00:00
abstract：:The primary aim of this study was to investigate if the expression of the DNA damage identifying protein DNA-PKcs known to be involved in DNA repair after treatment with ionising radiation can be used as a predictive marker for radiotherapy (RT) response in cervical cancer. Formalin-fixed primary tumour biopsies from ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603153
更新日期：2006-06-05 00:00:00
abstract：:Metastatic spread of some solid tumours is thought to depend upon the adhesion of tumour cells to the vascular endothelium followed by extravasation into surrounding tissues. We investigated the role of beta 1 integrins in the adhesion of the breast adenocarcinoma cell line MDA-MB-231 and the melanoma cell line RPMI-7...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.627
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:Veliparib is a potent poly(ADP-ribose) polymerase inhibitor. This phase 1 study aimed to establish the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of veliparib combined with various FOLFIRI regimens in patients with solid tumours. METHODS:Patients received veliparib (10-270 mg BID, days...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/s41416-018-0003-3
更新日期：2018-04-01 00:00:00
abstract：:In rapidly frozen livers from chickens affected with myeloblastosis and Marek's disease and from unaffected control birds there exists a strong correlation between catalase activity and catalase Electron Paramagnetic Resonance (EPR) signal intensities. The diseased chickens had activities and signals reduced to as lit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.189
更新日期：1984-09-01 00:00:00
abstract：:Many cancers express Fas ligand (FasL/CD95L) in vivo, and can kill lymphoid cells by Fas-mediated apoptosis in vitro. However, overexpression of recombinant FasL in murine tumour allografts revealed a potential antitumour effect of FasL, via recruitment of neutrophils. Transforming growth factor-beta1 (TGF-beta1) coul...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601240
更新日期：2003-10-06 00:00:00
abstract：:We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.103
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.3
更新日期：2015-03-03 00:00:00
abstract：:Besides cytotoxicity, taxanes induce other biological effects, especially in the immune system. Taxanes have demonstrated immunostimulatory effects against neoplasms, supporting the idea that these agents suppress cancer through several mechanisms and not solely through inhibiting cell division. The purpose of the pre...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.bjc.6600347
更新日期：2002-07-01 00:00:00
abstract：:T-lymphocyte maturation associated protein, MAL, has been described as a tumour-suppressor gene with diagnostic value in colorectal and oesophageal cancers, and can be inactivated by promoter hypermethylation. The aim of this study was to analyse the prevalence of MAL promoter hypermethylation and the association with...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604777
更新日期：2008-12-02 00:00:00
abstract：:Lung cancer is the primary cause of cancer mortality in developed countries. First diagnosis only when disease has already reached the metastatic phase is the main reason for failure in treatment. To this regard, although low-dose spiral computed tomography (CT) has proven to be effective in the early detection of lun...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605660
更新日期：2010-06-08 00:00:00
abstract：BACKGROUND:To evaluate the prognostic value of lymph node density (LND) in patients with lymph node-positive cervical cancer. METHODS:A total of 88 consecutive patients were included in our study. Patients were treated with cisplatin-based concomitant chemoradiotherapy after surgical staging was performed at the Medic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605801
更新日期：2010-08-24 00:00:00
abstract：:Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.27
更新日期：1987-02-01 00:00:00
abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.59
更新日期：1982-03-01 00:00:00
abstract：:In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1127
更新日期：2000-04-01 00:00:00
abstract：:Sera from 182 newly diagnosed breast cancer patients were assayed for antibodies to p53 using an enzyme-linked immunosorbent assay (ELISA) method, and antibodies were detected in 48 (26%) compared with 1 out of 76 (1.3%) normal control volunteers (P = 0.0001). In breast cancer patients, autoantibodies were found in al...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.219
更新日期：1994-06-01 00:00:00
abstract：:Local infiltrates of eosinophilic leucocytes and macrophages and the deposition of acid mucopolysaccharides (AMPS) in 72 operable primary lung cancers and 17 isolated pulmonary metastases of known origin were correlated to tumour stage (radically or non-radically operable) and clinical course, by following the patient...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.196
更新日期：1979-09-01 00:00:00
abstract：:The biguanide drug metformin profoundly affects cell metabolism, causing an impairment of the cell energy balance and triggering a plethora of pleiotropic effects that vary depending on the cellular or environmental context. Interestingly, a decade ago, it was observed that metformin-treated diabetic patients have a s...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2016.385
更新日期：2016-12-06 00:00:00
abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.184
更新日期：2011-07-12 00:00:00
abstract：BACKGROUND:We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). METHODS:Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.460
更新日期：2018-03-20 00:00:00
abstract：:Nine hundred and eighty-four breast cancer patients were interviewed regarding exogenous hormonal use. This represents a random sample of breast cancer patients in Southern Sweden referred to the Department of Oncology at Lund for treatment between 1978 and 1997 (excluding 1980 and 1981) with a 100% follow-up. Ever-us...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690543
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. METHODS:We performed a nested cas...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.148
更新日期：2016-06-28 00:00:00
abstract：BACKGROUND:Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported. METHODS:Tissue microarrays (TAMs) including 411 cases of CRC tissues and corresponding paracancerous tissues were used to examine the DKC1 expressio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0695-z
更新日期：2020-03-01 00:00:00
abstract：:In the district of Srikakulam in Andhra Pradesh in South India the habit of reverse smoking is widespread. In a house to house survey of oral cancer and precancerous conditions, comprising 10,169 villagers, 43·8% were reverse smokers; the female: male ratio being 1·7: 1. Ten previously undiagnosed cases of oral cancer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.2
更新日期：1971-03-01 00:00:00
abstract：BACKGROUND:Our previous study demonstrated that extracellular adenosine 5'-triphosphate (ATP) stimulated prostate cancer cell invasion via P2Y receptors. However, the purinergic receptor subtype(s) involved in this process remains unclear. Here we aimed to determine whether P2Y2, one subtype of P2Y receptors, was invol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.484
更新日期：2013-09-17 00:00:00
abstract：BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0600-9
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0910-y
更新日期：2020-08-01 00:00:00
abstract：:Capecitabine and docetaxel have considerable single-agent activity in gastric cancer with distinct mechanisms of action and no overlap of key toxicities. A synergistic interaction between these two drugs is mediated by taxane-induced upregulation of thymidine phosphorylase. We investigated the activity and the feasibi...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601724
更新日期：2004-04-05 00:00:00
abstract：:Photodynamic therapy is a potential treatment for superficial bladder cancer that utilizes photosensitizer drugs, which are activated by light to cause tissue destruction. However, first-generation photosensitizers cause prolonged phototoxicity, have poor tumour specificity and can accumulate within detrusor muscle, r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.637
更新日期：1998-10-01 00:00:00
