Lung cancer screening.

abstract：:PEP005 is a novel ingenol angelate that modulates protein kinases C (PKC) functions by activating PKC delta and inhibiting PKC alpha. This study assessed the antiproliferative effects of PEP005 alone and in combination with several other anticancer agents in a panel of 10 human cancer cell lines characterised for expr...

journal_title：British journal of cancer

authors： Benhadji KA,Serova M,Ghoul A,Cvitkovic E,Le Tourneau C,Ogbourne SM,Lokiec F,Calvo F,Hammel P,Faivre S,Raymond E

更新日期：2008-12-02 00:00:00

abstract：:A CD34-negative haematopoietic progenitor cell line, D064, derived from canine bone marrow stromal cells is able to differentiate into haematopoietic progenitors under the influence of growth factor-mediated signalling. While differentiating, these cells eventually start to express MHC class II molecules (DR homologue...

journal_title：British journal of cancer

authors： Huss R,Theis S,Deeg HJ

更新日期：1999-11-01 00:00:00

abstract：:There is a need to evaluate cancer services and provide a baseline on current treatment success and organization. This study shows that this process may be severely hindered by case note destruction or inaccessibility and incomplete information. This is an ongoing problem that needs to be addressed now. ...

journal_title：British journal of cancer

authors： Smith SJ,Muir KR,Wolstenholme JL,Thornhill KG,Zamorski A,Tolley K,Logan RF,Chilvers CE

更新日期：1997-01-01 00:00:00

abstract：:During the COVID-19 era, Chinese hospitals have developed a system that enables vulnerable cancer patients to continue to receive high-quality medical care, optimising their survival whilst protecting them. This includes use of digital quick codes, fever clinics and optimal scheduling. We wish to share our experiences...

journal_title：British journal of cancer

authors： Peng L,Yang JS,Stebbing J

更新日期：2020-07-01 00:00:00

abstract：:Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...

journal_title：British journal of cancer

authors： Lau WY,Leung WT,Ho S,Leung NW,Chan M,Lin J,Metreweli C,Johnson P,Li AK

更新日期：1994-11-01 00:00:00

abstract：:In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...

journal_title：British journal of cancer

authors： Ito I,Minegishi T,Fukuda J,Shinozaki H,Auersperg N,Leung PC

更新日期：2000-04-01 00:00:00

abstract：:Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressi...

journal_title：British journal of cancer

authors： Brodowicz T,Kandioler D,Tomek S,Ludwig C,Rudas M,Kunstfeld R,Koestler W,Hejna M,Budinsky A,Wiltschke C,Zielinski CC

更新日期：2001-11-30 00:00:00

abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...

journal_title：British journal of cancer

authors： Linton A,Cheng YY,Griggs K,Schedlich L,Kirschner MB,Gattani S,Srikaran S,Chuan-Hao Kao S,McCaughan BC,Klebe S,van Zandwijk N,Reid G

更新日期：2018-03-20 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) prognosis is strictly related to well-established clinicopathological parameters which have unfortunately become insufficient in the prognostic evaluation of this type of cancer. As p53 and bcl-2 gene deregulations are frequently involved in several types of epithelial malignancies, ...

journal_title：British journal of cancer

authors： Fontanini G,Vignati S,Bigini D,Mussi A,Lucchi M,Angeletti CA,Basolo F,Bevilacqua G

更新日期：1995-05-01 00:00:00

abstract：:Virus-directed enzyme prodrug therapy (VDEPT) utilising the bacterial enzyme nitroreductase delivered by a replication-defective adenovirus vector to activate the prodrug CB1954 is a promising strategy currently undergoing clinical trials in patients with a range of cancers. An understanding of the mechanism of tumour...

journal_title：British journal of cancer

authors： Palmer DH,Milner AE,Kerr DJ,Young LS

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The HMGA2 protein has experimentally been linked to EMT and cancer stemness. Recent studies imply that tumour-stroma interactions regulate these features and thereby contribute to tumour aggressiveness. METHODS:We analysed 253 cases of pancreatic ductal adenocarcinoma (PDAC) and 155 cases of ampullary adeno...

journal_title：British journal of cancer

authors： Strell C,Norberg KJ,Mezheyeuski A,Schnittert J,Kuninty PR,Moro CF,Paulsson J,Schultz NA,Calatayud D,Löhr JM,Frings O,Verbeke CS,Heuchel RL,Prakash J,Johansen JS,Östman A

更新日期：2017-06-27 00:00:00

abstract：:Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imagin...

journal_title：British journal of cancer

authors： Beaton L,Bandula S,Gaze MN,Sharma RA

更新日期：2019-04-01 00:00:00

abstract：:Immunoreactive and bioassayable plasma fibronectin (opsonic α(2) surface-binding (SB) glycoprotein) was measured during experimental Sarcoma-180 tumour growth in mice. Male C57BL/6 mice were challenged s.c. with 2 × 10(6) viable Sarcoma-180 tumour cells and evaluated sequentially in parallel with saline-injected contr...

journal_title：British journal of cancer

authors： Saba TM,Gregory TJ,Blumenstock FA

更新日期：1980-06-01 00:00:00

abstract：:No published data are available concerning the activity and tolerability of intramuscularly administered granulocyte colony-stimulating factor (G-CSF) in humans. To fill this gap, 19 patients with advanced ovarian cancer previously treated with at least one first-line chemotherapy cycle received the following myelosup...

journal_title：British journal of cancer

authors： Di Leo A,Bajetta E,Nolè F,Biganzoli L,Ferrari L,Oriana S,Riboldi G,Bohm S,Spatti G,Raspagliesi F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...

journal_title：British journal of cancer

authors： Kaliszczak M,van Hechanova E,Li Y,Alsadah H,Parzych K,Auner HW,Aboagye EO

更新日期：2018-11-01 00:00:00

abstract：:P450 reductase (NADPH:cytochrome P450 reductase, EC 1.6.2.4) is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine (SR 4233). Using a panel of six human breast adenocarcinoma cell lines we have examined the relationship between P450 reductase activity and sensitivity to tira...

journal_title：British journal of cancer

authors： Patterson AV,Barham HM,Chinje EC,Adams GE,Harris AL,Stratford IJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Radio- and chemotherapy (RT/CT) resistance hampers success in combating small and non-small cell lung cancers (SCLC/NSCLC). The underlying molecular mechanisms of RT/CT resistance of LCs are multifactorial and have been understood in part hitherto. miRNAs, key regulators of mRNAs, are well-recognised oncomir...

journal_title：British journal of cancer

authors： Salim H,Akbar NS,Zong D,Vaculova AH,Lewensohn R,Moshfegh A,Viktorsson K,Zhivotovsky B

更新日期：2012-10-09 00:00:00

abstract：:The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after injecting specimens with c...

journal_title：British journal of cancer

authors： Martin L,Holcombe C,Green B,Leinster SJ,Winstanley J

更新日期：1997-01-01 00:00:00

abstract：:The tumour suppressor gene CDKN2A, located on chromosome 9p21, encodes the cell cycle regulatory protein p16. Inactivation of the CDKN2A gene could lead to uncontrolled cell growth. In order to determine the role of CDKN2A in the development of sporadic ovarian cancer, loss of heterozygosity at 9p21-22, homozygous del...

journal_title：British journal of cancer

authors： Niederacher D,Yan HY,An HX,Bender HG,Beckmann MW

更新日期：1999-08-01 00:00:00

abstract：:In this study, the role of parity in conferring protection of the mammary gland against chemical carcinogenesis induced by 7,12-dimethylbenz(a)anthracene (DMBA) was investigated. Experiments were also carried out to determine if an 'interrupted' pregnancy was capable of reducing the incidence of mammary tumour inducti...

journal_title：British journal of cancer

authors： Sinha DK,Pazik JE,Dao TL

更新日期：1988-04-01 00:00:00

abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...

journal_title：British journal of cancer

authors： Rochlitz CF,Heide I,de Kant E,Neubauer A,Schmidt CA,Neuhaus P,Huhn D,Herrmann R

更新日期：1993-09-01 00:00:00

abstract：:DNA flow cytometry was performed on formalin fixed, paraffin embedded melanocytic naevi. DNA aneuploidy was detected in all three types of naevus but was significantly more frequent in those naevi accepted as precursors of malignancy: that is, dysplastic and congenital pigmented hairy naevi. It may be that the presenc...

journal_title：British journal of cancer

authors： Newton JA,Camplejohn RS,McGibbon DH

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC). METHODS:Here, we examined a possible prognostic value of FHL2 in CRC. Immunohistoche...

journal_title：British journal of cancer

authors： Verset L,Tommelein J,Moles Lopez X,Decaestecker C,Mareel M,Bracke M,Salmon I,De Wever O,Demetter P

更新日期：2013-07-09 00:00:00

abstract：:Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs,...

journal_title：British journal of cancer

authors： Volm M,Koomägi R,Mattern J,Stammler G

更新日期：1997-01-01 00:00:00

abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...

journal_title：British journal of cancer

authors： Robinson D,Møller H,Horwich A

更新日期：2007-02-12 00:00:00

abstract：:The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptor...

journal_title：British journal of cancer

authors： Sainsbury JR,Nicholson S,Angus B,Farndon JR,Malcolm AJ,Harris AL

更新日期：1988-10-01 00:00:00

abstract：:This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...

journal_title：British journal of cancer

authors： Couteau C,Chouaki N,Leyvraz S,Oulid-Aissa D,Lebecq A,Domenge C,Groult V,Bordessoule S,Janot F,De Forni M,Armand JP

更新日期：1999-10-01 00:00:00

abstract：:Pleural effusion fluid obtained from eleven patients with metastatic spread to the pleura was screened for the ability to cause the dispersal--'scattering'--of MDCK colonies in vitro. Four of these samples proved to be positive using this assay. Of these two had titres high enough to warrant further purification on a ...

journal_title：British journal of cancer

authors： Kenworthy P,Dowrick P,Baillie-Johnson H,McCann B,Tsubouchi H,Arakaki N,Daikuhara Y,Warn RM

更新日期：1992-08-01 00:00:00

abstract：:Pancreatic cancer is a highly lethal malignancy with a dismal 5-year survival of less than 5%. The scarcity of early biomarkers has considerably hindered our ability to launch preventive measures for this malignancy in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was repor...

journal_title：British journal of cancer

authors： Moniaux N,Chakraborty S,Yalniz M,Gonzalez J,Shostrom VK,Standop J,Lele SM,Ouellette M,Pour PM,Sasson AR,Brand RE,Hollingsworth MA,Jain M,Batra SK

更新日期：2008-05-06 00:00:00

abstract：:The tissue-specific translation elongation factor eEF1A2 is a potential oncogene that is overexpressed in human ovarian cancer. eEF1A2 is highly similar (98%) to the near-ubiquitously expressed eEF1A1 (formerly known as EF1-alpha) making analysis with commercial antibodies difficult. We wanted to establish the express...

journal_title：British journal of cancer

authors： Tomlinson VA,Newbery HJ,Bergmann JH,Boyd J,Scott D,Wray NR,Sellar GC,Gabra H,Graham A,Williams AR,Abbott CM

更新日期：2007-05-21 00:00:00