Lessons to Europe from China for cancer treatment during the COVID-19 pandemic.

abstract：BACKGROUND:For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS:The pCR individuals who received different ACT cycles were paired by propensity ...

journal_title：British journal of cancer

authors： He F,Ju HQ,Ding Y,Jiang Z,Li Z,Huang B,Wang X,Zhao Y,Li Y,Qi B,Luo W,Zhang Z,Pei Q,Chen H,Liu S,Pang X,Zheng J,Wang J,Ajani JA,Wan XB

更新日期：2020-10-01 00:00:00

abstract：:Proton pump inhibitor (PPI) use leads to hypergastrinaemia, which has been associated with gastrointestinal neoplasia. We evaluated the association between PPI use and risk of gastric cancer using population-based health-care registers in North Jutland, Denmark, during 1990-2003. We compared incidence rates among new ...

journal_title：British journal of cancer

authors： Poulsen AH,Christensen S,McLaughlin JK,Thomsen RW,Sørensen HT,Olsen JH,Friis S

更新日期：2009-05-05 00:00:00

abstract：:Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies. Survivin has four known alternative splice forms (Survivin, Survivin-2B, Survivin-deltaEx3, and Survivin-3B), and the recent literature suggests that these splice variants have unique functions and subcellular localisatio...

journal_title：British journal of cancer

authors： Fangusaro JR,Jiang Y,Holloway MP,Caldas H,Singh V,Boué DR,Hayes J,Altura RA

更新日期：2005-01-31 00:00:00

abstract：:The expression of peroxisome proliferator-activated receptor (PPAR)gamma in thyroid neoplasias and in normal thyroid (NT) tissues has not been fully investigated. The objectives of the present work were: to study and compare the relative expression of PPARgamma in normal, benign and malignant thyroid tissues and to co...

journal_title：British journal of cancer

authors： Marques AR,Espadinha C,Frias MJ,Roque L,Catarino AL,Sobrinho LG,Leite V

更新日期：2004-08-16 00:00:00

abstract：BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...

journal_title：British journal of cancer

authors： Kantelinen J,Kansikas M,Korhonen MK,Ollila S,Heinimann K,Kariola R,Nyström M

更新日期：2010-03-16 00:00:00

abstract：PURPOSE:To determine the feasibility of induction chemotherapy and chemo-IMRT in head and neck squamous cell cancers at risk of bilateral nodal spread (midline tumours) and to evaluate whether bilateral superficial lobe parotid-sparing IMRT can reduce the incidence of ⩾G2 subjective xerostomia. METHODS:Patients with m...

journal_title：British journal of cancer

authors： Miah AB,Schick U,Bhide SA,Guerrero-Urbano MT,Clark CH,Bidmead AM,Bodla S,Del Rosario L,Thway K,Wilson P,Newbold KL,Harrington KJ,Nutting CM

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Oestrogen (E2) induces apoptosis in long-term E2-deprived MCF7 cells (MCF7:5C). Taxanes have been used extensively in the treatment of early and advanced breast cancer. We have interrogated the sequence of events that involve the apoptotic signalling pathway induced by E2 in comparison with paclitaxel. METH...

journal_title：British journal of cancer

authors： Obiorah I,Sengupta S,Fan P,Jordan VC

更新日期：2014-03-18 00:00:00

abstract：:Forty-one human tumour cell lines were examined for the production of epidermal growth factor (EGF)/transforming growth factor (TGF)-alpha-like activity (EGF/TGF-alpha-LA), immunoreactive (IR-) EGF and IR-TGF-alpha. EGF/TGF-alpha-LA was determined by radioreceptor assay, in which the factors with capacity to bind to E...

journal_title：British journal of cancer

authors： Imanishi K,Yamaguchi K,Suzuki M,Honda S,Yanaihara N,Abe K

更新日期：1989-05-01 00:00:00

abstract：:We have investigated both the effects of X-rays on angiogenesis and the possible role of nitric oxide (NO) on the observed antiangiogenic effect of X-rays, using as an in vivo model the chick embryo chorioallantoic membrane (CAM). These effects were assessed both morphologically and biochemically, by measuring vascula...

journal_title：British journal of cancer

authors： Hatjikondi O,Ravazoula P,Kardamakis D,Dimopoulos J,Papaioannou S

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC who had...

journal_title：British journal of cancer

authors： Cunningham D,Wong RP,D'Haens G,Douillard JY,Robertson J,Stone AM,Van Cutsem E,HORIZON I study group.

更新日期：2013-02-19 00:00:00

abstract：:Rhizoxin is a tubulin-binding anti-neoplastic agent which is active in a range of murine tumour models. The recommended schedule, of intravenous (i.v.) bolus administration at a dose of 2 mg m-2 every 3 weeks, has been assessed in three phase II trials of ovarian, renal and colorectal cancer. In general terms the drug...

journal_title：British journal of cancer

authors： Kerr DJ,Rustin GJ,Kaye SB,Selby P,Bleehen NM,Harper P,Brampton MH

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:We studied the biological significance of genes involved in a novel t(8;12)(p21.3;p13.31) reciprocal translocation identified in cervical squamous cell carcinoma (SCC) cells. METHODS:The rearranged genes were identified by breakpoint mapping, long-range PCR and sequencing. We investigated gene expression in...

journal_title：British journal of cancer

authors： Carter SA,Foster NA,Scarpini CG,Chattopadhyay A,Pett MR,Roberts I,Coleman N

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:Most lung cancer patients are diagnosed at an advanced disease stage and predominantly receive palliative treatment, which increasingly consists of several chemotherapy lines. We report on patients' quality of life (QOL) to gain knowledge on QOL during and across multiple lines of chemotherapy. This includes...

journal_title：British journal of cancer

authors： Wintner LM,Giesinger JM,Zabernigg A,Sztankay M,Meraner V,Pall G,Hilbe W,Holzner B

更新日期：2013-10-29 00:00:00

abstract：:Over a 10 year period, between 1974-1984, 257 adult cases of tissue sarcoma have been evaluated in the Department of Medical Oncology, Christie Hospital, Manchester. At registration locally advanced or metastatic diseases was present in 162 (63%). The male/female ratio was 1.5:1 and median age 54 years (range 14-85). ...

journal_title：British journal of cancer

authors： Bramwell VH,Crowther D,Deakin DP,Swindell R,Harris M

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:First Spanish trial of Ewing sarcoma (ES) including adults and children with the aim to test the efficacy of Gemcitabine and Docetaxel (G/D) in newly diagnosed high-risk (HR) patients. METHODS:This was a prospective, multicentric, non-randomised, open study for patients ⩽40 years with newly diagnosed ES. HR...

journal_title：British journal of cancer

authors： Mora J,Castañeda A,Perez-Jaume S,Lopez-Pousa A,Maradiegue E,Valverde C,Martin-Broto J,Garcia Del Muro X,Cruz O,Cruz J,Martinez-Trufero J,Maurel J,Vaz MA,de Alava E,de Torres C

更新日期：2017-09-05 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted at low levels by normal luminal epithelial cells of the prostate and in significantly higher levels by prostate cancer cells. Therefore, PSA is a potential target for various immunotherapeutical approaches against prostate cancer. DNA vaccination has been i...

journal_title：British journal of cancer

authors： Pavlenko M,Roos AK,Lundqvist A,Palmborg A,Miller AM,Ozenci V,Bergman B,Egevad L,Hellström M,Kiessling R,Masucci G,Wersäll P,Nilsson S,Pisa P

更新日期：2004-08-16 00:00:00

abstract：:Nineteen benign human breast tumours, from 19 premenopausal patients, were processed into slices and each tumour was individually cultured for 2 days in Medium 199. The effects of bovine insulin (5.0 microgram/ml) human placental lactogen (10.0 microgram/ml) and human growth hormone (10.0 microgram/ml) on 3H-thymidine...

journal_title：British journal of cancer

authors： Welsch CW,Dombroske SE,McManus MJ

更新日期：1978-08-01 00:00:00

abstract：:The antiapoptotic Livin/ML-IAP gene has recently gained much attention as a potential new target for cancer therapy. Reports indicating that livin is expressed almost exclusively in tumours, but not in the corresponding normal tissue, suggested that the targeted inhibition of livin may present a novel tumour-specific ...

journal_title：British journal of cancer

authors： Wagener N,Crnković-Mertens I,Vetter C,Macher-Göppinger S,Bedke J,Gröne EF,Zentgraf H,Pritsch M,Hoppe-Seyler K,Buse S,Haferkamp A,Autschbach F,Hohenfellner M,Hoppe-Seyler F

更新日期：2007-11-05 00:00:00

abstract：:NAD(P)H:quinone oxidoreductase (NQO1, EC 1.6.99.2) is an obligate two-electron reductase that can either bioactivate or detoxify quinones and has been proposed to play an important role in chemoprevention. We have previously characterized a homozygous point mutation in the BE human colon carcinoma cell line that leads...

journal_title：British journal of cancer

authors： Traver RD,Siegel D,Beall HD,Phillips RM,Gibson NW,Franklin WA,Ross D

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...

journal_title：British journal of cancer

authors： De Silva N,Schulz L,Paterson A,Qain W,Secrier M,Godfrey E,Cheow H,O'Donovan M,Lao-Sirieix P,Jobanputra M,Hochhauser D,Fitzgerald R,Ford H

更新日期：2015-11-03 00:00:00

abstract：:Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very li...

journal_title：British journal of cancer

authors： Takagi Y,Osada H,Kuroishi T,Mitsudomi T,Kondo M,Niimi T,Saji S,Gazdar AF,Takahashi T,Minna JD,Takahashi T

更新日期：1998-05-01 00:00:00

abstract：:BNP7787 (disodium 2,2'-dithio-bis-ethane sulphonate; Tavocept) is a novel agent developed to protect against cisplatin (cis-diammine-dichloroplatinum(II))-associated chronic toxicities. In this study, we determined the recommended dose of BNP7787 when preceding a fixed dose of cisplatin, the pharmacokinetics (PKs) and...

journal_title：British journal of cancer

authors： Boven E,Westerman M,van Groeningen CJ,Verschraagen M,Ruijter R,Zegers I,van der Vijgh WJ,Giaccone G

更新日期：2005-05-09 00:00:00

abstract：:Reports are available on the studies of the cell cycle of several normal cell populations and of neoplastic effusions in man and experimental animals in vitro and in vivo at various stages of the growth. In the present work the cell cycle of 5 solid human tumours in vitro and the duration of their various intermitotic...

journal_title：British journal of cancer

authors： Kucheria K

更新日期：1970-06-01 00:00:00

abstract：:Patients with refractory metastatic renal cell carcinoma (RCC) were enrolled in a phase II study with teniposide (VM26) and cyclosporin A (CSA) to investigate (1) the effect of CSA on the response rate to VM26; and (2) the effect of CSA on the pharmacokinetics and pharmacodynamics of VM26. Sixteen patients initially r...

journal_title：British journal of cancer

authors： Toffoli G,Sorio R,Gigante M,Corona G,Galligioni E,Boiocchi M

更新日期：1997-01-01 00:00:00

abstract：:Pancreatic cancer is a highly lethal malignancy with a dismal 5-year survival of less than 5%. The scarcity of early biomarkers has considerably hindered our ability to launch preventive measures for this malignancy in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was repor...

journal_title：British journal of cancer

authors： Moniaux N,Chakraborty S,Yalniz M,Gonzalez J,Shostrom VK,Standop J,Lele SM,Ouellette M,Pour PM,Sasson AR,Brand RE,Hollingsworth MA,Jain M,Batra SK

更新日期：2008-05-06 00:00:00

abstract：:The aim of the study was to evaluate efficacy and tolerance of epirubicin and gemcitabine as first-line chemotherapy in patients with advanced non-small-cell lung cancer. A phase I study was performed with the combination of escalating doses of epirubicin intravenously on day 1 and a fixed dose of gemcitabine on days ...

journal_title：British journal of cancer

authors： van Putten JW,Eppinga P,Erjavec Z,de Leede G,Nabers J,Smeets JB,Th Sleijfer D,Groen HJ

更新日期：2000-02-01 00:00:00

abstract：:The relationship between hepatic arterial albumin microsphere distribution and hepatic arterial blood flow and the effects of regional angiotensin II were studied in a rat liver metastases model. Hooded-Lister rats were inoculated subcapsularly with 2 x 10(6) HSN sarcoma cells. At 20 days, hepatic arterial blood flow ...

journal_title：British journal of cancer

authors： Anderson JH,Angerson WJ,Willmott N,Kerr DJ,McArdle CS,Cooke TG

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:We previously showed that activation of the nuclear factor of activated T cells (NFAT)1/Fas ligand (FasL) pathway induces glioma cell death. Lithium (Li) is an inhibitor of glycogen synthase kinase (GSK)-3 that activates NFAT1/FasL signalling. Temozolomide (TMZ) inhibits GSK-3 and activates Fas in tumour pro...

journal_title：British journal of cancer

authors： Han S,Meng L,Jiang Y,Cheng W,Tie X,Xia J,Wu A

更新日期：2017-05-09 00:00:00

abstract：:Laminin-332 is major component of epithelial basement membrane, and has an important role in cell migration and tumour invasion. Recently, the phosphatidylinositol 3-kinase (PI3K) activation induced by laminin-332 during carcinogenesis or tumour invasion has been highlighted in skin squamous cell carcinoma. The expres...

journal_title：British journal of cancer

authors： Baba Y,Iyama KI,Hirashima K,Nagai Y,Yoshida N,Hayashi N,Miyanari N,Baba H

更新日期：2008-03-11 00:00:00

abstract：BACKGROUND:Erythropoietin-stimulating agents (ESAs) effectively decrease the transfusion requirements of patients with chemotherapy-induced anaemia (CIA). Recent studies indicate that ESAs increase mortality and accelerate tumour progression. The studies also identify a 1.6-fold increased risk of venous thromboembolism...

journal_title：British journal of cancer

authors： Fujisaka Y,Sugiyama T,Saito H,Nagase S,Kudoh S,Endo M,Sakai H,Ohashi Y,Saijo N

更新日期：2011-10-25 00:00:00