Abstract：
:Proton pump inhibitor (PPI) use leads to hypergastrinaemia, which has been associated with gastrointestinal neoplasia. We evaluated the association between PPI use and risk of gastric cancer using population-based health-care registers in North Jutland, Denmark, during 1990-2003. We compared incidence rates among new users of PPI (n=18,790) or histamine-2-antagonists (H2RAs) (n=17,478) and non-users of either drug. Poisson regression analysis was used to estimate incidence rate ratios (IRRs) adjusted for multiple confounders. We incorporated a 1-year lag time to address potential reverse causation. We identified 109 gastric cancer cases among PPI users and 52 cases among H2RA users. After incorporating the 1-year lag time, we observed IRRs for gastric cancer of 1.2 (95% CI: 0.8-2.0) among PPI users and 1.2 (95% CI: 0.8-1.8) among H2RA users compared with non-users. These estimates are in contrast to significant overall IRRs of 9.0 and 2.8, respectively, without the lag time. In lag time analyses, increased IRRs were observed among PPI users with the largest number of prescriptions or the longest follow-up compared with H2RA users or non-users. Although our results point to a major influence of reverse causation and confounding by indication on the association between PPI use and gastric cancer incidence, the finding of increased incidence among PPI users with most prescriptions and longest follow-up warrants further investigation.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Poulsen AH,Christensen S,McLaughlin JK,Thomsen RW,Sørensen HT,Olsen JH,Friis Sdoi
10.1038/sj.bjc.6605024subject
Has Abstractpub_date
2009-05-05 00:00:00pages
1503-7issue
9eissn
0007-0920issn
1532-1827pii
6605024journal_volume
100pub_type
杂志文章abstract：BACKGROUND:Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observatio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.637
更新日期：2013-11-12 00:00:00
abstract：:In oncology, prognostic markers are clinical measures used to help elicit an individual patient's risk of a future outcome, such as recurrence of disease after primary treatment. They thus facilitate individual treatment choice and aid in patient counselling. Evidence-based results regarding prognostic markers are the...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6604999
更新日期：2009-04-21 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690242
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0910-y
更新日期：2020-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604726
更新日期：2008-11-18 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-10-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603954
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604749
更新日期：2008-11-18 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605397
更新日期：2009-12-03 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.102
更新日期：1985-05-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603471
更新日期：2006-12-04 00:00:00
abstract：:We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960-1996 before they reached the age of 20 and compared them with 53 143 sex- and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic info...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602085
更新日期：2004-08-31 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2013.282
更新日期：2013-07-09 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604028
更新日期：2007-11-05 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0805-y
更新日期：2020-05-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.185
更新日期：2012-06-05 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601988
更新日期：2004-08-16 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.508
更新日期：1995-11-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602690
更新日期：2005-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.283
更新日期：1991-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601218
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doi：10.1038/sj.bjc.6602961
更新日期：2006-02-27 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690494
更新日期：1999-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.389
更新日期：1992-11-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.137
更新日期：1982-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605236
更新日期：2009-09-15 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.174
更新日期：1980-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604258
更新日期：2008-04-22 00:00:00
abstract：:Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpre...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605983
更新日期：2011-01-04 00:00:00
abstract：:Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604010
更新日期：2007-10-22 00:00:00
