Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial.

abstract：BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospi...

journal_title：British journal of cancer

authors： Batty GD,Whitley E,Gale CR,Osborn D,Tynelius P,Rasmussen F

更新日期：2012-05-22 00:00:00

abstract：:Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that ...

journal_title：British journal of cancer

authors： Leach MO,Brindle KM,Evelhoch JL,Griffiths JR,Horsman MR,Jackson A,Jayson GC,Judson IR,Knopp MV,Maxwell RJ,McIntyre D,Padhani AR,Price P,Rathbone R,Rustin GJ,Tofts PS,Tozer GM,Vennart W,Waterton JC,Williams SR,Work

更新日期：2005-05-09 00:00:00

abstract：:A human tamoxifen-resistant mammary carcinoma, MaCa 3366/TAM, originating from a sensitive parental xenograft 3366 was successfully established by treatment of tumour-bearing nude mice with 1-50 mg kg(-1) tamoxifen for 3 years during routine passaging. Both tumours did not differ significantly in OR- and PR-positivity...

journal_title：British journal of cancer

authors： Naundorf H,Becker M,Lykkesfeldt AE,Elbe B,Neumann C,Büttner B,Fichtner I

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:To evaluate the prognostic value of lymph node density (LND) in patients with lymph node-positive cervical cancer. METHODS:A total of 88 consecutive patients were included in our study. Patients were treated with cisplatin-based concomitant chemoradiotherapy after surgical staging was performed at the Medic...

journal_title：British journal of cancer

authors： Polterauer S,Hefler L,Seebacher V,Rahhal J,Tempfer C,Horvat R,Reinthaller A,Grimm C

更新日期：2010-08-24 00:00:00

abstract：:Squamous carcinoma of the oropharynx presents with symptoms common to many benign diseases, and this can cause delay in referral to secondary care. We investigate delay in referral, defining this as the time from symptom-onset to date of general practitioners referral letter to secondary care, and the effect of that d...

journal_title：British journal of cancer

authors： Pitchers M,Martin C

更新日期：2006-04-10 00:00:00

abstract：:Testicular germ cell tumour (GCT) is not an AIDS-defining illness despite an increased incidence in men with HIV infection. We performed a matched case-control study comparing outcomes in HIV-positive men and the general population with GCT, using three age and stage matched controls for each case. There was no differ...

journal_title：British journal of cancer

authors： Powles T,Bower M,Shamash J,Stebbing J,Ong J,Daugaard G,De Ruiter A,Johnson M,Fisher M,Anderson J,Nelson M,Gazzard B,Oliver T

更新日期：2004-04-19 00:00:00

abstract：:Thymidine incorporation in vitro by remission lymphocytes from a total of 6 patients with acute myeloid leukaemia (AML) was measured following stimulation by autochthonous and allogeneic AML blasts and cell lines. The early peak response to autochthonous blasts in 2 of these patients (48-72 h) is consistent with the c...

journal_title：British journal of cancer

authors： Taylor GM,Freeman CB,Harris R

更新日期：1976-05-01 00:00:00

abstract：:Accumulation of mutations in tumour suppressor genes and oncogenes has been proposed to underlie the initiation and progression of sporadic colorectal cancer (CRC). Evidence is accumulating to suggest that the caudal homeobox gene CDX2 is implicated in the pathogenesis of CRC. The CDX2 transcription factor is expresse...

journal_title：British journal of cancer

authors： Sivagnanasundaram S,Islam I,Talbot I,Drummond F,Walters JR,Edwards YH

更新日期：2001-01-01 00:00:00

abstract：:Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant human prostate carcinoma cells. To investigate further the function o...

journal_title：British journal of cancer

authors： Ranganathan S,McCauley RA,Dexter DW,Hudes GR

更新日期：2001-09-01 00:00:00

abstract：:Urethane was found to be uniformly distributed in all the major organs of foetal, young and adult ICR/Jcl mice and then to disappear rapidly as measured by the incorporation of urethane-carbonyl-14C, thus permitting the accurate comparison of tumour susceptibility of cells in various organs of mice at different ages. ...

journal_title：British journal of cancer

authors： Nomura T

更新日期：1976-05-01 00:00:00

abstract：:We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, partic...

journal_title：British journal of cancer

authors： Gunnell D,Oliver SE,Peters TJ,Donovan JL,Persad R,Maynard M,Gillatt D,Pearce A,Hamdy FC,Neal DE,Holly JM

更新日期：2003-06-02 00:00:00

abstract：:Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...

journal_title：British journal of cancer

authors： Bridgewater J,van Laar R,Floore A,Van'T Veer L

更新日期：2008-04-22 00:00:00

abstract：:Although it is generally accepted that proteolytic degradation is an important mechanism used by malignant cells in the process of metastasis, comparatively little is known about the regulation of molecules responsible for proteolysis and how they become de-regulated during human tumour progression. Using a geneticall...

journal_title：British journal of cancer

authors： MacDougall JR,Bani MR,Lin Y,Muschel RJ,Kerbel RS

更新日期：1999-05-01 00:00:00

abstract：:Telomerase is a specialized ribonucleoprotein polymerase that directs the synthesis of telomerase repeats at chromosome ends. Accumulating evidence has indicated that telomerase is stringently repressed in normal human somatic tissues but reactivated in cancers and immortal cells, suggesting that activation of telomer...

journal_title：British journal of cancer

authors： Cheng AJ,Lin JD,Chang T,Wang TC

更新日期：1998-06-01 00:00:00

abstract：:Electron spin resonance (ESR) spectroscopy was used to examine changes in the concentration of paramagnetic metal ions in Yoshida tumours carried by female Wistar rats. Blood, spleen and lymph nodes from these animals were also examined by ESR. A decrease in the concentration of a paramagnetic species associated with ...

journal_title：British journal of cancer

authors： Dodd NJ,Silcock JM

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the safety of neoadjuvant chemoradiation using radiotherapy (RT) combined with concurrent capecitabine and irinotecan for locally advanced rectal cancer before surgery. METHODS:Forty-six patients were recruited and treated on the basis that MRI scanning had shown poo...

journal_title：British journal of cancer

authors： Gollins SW,Myint S,Susnerwala S,Haylock B,Wise M,Topham C,Samuel L,Swindell R,Morris J,Mason L,Levine E

更新日期：2009-09-15 00:00:00

abstract：:Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 solub...

journal_title：British journal of cancer

authors： Iqbal MJ,Colletta AA,Houmayoun-Valyani SD,Baum M

更新日期：1986-09-01 00:00:00

abstract：:Accuracy in the assessment of performance status by oncologists has not been well evaluated. We investigated possible discrepancies in the assessment of performance status among patients, nurses, and oncologists, and evaluated the prognostic importance of each assessment. Two hundred and six inpatients with inoperable...

journal_title：British journal of cancer

authors： Ando M,Ando Y,Hasegawa Y,Shimokata K,Minami H,Wakai K,Ohno Y,Sakai S

更新日期：2001-11-30 00:00:00

abstract：:Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-kappaB (NF-kappaB). Both iNOS activation and radioresponse were impaired by the NF-kappaB inhibitors phenylarsin...

journal_title：British journal of cancer

authors： De Ridder M,Van den Berge DL,Verovski VN,Monsaert C,Wauters N,Storme GA

更新日期：2003-01-13 00:00:00

abstract：:In locally advanced undifferentiated nasopharyngeal carcinoma (UNPC), concomitant chemo-radiotherapy is the only strategy that gave better results over radiation alone in a phase III trial. Adding effective chemotherapy to a concomitant chemo-radiotherapy programme may be a way to improve the results further. 30 patie...

journal_title：British journal of cancer

authors： Benasso M,Sanguineti G,D'Amico M,Corvò R,Ricci I,Numico G,Guarneri D,Vitale V,Pallestrini E,Santelli A,Rosso R

更新日期：2000-12-01 00:00:00

abstract：:Expression of the 37-kDa laminin binding protein (37LBP/p40), a precursor of the 67-kDa laminin receptor, is well-correlated with the biological aggressiveness of cancer cells. To elucidate the direct role played by 37LBP/p40 in cancer cells, a murine lung cancer cell line T11, the 37LBP/p40 expression of which was re...

journal_title：British journal of cancer

authors： Satoh K,Narumi K,Abe T,Sakai T,Kikuchi T,Tanaka M,Shimo-Oka T,Uchida M,Tezuka F,Isemura M,Nukiwa T

更新日期：1999-06-01 00:00:00

abstract：:The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...

journal_title：British journal of cancer

authors： Olsson H,Bladström A,Ingvar C,Möller TR

更新日期：2001-09-01 00:00:00

abstract：:Activation of Met by its ligand HGF has been shown to elicit both mitogenic and motogenic responses in thyrocytes in vitro. In the present study we have investigated the expression of Met in human anaplastic thyroid carcinoma cells in culture. There was a variation in expression level and size of Met in the different ...

journal_title：British journal of cancer

authors： Bergström JD,Hermansson A,Diaz de Ståhl T,Heldin NE

更新日期：1999-05-01 00:00:00

abstract：:Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...

journal_title：British journal of cancer

authors： Costa-Pereira AP,Cotter TG

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironm...

journal_title：British journal of cancer

authors： Basanta D,Scott JG,Fishman MN,Ayala G,Hayward SW,Anderson AR

更新日期：2012-01-03 00:00:00

abstract：:There is increasing evidence that essential fatty acids (EFA) may have a role to play in the aetiology of some types of cancer although their precise mode of action is unknown. Differences in the metabolism of EFA between patients with benign or malignant prostatic disease may help to elucidate their role in the latte...

journal_title：British journal of cancer

authors： Chaudry A,McClinton S,Moffat LE,Wahle KW

更新日期：1991-12-01 00:00:00

abstract：:The aim of this study was to investigate the expression of the protein tyrosine phosphatases (PTP) PRL-1, PRL-2, and PRL-3 in human breast cancer and to evaluate its clinical and prognostic significance. PRL-PTP mRNA expression was examined in malignant (n = 7) and nonmalignant (n = 7) cryoconserved breast tissue samp...

journal_title：British journal of cancer

authors： Radke I,Götte M,Kersting C,Mattsson B,Kiesel L,Wülfing P

更新日期：2006-08-07 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in...

journal_title：British journal of cancer

authors： Surakhy M,Wallace M,Bond E,Grochola LF,Perez H,Di Giovannantonio M,Zhang P,Malkin D,Carter H,Parise IZS,Zambetti G,Komechen H,Paraizo MM,Pagadala MS,Pinto EM,Lalli E,Figueiredo BC,Bond GL

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...

journal_title：British journal of cancer

authors： Pogoda JM,Nichols PW,Ross RK,Stram DO,Thomas DC,Preston-Martin S

更新日期：2011-04-26 00:00:00

abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...

journal_title：British journal of cancer

authors： Hardell L,Sandström A

更新日期：1979-06-01 00:00:00