Prognostic value of performance status assessed by patients themselves, nurses, and oncologists in advanced non-small cell lung cancer.

Abstract:

:Accuracy in the assessment of performance status by oncologists has not been well evaluated. We investigated possible discrepancies in the assessment of performance status among patients, nurses, and oncologists, and evaluated the prognostic importance of each assessment. Two hundred and six inpatients with inoperable, advanced non-small cell lung cancer were investigated prospectively. Weighted Kappa statistics for inter-observer agreement were 0.53 between oncologists and patients and 0.63 between oncologists and nurses. There was a significant difference among the assessments by the three groups (P < 0.001). Oncologists gave the healthiest performance status assessment, nurses an intermediate assessment, and patients the poorest. When included separately in the Cox model, the assessment by each group was significantly correlated with survival. However, the assessment by the patients themselves failed to distinguish survival of patients with performance status 1 and 2. Among the three models including patient-, nurse-, and oncologist-assessed PS, that including oncologist-assessed PS best fitted to the observed survival data. These results showed that the assessment by the patients themselves is different from those by the nurses and the oncologists and provided additional support for the use of the assessment by oncologists in clinical oncology.

journal_name

Br J Cancer

authors

Ando M,Ando Y,Hasegawa Y,Shimokata K,Minami H,Wakai K,Ohno Y,Sakai S

doi

10.1054/bjoc.2001.2162

subject

Has Abstract

pub_date

2001-11-30 00:00:00

pages

1634-9

issue

11

eissn

0007-0920

issn

1532-1827

pii

S0007092001921627

journal_volume

85

pub_type

杂志文章
  • Metabolism of the broad-spectrum neuropeptide growth factor antagonist: [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P.

    abstract::Broad-spectrum neuropeptide growth factor antagonists, such as [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P (antagonist D) and [Arg6, D-Trp7,9, NmePhe8]substance P(6-11) (antagonist G), are currently being investigated as possible anti-tumour agents. These compounds are hoped to be effective against neuropeptide-drive...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.126

    authors: Jones DA,Cummings J,Langdon SP,Maclellan AJ,Higgins T,Rozengurt E,Smyth JF

    更新日期:1996-03-01 00:00:00

  • International consensus guidelines for scoring the histopathological growth patterns of liver metastasis.

    abstract:BACKGROUND:Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,实务指引

    doi:10.1038/bjc.2017.334

    authors: van Dam PJ,van der Stok EP,Teuwen LA,Van den Eynden GG,Illemann M,Frentzas S,Majeed AW,Eefsen RL,Coebergh van den Braak RRJ,Lazaris A,Fernandez MC,Galjart B,Laerum OD,Rayes R,Grünhagen DJ,Van de Paer M,Sucaet Y,Mudhar H

    更新日期:2017-11-07 00:00:00

  • The induction of rat bladder cancer by 2-naphthylamine.

    abstract::The widely held belief that 2-naphthylamine is not carcinogenic for the rat has been re-examined. Twenty female Wistar rats were dosed by gastric intubation weekly for 57 weeks with 2-naphthylamine, 300 mg/kg body wt, in arachis oil and 20 controls were given arachis oil alone. Animals which became moribund were kille...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1982.250

    authors: Hicks RM,Wright R,Wakefield JS

    更新日期:1982-10-01 00:00:00

  • Progression and survival in prostatic adenocarcinoma: a comparison of clinical stage, Gleason grade, S-phase fraction and DNA ploidy.

    abstract::Clinical data were reviewed in 325 patients with prostatic adenocarcinoma followed up for a mean of 13 years. Paraffin-embedded tumour biopsy specimens from the primary tumours were available for flow cytometry (FCM) in 273 cases. Intra-tumour heterogeneity in DNA index (DI) was found in 4% of the tumours (54 cases we...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1994.298

    authors: Vesalainen S,Nordling S,Lipponen P,Talja M,Syrjänen K

    更新日期:1994-08-01 00:00:00

  • Downregulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma.

    abstract::Because the focus of nasopharyngeal carcinoma (NPC) is very close to intracranial organs, it often makes incursions into cranial cavity. Identification of intracranial invasion-associated indicators will provide potential therapeutic targets for NPC patients with intracranial invasion. In this regard, Human Xpro HC-pl...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6604167

    authors: Liu SJ,Sun YM,Tian DF,He YC,Zeng L,He Y,Ling CQ,Sun SH

    更新日期:2008-01-29 00:00:00

  • Detailed cytogenetic study of a metastatic bronchial carcinoma.

    abstract::Karyotyping and marker analysis of G- and C-banded metaphases from a metastatic bronchial carcinoma revealed a dominant stemline with five markers and four sidelines with additional markers. One to three minute bodies were noted in the majority of cells and these were classified as markers. On the basis of this analys...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1976.162

    authors: Pickthall VJ

    更新日期:1976-09-01 00:00:00

  • A human testicular teratoma serially transplanted in immune-deprived mice.

    abstract::Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1979.104

    authors: Selby PJ,Heyderman E,Gibbs J,Peckham MJ

    更新日期:1979-05-01 00:00:00

  • Relationship between physician and patient assessment of performance status and survival in a large cohort of patients with haematologic malignancies.

    abstract:BACKGROUND:Few studies have investigated the relationship between physician and patient-assessed performance status (PS) in blood cancers. METHODS:Retrospective analysis among 1418 patients with haematologic malignancies seen at Dana-Farber Cancer Institute between 2007 and 2014. We analysed physician-patient agreemen...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2016.260

    authors: Liu MA,Hshieh T,Condron N,Wadleigh M,Abel GA,Driver JA

    更新日期:2016-09-27 00:00:00

  • The effects of transdermal and oral oestrogen replacement therapy on colorectal cancer risk in postmenopausal women.

    abstract::The aim of this study was to examine the effects of oral and transdermal oestrogen replacement therapy on the risk of colorectal cancer. Data from a nested case-control study, designed to investigate the effect of hormone replacement therapy (HRT) on colorectal cancer were analysed. New cases of colorectal cancer, dia...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6601438

    authors: Csizmadi I,Collet JP,Benedetti A,Boivin JF,Hanley JA

    更新日期:2004-01-12 00:00:00

  • Vinorelbine and gemcitabine vs vinorelbine and carboplatin as first-line treatment of advanced NSCLC. A phase III randomised controlled trial by the Norwegian Lung Cancer Study Group.

    abstract:BACKGROUND:Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective and better tolerated. We conducted a national, randomised study to compare a non-platinum with a pl...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1038/bjc.2012.284

    authors: Fløtten Ø,Grønberg BH,Bremnes R,Amundsen T,Sundstrøm S,Rolke H,Hornslien K,Wentzel-Larsen T,Aasebø U,von Plessen C

    更新日期:2012-07-24 00:00:00

  • Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin.

    abstract::Photoradiation therapy of cancer in the presence of haematoporphyrin derivative is based on a retention of porphyrin in malignant tissue. After long term incubation of NHIK 3025 cells in the presence of 25 microgram ml-1 haematoporphyrin derivative, one fraction is easily removed from the cells by washing with a serum...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1983.154

    authors: Christensen T,Sandquist T,Feren K,Waksvik H,Moan J

    更新日期:1983-07-01 00:00:00

  • Costs and consequences of different chemotherapy regimens in metastatic colorectal cancer.

    abstract::An economic sub-study was run alongside a large multi-centre randomised trial (MRC-CR06) comparing three chemotherapy regimens; de Gramont, Lokich and raltitrexed in patients with metastatic colorectal cancer. Patients in six of 45 centres in the main trial were approached to take part in the sub-study. Chemotherapy d...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1038/sj.bjc.6600273

    authors: Hale JP,Cohen DR,Maughan TS,Stephens RJ

    更新日期:2002-06-05 00:00:00

  • In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product.

    abstract::The c-erbB-2 product is thought to be a unique and useful target for antibody therapy of cancers overexpressing the c-erbB-2 gene. In vitro and in vivo anti-tumour effects of a humanised antibody against the extracellular domain of the c-erbB-2 gene product, rhu4D5, were examined. Rhu4D5 was less effective than its mu...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.259

    authors: Tokuda Y,Ohnishi Y,Shimamura K,Iwasawa M,Yoshimura M,Ueyama Y,Tamaoki N,Tajima T,Mitomi T

    更新日期:1996-06-01 00:00:00

  • Impact of non-axillary sentinel node biopsy on staging and treatment of breast cancer patients.

    abstract::The purpose of this study was to evaluate the occurrence of lymphatic drainage to non-axillary sentinel nodes and to determine the implications of this phenomenon. A total of 549 breast cancer patients underwent lymphoscintigraphy after intratumoural injection of (99m)Tc-nanocolloid. The sentinel node was intraoperati...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/sj.bjc.6600359

    authors: Tanis PJ,Nieweg OE,Valdés Olmos RA,Peterse JL,Rutgers EJ,Hoefnagel CA,Kroon BB

    更新日期:2002-09-23 00:00:00

  • Bone metastases in childhood renal tumours.

    abstract::Analysis of data from 1434 children with primary renal tumours revealed 57 who developed bone metastases. Of these, 54 were initially recorded as nephroblastoma. Fifty-two of the 57 cases were reviewed histologically, and only 18 were found to be Wilms' tumours. Twenty-three were classified as "Bone-Metastasizing Rena...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1980.163

    authors: Marsden HB,Lennox EL,Lawler W,Kinnier-Wilson LM

    更新日期:1980-06-01 00:00:00

  • Activity of high-dose epirubicin combined with gemcitabine in advanced non-small-cell lung cancer: a multicenter phase I and II study.

    abstract::The aim of the study was to evaluate efficacy and tolerance of epirubicin and gemcitabine as first-line chemotherapy in patients with advanced non-small-cell lung cancer. A phase I study was performed with the combination of escalating doses of epirubicin intravenously on day 1 and a fixed dose of gemcitabine on days ...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1054/bjoc.1999.1003

    authors: van Putten JW,Eppinga P,Erjavec Z,de Leede G,Nabers J,Smeets JB,Th Sleijfer D,Groen HJ

    更新日期:2000-02-01 00:00:00

  • Correction: Chromatin structure, transcriptional activity and DNA repair efficiency affect the outcome of chemotherapy in multiple myeloma.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:British journal of cancer

    pub_type: 已发布勘误

    doi:10.1038/s41416-020-0830-x

    authors: Gkotzamanidou M,Sfikakis PP,Kyrtopoulos SA,Bamia C,Dimopoulos MA,Souliotis VL

    更新日期:2020-05-01 00:00:00

  • DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?

    abstract::DT-diaphorase (DTD) is an important enzyme for the bioreductive activation of the new alkylating indoloquinone EO9. In preclinical studies, EO9 has shown selective anti-tumour activity against solid tumours and under hypoxic conditions. The levels of three reductive enzymes have been determined in three types of human...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1995.433

    authors: Smitskamp-Wilms E,Giaccone G,Pinedo HM,van der Laan BF,Peters GJ

    更新日期:1995-10-01 00:00:00

  • Cellular localisation of tumour antigen (TA-4) in normal, dysplastic and neoplastic squamous epithelia of the upper aerodigestive tract.

    abstract::We report the use of tumour antigen (TA-4) polyclonal antiserum to assess the level and pattern of TA-4 antigen expression in formalin-fixed paraffin-embedded tissue sections from 110 patients with a range of normal, dysplastic and malignant squamous epithelia from various sites in the upper aerodigestive tract. There...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1990.140

    authors: Kearsley JH,Stenzel DJ,Sculley TB,Cooke RA

    更新日期:1990-04-01 00:00:00

  • Neuromuscular toxicities of paclitaxel 210 mg m(-2) by 3-hour infusion.

    abstract::We retrospectively analysed neuromuscular toxicity associated with paclitaxel 210 mg m(-2) given by 3-h infusion in 247 patients. The severity correlated significantly with total cumulative dose, but could not be predicted by the pretreatment clinical variables or by pharmacokinetic parameters. The toxicity tended to ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1998.278

    authors: Kunitoh H,Saijo N,Furuse K,Noda K,Ogawa M

    更新日期:1998-05-01 00:00:00

  • Enzymic retrodifferentiation during hepatocarcinogenesis and liver regeneration in rats in vivo.

    abstract::The work presented here has concerned the study of early, as well as late, enzymic changes occurring during diethylnitrosamine-induced hepatocarcinogenesis and liver regeneration after partial hepatectomy in comparison with normal liver differentiation. Rank correlation analysis of the enzyme data suggested a step-wis...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1983.222

    authors: Curtin NJ,Snell K

    更新日期:1983-10-01 00:00:00

  • Circulating tumour cell-derived plastin3 is a novel marker for predicting long-term prognosis in patients with breast cancer.

    abstract:BACKGROUND:Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial-mesenchymal transition-related biomarker plastin3 (PLS3) in peripheral blood could be a prognostic factor in breast cancer. METHODS...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2015.132

    authors: Ueo H,Sugimachi K,Gorges TM,Bartkowiak K,Yokobori T,Müller V,Shinden Y,Ueda M,Ueo H,Mori M,Kuwano H,Maehara Y,Ohno S,Pantel K,Mimori K

    更新日期:2015-04-28 00:00:00

  • DNA damage and repair in tumour and non-tumour tissues of mice induced by nicotinamide.

    abstract::In vivo DNA damage and repair was induced by nicotinamide (NAM) in adenotype 12 virus-induced mouse sarcoma A12B3 and sarcoma F inoculated into CBA mice. DNA damage, NAM and NAD concentrations were measured after in vivo exposure to NAM, in tumours and spleens by alkaline elution and by HPLC analysis. Our results indi...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1996.367

    authors: Olsson AR,Sheng Y,Pero RW,Chaplin DJ,Horsman MR

    更新日期:1996-08-01 00:00:00

  • The potential application of a transcriptionally regulated oncolytic herpes simplex virus for human cancer therapy.

    abstract:BACKGROUND:Emerging studies have shown the potential benefit of arming oncolytic viruses with therapeutic genes. However, most of these therapeutic genes are placed under the regulation of ubiquitous viral promoters. Our goal is to generate a safer yet potent oncolytic herpes simplex virus type-1 (HSV-1) for cancer the...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2013.692

    authors: Miao L,Fraefel C,Sia KC,Newman JP,Mohamed-Bashir SA,Ng WH,Lam PY

    更新日期:2014-01-07 00:00:00

  • Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

    abstract:BACKGROUND:Chromosomal instability (CIN) is a common trait of cancer characterised by the continuous gain and loss of chromosomes during mitosis. Excessive levels of CIN can suppress tumour growth, providing a possible therapeutic strategy. The Mps1/TTK kinase has been one of the prime targets to explore this concept, ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-018-0081-2

    authors: Maia ARR,Linder S,Song JY,Vaarting C,Boon U,Pritchard CEJ,Velds A,Huijbers IJ,van Tellingen O,Jonkers J,Medema RH

    更新日期:2018-06-01 00:00:00

  • Long-term use of lithium and risk of colorectal adenocarcinoma: a nationwide case-control study.

    abstract:BACKGROUND:Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study. METHODS:We used the Danish Cancer Registry to identify all patients diagnosed with incident co...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2016.10

    authors: Pottegård A,Ennis ZN,Hallas J,Jensen BL,Madsen K,Friis S

    更新日期:2016-03-01 00:00:00

  • Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.

    abstract::The tumour suppressor gene p53 has been found to be mutated or inactivated at high frequency in several common human tumours. We have examined a series of exocrine pancreatic carcinomas for over-expression of mutant forms of p53 by immunohistochemistry with a panel of specific antibodies. We found immunodetectable p53...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1991.467

    authors: Barton CM,Staddon SL,Hughes CM,Hall PA,O'Sullivan C,Klöppel G,Theis B,Russell RC,Neoptolemos J,Williamson RC

    更新日期:1991-12-01 00:00:00

  • First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor.

    abstract:BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/s41416-020-0916-5

    authors: Plummer R,Dua D,Cresti N,Drew Y,Stephens P,Foegh M,Knudsen S,Sachdev P,Mistry BM,Dixit V,McGonigle S,Hall N,Matijevic M,McGrath S,Sarker D

    更新日期:2020-08-01 00:00:00

  • Immunofluorescent detection of hormone receptors in cutaneous melanocytic tumours.

    abstract::Immunofluorescent assessment of hormone receptors in melanocytic tumours is quite feasible without loss of diagnostic material, in contrast to the impracticability of quantitative biochemical assays. Using this method, oestrogen receptors were demonstrated in 4/6, and progesterone receptors in 3/5 patients with metast...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1981.95

    authors: Thompson AJ,Cook MG,Gill PG

    更新日期:1981-05-01 00:00:00

  • Electrophoretic mobility of mouse T-cell hybrids.

    abstract::The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1981.255

    authors: Bubeník J,Perlmann P,Jónsdóttir I,Kypĕnová H,Bubeníková D,Símová J

    更新日期:1981-11-01 00:00:00