Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

abstract：:In the present multicentre randomized phase II trial, the activity and toxicity of three platinum-based combination regimens for the treatment of advanced non-small-cell lung cancer (NSCLC) were evaluated. The three regimens were: MVP (mitomycin-C 6 mg m(-2) on day 1, vindesine 3 mg m(-2) on days 1 and 15, and cisplat...

journal_title：British journal of cancer

authors： Baldini E,Tibaldi C,Ardizzoni A,Salvati F,Antilli A,Portalone L,Barbera S,Romano F,De Marinis F,Migliorino MR,Noseda MA,Borghini U,Crippa M,Ferrara G,Raimondi M,Fioretti M,Bandera M,Pennucci MC,Galeasso G,Cacciani G

更新日期：1998-06-01 00:00:00

abstract：:Eighty-nine fresh tissue samples from flat colonic mucosa, polypoid lesions, macroscopically evident carcinomas, and metastatic carcinomas from ten patients with longstanding ulcerative colitis (greater than or equal to 8 years duration) were analysed by DNA flow cytometry and light microscopy. Of a total of ten carci...

journal_title：British journal of cancer

authors： Meling GI,Clausen OP,Bergan A,Schjølberg A,Rognum TO

更新日期：1991-08-01 00:00:00

abstract：:Several radiotherapeutic schedules compatible with continued structural-functional integrity of the gastrointestinal (GI) mucosa were compared utilizing the P815X2 murine mastocytoma grown as a solid subcutaneous tumour. Both the tumour and underlying normal tissues were irradiated during the treatments. The tumour ex...

journal_title：British journal of cancer

authors： Schenken LL,Poulakos L,Hagemann RF

更新日期：1975-02-01 00:00:00

abstract：:Analysis of data from 1434 children with primary renal tumours revealed 57 who developed bone metastases. Of these, 54 were initially recorded as nephroblastoma. Fifty-two of the 57 cases were reviewed histologically, and only 18 were found to be Wilms' tumours. Twenty-three were classified as "Bone-Metastasizing Rena...

journal_title：British journal of cancer

authors： Marsden HB,Lennox EL,Lawler W,Kinnier-Wilson LM

更新日期：1980-06-01 00:00:00

abstract：:The influence of anthracyclines on membrane permeability functions has been investigated in HeLa cells by monitoring the efflux of fluorescein. Release of the fluorescent dye, dependent on the metabolic energy supply, occurs after the intracellular accumulation and enzymatic hydrolysis of the non-fluorescent substrate...

journal_title：British journal of cancer

authors： Croce AC,Prosperi E,Supino R,Bottiroli G

更新日期：1986-12-01 00:00:00

abstract：:Previously, we reported that Bcl-2 was frequently expressed in renal cell carcinoma (RCC) specimens, but p53 mutation was a rare event. However, it was unclear whether Bcl-2 positivity was associated with the clinicopathological characteristics and prognosis in RCC. Therefore, we investigated the expression of Bcl-2 p...

journal_title：British journal of cancer

authors： Itoi T,Yamana K,Bilim V,Takahashi K,Tomita F

更新日期：2004-01-12 00:00:00

abstract：:To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after ...

journal_title：British journal of cancer

authors： Watanabe Y,Koi M,Hemmi H,Hoshai H,Noda K

更新日期：2001-09-28 00:00:00

abstract：:High levels of loss of distal markers on 17p13.3 in breast cancer suggested the presence within the region of at least one tumour-suppressor gene. Here we describe the derivation of two biallelic polymorphisms from the 17p telomeric yeast artificial chromosome (YAC) TYAC98. Polymerase chain reaction-restriction fragme...

journal_title：British journal of cancer

authors： White GR,Stack M,Santibáñez-Koref M,Liscia DS,Venesio T,Wang JC,Helms C,Donis-Keller H,Betticher DC,Altermatt HJ,Hoban PR,Heighway J

更新日期：1996-09-01 00:00:00

abstract：:Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on th...

journal_title：British journal of cancer

authors： Workman P,Aboagye EO,Balkwill F,Balmain A,Bruder G,Chaplin DJ,Double JA,Everitt J,Farningham DA,Glennie MJ,Kelland LR,Robinson V,Stratford IJ,Tozer GM,Watson S,Wedge SR,Eccles SA,Committee of the National Cancer Researc

更新日期：2010-05-25 00:00:00

abstract：BACKGROUND:The role of telomerase reverse transcriptase (TERT) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT promoter mutations (TERTp-mut) in gliomas and evidence that the TERT SNP genetic rs2736100 influences glioma risk. TERTp-mut creates a binding site for Ets/TCF transc...

journal_title：British journal of cancer

authors： Labussière M,Di Stefano AL,Gleize V,Boisselier B,Giry M,Mangesius S,Bruno A,Paterra R,Marie Y,Rahimian A,Finocchiaro G,Houlston RS,Hoang-Xuan K,Idbaih A,Delattre JY,Mokhtari K,Sanson M

更新日期：2014-11-11 00:00:00

abstract：:The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...

journal_title：British journal of cancer

authors： Awasthi S,Sharma R,Singhal SS,Herzog NK,Chaubey M,Awasthi YC

更新日期：1994-08-01 00:00:00

abstract：:Patients affected by squamous cell carcinoma of the head and neck (HNSCC) show frequent occurrence of multiple cancers and widespread precancerous lesions in the mucosa of the upper respiratory tract, a phenomenon known as field cancerization. In this study, we investigated the role of genetic instability in the devel...

journal_title：British journal of cancer

authors： Piccinin S,Gasparotto D,Vukosavljevic T,Barzan L,Sulfaro S,Maestro R,Boiocchi M

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S phase specific using...

journal_title：British journal of cancer

authors： Znojek P,Willmore E,Curtin NJ

更新日期：2014-09-23 00:00:00

abstract：:The matrix metalloprotease MMP-9 localizes to tumour-associated macrophages in human ovarian cancer but little is known of its regulation. Co-culture of human ovarian cancer cells (PEO-1) and a monocytic cell line (THP-1) led to production of 92-kDa proMMP-9. PEO-1-conditioned medium (CM) also stimulated THP-1 cells o...

journal_title：British journal of cancer

authors： Leber TM,Balkwill FR

更新日期：1998-09-01 00:00:00

abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...

journal_title：British journal of cancer

authors： Nita ME,Nagawa H,Tominaga O,Tsuno N,Fujii S,Sasaki S,Fu CG,Takenoue T,Tsuruo T,Muto T

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. METHODS:A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to eva...

journal_title：British journal of cancer

authors： Schneider BP,Li L,Shen F,Miller KD,Radovich M,O'Neill A,Gray RJ,Lane D,Flockhart DA,Jiang G,Wang Z,Lai D,Koller D,Pratt JH,Dang CT,Northfelt D,Perez EA,Shenkier T,Cobleigh M,Smith ML,Railey E,Partridge A,Gralo

更新日期：2014-09-09 00:00:00

abstract：:In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-c...

journal_title：British journal of cancer

authors： Cragg MS,Zhang L,French RR,Glennie MJ

更新日期：1999-02-01 00:00:00

abstract：:Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...

journal_title：British journal of cancer

authors： Dowsett M,Shearer RJ,Ponder BA,Malone P,Jeffcoate SL

更新日期：1988-02-01 00:00:00

abstract：:Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...

journal_title：British journal of cancer

authors： Wang ZJ,Churchman M,Campbell IG,Xu WH,Yan ZY,McCluggage WG,Foulkes WD,Tomlinson IP

更新日期：1999-04-01 00:00:00

abstract：:We have established a novel ascites tumour model (MDA435/LCC6) from the oestrogen receptor-negative, invasive and metastatic MDA-MB-435 human breast cancer cell line. MDA435/LCC6 cells grow as both malignant ascites and solid tumours in vivo in nude mice and nude rats, with a tumour incidence of approximately 100%. Un...

journal_title：British journal of cancer

authors： Leonessa F,Green D,Licht T,Wright A,Wingate-Legette K,Lippman J,Gottesman MM,Clarke R

更新日期：1996-01-01 00:00:00

abstract：:BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...

journal_title：British journal of cancer

authors： Chieco-Bianchi L,Collavo D,Biasi G,Colombatti A

更新日期：1973-09-01 00:00:00

abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...

journal_title：British journal of cancer

authors： Péron J,Roy P,Ding K,Parulekar WR,Roche L,Buyse M

更新日期：2015-03-17 00:00:00

abstract：:A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the presence, viral load and integration status of 'high-risk' types of human papillomavirus (HR-HPV). The samples were assayed using newly developed methods based on real-time PCR. Two methods for the extraction of DNA from the paraffi...

journal_title：British journal of cancer

authors： Andersson S,Safari H,Mints M,Lewensohn-Fuchs I,Gyllensten U,Johansson B

更新日期：2005-06-20 00:00:00

abstract：BACKGROUND:Human polypyrimidine tract binding protein 3 (PTBP3) was first discovered in 1999 and has been well characterised as a differentiation regulator. However, its role in human cancer has rarely been reported. Our previous study revealed increased PTBP3 protein level in gastric cancer tissues. Downregulation of ...

journal_title：British journal of cancer

authors： Liang X,Shi H,Yang L,Qiu C,Lin S,Qi Y,Li J,Zhao A,Liu J

更新日期：2017-03-28 00:00:00

abstract：:Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours. Infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regardi...

journal_title：British journal of cancer

authors： Heselmeyer K,du Manoir S,Blegen H,Friberg B,Svensson C,Schröck E,Veldman T,Shah K,Auer G,Ried T

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...

journal_title：British journal of cancer

authors： Wang X,Zhao L,Liu H,Zhong D,Liu W,Shan G,Dong F,Gao W,Bai C,Li X

更新日期：2016-06-14 00:00:00

abstract：:One hundred and eighteen doctors who treat pulmonary neoplasms in Ontario were asked how they would wish to be treated if they had non-small cell lung cancer. Four different scenarios were given. The physicians were then asked if they would consent to take part as subjects in one or more clinical trials for which they...

journal_title：British journal of cancer

authors： Mackillop WJ,Ward GK,O'Sullivan B

更新日期：1986-10-01 00:00:00

abstract：:Two policies of palliative thoracic radiotherapy for non-small-cell lung cancer have been compared in a randomised multicentre controlled trial. A total of 369 patients with inoperable, histologically or cytologically confirmed disease, too advanced for radical 'curative' radiotherapy, and with their main symptoms rel...

journal_title：British journal of cancer

authors：

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Locally advanced oesophageal cancer (LAEC) is associated with poor survival and more effective treatments are needed. The aim of this phase I trial was to assess the maximum tolerated dose (MTD) of a novel weekly docetaxel and cisplatin regimen concurrent with radical radiotherapy. METHODS:Patients with unr...

journal_title：British journal of cancer

authors： Day FL,Leong T,Ngan S,Thomas R,Jefford M,Zalcberg JR,Rischin D,McKendick J,Milner AD,Di Iulio J,Matera A,Michael M

更新日期：2011-01-18 00:00:00

abstract：:Sodium polyanethol sulphonate (SPS) when incorporated into rat erythrocyte lysate (REL) containing semi-solid agar medium at 1 mg ml-1. markedly enhanced colony formation by a number of anchorage-independent cell lines. REL usually needed to be included for the expression of SPS induced potentiation as in its absence ...

journal_title：British journal of cancer

authors： Sheridan JW,Bishop CJ,Simmons RJ,Ward CJ,Baumann KC

更新日期：1984-11-01 00:00:00