Abstract:
:Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen levels throughout the day in two studies on 11 such patients. Whilst AG combined with HC led to a significant suppression of both testosterone and androstenedione levels, the suppression with HC alone was significantly greater, indicating that any beneficial clinical effects of AG in these patients is not due to its suppression of adrenal androgen secretion.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Dowsett M,Shearer RJ,Ponder BA,Malone P,Jeffcoate SLdoi
10.1038/bjc.1988.40subject
Has Abstractpub_date
1988-02-01 00:00:00pages
190-2issue
2eissn
0007-0920issn
1532-1827journal_volume
57pub_type
杂志文章abstract:BACKGROUND:Random error in the numbers of avoidable deaths among cancer patients has not been considered in earlier studies. METHODS:Methods to obtain valid confidence intervals (CIs) for numbers of avoidable deaths were developed. The excess mortality rates were estimated for patients diagnosed with colon cancer in f...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.169
更新日期:2012-05-22 00:00:00
abstract::Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.104
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There are no diagnostic biomarkers for early detection of OPSCC. METHODS:Serum from 25...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0162-2
更新日期:2018-07-01 00:00:00
abstract::Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its expression in pancreatic cancer has not yet been clinically reported. In this study, we investigated the relationship between CD133 expression and clinicopathological factors in pancreatic cancer. Pancreatic head carcinoma speci...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604307
更新日期:2008-04-22 00:00:00
abstract::To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.252
更新日期:1992-08-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common complication of lung cancer. In this study, we assessed the feasibility of detection of EGFR mutations in samples of pleura...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603428
更新日期:2006-11-20 00:00:00
abstract::The relationship between skin tumours in man and exposure to polyaromatic hydrocarbons has been studied in lathe operators exposed to cutting oils. Seven cases of scrotal cancer and 13 cases of senile keratosis and keratoacanthoma were observed. The risk varied as the 1.6th power of duration of exposure for cancer on ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.435
更新日期:1990-12-01 00:00:00
abstract::Advanced or metastatic disease is common in both oesophagogastric and colorectal cancers, with poor 5-year survival despite palliative chemotherapy. We have investigated the sensitivity of gastrointestinal tumours to gemcitabine in combination with mitomycin C (GeM), using a modified ex vivo ATP-based tumour chemosens...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601403
更新日期:2003-12-15 00:00:00
abstract:BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.184
更新日期:2011-07-12 00:00:00
abstract::Pancreatic cancer is a highly lethal malignancy with a dismal 5-year survival of less than 5%. The scarcity of early biomarkers has considerably hindered our ability to launch preventive measures for this malignancy in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was repor...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604329
更新日期:2008-05-06 00:00:00
abstract::Using the breast carcinoma cell line MDA-MB 468 as immunogen, we have produced six new rat monoclonal antibodies (mAbs) against the human EGF receptor (EGFR) and are investigating their use for diagnostic and therapeutic applications in cancer patients whose tumours overexpress these receptors. The mAbs (three IgG2b a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.48
更新日期:1993-02-01 00:00:00
abstract::Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have hist...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1971.40
更新日期:1971-06-01 00:00:00
abstract::Multidrug resistance (MDR) is the major confounding factor in adjuvant solid tumour chemotherapy. Increasing intracellular amounts of chemotherapeutics to circumvent MDR may be achieved by a novel delivery method, photochemical internalisation (PCI). PCI consists of the co-administration of drug and photosensitiser; u...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603895
更新日期:2007-08-20 00:00:00
abstract::This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL-1 locus, in 60% of mantle cell lymphomas. The BCL-2 gene, located at band 18q21, was rearrange...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.279
更新日期:1997-01-01 00:00:00
abstract::Two policies of palliative thoracic radiotherapy for non-small-cell lung cancer have been compared in a randomised multicentre controlled trial. A total of 369 patients with inoperable, histologically or cytologically confirmed disease, too advanced for radical 'curative' radiotherapy, and with their main symptoms rel...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1991.62
更新日期:1991-02-01 00:00:00
abstract::Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. We report lymphocytic DPD data concerning a group of 53 patients (23 men, 30 women, mean age 58, range 36-73), treated by 5-FU-based chemotherapy in different French institutions and who developed unantic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690098
更新日期:1999-02-01 00:00:00
abstract::Dendritic cells (DC) are professional antigen-presenting cells that play a pivotal role in the induction of immunity. Ex vivo-generated, tumour antigen-loaded mature DC are currently exploited as cancer vaccines in clinical studies. However, antigen loading and maturation of DC directly in vivo would greatly facilitat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603341
更新日期:2006-10-09 00:00:00
abstract::Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,实务指引
doi:10.1038/sj.bjc.6605029
更新日期:2009-05-19 00:00:00
abstract::Epidemiological evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) to a greater degree than other non-gastrointestinal cancers, but the molecular basis for this difference is unknown. We previously reported that aspirin induces signal-specific I kappa B alpha...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601913
更新日期:2004-07-19 00:00:00
abstract::Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2016.115
更新日期:2016-05-24 00:00:00
abstract::The aim of this study was to assess the relationship between haemoglobin level and quality-of-life in anaemic cancer patients. Patients, diagnosed with one of four cancers, were recruited if their haemoglobin level was <12 g dl(-1) (female) or <13 g dl(-1) (male). The condition-specific Functional Assessment of Cancer...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.bjc.6600247
更新日期:2002-04-22 00:00:00
abstract::Overexpression of the MDR1 product, P-glycoprotein (Pgp), has been shown to be one of the mechanisms underlying the development of multidrug resistance (MDR). Recently, one mutant p53 has been shown to stimulate the MDR1 gene promoter in vitro, whereas wild-type p53 repressed this activity. We measured Pgp and p53 exp...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.329
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse. METHOD:The aim of this study was to compare tumour stage and survival of IBD patients...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605359
更新日期:2009-11-17 00:00:00
abstract::By using a quantitative RNA-RNA solution hybridisation method, the average number of mdr1 RNA transcripts per cell was measured in total nucleic acid extracts of leukaemic cells from patients with acute leukaemia. The results in different types of leukaemia were (number of patients with detectable mdr1 RNA/total numbe...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.255
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:The intestinal uptake of the taxanes paclitaxel and docetaxel is seriously hampered by drug efflux through P-glycoprotein (P-gp) and drug metabolism via cytochrome P450 (CYP) 3A. The resulting low oral bioavailability can be boosted by co-administration of P-gp or CYP3A4 inhibitors. METHODS:Paclitaxel or do...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.222
更新日期:2014-05-27 00:00:00
abstract::A clinical trial conducted according to a schedule of interim analyses written into the protocol, and stopped according to a predetermined rule, is known to statisticians as a sequential clinical trial. This methodology is becoming more widely used in trials concerning life-threatening diseases because of its ability ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.500
更新日期:1993-12-01 00:00:00
abstract::Associations between work in the electrical and electronic industry and cancer incidence were assessed using data for 371 890 cancers registered in England between 1981 and 1987, of which 7981 were in electrical workers. Proportional registration ratios (PRRs) were calculated, both with and without the commonest cance...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.167
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those for which epigenetic si...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.104
更新日期:2013-04-02 00:00:00
abstract::The purpose of the study was to evaluate the influence of baseline haemoglobin level in predicting response to 5-fluorouracil (5FU)-based first-line chemotherapy in advanced colorectal cancer patients. Data from 631 patients were collected from three different institutions. Globally, overall response rate was 35.8% (2...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/sj.bjc.6603204
更新日期:2006-07-03 00:00:00
abstract::The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.255
更新日期:1981-11-01 00:00:00