Abstract:
:By using a quantitative RNA-RNA solution hybridisation method, the average number of mdr1 RNA transcripts per cell was measured in total nucleic acid extracts of leukaemic cells from patients with acute leukaemia. The results in different types of leukaemia were (number of patients with detectable mdr1 RNA/total number of patients; median number of transcripts per cell in samples with detectable mdr1 RNA); de novo untreated acute myelocytic leukaemia (AML): 20/44; 0.7, secondary acute myelocytic leukaemia: 8/13; 1.1, acute lymphocytic (ALL) and undifferentiated leukaemia: 5/14; 0.6, relapsed leukaemia: 7/15; 0.7. Forty-six patients with de novo untreated acute leukaemia (AML: n = 34, ALL: n = 12) were evaluable for response to induction chemotherapy. Twelve of 18 patients (67%) with detectable mdr1 RNA levels achieved complete remission compared to 23 of 28 (82%) with undetectable levels (P = 0.40). The remission duration tended to be longer among patients with undetectable mdr1 RNA (P = 0.08). Leukaemic cells were analysed on consecutive occasions in 12 patients. The level of expression increased in four and decreased in two. In conclusion, expression of mdr1 RNA is common in acute untreated leukaemia. However, treatment with cytostatic drugs seems only rarely to increase the proportion of leukaemic cells that express mdr1 RNA. Expression of the mdr1 gene could be one of several equally important factors contributing to drug resistance in acute leukaemia.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Gruber A,Vitols S,Norgren S,Areström I,Peterson C,Björkholm M,Reizenstein P,Luthman Hdoi
10.1038/bjc.1992.255subject
Has Abstractpub_date
1992-08-01 00:00:00pages
266-72issue
2eissn
0007-0920issn
1532-1827journal_volume
66pub_type
杂志文章abstract::Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.298
更新日期:1993-07-01 00:00:00
abstract::We investigated the effects of interleukin-2 (IL-2) exposure on T-cell signal transduction molecules and apoptosis markers in tumour-infiltrating lymphocytes (TIL) isolated from 20 melanoma and 16 colorectal carcinoma metastases and expanded in vitro for therapeutic reinfusion. Before IL-2 culture, TIL showed undetect...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600679
更新日期:2003-01-27 00:00:00
abstract::The MIB-1 antibody has been raised against recombinant parts of the Ki-67 antigen and, unlike Ki-67, has wider application to routinely fixed specimens. The aim of this study was to compare the usefulness of MIB-1 with S-phase fraction (SPF) as a measure of proliferation. A total of 75 patients with operable breast ca...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.111
更新日期:1996-03-01 00:00:00
abstract::This corrects the article DOI: 10.1038/bjc.2017.85. ...
journal_title:British journal of cancer
pub_type: 杂志文章,已发布勘误
doi:10.1038/bjc.2017.437
更新日期:2018-03-20 00:00:00
abstract::People affected by cancer want information about their prognosis but clinicians have trouble estimating and talking about it. We sought to determine the nature and accuracy of medical oncologists' estimates of life expectancy in newly referred patients with incurable cancer. With reference to each patient, medical onc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602908
更新日期:2006-01-30 00:00:00
abstract::We have previously shown that epidermal growth factor (EGF) enhances the in vitro and in vivo sensitivity of human ovarian carcinoma 2008 cells to cisplatin. EGF was found to enhance selectively the in vivo toxicity of cisplatin to 2008 cell xenografts without altering the toxicity of cisplatin to non-malignant target...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.382
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). METHODS:Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.460
更新日期:2018-03-20 00:00:00
abstract::There is increasing evidence of a systemic inflammatory response associated with malignancy, which may have an impact on both drug disposition and resistance to cytotoxic therapy. The impact of inflammation on drug disposition was studied in mice bearing a number of common tumour xenografts. C57BL/6 mice were inoculat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604101
更新日期:2008-01-15 00:00:00
abstract::Nerve growth factor (NGF) administration to athymic mice with transplanted human bromocriptine-resistant prolactinoma, results in the expression of dopamine D-2 receptors in the tumour and restores sensitivity to subsequent treatment with bromocriptine, which then produces normalisation of plasma prolactin and tumour ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.520
更新日期:1995-12-01 00:00:00
abstract::We used a nested case-control design on data from men in four prospective studies (from the UK, Maryland in the USA, and two from Finland) with available stored serum samples to determine whether there was an advantage in measuring both free prostate-specific antigen (PSA) and total PSA as a potential screening test f...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0988
更新日期:2000-02-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.280
更新日期:2016-10-11 00:00:00
abstract::A previous publication (Leith et al., 1992) showed that administration of basic fibroblast growth factor (FGF-2, 0.25 mg kg-1, q.i.d. x 7) to mice bearing xenografted DLD-2 human colon cancers would increase treated tumour growth rates as compared to control neoplasms. Additionally, at the end of the 7 day treatment p...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.418
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:We previously showed that activation of the nuclear factor of activated T cells (NFAT)1/Fas ligand (FasL) pathway induces glioma cell death. Lithium (Li) is an inhibitor of glycogen synthase kinase (GSK)-3 that activates NFAT1/FasL signalling. Temozolomide (TMZ) inhibits GSK-3 and activates Fas in tumour pro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.89
更新日期:2017-05-09 00:00:00
abstract:BACKGROUND:Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express d...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.415
更新日期:2014-09-23 00:00:00
abstract::An enzyme activity with the characteristics of reverse transcriptase was detected in marrow from patients with leukaemia in relapse and in firm haematological remission. The endogenous enzyme activities increased following culture, and in remission patients the enzyme activities reached levels equal to or exceeding th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1974.95
更新日期:1974-06-01 00:00:00
abstract::Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cel...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690563
更新日期:1999-07-01 00:00:00
abstract::The integrin alpha(v)beta6 is not detectable on normal keratinocytes in vivo but expression is increased significantly in oral squamous cell carcinoma where this heterodimer has been shown to play a role in cell migration, invasion and protease expression. Although regarded initially as a fibronectin receptor, alpha(v...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600545
更新日期:2002-10-07 00:00:00
abstract:BACKGROUND:Only a small proportion of patients respond to anti-VEGF therapy, pressing the need for a reliable biomarker that can identify patients who will benefit. We studied the biological activity of anti-VEGF antibodies in patients' blood during anti-VEGF therapy by using the Ba/F3-VEGFR2 cell line, which is depend...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.275
更新日期:2016-10-11 00:00:00
abstract::The family history of cancer in children treated for a solid malignant tumour in the Paediatric Oncology Department at Institute Gustave-Roussy, has been investigated. In order to determine the role of germline p53 mutations in genetic predisposition to childhood cancer, germline p53 mutations were sought in individua...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1167
更新日期:2000-06-01 00:00:00
abstract::Summary Antibodies against Candida albicans antigenic determinants have been reported to cross-react with human tumour cells. We have found that two monoclonal antibodies, C6 and PA1OF, developed at our laboratory against C. albicans antigenic determinants, cross-react with human ovarian cancer on Western blots and im...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.167
更新日期:1998-03-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.223
更新日期:1981-10-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.172
更新日期:1978-07-01 00:00:00
abstract::We empirically evaluated the performance of a new method for age adjustment of cancer survival compared to traditional age adjustment using data from the Finnish Cancer Registry. We find that both methods provide almost identical results for absolute survival but the new method generally provides more meaningful estim...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602704
更新日期:2005-08-08 00:00:00
abstract:BACKGROUND:Inter-individual differences in dihydropyrimidine dehydrogenase (DPYD encoding DPD) and thiopurine S-methyltransferase (TPMT) activity are important predictors for fluoropyrimidine and thiopurine toxicity. While several variants in these genes are known to decrease enzyme activities, many additional genetic ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01084-0
更新日期:2020-12-01 00:00:00
abstract::Previous studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of thyroglobulin (TG) mRNA in the peripheral blood of patients with differentiated thyroid carcinoma. To evaluate this usefulness, we measured TG mRNA in the peripheral blood of patients diagnos...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1904
更新日期:2001-07-06 00:00:00
abstract:BACKGROUND:Aspirin use has been shown to lower incidence and mortality in cancer patients. The aim of this population-based study was to determine the effect of postdiagnosis low-dose aspirin use on survival of patients with oesophageal cancer. METHODS:Patients with oesophageal cancer (1998-2010) were selected from th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.65
更新日期:2016-04-26 00:00:00
abstract:BACKGROUND:Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yielded clinical responses...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
abstract::Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to investigate the possible implication of the DNA repair DNA-PK complex. The activity of the DNA-PK complex, i.e....
journal_title:British journal of cancer
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doi:10.1054/bjoc.2000.1258
更新日期:2000-08-01 00:00:00
abstract::To examine whether weight loss at presentation influences outcome in patients who received chemotherapy for lung cancer or mesothelioma. Multivariate analysis of prospectively collected data 1994-2001. Data were available for age, gender, performance status, histology, stage, response, toxicity, progression-free and o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601781
更新日期:2004-05-17 00:00:00
abstract::Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We transfected the MDA...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690685
更新日期:1999-09-01 00:00:00