Abstract：
BACKGROUND:Aspirin use has been shown to lower incidence and mortality in cancer patients. The aim of this population-based study was to determine the effect of postdiagnosis low-dose aspirin use on survival of patients with oesophageal cancer. METHODS:Patients with oesophageal cancer (1998-2010) were selected from the Eindhoven Cancer Registry and linked with outpatient pharmacy data regarding aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). Users were subdivided into both prediagnosis and postdiagnosis or only postdiagnosis users. Parametric survival models with an exponential (Poisson) distribution were used with non-specific death as endpoint. RESULTS:In this study 560 patients were included. Overall, 157 patients (28.0%) were non-users, 293 patients (52.3%) pre- and postdiagnosis (89 aspirin and 204 NSAID users) and 110 patients (19.6%) only postdiagnosis users (16 aspirin and 94 NSAID users). Postdiagnosis aspirin use was associated with overall survival (RR 0.45 (95% CI 0.34-0.60; P<0.001); adjusted rate ratio was 0.42 (95% CI: 0.30-0.57; P<0.001). Postdiagnosis use of NSAIDs was associated with overall survival (RR 0.61 (95% CI 0.49-0.76; <0.001); however, adjusted analyses did not show a significant association with a rate ratio of 0.84 (95% CI 0.66-1.07; P=0.2). CONCLUSIONS:Our study shows that postdiagnosis aspirin use might be associated with a higher survival rate in oesophageal cancer patients. A randomised clinical trial is needed to verify our observations of possible postdiagnosis aspirin use benefit.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
van Staalduinen J,Frouws M,Reimers M,Bastiaannet E,van Herk-Sukel MP,Lemmens V,de Steur WO,Hartgrink HH,van de Velde CJ,Liefers GJdoi
10.1038/bjc.2016.65subject
Has Abstractpub_date
2016-04-26 00:00:00pages
1053-9issue
9eissn
0007-0920issn
1532-1827pii
bjc201665journal_volume
114pub_type
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journal_title：British journal of cancer
pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2017.252
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6603414
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
doi：10.1038/bjc.1992.255
更新日期：1992-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.240
更新日期：1978-10-01 00:00:00
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更新日期：2015-12-01 00:00:00
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pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601724
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doi：10.1038/bjc.1998.330
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doi：10.1054/bjoc.2000.1308
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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