Abstract:
BACKGROUND:We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients. METHODS:Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, and elderly) was estimated by Kaplan-Meier survival curves and multivariable Cox-proportional hazards modelling. RESULTS:A total of 461 patients had localised disease at diagnosis. The 5-year overall survival (OS) was 89.3±4.6%, 73.0±3.8%, 54.7±3.6%, and 43.0±7.0% in children (n=54), AYAs (n=148), adults (n=204), and elderly (n=55), respectively. Treatment modalities had no significant effect on survival in the univariable analysis. Multivariable analysis identified age at diagnosis, tumour localisation, and tumour size as significant factors affecting OS. Both tumour localisation and size were equally distributed over the age groups. CONCLUSIONS:We show that outcome of synovial sarcoma patients significantly decreases with age regardless of primary tumour site, size, and treatment.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Vlenterie M,Ho VK,Kaal SE,Vlenterie R,Haas R,van der Graaf WTdoi
10.1038/bjc.2015.375subject
Has Abstractpub_date
2015-12-01 00:00:00pages
1602-6issue
11eissn
0007-0920issn
1532-1827pii
bjc2015375journal_volume
113pub_type
杂志文章abstract::This study sought to use a microdialysis technique to relate clinical and biochemical responses to the time course of melphalan concentrations in the subcutaneous interstitial space and in tumour tissue (melanoma, malignant fibrous histiocytoma, Merkel cell tumour and osteosarcoma) in patients undergoing regional chem...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
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更新日期:2001-07-20 00:00:00
abstract:BACKGROUND:Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. Patients who respond poorly to chemotherapy have a higher risk of metastatic disease and 5-year survival rates of only 10-20%. Therefore, identifying molecular targets that are specific for OS, or more specifically, metasta...
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journal_title:British journal of cancer
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journal_title:British journal of cancer
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