Abstract：
BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and updated biennially. Clinical features of prostate cancer included localised, advanced, lethal, low-grade, intermediate-grade, and high-grade. Molecular features included TMPRSS2: ERG and PTEN subtypes. Cox proportional hazards regression models were used to evaluate the association between diabetes and incidence of subtype-specific prostate cancer. RESULTS:During 28 years of follow-up, we documented 6733 incident prostate cancer cases. Relative to men free from diabetes, men with diabetes had lower risks of total (HR: 0.82, 95% CI: 0.75-0.90), localised (HR: 0.82, 95% CI: 0.74-0.92), low-and intermediate-grade prostate cancer (HR: 0.77, 95% CI: 0.66-0.90; HR: 0.77, 95% CI: 0.65-0.91, respectively). For molecular subtypes, the HRs for ERG-negative and ERG-positive cases were 0.63 (0.42-0.95) and 0.72 (0.46-1.12); and for PTEN-intact and PTEN-loss cases were 0.69 (0.48-0.98) and 0.52 (0.19-1.41), respectively. CONCLUSION:Besides providing advanced evidence for the inverse association between diabetes and prostate cancer, this study is the first to report associations between diabetes and ERG/PTEN defined prostate cancers.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Feng X,Song M,Preston MA,Ma W,Hu Y,Pernar CH,Stopsack KH,Ebot EM,Fu BC,Zhang Y,Li N,Dai M,Liu L,Giovannucci EL,Mucci LAdoi
10.1038/s41416-020-0910-ysubject
Has Abstractpub_date
2020-08-01 00:00:00pages
657-665issue
4eissn
0007-0920issn
1532-1827pii
10.1038/s41416-020-0910-yjournal_volume
123pub_type
杂志文章abstract：:The prevalence (lifetime occurrence) rate of cancers of the reproductive system (uterus, ovary, cervix and vagina) and breast cancer was determined for 5,398 living alumnae, 2,622 of whom were former college athletes and 2,776 non-athletes, from data on medical and reproductive history, athletic training and diet. The...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.273
更新日期：1985-12-01 00:00:00
abstract：:Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.0...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601747
更新日期：2004-04-19 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.388
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Preoperative radiotherapy (RT) is commonly used to treat localised soft-tissue sarcomas (STS). Hypoxia is an important determinant of radioresistance. Whether antiangiogenic therapy can 'normalise' tumour vasculature, thereby improving oxygenation, remains unknown. METHODS:Two cohorts were prospectively enr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.537
更新日期：2014-12-09 00:00:00
abstract：BACKGROUND:Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure to infectious agents, normal delivery, and exposure to animals in early life) have been suggested to decrease the risk of childhood acute lymphoblastic leukaemia (ALL). METHODS:The national registry-based case-con...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.53
更新日期：2015-03-17 00:00:00
abstract：:Delays in cancer diagnosis and treatment due to the COVID-19 pandemic is a widespread source of concern, but the scale of the challenge for different tumour sites is not known. Routinely collected NHS England Cancer Waiting Time data were analysed to compare activity for breast cancer in the first 6 months of 2020 com...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01182-z
更新日期：2020-11-30 00:00:00
abstract：:Tumorigenic mouse lung-derived type 2 cell lines have large reductions in both beta-adrenergic-stimulated cAMP production and ligand binding to beta-adrenergic receptors. These tumorigenic cells are also relatively insensitive to glucocorticoids. Because glucocorticoids regulate both beta-adrenergic receptor expressio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.377
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Patients with borderline resectable pancreatic cancer (BRPC) have poor prognosis with upfront surgery. METHODS:This was a single-arm Phase 2 trial for clinical and biomarker analysis. The primary endpoint is 1-year progression-free survival (PFS) rate. Patients received 8 cycles of neoadjuvant modified (m) ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0867-x
更新日期：2020-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2017.281
更新日期：2017-10-10 00:00:00
abstract：:We investigated whether cholecystectomy is associated with subsequent cancer and, if so, whether the association is likely to be causal, by undertaking a retrospective cohort study using linked medical statistics, comprising a cholecystectomy group (n=39 254) and a reference cohort admitted for a range of other medica...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602392
更新日期：2005-04-11 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602173
更新日期：2004-10-18 00:00:00
abstract：:Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of human pancreatic and cervical cancer cells in soft agar and delays growth of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600186
更新日期：2002-04-08 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603171
更新日期：2006-06-05 00:00:00
abstract：:The response of 6 human colorectal tumour xenografts to 7 cytotoxic agents have been established. Tumour responses have been quantified by growth inhibition, and the time taken for 3H-thymidine fractional incorporation (TFI) to recover to the control value after treatment. The chemosensitivity of each tumour line to a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.122
更新日期：1978-05-01 00:00:00
abstract：BACKGROUND:Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the role of ROC1 in the mal...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.444
更新日期：2016-02-02 00:00:00
abstract：:Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690271
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Inter-individual differences in dihydropyrimidine dehydrogenase (DPYD encoding DPD) and thiopurine S-methyltransferase (TPMT) activity are important predictors for fluoropyrimidine and thiopurine toxicity. While several variants in these genes are known to decrease enzyme activities, many additional genetic ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01084-0
更新日期：2020-12-01 00:00:00
abstract：:Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variet...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2014.610
更新日期：2015-01-20 00:00:00
abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) is characterised by the loss of cell-to-cell adhesion and gaining of mesenchymal phenotypes. Epithelial-mesenchymal transition is proposed to occur in various developmental processes and cancer progression. 'Cadherin switch', a process in which cells shift to express d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.415
更新日期：2014-09-23 00:00:00
abstract：:To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Scotti...
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pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6604155
更新日期：2008-02-26 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6604872
更新日期：2009-02-24 00:00:00
abstract：BACKGROUND:Doxorubicin and cyclophosphamide (AC) therapy is an effective treatment for early-stage breast cancer. Doxorubicin is a substrate for ABCB1 and SLC22A16 transporters. Cyclophosphamide is a prodrug that requires oxidation to 4-hydroxycyclophosphamide, which yields a cytotoxic alkylating agent. The initial oxi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605587
更新日期：2010-03-16 00:00:00
abstract：:Rhizoxin is a tubulin-binding anti-neoplastic agent which is active in a range of murine tumour models. The recommended schedule, of intravenous (i.v.) bolus administration at a dose of 2 mg m-2 every 3 weeks, has been assessed in three phase II trials of ovarian, renal and colorectal cancer. In general terms the drug...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1995.498
更新日期：1995-11-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.32
更新日期：1984-02-01 00:00:00
abstract：:Human monocytes can be induced to synthesize a cytotoxin which affects certain tumour cell lines. The interaction of monocyte cytotoxin with a susceptible cell line (L929) has been studied to obtain clues to the mode of action of the cytotoxin. The cytotoxin acts directly on the cells rather than on the culture medium...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.205
更新日期：1983-09-01 00:00:00
abstract：:We evaluated whether social deprivation affected decision-making for breast cancer surgery. Of 3419 patients, 53.6% had mastectomy and this was predicted by deprivation, age, tumour size and hospital, all of which retained significance on multivariate analysis, except deprivation. Pathological characteristics and surg...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602390
更新日期：2005-02-28 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.204
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:Despite recent advances in cancer therapy, the 5-year survival rate for Ewing's sarcoma is still very low, and new therapeutic approaches are necessary. It was found previously that melatonin induces cell death in the Ewing's sarcoma cell line, SK-N-MC, by activating the extrinsic apoptotic pathway. METHODS...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.66
更新日期：2012-03-27 00:00:00
abstract：:Dormant and regressing implants of C3H mammary carcinoma MC2 were always found to be surrounded by a cellular fibrous capsule where macrophages and T cells predominated as the cellular elements. Macrophages were always closely associated with the collagen deposition, and stained with anti-collagen type I immuno-peroxi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.169
更新日期：1991-05-01 00:00:00
abstract：:Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha) have recently been shown to induce both inflammatory and anti-infla...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602568
更新日期：2005-05-23 00:00:00
