Hyperthermia enhances the reactivation of irradiated adenovirus in HeLa cells.

abstract：:Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many human cancers. Previously, to identify candidate epigenetically inactivated TSGs in renal cell carcinoma (RCC), we monitored changes in gene expression in four RCC cell lines after tr...

journal_title：British journal of cancer

authors： Morris MR,Gentle D,Abdulrahman M,Clarke N,Brown M,Kishida T,Yao M,Teh BT,Latif F,Maher ER

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...

journal_title：British journal of cancer

authors： Mashima T,Iwasaki R,Kawata N,Kawakami R,Kumagai K,Migita T,Sano T,Yamaguchi K,Seimiya H

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Cancer cachexia is a complex wasting syndrome affecting patients with advanced cancer, with systemic inflammation as a key component in pathogenesis. Protein degradation and release of amino acids (AAs) in skeletal muscle are stimulated in cachexia. Here, we define factors contributing to serum AA levels in ...

journal_title：British journal of cancer

authors： Sirniö P,Väyrynen JP,Klintrup K,Mäkelä J,Karhu T,Herzig KH,Minkkinen I,Mäkinen MJ,Karttunen TJ,Tuomisto A

更新日期：2019-01-01 00:00:00

abstract：:The level of expression of keratinocyte growth factor (KGF) mRNA has been measured in human breast cell lines, purified populations of epithelial cells, myoepithelial cells and fibroblasts from reduction mammoplasty tissue and a panel of 42 breast cancers and 30 non-malignant human breast tissues using a semiquantitat...

journal_title：British journal of cancer

authors： Bansal GS,Cox HC,Marsh S,Gomm JJ,Yiangou C,Luqmani Y,Coombes RC,Johnston CL

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Earlier studies have shown raised risks of leukaemia and non-Hodgkin lymphoma in children, teenagers and young adults resident either at birth or diagnosis in Seascale. Some increases in cancer risk in these age groups have also been noted among those living around Dounreay. We aimed to update previous analy...

journal_title：British journal of cancer

authors： Bunch KJ,Vincent TJ,Black RJ,Pearce MS,McNally RJ,McKinney PA,Parker L,Craft AW,Murphy MF

更新日期：2014-10-28 00:00:00

abstract：:Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease...

journal_title：British journal of cancer

authors： Matthews N,Whitehead RH

更新日期：1976-12-01 00:00:00

abstract：:To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libr...

journal_title：British journal of cancer

authors： Shi YY,Wang HC,Yin YH,Sun WS,Li Y,Zhang CQ,Wang Y,Wang S,Chen WF

更新日期：2005-03-14 00:00:00

abstract：BACKGROUND:We studied the biological significance of genes involved in a novel t(8;12)(p21.3;p13.31) reciprocal translocation identified in cervical squamous cell carcinoma (SCC) cells. METHODS:The rearranged genes were identified by breakpoint mapping, long-range PCR and sequencing. We investigated gene expression in...

journal_title：British journal of cancer

authors： Carter SA,Foster NA,Scarpini CG,Chattopadhyay A,Pett MR,Roberts I,Coleman N

更新日期：2012-08-07 00:00:00

abstract：:Until recently, endocrine therapy for breast cancer was relatively simple. If the tumour expressed hormone receptors, regardless of stage and age, tamoxifen was indicated. While this largely remains the case for premenopausal women, clinical trials in postmenopausal women have broadened our choice to include one of th...

journal_title：British journal of cancer

authors： Wong ZW,Ellis MJ

更新日期：2004-01-12 00:00:00

abstract：:The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...

journal_title：British journal of cancer

authors： Beck SA,Tisdale MJ

更新日期：1990-09-01 00:00:00

abstract：:A CD34-negative haematopoietic progenitor cell line, D064, derived from canine bone marrow stromal cells is able to differentiate into haematopoietic progenitors under the influence of growth factor-mediated signalling. While differentiating, these cells eventually start to express MHC class II molecules (DR homologue...

journal_title：British journal of cancer

authors： Huss R,Theis S,Deeg HJ

更新日期：1999-11-01 00:00:00

abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...

journal_title：British journal of cancer

authors： de Bruin PA,Verspaget HW,Griffioen G,Verheijen JH,Dooijewaard G,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:The activity of ZD 1839 on brain metastases (BM) from Non-Small-Cell Lung Cancer (NSCLC) is unknown. We report four cases of BM responding to ZD 1839 theraphy. ...

journal_title：British journal of cancer

authors： Cappuzzo F,Calandri C,Bartolini S,Crinò L

更新日期：2003-07-21 00:00:00

abstract：BACKGROUND:Gemcitabine-based chemotherapy is the standard treatment for pancreatic cancer. However, the issue of resistance remains unresolved. The aim of this study was to identify microRNAs (miRNAs) that govern the resistance to gemcitabine in pancreatic cancer. METHODS:miRNA microarray analysis using gemcitabine-re...

journal_title：British journal of cancer

authors： Iwagami Y,Eguchi H,Nagano H,Akita H,Hama N,Wada H,Kawamoto K,Kobayashi S,Tomokuni A,Tomimaru Y,Mori M,Doki Y

更新日期：2013-07-23 00:00:00

abstract：:Hypoxic cells in KHT sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome Hoechst 33342. Tumour-bearing female C3H/HeJ mice were injected i.v. with 10 micrograms g-1 Hoechst 33342 and the cells derived from the tumours sorted on the basis of their ...

journal_title：British journal of cancer

authors： Siemann DW,Keng PC

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...

journal_title：British journal of cancer

authors： Niho S,Ikeda N,Michimae H,Suzuki K,Sakai H,Kaburagi T,Minato K,Kato T,Okamoto H,Seto T,Hosomi Y,Shimizu K,Oshita F,Kunitoh H,Tsuboi M,Takeuchi M,Watanabe K

更新日期：2013-08-06 00:00:00

abstract：:A retrospective analysis of 321 gastric cancer patients was made to assess the prognostic value of TNM classification, tumour differentiation, Laurén classification, proliferative rate, inflammatory reaction and tumour invasion in vascular or neural structures of the gastric wall. The TNM classification showed the str...

journal_title：British journal of cancer

authors： Setälä LP,Kosma VM,Marin S,Lipponen PK,Eskelinen MJ,Syrjänen KJ,Alhava EM

更新日期：1996-09-01 00:00:00

abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

journal_title：British journal of cancer

authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

更新日期：2006-03-27 00:00:00

abstract：:In recent years, large discrepancies were described in the success rate of the tyrosinase reverse transcription polymerase chain reaction (RT-PCR) for detecting melanoma cells in the peripheral blood of melanoma patients. We present a quality control study in which we analysed the reproducibility of detection of tyros...

journal_title：British journal of cancer

authors： de Vries TJ,Fourkour A,Punt CJ,van de Locht LT,Wobbes T,van den Bosch S,de Rooij MJ,Mensink EJ,Ruiter DJ,van Muijen GN

更新日期：1999-05-01 00:00:00

abstract：:In the UK, 10% of patients diagnosed with rectal cancer have inoperable disease at presentation. This study ascertained whether the resectability rate of inoperable locally advanced rectal cancer was improved by administration of intravenous irinotecan, 5-fluorouracil (5-FU) and pelvic radiotherapy. During phase I of ...

journal_title：British journal of cancer

authors： Iles S,Gollins S,Susnerwala S,Haylock B,Myint S,Biswas A,Swindell R,Levine E

更新日期：2008-04-08 00:00:00

abstract：:Patients with advanced malignant disease show an apparent lesser degree of lymphocyte sensitization to cancer antigen when tested under standard conditions than do early cases. In the serum of cancer patients there is a lymphocyte response depressing factor whose titre rises as the neoplasm becomes more extensive. The...

journal_title：British journal of cancer

authors： Field EJ,Caspary EA

更新日期：1972-06-01 00:00:00

abstract：:Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significant...

journal_title：British journal of cancer

authors： Heuch JM,Heuch I,Kvåle G

更新日期：1996-10-01 00:00:00

abstract：:Both host carbogen (95% oxygen/5% carbon dioxide) breathing and nicotinamide administration enhance tumour radiotherapeutic response and are being re-evaluated in the clinic. Non-invasive magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) methods have been used to give information on the ef...

journal_title：British journal of cancer

authors： Robinson SP,Howe FA,Stubbs M,Griffiths JR

更新日期：2000-06-01 00:00:00

abstract：:The incidence of ovarian, cervical, lung and prostatic cancer was higher in second-generation Irish living in England and Wales than in all other persons in England and Wales. A higher incidence of ovarian cancer was not found in first-generation Irish. Differences in socioeconomic status did not explain these pattern...

journal_title：British journal of cancer

authors： Harding S

更新日期：1998-10-01 00:00:00

abstract：:Loss of the short arm of chromosome 1 is a hallmark of oligodendroglial tumours (OTs). Deletion mapping studies in OTs have revealed multiple commonly deleted regions on chromosome 1p, suggesting that there are more than one tumour suppressor gene. To map critical deletion regions on 1p, a series of 25 OTs were examin...

journal_title：British journal of cancer

authors： Dong Z,Pang JS,Ng MH,Poon WS,Zhou L,Ng HK

更新日期：2004-09-13 00:00:00

abstract：:Between 1971 and 1988, 20 patients with previously undiagnosed non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery. The first treatment after surgery was chemotherapy in nine and radiotherapy in 11 patients. At presentat...

journal_title：British journal of cancer

authors： Eeles RA,O'Brien P,Horwich A,Brada M

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Glioma stem-like cell (GSC) properties are responsible for gliomagenesis and recurrence. GSCs are invasive but its mechanism remains to be elucidated. Here, we attempted to identify the molecules that promote invasion in GSCs. METHODS:Neurospheres and CD133⁺ cells were collected from glioblastoma (GBM) spec...

journal_title：British journal of cancer

authors： Nakada M,Nambu E,Furuyama N,Yoshida Y,Takino T,Hayashi Y,Sato H,Sai Y,Tsuji T,Miyamoto KI,Hirao A,Hamada JI

更新日期：2013-06-25 00:00:00

abstract：:This is the first study to investigate the associations of IGF-1, IGF-2 and IGFBP-3 concentrations with the risk of colorectal cancer in prospectively collected blood samples from an Oriental population. Between 1986 and 1989 serum samples were collected at baseline from 18 244 men, aged 45-65 years, without a history...

journal_title：British journal of cancer

authors： Probst-Hensch NM,Yuan JM,Stanczyk FZ,Gao YT,Ross RK,Yu MC

更新日期：2001-11-30 00:00:00

abstract：:Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes selected for resistance against doxorubicin, melphalan, teniposide and vincristine, were profiled for mRNA expre...

journal_title：British journal of cancer

authors： Rickardson L,Fryknäs M,Dhar S,Lövborg H,Gullbo J,Rydåker M,Nygren P,Gustafsson MG,Larsson R,Isaksson A

更新日期：2005-08-22 00:00:00

abstract：:All hospital-treated cases of Burkitt's lymphoma (BL), with onset of symptoms in the period 1963-68 and resident in the Lango and Acholi districts of Uganda, were identified. The average annual incidence of BL in the 6-year period was 1-87 X 10(-5), similar to that in the adjacent West Nile district. Contrary to findi...

journal_title：British journal of cancer

authors： Morrow RH,Pike MC,Smith PG

更新日期：1977-05-01 00:00:00