Expression of keratinocyte growth factor and its receptor in human breast cancer.

abstract：:Women with a family history of breast cancer generally self-refer because they have a feeling that their risk is high. However, they have, in general, only a hazy notion of the population risk of breast cancer and their own risk in relation to this. It is probable that they are helped by genetic counselling and, if at...

journal_title：British journal of cancer

authors： Evans DG,Blair V,Greenhalgh R,Hopwood P,Howell A

更新日期：1994-11-01 00:00:00

abstract：:One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Eleven patients have been excluded from detailed analysis because they either received involved field radiotherapy (R...

journal_title：British journal of cancer

authors： Ganesan TS,Wrigley PF,Murray PA,Stansfeld AG,d'Ardenne AJ,Arnott S,Jones A,Shand WS,Malpas JS,Lister TA

更新日期：1990-08-01 00:00:00

abstract：:Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to tr...

journal_title：British journal of cancer

authors： McDonald SL,Silver A

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the 'Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it can be potentially targete...

journal_title：British journal of cancer

authors： Sanchez WY,McGee SL,Connor T,Mottram B,Wilkinson A,Whitehead JP,Vuckovic S,Catley L

更新日期：2013-04-30 00:00:00

abstract：:In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...

journal_title：British journal of cancer

authors： Ito I,Minegishi T,Fukuda J,Shinozaki H,Auersperg N,Leung PC

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associ...

journal_title：British journal of cancer

authors： Bamia C,Lagiou P,Jenab M,Aleksandrova K,Fedirko V,Trichopoulos D,Overvad K,Tjønneland A,Olsen A,Clavel-Chapelon F,Boutron-Ruault MC,Kvaskoff M,Katzke VA,Kühn T,Boeing H,Nöthlings U,Palli D,Sieri S,Panico S,Tumino R

更新日期：2015-03-31 00:00:00

abstract：:A multicentre phase 2 trial (single-stage design) was undertaken to test the efficacy and toxicity of carboplatin (AUC 6 according to Calvert) plus paclitaxel (175 mg/m(2)3-h infusion) every 4 weeks in the first line treatment of patients affected by extensive small cell lung cancer. The primary end-point of the trial...

journal_title：British journal of cancer

authors： Gridelli C,Manzione L,Perrone F,Veltri E,Cioffi R,Caprio MG,Frontini L,Rossi A,Barletta E,Barzelloni ML,Bilancia D,Gallo C

更新日期：2001-01-05 00:00:00

abstract：:Pulmonary metastasectomy is widely and increasingly practiced in the belief that this intervention can cure patients with colorectal cancer, and that without it few survive 5 years. No good evidence exists supporting such convictions, indeed recent trial results challenge them. What evidence underpins this acceptance ...

journal_title：British journal of cancer

authors： Macbeth F,Fallowfield L

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The need to unfold the underlying mechanisms of lung cancer aggressiveness, the deadliest cancer in the world, is of prime importance. Because Fas-associated death domain protein (FADD) is the key adaptor molecule transmitting the apoptotic signal delivered by death receptors, we studied the presence and cor...

journal_title：British journal of cancer

authors： Cimino Y,Costes A,Damotte D,Validire P,Mistou S,Cagnard N,Alifano M,Régnard JF,Chiocchia G,Sautès-Fridman C,Tourneur L

更新日期：2012-06-05 00:00:00

abstract：:Van Trommel et al have previously shown that serum human chorionic gonadotropin (hCG) cutoff levels can provide early prediction of resistance to first-line methotrexate (MTX) in patients with persistent trophoblastic disease (PTD). In this study, we validate this approach of prediction of resistance to single-agent c...

journal_title：British journal of cancer

authors： Kerkmeijer LG,Thomas CM,Harvey R,Sweep FC,Mitchell H,Massuger LF,Seckl MJ

更新日期：2009-03-24 00:00:00

abstract：:The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...

journal_title：British journal of cancer

authors： Pettersen EO,Lindmo T

更新日期：1983-12-01 00:00:00

abstract：:A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...

journal_title：British journal of cancer

authors： Lindahl T

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:The detection of V600E BRAF mutation in melanoma is fundamental since here BRAF inhibitors represent an effective treatment. Non-V600E BRAF mutations that may also respond are not detected by certain screening methods. Thus, knowledge about detection of these mutations is needed. METHODS:A total of 276 tumo...

journal_title：British journal of cancer

authors： Heinzerling L,Kühnapfel S,Meckbach D,Baiter M,Kaempgen E,Keikavoussi P,Schuler G,Agaimy A,Bauer J,Hartmann A,Kiesewetter F,Schneider-Stock R

更新日期：2013-05-28 00:00:00

abstract：:Cytochrome P450 3A is a drug-metabolising enzyme activity due to CYP3A4 and CYP3A5 gene products, that is involved in the inactivation of anticancer drugs. This study analyses the potential of cytochrome P450 3A enzyme in human colorectal cancer to impact anticancer therapy with drugs that are cytochrome P450 3A subst...

journal_title：British journal of cancer

authors： Martínez C,García-Martín E,Pizarro RM,García-Gamito FJ,Agúndez JA

更新日期：2002-09-09 00:00:00

abstract：:The syndecans, a family of cell-surface heparan sulphate proteoglycans, have been proposed to mediate cellular interactions with extracellular effector molecules, such as growth factors and components of the extracellular matrix, during critical phases of development. Transcripts of all four syndecans are expressed at...

journal_title：British journal of cancer

authors： Wong ZM,Choo B,Li M,Carey DJ,Cano-Gauci DF,Buick RN

更新日期：1998-03-01 00:00:00

abstract：:The childhood peak of common acute lymphoblastic leukaemia has been proposed as being a rare response to delayed exposure to a common infection. In this context, factors related to the child's immune system are of special interest. Information on such factors was obtained in a recent German case-control study comprisi...

journal_title：British journal of cancer

authors： Schüz J,Kaletsch U,Meinert R,Kaatsch P,Michaelis J

更新日期：1999-05-01 00:00:00

abstract：:Oestrogen (RE) and progesterone (RP) cytosolic receptors have been studied in 59 clinically inflammatory tumours of the human breast. The results were compared to those obtained in a series of 496 operable tumours. A single saturating dose of oestradiol for RE and R 5020 for RP was used and the cut-off between negativ...

journal_title：British journal of cancer

authors： Delarue JC,May-Levin F,Mouriesse H,Contesso G,Sancho-Garnier H

更新日期：1981-12-01 00:00:00

abstract：:5'-nucleotidase activity, arachidonate metabolism and adenosine uptake were measured in P388 murine leukaemia cells and in a subline resistant to doxorubicin. These membranes related activities were found to be increased in the doxorubicin resistant cell line, compared to the drug sensitive cells. It is suggested that...

journal_title：British journal of cancer

authors： Ramu A,Glaubiger D,Soprey P,Reaman GH,Feuerstein N

更新日期：1984-04-01 00:00:00

abstract：:Besides its cardiotoxic effect, doxorubicin also elicits inflammatory effects in vivo. 7-Monohydroxyethylrutoside (monoHER) has recently been used as a protector against doxorubicin-induced cardiotoxicity in vivo. It is not known yet whether monoHER can also protect against doxorubicin-induced inflammatory effects. Th...

journal_title：British journal of cancer

authors： Abou El Hassan MA,Verheul HM,Jorna AS,Schalkwijk C,van Bezu J,van der Vijgh WJ,Bast A

更新日期：2003-07-21 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC). METHODS:The number of CD8+ tumour-infiltrating immune cells (TIICs) and PD-1+ TII...

journal_title：British journal of cancer

authors： Hatogai K,Fujii S,Kitano S,Kojima T,Daiko H,Yoshino T,Ohtsu A,Takiguchi Y,Doi T,Ochiai A

更新日期：2020-02-01 00:00:00

abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...

journal_title：British journal of cancer

authors： Morrison AS,Verhoek WG,Leck I,Aoki K,Ohno Y,Obata K

更新日期：1982-03-01 00:00:00

abstract：:Lymphoma of the mucosa-associated lymphoid tissue (MALT) type usually arises in MALT acquired through chronic antigenic stimulation triggered by persistent infection and/or autoimmune processes. Due to specific ligand-receptor interactions between lymphoid cells and high-endothelial venules of MALT, both normal and ne...

journal_title：British journal of cancer

authors： Raderer M,Vorbeck F,Formanek M,Osterreicher C,Valencak J,Penz M,Kornek G,Hamilton G,Dragosics B,Chott A

更新日期：2000-08-01 00:00:00

abstract：:This cross-sectional survey aimed to evaluate the prevalence of burnout and estimated psychiatric disorders among haemato-oncology healthcare professionals in Italy. The aspects of work that respondents perceive as stressful and satisfying have also been examined. The assessments were made using the Maslach Burnout In...

journal_title：British journal of cancer

authors： Bressi C,Manenti S,Porcellana M,Cevales D,Farina L,Felicioni I,Meloni G,Milone G,Miccolis IR,Pavanetto M,Pescador L,Poddigue M,Scotti L,Zambon A,Corrao G,Lambertenghi-Deliliers G,Invernizzi G

更新日期：2008-03-25 00:00:00

abstract：BACKGROUND:The Obermair nomogram was recently developed to predict the risk of relapse in patients with borderline ovarian tumours (BOTs) based on five readily available clinical, biological, and pathological characteristics. We set out to externally validate and assess its robustness using a multi-institutional BOT da...

journal_title：British journal of cancer

authors： Bendifallah S,Uzan C,Fauvet R,Morice P,Darai E

更新日期：2013-11-26 00:00:00

abstract：:In a case-control study using a large UK primary care database, we found that non-steroidal anti-inflammatory drugs had no protective effect against biliary carcinomas (cholangiocarcinoma and gall bladder cancer). Increased risks were observed for cigarette smoking, diabetes, gallstone disease and obesity. ...

journal_title：British journal of cancer

authors： Grainge MJ,West J,Solaymani-Dodaran M,Aithal GP,Card TR

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We ha...

journal_title：British journal of cancer

authors： Shimwell NJ,Ward DG,Mohri Y,Mohri T,Pallan L,Teng M,Miki YC,Kusunoki M,Tucker O,Wei W,Morse J,Johnson PJ

更新日期：2012-10-23 00:00:00

abstract：:For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...

journal_title：British journal of cancer

authors： Evison M,AstraZeneca UK Limited.

更新日期：2020-12-01 00:00:00

abstract：:Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 recepto...

journal_title：British journal of cancer

authors： Rivera E,Arrieta O,Guevara P,Duarte-Rojo A,Sotelo J

更新日期：2001-11-02 00:00:00

abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...

journal_title：British journal of cancer

authors： Depuydt CE,Vereecken AJ,Salembier GM,Vanbrabant AS,Boels LA,van Herck E,Arbyn M,Segers K,Bogers JJ

更新日期：2003-02-24 00:00:00