Abstract:
:A CD34-negative haematopoietic progenitor cell line, D064, derived from canine bone marrow stromal cells is able to differentiate into haematopoietic progenitors under the influence of growth factor-mediated signalling. While differentiating, these cells eventually start to express MHC class II molecules (DR homologues) on their surface. The stable transfection of the fibroblast-like wild-type cells with retroviral constructs containing the cDNA for the canine MHC class II DR-genes (DRA and DRB) induces a change in morphology, accelerates cell cycle progression and leads to a loss of anchorage-dependent growth. Transfected cells show features of an immature stem cell leukaemia, such as giant cell formation. In wild-type D064 cells the accumulation of the cyclin-dependent kinase inhibitor (cdki) p27kip-1 induces differentiation, which is dependent upon signalling via the ligand for the tyrosine kinase receptor c-kit (stem cell factor). DR-transfected cells instead apparently grow independently of any growth factor-mediated signals and express high levels of the cdkis p27kip-1 and especially p21(waf-1/cip-1), concurrently with accelated cell cycle progression. In contrast to the overexpression of cdkis and despite accelerated cell cycle progression, the expression of the G2/M phase transition kinase p34cdc2 is significantly reduced in DR-transfected and transformed cells as compared to the haematopoietic wild-type cell line D064. This might suggest a possible alternative cell cycle progression pathway in this experimental stem cell leukaemia by by-passing the G0/G1 phase arrest, although retinoblastoma (Rb)-phosphorylation remains unaltered. These results provide evidence that mechanisms normally controlling the cell cycle and early haematopoietic differentiation are disrupted by the constitutive transcription and expression of MHC class II genes (DR) leading to a progression and growth of this experimental stem cell leukaemia independent from cell cycle controlling regulators such as p27 and p21.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Huss R,Theis S,Deeg HJdoi
10.1038/sj.bjc.6690768subject
Has Abstractpub_date
1999-11-01 00:00:00pages
808-13issue
5eissn
0007-0920issn
1532-1827journal_volume
81pub_type
杂志文章abstract:BACKGROUND:Whether red and processed meat consumption is a risk factor for pancreatic cancer remains unclear. We conducted a meta-analysis to summarise the evidence from prospective studies of red and processed meat consumption and pancreatic cancer risk. METHODS:Relevant studies were identified by searching PubMed an...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/bjc.2011.585
更新日期:2012-01-31 00:00:00
abstract::In vivo growth characteristics of myeloid leukaemia induced by whole-body irradiation of CBA/H male mice were examined in the strain of origin by procedures expected to enhance or depress immunological responses. Syngeneic growth in vivo (survival time and frequency of takes) was not modified by attempted active immun...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.68
更新日期:1982-03-01 00:00:00
abstract::The hypothesis is advanced that abnormalities of the chromosome group 17,18 play a special role in the genesis and/or evolution of some reticuloendothelial neoplasms. Aberrations of the group 17,18 chromosomes in tumour cells exceed in variety the reported anomaliesof any other chromosome. Both the frequency of these ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1970.11
更新日期:1970-03-01 00:00:00
abstract::Aminoglutethimide without glucocorticoid has been shown to be a clinically effective treatment for postmenopausal breast cancer in low dosage (250 mg day-1). The mechanism of action of this approach is thought to be the inhibition of peripheral aromatase, the enzyme which converts androstenedione to oestrone. The acti...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.144
更新日期:1985-07-01 00:00:00
abstract::Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.512
更新日期:1993-12-01 00:00:00
abstract::Increased fibre intake has been shown to reduce serum oestrogen concentrations. We hypothesized that fibre exerts this effect by decreasing the time available for reabsorption of oestrogens in the colon. We tested this in volunteers by measuring changes in serum oestrogen levels in response to manipulation of intestin...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1997.397
更新日期:1997-01-01 00:00:00
abstract::The objective of the study was to evaluate the effect of neoadjuvant chemotherapy on the survival of patients with oropharyngeal cancer. Patients with a squamous cell carcinoma of the oropharynx for whom curative radiotherapy or surgery was considered feasible were entered in a multicentric randomized trial comparing ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1054/bjoc.2000.1512
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Oestrogen (E2) induces apoptosis in long-term E2-deprived MCF7 cells (MCF7:5C). Taxanes have been used extensively in the treatment of early and advanced breast cancer. We have interrogated the sequence of events that involve the apoptotic signalling pathway induced by E2 in comparison with paclitaxel. METH...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.50
更新日期:2014-03-18 00:00:00
abstract::Members of the public are increasingly consulted over health care and research priorities. Patient involvement in determining cancer research priorities, however, has remained underdeveloped. This paper presents the findings of the first consultation to be conducted with UK cancer patients concerning research prioriti...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603662
更新日期:2007-03-26 00:00:00
abstract::Flavone acetic acid (FAA) was administered at a dose of 4.8 g m-2 over 1 h to patients with advanced malignant disease in combination with Interleukin II. A new high performance liquid chromatography method is described to determine both the parent compound and eight drug-related products, and the conditions required ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.250
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:The association between gall bladder removal (cholecystectomy) and hepatocellular carcinoma warrants investigation. An increased intrahepatic bile duct pressure following cholecystectomy might cause chronic inflammation in the surrounding liver tissue, which might induce cancer development. METHODS:A nation...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.181
更新日期:2011-06-28 00:00:00
abstract:BACKGROUND:It has been reported that although young patients present with more advanced disease, when adjusted for stage, cancer-specific survival is not different after surgery for colorectal cancer. However, few studies have examined non-cancer survival in young patients and 10-year survival has rarely been reported....
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605222
更新日期:2009-08-18 00:00:00
abstract::Small cell bronchial carcinoma (SCC) xenografts with differing sensitivity to cyclophosphamide (CY) were investigated using a variety of techniques. Two xenografts (HX78 and HX88) were relatively sensitive to CY, one xenograft (HX72) was inherently resistant to CY and a fourth xenograft (HX78Cy) was a CY induced resis...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.98
更新日期:1985-05-01 00:00:00
abstract::Pancreatic tumours are scirrhous, avascular tumours, suggesting that they may produce angiogenesis inhibitors that suppress the growth of the vasculature to the tumour and metastases. We have sought evidence for the angiogenesis inhibitor, endostatin, in normal and cancerous pancreatic tissue. Using Western blotting, ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602234
更新日期:2005-01-17 00:00:00
abstract::Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer. Hormonal escape of prostate tumours is marked by many biological changes, including mucinous and neuroendocrine differentiation. Since expression of several muc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601570
更新日期:2004-02-09 00:00:00
abstract::Pancreatic cancers occurring in carriers of a pathogenic germline alteration in BRCA1/2 (gBRCA1/2) are assumed to demonstrate homologous recombination repair deficiency (HRD), associated with sensitivity to platinum-based chemotherapy and synthetic lethality with PARP inhibitors (PARPi). However, primary and secondary...
journal_title:British journal of cancer
pub_type: 评论,社论
doi:10.1038/s41416-019-0645-9
更新日期:2020-02-01 00:00:00
abstract::ERBB2 is frequently amplified in breast tumours as part of a wide region of amplification on chromosome 17q21. This amplicon contains many candidate genes for breast cancer susceptibility. We used a genetic association study design to determine if common genetic variation (frequency>or=5%) in a 400-kb region surroundi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603473
更新日期:2006-12-18 00:00:00
abstract::A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.26
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Faecal immunochemical tests (FITs) have replaced guaiac-based faecal occult blood test (gFOBTs) in several colorectal cancer (CRC) screening programmes. We aimed to evaluate the benefits of this transition based on the Wallonia-Brussels-organised CRC screening programme. METHODS:A total of 1,569,868 individ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0754-5
更新日期:2020-03-01 00:00:00
abstract::An economic sub-study was run alongside a large multi-centre randomised trial (MRC-CR06) comparing three chemotherapy regimens; de Gramont, Lokich and raltitrexed in patients with metastatic colorectal cancer. Patients in six of 45 centres in the main trial were approached to take part in the sub-study. Chemotherapy d...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.bjc.6600273
更新日期:2002-06-05 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.505
更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6602085
更新日期:2004-08-31 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6600030
更新日期:2002-01-07 00:00:00
abstract::The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.16
更新日期:1987-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2011.104
更新日期:2011-04-12 00:00:00
abstract::The tumour suppressor gene CDKN2A, located on chromosome 9p21, encodes the cell cycle regulatory protein p16. Inactivation of the CDKN2A gene could lead to uncontrolled cell growth. In order to determine the role of CDKN2A in the development of sporadic ovarian cancer, loss of heterozygosity at 9p21-22, homozygous del...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690621
更新日期:1999-08-01 00:00:00
abstract::The aim of this paper was to provide epidemiological evidence to support the notion that cervical intraepithelial neoplasia (CIN) without human papillomavirus (HPV) is a true entity. If a diagnosis of HPV-negative cervical neoplasia is erroneous, one would not expect there to be any differences in risk factors between...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.146
更新日期:1996-03-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1977.49
更新日期:1977-03-01 00:00:00
abstract::The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602171
更新日期:2004-10-18 00:00:00
abstract::Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690323
更新日期:1999-04-01 00:00:00