Abstract:
:ERBB2 is frequently amplified in breast tumours as part of a wide region of amplification on chromosome 17q21. This amplicon contains many candidate genes for breast cancer susceptibility. We used a genetic association study design to determine if common genetic variation (frequency>or=5%) in a 400-kb region surrounding ERBB2 and containing the PPARBP, CRK7, NEUROD2, PPP1R1B, STARD3, TCAP, PNMT, CAB2, ERBB2, C17ORF37, GRB7 and ZNFN1A3 genes, was associated with breast cancer risk. Sixteen tagging single-nucleotide polymorphisms (tSNPs) selected within blocks of linkage disequilibrium from the HapMap database, one HapMap singleton SNP, and six additional SNPs randomly selected from dbSNP were genotyped using Taqman in a large study set of British women (2275 cases, 2280 controls). We observed no association between any of the genotypes or associated haplotypes and disease risk. In order to simulate unidentified SNPs, we performed the leave-one-out cross-validation procedure on the HapMap data; over 90% of the common genetic variation was well represented by tagging polymorphisms. We are therefore likely to have tagged any common variants present in our population. In summary, we found no association between common genetic variation in the 17q21 ERBB2 amplicon and breast cancer risk in British women.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Benusiglio PR,Pharoah PD,Smith PL,Lesueur F,Conroy D,Luben RN,Dew G,Jordan C,Dunning A,Easton DF,Ponder BAdoi
10.1038/sj.bjc.6603473subject
Has Abstractpub_date
2006-12-18 00:00:00pages
1689-95issue
12eissn
0007-0920issn
1532-1827pii
6603473journal_volume
95pub_type
杂志文章abstract::Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.294
更新日期:1996-06-01 00:00:00
abstract::Patients with rectal cancer are at high risk of disease recurrence despite neoadjuvant radiochemotherapy with 5-Fluorouracil (5FU), a regimen that is now widely applied. In order to develop a regimen with increased antitumour activity, we previously established the recommended dose of neoadjuvant CPT-11 (three times w...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.bjc.6603322
更新日期:2006-09-18 00:00:00
abstract:BACKGROUND:Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Althoug...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.280
更新日期:2016-10-11 00:00:00
abstract::Detailed data and statistics per each morphological site of various digestive neoplasms were obtained for the period 1976-87 from the Vaud Cancer Registry datafile, a population-based cancer registration scheme covering about 530,000 inhabitants from the French-speaking part of Switzerland. Tabulations presented inclu...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.132
更新日期:1991-04-01 00:00:00
abstract::The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.278
更新日期:1994-08-01 00:00:00
abstract::The effects of suramin, an inhibitor of growth factor mitogenic activity, were evaluated on basic fibroblast growth factor (bFGF)-induced proliferation of bovine aortic endothelial cells and on angiogenesis in the chorioallantoic membrane (CAM) of chick embryos. The role of bFGF gene expression in endothelial cell gro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.457
更新日期:1993-11-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.393
更新日期:1995-09-01 00:00:00
abstract::Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Resea...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600194
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abstract::Up to 60% of gastro-oesophageal junction (GEJ) adenocarcinomas show nuclear beta-catenin expression, pointing to activated T-cell factor (TCF)/beta-catenin-driven gene transcription. We demonstrate in five human GEJ adenocarcinoma cell lines that nuclear beta-catenin expression indeed correlates with enhanced TCF-medi...
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6601589
更新日期:2004-02-23 00:00:00
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pub_type: 杂志文章
doi:10.1054/bjoc.1999.0890
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-019-0621-4
更新日期:2020-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2012.100
更新日期:2012-04-24 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-05-24 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.468
更新日期:2013-09-03 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.1994.105
更新日期:1994-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/bjc.1996.7
更新日期:1996-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.501
更新日期:2014-12-09 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605661
更新日期:2010-05-11 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.268
更新日期:1988-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6601022
更新日期:2003-07-21 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603626
更新日期:2007-03-26 00:00:00
abstract::This study was undertaken to determine the prevalence of anti-cardiolipin antibodies (ACLAs) in patients with malignancy and to investigate a possible association of ACLAs with thromboembolic events in such patients. The study included 216 patients with solid and non-solid malignancies and an age-matched control group...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.353
更新日期:1995-08-01 00:00:00
abstract::In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.5
更新日期:1993-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.285
更新日期:1988-11-01 00:00:00
abstract::Women with gross cystic breast disease may have an increased risk of breast cancer. In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. For this, oestrogen receptor-positive (ER+) MCF-7 or MDA-MB...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0948
更新日期:2000-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.97
更新日期:1988-04-01 00:00:00
abstract::MDM2 is an oncoprotein that inhibits p53 tumour-suppressor protein. Amplification of the MDM2 gene and overexpression of its protein have been observed in some human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To determine the clinicopathological and prognos...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.221
更新日期:1997-01-01 00:00:00
abstract::Heterogeneity of DNA content in multiple hepatocellular carcinomas (HCCs) was investigated by flow cytometry in 62 tumours from 26 patients who had undergone surgical treatment for multiple synchronous HCCs. Heterogeneity of DNA content was defined (a) when tumours had a different DNA ploidy pattern or (b) when the di...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.387
更新日期:1997-01-01 00:00:00