当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Acquisition of platinum drug resistance and platinum cross resistance patterns in a panel of human ovarian carcinoma xenografts.

Acquisition of platinum drug resistance and platinum cross resistance patterns in a panel of human ovarian carcinoma xenografts.

Abstract：

:In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been generated to CDDP (three lines), CBDCA (one line), CHIP (three lines) and tetraplatin (one line) either by treatment in vivo or (for one line to CDDP) through exposure in vitro and subsequent transfer to mice. With the four tumours where resistance was generated using CDDP or CBDCA, a complete cross-resistance to the remaining platinum agents studied was observed. In contrast, in one of three lines with derived resistance to the platinum (IV) agent, CHIP, (PXN/951) a retention in sensitivity was observed with CDDP and CBDCA. Only one of the six parent tumour lines (PXN/100) was markedly sensitive to tetraplatin. Where resistance was generated to tetraplatin (PXN/100T) there was some retention of activity by CDDP. For the CDDP-resistant line established in vitro, there was a close agreement between the cross-resistance profile obtained in vitro vs that obtained in vivo. This tumour panel may be useful in the elucidation of cellular and molecular resistance mechanisms to platinum drugs operative in vivo. Moreover, as they appear to mimic the clinical observations of shared cross-resistance between CDDP, CBDCA and CHIP, they may represent valuable preclinical evaluation models for the discovery of drugs capable of conferring responses in CDDP-refractory ovarian cancer.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Jones M,Siracky J,Kelland LR,Harrap KR

doi

10.1038/bjc.1993.5

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

24-9

issue

1

eissn

0007-0920

issn

1532-1827

journal_volume

67

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Prognostic implication of mucinous histology in colorectal cancer patients treated with adjuvant FOLFOX chemotherapy.

    abstract：BACKGROUND:There have been controversies in prognostic impact of mucinous histology on colorectal cancer, and its implication in patients treated with adjuvant 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is unclear. METHODS:Stage II and III colorectal cancer patients who underwent curative resection followed ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.232

    authors： Lee DW,Han SW,Lee HJ,Rhee YY,Bae JM,Cho NY,Lee KH,Kim TY,Oh DY,Im SA,Bang YJ,Jeong SY,Park KJ,Park JG,Kang GH,Kim TY

    更新日期：2013-05-28 00:00:00

  • DNA interstrand cross-linking and cytotoxicity induced by chloroethylnitrosoureas and cisplatin in human glioma cell lines which vary in cellular concentration of O6-alkylguanine-DNA alkyltransferase.

    abstract：:Fifteen human glioma cell lines were examined for their sensitivity to 1,3-bis(chloroethyl)-nitrosourea (BCNU, carmustine) and cis-dichlorodiamminoplatinum (cisplatin), the induction of DNA interstrand cross-linking (DNA-ISC) induced by the two agents and cellular O6-alkylguanine alkyltransferase (ATase) activity. Cel...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.87

    authors： Beith J,Hartley J,Darling J,Souhami R

    更新日期：1997-01-01 00:00:00

  • Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells.

    abstract：:We report that all- trans retinoic acid (ATRA) enhanced the toxicity of docetaxel against DU145 and LNCaP prostate cancer cells, and that the nature of the interaction between ATRA and docetaxel was highly synergistic. Docetaxel-induced apoptotic cell death was associated with phosphorylation and hence inactivation of...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2001.1818

    authors： Nehmé A,Varadarajan P,Sellakumar G,Gerhold M,Niedner H,Zhang Q,Lin X,Christen RD

    更新日期：2001-06-01 00:00:00

  • Morphometric grading of breast cancer: thresholds for tubular differentiation.

    abstract：:We evaluated the degree of tubular differentiation in 172 samples of invasive ductal breast cancer in order to determine numerical thresholds for histological breast cancer grading. The tubular differentiation in each sample was defined as the fraction of fields showing tubular differentiation (FTD). The analysis was ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1222

    authors： Kronqvist P,Kuopio T,Collan Y

    更新日期：2000-05-01 00:00:00

  • Epidemiological evidence of cervical intraepithelial neoplasia without the presence of human papillomavirus.

    abstract：:The aim of this paper was to provide epidemiological evidence to support the notion that cervical intraepithelial neoplasia (CIN) without human papillomavirus (HPV) is a true entity. If a diagnosis of HPV-negative cervical neoplasia is erroneous, one would not expect there to be any differences in risk factors between...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.146

    authors： Burger MP,Hollema H,Pieters WJ,Schröder FP,Quint WG

    更新日期：1996-03-01 00:00:00

  • DNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive women.

    abstract：BACKGROUND:Primary high-risk human papillomavirus (hrHPV) testing in cervical cancer screening shows relatively low specificity, which makes triage testing necessary. In this study, DNA methylation analysis was compared with cytology for triage testing in hrHPV-positive women. Moreover, feasibility of DNA methylation a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.392

    authors： Boers A,Bosgraaf RP,van Leeuwen RW,Schuuring E,Heideman DA,Massuger LF,Verhoef VM,Bulten J,Melchers WJ,van der Zee AG,Bekkers RL,Wisman GB

    更新日期：2014-09-09 00:00:00

  • Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer.

    abstract：BACKGROUND:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CR...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.489

    authors： Snoeren N,Emmink BL,Koerkamp MJ,van Hooff SR,Goos JA,van Houdt WJ,de Wit M,Prins AM,Piersma SR,Pham TV,Belt EJ,Bril H,Stockmann HB,Meijer GA,van Hillegersberg R,Holstege FC,Jimenez CR,Fijneman RJ,Kranenburg OW,Rinke

    更新日期：2013-09-17 00:00:00

  • Geographic and ethnic differences in childhood leukaemia and lymphoma survival: comparisons of Philippine residents, Asian Americans and Caucasians in the United States.

    abstract：BACKGROUND:Childhood cancer survival estimates from developing nations are rare. METHODS:Using the US SEER and the Manila and Rizal Cancer Registry databases in the Philippines, 5-year survival for childhood leukaemia and lymphoma in 2001-2005 among Asian Americans were compared with both Filipinos and Caucasians in t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605703

    authors： Redaniel MT,Laudico A,Mirasol-Lumague MR,Alcasabas AP,Pulte D,Brenner H

    更新日期：2010-06-29 00:00:00

  • Models for skin tumour risks in workers exposed to mineral oils.

    abstract：:The relationship between skin tumours in man and exposure to polyaromatic hydrocarbons has been studied in lathe operators exposed to cutting oils. Seven cases of scrotal cancer and 13 cases of senile keratosis and keratoacanthoma were observed. The risk varied as the 1.6th power of duration of exposure for cancer on ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.435

    authors： Järvholm B,Easton D

    更新日期：1990-12-01 00:00:00

  • Allostimulation of patients' lymphocytes generates both T and NK-like cells cytotoxic for autologous melanoma.

    abstract：:Killing of autologous melanoma (auto-Me) was obtained with pooled allostimulated peripheral blood lymphocytes (PBL) in 34/42 cases and found not to be due to a cross-reactivity between melanoma and allogeneic normal antigens. To see whether generation of tumour cytotoxic PBL by allostimulation was due to release of IL...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.151

    authors： Balsari A,Fossati G,Taramelli D,Tona G,Delia D,Giardini R,Parmiani G

    更新日期：1985-07-01 00:00:00

  • Cancers in the first-degree relatives of children with brain tumours.

    abstract：:We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for b...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1252

    authors： Hemminki K,Li X,Vaittinen P,Dong C

    更新日期：2000-08-01 00:00:00

  • Effect of active immunization with irradiated tumour cells on specific serum inhibitors of cell-mediated immunity in patients with disseminated cancer.

    abstract：:The sera from patients with advanced cancer were tested for their specific inhibitory effects on the cytotoxicity of autologous lymphocytes on tumour cells in a microculture assay. By adding a standard volume of the sera to suspensions of well-washed lymphocytes the inhibitory effect was quantitated by comparison with...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.67

    authors： Currie GA

    更新日期：1973-07-01 00:00:00

  • Association of rib anomalies and childhood cancers.

    abstract：BACKGROUND:Congenital anomalies have been found more often in children with cancer than in those without. Rib abnormalities (RAs) have been associated with childhood cancer; however, studies have differed in the type of RAs and cancers implicated. METHODS:Rib abnormalities were assessed predominantly by X-ray in a hos...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.366

    authors： Zierhut H,Murati M,Holm T,Hoggard E,Spector LG

    更新日期：2011-10-25 00:00:00

  • Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative.

    abstract：BACKGROUND:Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death. METHODS:The DII was calculated from a baseline food freque...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.98

    authors： Tabung FK,Steck SE,Liese AD,Zhang J,Ma Y,Caan B,Chlebowski RT,Freudenheim JL,Hou L,Mossavar-Rahmani Y,Shivappa N,Vitolins MZ,Wactawski-Wende J,Ockene JK,Hébert JR

    更新日期：2016-05-24 00:00:00

  • Serum amyloid A (SAA): a novel biomarker for uterine serous papillary cancer.

    abstract：BACKGROUND:Uterine serous papillary carcinoma (USPC) is a biologically aggressive variant of endometrial cancer. We investigated the expression of Serum Amyloid A (SAA) and evaluated its potential as a serum biomarker in USPC patients. METHODS:SAA gene and protein expression levels were evaluated in USPC and normal en...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605129

    authors： Cocco E,Bellone S,El-Sahwi K,Cargnelutti M,Casagrande F,Buza N,Tavassoli FA,Siegel ER,Visintin I,Ratner E,Silasi DA,Azodi M,Schwartz PE,Rutherford TJ,Pecorelli S,Santin AD

    更新日期：2009-07-21 00:00:00

  • Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas.

    abstract：:Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha) have recently been shown to induce both inflammatory and anti-infla...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602568

    authors： Gubbay O,Guo W,Rae MT,Niven D,Langdon SP,Hillier SG

    更新日期：2005-05-23 00:00:00

  • Stathmin levels alter PTPN14 expression and impact neuroblastoma cell migration.

    abstract：BACKGROUND:Stathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin's role on the metastatic process, we performed integrated mRNA-miRNA expression analysis to identify pathways regulated by stathmin. METHODS:MiRNA and gene arrays followed by miRNA-target-gene integration...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0669-1

    authors： Po'uha ST,Le Grand M,Brandl MB,Gifford AJ,Goodall GJ,Khew-Goodall Y,Kavallaris M

    更新日期：2020-02-01 00:00:00

  • Effect of megestrol acetate on weight loss induced by tumour necrosis factor alpha and a cachexia-inducing tumour (MAC16) in NMRI mice.

    abstract：:The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.310

    authors： Beck SA,Tisdale MJ

    更新日期：1990-09-01 00:00:00

  • Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy.

    abstract：:Elderly patients are recommended to have a reduced starting dose (300 mg m(-2) once every 3 weeks) of irinotecan monotherapy. The aims of this analysis are to compare toxicity and survival according to age, performance status (PS), gender and prior radical pelvic radiotherapy (RT). The primary end points were overall ...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1038/sj.bjc.6602169

    authors： Chau I,Norman AR,Cunningham D,Waters JS,Topham C,Middleton G,Hill M,Ross PJ,Katopodis R,Stewart G,Oates JR

    更新日期：2004-10-18 00:00:00

  • The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.

    abstract：:Clonogenic survival of HeLa, Chinese hamster and HaK cells after treatment with a range of cisplatin concentrations and exposure times was determined and cellular platinum concentrations were measured by PIXE. It was demonstrated that cisplatin cytotoxicity of the three cell lines varied considerably as a function of ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1986.168

    authors： Eichholtz-Wirth H,Hietel B

    更新日期：1986-08-01 00:00:00

  • A preliminary study of intravenous methanol extraction residue of BCG in treatment of advanced cancer.

    abstract：:Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was e...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/bjc.1977.198

    authors： Robinson E,Bartal A,Honigman J,Cohen Y

    更新日期：1977-09-01 00:00:00

  • Human primary brain tumour metabolism in vivo: a phosphorus magnetic resonance spectroscopy study.

    abstract：:Magnetic resonance spectroscopy was used to study intracellular pH and compounds which contain phosphorus in normal human brain and primary brain tumours non-invasively. In normal subjects (n = 7) intracellular pH (pHi) of the brain was 7.03 +/- 0.02 (mean +/- s.e.m.). The pHi did not vary between superficial (2 cm, m...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1989.300

    authors： Cadoux-Hudson TA,Blackledge MJ,Rajagopalan B,Taylor DJ,Radda GK

    更新日期：1989-09-01 00:00:00

  • On the age-dependent association between cancer of the breast and of the endometrium. A nationwide cohort study.

    abstract：:The association between breast and endometrial cancer was investigated in a cohort consisting of 60,065 subjects (99% of all women in whom a first breast cancer was diagnosed in Sweden in 1960-63 and 1968-81). Complete follow-up until 1981 revealed a total of 260 endometrial cancers, as against an expected number of 1...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.16

    authors： Adami HO,Krusemo UB,Bergkvist L,Persson I,Pettersson B

    更新日期：1987-01-01 00:00:00

  • The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation.

    abstract：:Eighty-two patients were randomly allocated to receive intravenous acyclovir 5 mg kg-1 t.d.s. for 23 days followed by oral acyclovir 800 mg 6-hourly for 6 months or matching placebos after allogeneic bone marrow transplantation. Herpes simplex and varicella zoster virus infections were significantly reduced during the...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1989.88

    authors： Selby PJ,Powles RL,Easton D,Perren TJ,Stolle K,Jameson B,Fiddian AP,Tryhorn Y,Stern H

    更新日期：1989-03-01 00:00:00

  • Intrathecal chemotherapy. Selection of cytostatic agents.

    abstract：:Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of variou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1970.59

    authors： Hayakawa T,Yamada R,Kanai N,Kuroda R,Ushio Y,Higashi H,Mogami H

    更新日期：1970-09-01 00:00:00

  • Nitroimidazole adducts as markers for tissue hypoxia: mechanistic studies in aerobic normal tissues and tumour cells.

    abstract：:Two aspects of the aerobic metabolism of nitroimidazole markers for hypoxia were investigated. Several normal murine tissues which are likely to be well oxygenated bind misonidazole at rates comparable to those of hypoxic regions in tumours. The possibility that this aerobic activation occurs via an oxygen independent...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.418

    authors： Parliament MB,Wiebe LI,Franko AJ

    更新日期：1992-12-01 00:00:00

  • Comparison of mesna with forced diuresis to prevent cyclophosphamide induced haemorrhagic cystitis in marrow transplantation: a prospective randomised study.

    abstract：:A prospective randomised study was carried out to compare the effect of mesna (2-mercaptoethane sulphonate sodium) with that of forced diuresis in preventing cyclophosphamide induced haemorrhagic cystitis in marrow transplant recipients. Sixty-one consecutive BMT recipients were randomised for treatment with forced di...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1984.252

    authors： Hows JM,Mehta A,Ward L,Woods K,Perez R,Gordon MY,Gordon-Smith EC

    更新日期：1984-12-01 00:00:00

  • Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study.

    abstract：:Raised risks of several cancers have been found in patients with type II diabetes, but there are few data on cancer risk in type I diabetes. We conducted a cohort study of 28 900 UK patients with insulin-treated diabetes followed for 520 517 person-years, and compared their cancer incidence and mortality with national...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602611

    authors： Swerdlow AJ,Laing SP,Qiao Z,Slater SD,Burden AC,Botha JL,Waugh NR,Morris AD,Gatling W,Gale EA,Patterson CC,Keen H

    更新日期：2005-06-06 00:00:00

  • Soluble and nuclear oestrogen receptor status in human breast cancer in relation to prognosis.

    abstract：:The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- di...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.9

    authors： Leake RE,Laing L,McArdle C,Smith DC

    更新日期：1981-01-01 00:00:00

  • Quality of life after prostate cancer treatments in patients comparable at baseline.

    abstract：BACKGROUND:Previous studies on the effects of different prostate cancer treatments on quality of life, were confounded because patients were not comparable. This study examined treatment effects in more comparable groups. METHODS:From 2008-2011, 240 patients with localised prostate cancer were selected to be eligible ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.181

    authors： van Tol-Geerdink JJ,Leer JW,van Oort IM,van Lin EJ,Weijerman PC,Vergunst H,Witjes JA,Stalmeier PF

    更新日期：2013-05-14 00:00:00