Abstract：
BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 with locally advanced tumour and 12 with metastases) had positive tumour EGFR expression. The cetuximab loading dose (400 mg m⁻²) was followed by 250 mg m⁻² per week. Locally advanced tumours were irradiated (mean dose 65 Gy) and treated with concomitant cisplatin (75 mg m⁻², intravenously). Patients with metastases received concomitant cisplatin and 5-fluorouracil (4 × 1000 mg m⁻²). RESULTS:For patients with locally advanced disease (median follow-up: 52 months), the median progression-free survival (PFS) was 64 months and the 2-year overall survival (OS) rate was 100%. For patients with metastases (median follow-up: 72 months), the median PFS and OS were 13 and 24 months, respectively. In both groups the objective response rate was >40%. Skin rash, in-field dermatitis, mucositis and vomiting were the most frequent grade 3/4 adverse events. CONCLUSION:In this single-arm study, the efficacy of cetuximab plus chemoradio- or chemotherapy appeared favourable as compared with historical controls. All side effects were manageable and did not hamper the treatment.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Hitre E,Budai B,Takácsi-Nagy Z,Rubovszky G,Tóth E,Remenár É,Polgár C,Láng Idoi
10.1038/bjc.2013.468subject
Has Abstractpub_date
2013-09-03 00:00:00pages
1117-22issue
5eissn
0007-0920issn
1532-1827pii
bjc2013468journal_volume
109pub_type
杂志文章abstract：:Two policies of palliative thoracic radiotherapy for non-small-cell lung cancer have been compared in a randomised multicentre controlled trial. A total of 369 patients with inoperable, histologically or cytologically confirmed disease, too advanced for radical 'curative' radiotherapy, and with their main symptoms rel...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1991.62
更新日期：1991-02-01 00:00:00
abstract：BACKGROUND:Metastatic clear cell renal cell carcinoma (ccRCC) patients have <9% 5-year survival rate, do not respond well to targeted therapy and eventually develop resistance. A better understanding of molecular pathways of RCC metastasis is the basis for the discovery of novel prognostic markers and targeted therapie...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.828
更新日期：2014-03-04 00:00:00
abstract：:Ultrafiltrates from spleen inhibited both DNA synthesis and the proliferation of normal lymphocytes stimulated inculture from both mouse and man without apparent cytotoxicity. However, the same doses of this spleen ultrafiltrate will kill up to two-thirds of the leukaemic lymphoblasts from both mouse and man after 24 ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.280
更新日期：1975-12-01 00:00:00
abstract：BACKGROUND:Gestational trophoblastic diseases (GTDs) are related to trophoblasts, and human chorionic gonadotropin (hCG) is secreted by GTDs as well as normal placentas. However, the asparagine-linked sugar chains on hCG contain abnormal biantennary structures in invasive mole and choriocarcinoma, but not normal pregna...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.496
更新日期：2012-12-04 00:00:00
abstract：:The molecular events that drive the initiation and progression of ovarian adenocarcinoma are not well defined. We have investigated changes in gene expression in ovarian cancer cell lines compared to an immortalized human ovarian surface epithelial cell line (HOSE) using a cDNA array. We identified 17 genes that were ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1620
更新日期：2001-02-02 00:00:00
abstract：:Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603140
更新日期：2006-05-22 00:00:00
abstract：BACKGROUND:Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS:Tumour-infiltr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605438
更新日期：2009-12-01 00:00:00
abstract：:We investigated whether dietary intakes of total fat, monounsaturated fat (MUFA), polyunsaturated fat (PUFA) and saturated fat (SFA) were associated with breast cancer risk in a prospective cohort of 49 261 Swedish women (30-49 years at enrolment), which yielded 974 breast cancer cases by December 2005. Further, we ev...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604033
更新日期：2007-12-03 00:00:00
abstract：:Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up. The preoperative concentrations of C1-INH and C4 were higher (P < 0.0005 and P < 0.005) and IgG lower (P < 0.0005) in 50 patients with ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.376
更新日期：1992-11-01 00:00:00
abstract：:Little is known about chemoradiotherapy (CRT) in elderly patients with a locally advanced oesophageal cancer (OC). The aim of our study was to evaluate the tolerance and the outcome of elderly patients older than 70 years treated with CRT for a non-metastatic OC. Chemoradiotherapy was based on radiotherapy combined wi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604749
更新日期：2008-11-18 00:00:00
abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.129
更新日期：2012-05-08 00:00:00
abstract：BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.40
更新日期：2013-03-05 00:00:00
abstract：BACKGROUND:Extracellular matrix (ECM) plays a crucial role in tumour behaviour. Prolyl-4-hydroxlase-A2 (P4HA2) is a key enzyme in ECM remodelling. This study aims to evaluate the prognostic significance of P4HA2 in breast ductal carcinoma in situ (DCIS). METHODS:P4HA2 expression was assessed immunohistochemically in m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0337-x
更新日期：2018-12-01 00:00:00
abstract：:Targeting growth-regulatory pathways is a promising approach in cancer treatment. A prerequisite to the development of such therapies is characterisation of tumour growth regulation in the particular tumour cell type of interest. In order to gain insight into molecular mechanisms underlying proliferative responses in ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602535
更新日期：2005-04-25 00:00:00
abstract：BACKGROUND:The Obermair nomogram was recently developed to predict the risk of relapse in patients with borderline ovarian tumours (BOTs) based on five readily available clinical, biological, and pathological characteristics. We set out to externally validate and assess its robustness using a multi-institutional BOT da...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2013.678
更新日期：2013-11-26 00:00:00
abstract：BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-l...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01029-7
更新日期：2020-10-01 00:00:00
abstract：:In a study involving 50 breast cancer tumours, we compared two oestrogen receptor (ER) detection methods developed by us--a microplate immunoenzymometric assay (EIA96) and an immunohistochemistry kit (HistoCIS-ER)--with the radioligand assay (RLA), the Abbott immunoenzymometric assay ER-EIA and the reverse transcripta...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.418
更新日期：1997-01-01 00:00:00
abstract：:Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0961-0
更新日期：2020-09-01 00:00:00
abstract：:Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690271
更新日期：1999-04-01 00:00:00
abstract：:The humanised form of an antagonistic anti-IGF-1R mAb (AVE1642) selectively inhibits the growth of CD45(neg) myeloma cells. AVE1642 strongly increased bortezomib-induced apoptosis, correlated with an increase of Noxa expression. These results support the therapeutic use of anti-IGF-1R/bortezomib in CD45(neg) Myeloma p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604839
更新日期：2009-01-27 00:00:00
abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.379
更新日期：1993-09-01 00:00:00
abstract：:While statins have been highly effective for lowering serum cholesterol and reducing the incidence of coronary events, they have multiple other effects. Certain statins block the interaction of adhesion molecules that are important for cell-cell interactions including those between EBV-transformed B cells. These same ...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602561
更新日期：2005-05-09 00:00:00
abstract：:Fine needle aspiration (FNA) biopsy is the least invasive method of sampling breast cancer in vivo and provides material for breast cancer diagnosis. FNA has also been used to examine cellular markers to predict and monitor the effects of therapy. The aim of this study was to assess the accuracy of using FNA material ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2064
更新日期：2001-10-19 00:00:00
abstract：BACKGROUND:Ezrin, which is known as a cytoskeleton linker protein, is closely linked with the metastatic progression of cancer and is frequently abnormally expressed in aggressive cancer types. However, the possible involvement of Ezrin in metastasis and angiogenesis in breast cancer remains unclear. METHODS:Immunohis...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0383-z
更新日期：2019-04-01 00:00:00
abstract：:The purpose of this study was to address the prognostic significance of circulating melanoma cells by reverse transcriptase-polymerase chain reaction in the peripheral blood of stage IIB and III melanoma patients on high-dose adjuvant interferon at multiple sequential time points from initiation of treatment. Tyrosina...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600419
更新日期：2002-07-15 00:00:00
abstract：BACKGROUND:Children with cancer are frequently immunocompromised. While children are generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the risk in children with cancer is unavailable. We aimed to produce evidence of the incidence and outcomes fr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01181-0
更新日期：2020-12-10 00:00:00
abstract：:Iodine-123-labelled tumour associated monoclonal antibody HMFG2 was administered intralymphatically at a time that cannulation of pedal lymphatic vessels was performed for standard lymphangiography in 6 patients with cervical cancer. Gamma camera images were taken at 2 h and 24 h after injection of antibody and at a s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.125
更新日期：1985-06-01 00:00:00
abstract：:We investigated whether cholecystectomy is associated with subsequent cancer and, if so, whether the association is likely to be causal, by undertaking a retrospective cohort study using linked medical statistics, comprising a cholecystectomy group (n=39 254) and a reference cohort admitted for a range of other medica...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602392
更新日期：2005-04-11 00:00:00
abstract：:Cultured cells maintained in very low oxygen levels alter their structure, metabolism and genetic expression. Culture conditions for cells were modified to minimise variation of nutrients and to allow normal survival levels after 24 h of hypoxic exposure. Under these hypoxic conditions, glucose consumption and lactate...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.264
更新日期：1990-08-01 00:00:00
abstract：:We investigated expression of a human p53-inducible gene, P2XM, a member of the P2X-receptor family of ATP-gated ion channels, in 56 human primary soft-tissue tumours including 47 sarcomas and nine benign tumors. Among the 47 sarcomas examined by reverse transcription polymerase chain reaction, 12 had lost expression ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690484
更新日期：1999-06-01 00:00:00
