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Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells.

Abstract：

:Targeting growth-regulatory pathways is a promising approach in cancer treatment. A prerequisite to the development of such therapies is characterisation of tumour growth regulation in the particular tumour cell type of interest. In order to gain insight into molecular mechanisms underlying proliferative responses in neuroendocrine (NE) gastrointestinal (GI) tumours, we investigated gene expression in human carcinoid BON cells after exposure to gastrin, hepatocyte growth factor (HGF), pituitary adenylate cyclase-activating polypeptide or epidermal growth factor. We particularly focused on gastrin- and HGF-induced gene expression, and identified 95 gastrin- and 101 HGF-responsive genes. The majority of these genes are known mediators of processes central in tumour biology, and a number of them have been associated with poor prognosis and metastasis in cancer patients. Furthermore, we identified 12 genes that were regulated by all four factors, indicating that they may be universally regulated during NE GI tumour cell proliferation. Our findings provide useful hypotheses for further studies aimed to search for new therapeutic targets as well as tumour markers in NE GI tumours.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Hofsli E,Thommesen L,Yadetie F,Langaas M,Kusnierczyk W,Falkmer U,Sandvik AK,Laegreid A

doi

10.1038/sj.bjc.6602535

subject

Has Abstract

pub_date

2005-04-25 00:00:00

pages

1506-16

issue

8

eissn

0007-0920

issn

1532-1827

pii

6602535

journal_volume

92

pub_type

杂志文章

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