A multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours.

abstract：:Iodine-123-labelled tumour associated monoclonal antibody HMFG2 was administered intralymphatically at a time that cannulation of pedal lymphatic vessels was performed for standard lymphangiography in 6 patients with cervical cancer. Gamma camera images were taken at 2 h and 24 h after injection of antibody and at a s...

journal_title：British journal of cancer

authors： Epenetos AA

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:New prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence and association with outcome of circulating tumour DNA (ctDNA) using next-generation sequencing (NGS) assays. METHODS:A NGS hybrid capture ass...

journal_title：British journal of cancer

authors： Shulman DS,Klega K,Imamovic-Tuco A,Clapp A,Nag A,Thorner AR,Van Allen E,Ha G,Lessnick SL,Gorlick R,Janeway KA,Leavey PJ,Mascarenhas L,London WB,Vo KT,Stegmaier K,Hall D,Krailo MD,Barkauskas DA,DuBois SG,Crompton B

更新日期：2018-08-01 00:00:00

abstract：:Tumour recurrence and metastases of hepatocellular carcinoma (HCC) after hepatectomy are the major obstacles of long-term survival. The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy. Seventy-two pairs of RNA and 10...

journal_title：British journal of cancer

authors： Ng KT,Man K,Sun CK,Lee TK,Poon RT,Lo CM,Fan ST

更新日期：2006-10-23 00:00:00

abstract：:The aim of the study was to investigate the association of physician communication behaviours as perceived by the patient with patient reported satisfaction, distress, cancer-related self-efficacy, and perceived control over the disease in cancer patients. Questionnaires measuring distress, self-efficacy, and perceive...

journal_title：British journal of cancer

authors： Zachariae R,Pedersen CG,Jensen AB,Ehrnrooth E,Rossen PB,von der Maase H

更新日期：2003-03-10 00:00:00

abstract：:In 1985 a second randomisation was initiated for women in the treatment arm of the Scottish Tamoxifen Trial either to stop tamoxifen at 5 years or to continue indefinitely. A preliminary analysis of outcome in 342 patients at a median follow-up of 6 years suggests that a worthwhile gain in disease control from continu...

journal_title：British journal of cancer

authors： Stewart HJ,Forrest AP,Everington D,McDonald CC,Dewar JA,Hawkins RA,Prescott RJ,George WD

更新日期：1996-07-01 00:00:00

abstract：:Hypoxic cells in KHT sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome Hoechst 33342. Tumour-bearing female C3H/HeJ mice were injected i.v. with 10 micrograms g-1 Hoechst 33342 and the cells derived from the tumours sorted on the basis of their ...

journal_title：British journal of cancer

authors： Siemann DW,Keng PC

更新日期：1988-09-01 00:00:00

abstract：:The relationship between hormone replacement treatment (HRT) and breast cancer risk was analysed using data from a case-control study conducted between June 1991 and February 1994 in six Italian centres on 2569 patients aged below 75 with histologically confirmed breast cancer and 2588 controls admitted to hospital fo...

journal_title：British journal of cancer

authors： La Vecchia C,Negri E,Franceschi S,Favero A,Nanni O,Filiberti R,Conti E,Montella M,Veronesi A,Ferraroni M

更新日期：1995-07-01 00:00:00

abstract：:Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was e...

journal_title：British journal of cancer

authors： Robinson E,Bartal A,Honigman J,Cohen Y

更新日期：1977-09-01 00:00:00

abstract：:In Vaud, Switzerland, the incidence of carcinoids based on 218 malignant and 215 benign cases rose from 19.6/10(6)in 1974-85 to 28. 2/10(6)in 1986-97, more so among males and malignant neoplasms. Lung was the commonest site for malignant and large intestine for benign carcinoids. Sixty-eight (16%) carcinoids had anoth...

journal_title：British journal of cancer

authors： Levi F,Te VC,Randimbison L,Rindi G,La Vecchia C

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial-mesenchymal transition-related biomarker plastin3 (PLS3) in peripheral blood could be a prognostic factor in breast cancer. METHODS...

journal_title：British journal of cancer

authors： Ueo H,Sugimachi K,Gorges TM,Bartkowiak K,Yokobori T,Müller V,Shinden Y,Ueda M,Ueo H,Mori M,Kuwano H,Maehara Y,Ohno S,Pantel K,Mimori K

更新日期：2015-04-28 00:00:00

abstract：:The use of more lipophilic derivatives of 5-aminolevulinic acid (ALA) is expected to have better diffusing properties, and after conversion into the parent ALA, to reach a higher protoporphyrin IX (PPIX) formation rate, thus improving the efficacy of topical photodynamic therapy (PDT). Here we have analysed the behavi...

journal_title：British journal of cancer

authors： Casas A,Fukuda H,Di Venosa G,Batlle A

更新日期：2001-07-20 00:00:00

abstract：:In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients p...

journal_title：British journal of cancer

authors： Eschwège P,Moutereau S,Droupy S,Douard R,Gala JL,Benoit G,Conti M,Manivet P,Loric S

更新日期：2009-02-24 00:00:00

abstract：:Based on observations that for certain cancers, mortality varies according to sun exposure, vitamin D has been proposed to influence on disease progression. This study aims to investigate whether serum levels of 25(OH)D are associated with prognosis in patients with prostate cancer. In total, 160 patients with a serum...

journal_title：British journal of cancer

authors： Tretli S,Hernes E,Berg JP,Hestvik UE,Robsahm TE

更新日期：2009-02-10 00:00:00

abstract：BACKGROUND:The conventional treatment options for advanced gastric patients remain unsatisfactory in terms of response rate, response duration, toxicity, and overall survival benefit. The purpose of this phase II study was to evaluate the activity and safety of cetuximab combined with cisplatin and docetaxel as a first...

journal_title：British journal of cancer

authors： Pinto C,Di Fabio F,Barone C,Siena S,Falcone A,Cascinu S,Rojas Llimpe FL,Stella G,Schinzari G,Artale S,Mutri V,Giaquinta S,Giannetta L,Bardelli A,Martoni AA

更新日期：2009-10-20 00:00:00

abstract：:Although patients with superficial bladder cancer (Ta, T1) have a generally good prognosis, those patients who develop muscle-invasive tumours or metastatic disease at recurrence do poorly clinically. In the current study 69 patients undergoing complete transurethral resection for superficial transitional cell cancer ...

journal_title：British journal of cancer

authors： Serth J,Kuczyk MA,Bokemeyer C,Hervatin C,Nafe R,Tan HK,Jonas U

更新日期：1995-01-01 00:00:00

abstract：:This study addresses the hypothesis that altered expression of oestrogen receptor-beta and/or altered relative expression of coactivators and corepressors of oestrogen receptors are associated with and may be mechanisms of de novo tamoxifen resistance in oestrogen receptor positive breast cancer. All cases were oestro...

journal_title：British journal of cancer

authors： Murphy LC,Leygue E,Niu Y,Snell L,Ho SM,Watson PH

更新日期：2002-12-02 00:00:00

abstract：:Mismatch repair (MMR) deficiency in tumours from patients with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome is mainly caused by mutations in the MLH1, MSH2, and MSH6 genes. A major challenge in the clinical management of patients with suspected HNPCC is the frequent occurrence of missense mutations i...

journal_title：British journal of cancer

authors： Kariola R,Hampel H,Frankel WL,Raevaara TE,de la Chapelle A,Nyström-Lahti M

更新日期：2004-10-04 00:00:00

abstract：:The effects of steroid hormones are pleiotropic. Similarly, non-steroidal oestrogen receptor antagonists such as tamoxifen exert partial agonistic effects with a species- and tissue-specific pattern. Conversely, little is known of the biological effects of non-steroidal anti-androgens, whose role has been investigated...

journal_title：British journal of cancer

authors： Decensi A,Torrisi R,Fontana V

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and focal adhesion kinase for the treatment of ovarian cancer. METHODS:We examined the effects of dasati...

journal_title：British journal of cancer

authors： Konecny GE,Glas R,Dering J,Manivong K,Qi J,Finn RS,Yang GR,Hong KL,Ginther C,Winterhoff B,Gao G,Brugge J,Slamon DJ

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:Clear cell renal cancer frequently harbours von Hippel-Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours. ...

journal_title：British journal of cancer

authors： McCormick RI,Blick C,Ragoussis J,Schoedel J,Mole DR,Young AC,Selby PJ,Banks RE,Harris AL

更新日期：2013-03-19 00:00:00

abstract：:The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen mibolerone (7 alpha-17 alpha-Dimethyl-19-nortestosterone) reversibly inhibits the proliferation of LNCaP cells...

journal_title：British journal of cancer

authors： Wolf DA,Kohlhuber F,Schulz P,Fittler F,Eick D

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Gemcitabine-based chemotherapy is the standard treatment for pancreatic cancer. However, the issue of resistance remains unresolved. The aim of this study was to identify microRNAs (miRNAs) that govern the resistance to gemcitabine in pancreatic cancer. METHODS:miRNA microarray analysis using gemcitabine-re...

journal_title：British journal of cancer

authors： Iwagami Y,Eguchi H,Nagano H,Akita H,Hama N,Wada H,Kawamoto K,Kobayashi S,Tomokuni A,Tomimaru Y,Mori M,Doki Y

更新日期：2013-07-23 00:00:00

abstract：BACKGROUND:Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS:We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC)...

journal_title：British journal of cancer

authors： Häyry V,Kågedal Å,Hjalmarsson E,Neves da Silva PF,Drakskog C,Margolin G,Georén SK,Munck-Wikland E,Winqvist O,Cardell LO

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Recently, many studies have suggested a possible adjuvant role of aspirin in colorectal cancer, reporting a positive prognostic effect with its use in patients with established disease. The aim of this study was to investigate the anticancer effect of aspirin use during preoperative chemoradiation for rectal...

journal_title：British journal of cancer

authors： Restivo A,Cocco IM,Casula G,Scintu F,Cabras F,Scartozzi M,Zorcolo L

更新日期：2015-10-20 00:00:00

abstract：:Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated by a complex network of factors produced by both stromal cells and neoplastic cells within solid tumours. The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to...

journal_title：British journal of cancer

authors： Leek RD,Landers R,Fox SB,Ng F,Harris AL,Lewis CE

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 2D6 (CYP2D6) has a crucial role in the metabolic conversion of tamoxifen into the active metabolite endoxifen. In this cohort study, the effect of CYP2D6-predicted phenotype, defined as the combined effect of CYP2D6 genetic variation and concomitant use of CYP2D6-inhibiting medication, on tim...

journal_title：British journal of cancer

authors： Lammers LA,Mathijssen RH,van Gelder T,Bijl MJ,de Graan AJ,Seynaeve C,van Fessem MA,Berns EM,Vulto AG,van Schaik RH

更新日期：2010-09-07 00:00:00

abstract：:Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after CC1(4), tumours for...

journal_title：British journal of cancer

authors： Pound AW,Lawson TA,Horn L

更新日期：1973-06-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of oral S-1, a dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine, were compared with those of protracted venous infusion (PVI) of 5-fluorouracil (5-FU). In all, 10 patients with gastric cancer received PVI of 5-FU at a dose of 250 mg m(-2) day(-1) for 5 days. A...

journal_title：British journal of cancer

authors： Yamada Y,Hamaguchi T,Goto M,Muro K,Matsumura Y,Shimada Y,Shirao K,Nagayama S

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:A combination of S-1 and cisplatin has been shown to be effective with acceptable safety for the first-line treatment of far-advanced gastric cancer in Japan. This is the first randomised phase II trial to compare S-1+paclitaxel with S-1+cisplatin in this setting. METHODS:Patients with unresectable and/or r...

journal_title：British journal of cancer

authors： Mochiki E,Ogata K,Ohno T,Toyomasu Y,Haga N,Fukai Y,Aihara R,Ando H,Uchida N,Asao T,Kuwano H,North Kanto Gastric Cancer Study Group.

更新日期：2012-06-26 00:00:00

abstract：BACKGROUND:Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS:We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS:A high protein e...

journal_title：British journal of cancer

authors： Langers AM,Verspaget HW,Hawinkels LJ,Kubben FJ,van Duijn W,van der Reijden JJ,Hardwick JC,Hommes DW,Sier CF

更新日期：2012-04-24 00:00:00