Increased carcinogenic action of dimethylnitrosamine after prior administration of carbon tetrachloride.

abstract：BACKGROUND:Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethano...

journal_title：British journal of cancer

authors： Schmitt J,Noble A,Otsuka M,Berry P,Maitland NJ,Rumsby MG

更新日期：2014-10-14 00:00:00

abstract：:Using the DMBA-induced mammary tumour as a model, the effect of hormone manipulation on steroid sulphurylation and on oxidative and reductive metabolism has been investigated. Oestradiol-17 beta, or oestradiol-17 beta + progesterone, administered to oophorectomized animals, had no effect on adenosine-3'-phosphate-5'-p...

journal_title：British journal of cancer

authors： Li K,Chandra DP,Pewnim T,Foo T,Adams JB

更新日期：1980-01-01 00:00:00

abstract：:The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents....

journal_title：British journal of cancer

authors： Boven E,Schipper H,Erkelens CA,Hatty SA,Pinedo HM

更新日期：1993-07-01 00:00:00

abstract：:To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expre...

journal_title：British journal of cancer

authors： Verburg FA,Lips CJ,Lentjes EG,de Klerk JM

更新日期：2004-07-19 00:00:00

abstract：BACKGROUND:Gamma-glutamyltransferase (GGT) - a membrane-bound enzyme crucially involved in the cell's detoxification pathway and apoptotic balance - is involved in tumour development, progression and chemotherapy resistance. Elevated GGT serum levels are associated with increased cancer risk in women and worse prognosi...

journal_title：British journal of cancer

authors： Grimm C,Hofstetter G,Aust S,Mutz-Dehbalaie I,Bruch M,Heinze G,Rahhal-Schupp J,Reinthaller A,Concin N,Polterauer S

更新日期：2013-08-06 00:00:00

abstract：:Various procedures for immunoprotection in the A-SW mouse SEWA tumour system were compared. Four types of protector agents were used: polyoma virus, allogeneic S724 cells, A9/SEWA hybrid cells and xenogeneic ST(py) cells. Several injection schedules were also employed. On the whole, reasonable immunoprotection was obt...

journal_title：British journal of cancer

authors： Favre R,Carcassonne Y,Meyer G

更新日期：1974-04-01 00:00:00

abstract：:Circulating serum factors have been said to abrogate the effects of immune response in cancer, i.e. "blocking" and "antigenic inhibition". The aim of this investigation was to isolate such specific factors in a purified and native state. F(ab)2 fragments isolated from hypernephroma were insolubilized on the surfaces o...

journal_title：British journal of cancer

authors： Langvad E,Hydén H,Wolf H,Kroeigaard N

更新日期：1975-12-01 00:00:00

abstract：:Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...

journal_title：British journal of cancer

authors： Tokunaga T,Tsuchida T,Kijima H,Okamoto K,Oshika Y,Sawa N,Ohnishi Y,Yamazaki H,Miura S,Ueyama Y,Nakamura M

更新日期：2000-09-01 00:00:00

abstract：:Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultrastructural level. Consequently, the clinically relevant distinction between primary clear cell sarcoma and metastatic me...

journal_title：British journal of cancer

authors： Langezaal SM,Graadt van Roggen JF,Cleton-Jansen AM,Baelde JJ,Hogendoorn PC

更新日期：2001-02-01 00:00:00

abstract：:The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...

journal_title：British journal of cancer

authors： Olsson H,Bladström A,Ingvar C,Möller TR

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...

journal_title：British journal of cancer

authors： Boland JW,McWilliams K,Ahmedzai SH,Pockley AG

更新日期：2014-08-26 00:00:00

abstract：:Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (<20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma tha...

journal_title：British journal of cancer

authors： Chanudet E,Adam P,Nicholson AG,Wotherspoon AC,Ranaldi R,Goteri G,Pileri SA,Ye H,Müller-Hermelink HK,Du MQ

更新日期：2007-10-08 00:00:00

abstract：:To invade and metastasize, carcinomas must penetrate or lose their epithelial basement membrane (EBM), and then penetrate basement membranes (BMs) surrounding blood vessels, lymphatics, nerves and muscle cells. Knowledge of the composition of different BMs is necessary, so that appropriate antibodies and DNA probes ar...

journal_title：British journal of cancer

authors： Hewitt RE,Powe DG,Morrell K,Balley E,Leach IH,Ellis IO,Turner DR

更新日期：1997-01-01 00:00:00

abstract：:Expression of CDX2, a caudal-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of C...

journal_title：British journal of cancer

authors： Yagi OK,Akiyama Y,Yuasa Y

更新日期：1999-02-01 00:00:00

abstract：:Angiopoietin-1 is an important regulator of endothelial cell survival. Angiopoietin-1 also reduces vascular permeability mediated by vascular endothelial growth factor. The effects of angiopoietin-1 on tumour growth and angiogenesis are controversial. We hypothesised that angiopoietin-1 would decrease tumour growth an...

journal_title：British journal of cancer

authors： Stoeltzing O,Ahmad SA,Liu W,McCarty MF,Parikh AA,Fan F,Reinmuth N,Bucana CD,Ellis LM

更新日期：2002-11-04 00:00:00

abstract：:Expression of the calcium-dependent cell-cell adhesion molecule E-cadherin has been examined in 187 primary breast carcinomas using an immunohistochemical technique. The pattern and extent of reactivity has been correlated with clinicopathological data including tumour type, grade and lymph node status and with other ...

journal_title：British journal of cancer

authors： Jones JL,Royall JE,Walker RA

更新日期：1996-10-01 00:00:00

abstract：:A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin....

journal_title：British journal of cancer

authors： Gonzalez MA,Biswas S,Clifton L,Corrie PG

更新日期：2003-08-04 00:00:00

abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...

journal_title：British journal of cancer

authors： Nita ME,Nagawa H,Tominaga O,Tsuno N,Fujii S,Sasaki S,Fu CG,Takenoue T,Tsuruo T,Muto T

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Risk factors for the development of myelodysplastic syndromes (MDS) include age, exposure to ionising radiation, and cytotoxic drug treatment. Recently, asthma also has been suggested as a risk factor for MDS. METHODS:We undertook this nationwide population-based cohort study on patients with a first-time h...

journal_title：British journal of cancer

authors： Frederiksen H,Farkas DK,Horváth-Puhó E,Nørgaard JM,Nørgaard M,Sørensen HT

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:A dose-dense strategy has been considered to improve results of adjuvant chemotherapy for breast cancer. This randomised phase II trial investigated the feasibility of this approach with sequential anthracyclines and taxanes-based chemotherapy. METHODS:Patients with high-risk node-positive breast cancer wer...

journal_title：British journal of cancer

authors： Brain E,Levy C,Serin D,Roché H,Spielmann M,Delva R,Veyret C,Mauriac L,Rios M,Martin AL,Jimenez M,Asselain B,Gauthier M,Bonnetain F,Fumoleau P

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:We analysed critically the potential usefulness of RNA- and DNA-based biomarkers in supporting conventional histological diagnostic tests for prostate carcinoma (PCa) detection. METHODS:Microarray profiling of gene expression and DNA methylation was performed on 16 benign prostatic hyperplasia (BPH) and 32 ...

journal_title：British journal of cancer

authors： Paziewska A,Dabrowska M,Goryca K,Antoniewicz A,Dobruch J,Mikula M,Jarosz D,Zapala L,Borowka A,Ostrowski J

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS:Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comp...

journal_title：British journal of cancer

authors： Shu X,Hildebrandt MA,Gu J,Tannir NM,Matin SF,Karam JA,Wood CG,Wu X

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:The need to unfold the underlying mechanisms of lung cancer aggressiveness, the deadliest cancer in the world, is of prime importance. Because Fas-associated death domain protein (FADD) is the key adaptor molecule transmitting the apoptotic signal delivered by death receptors, we studied the presence and cor...

journal_title：British journal of cancer

authors： Cimino Y,Costes A,Damotte D,Validire P,Mistou S,Cagnard N,Alifano M,Régnard JF,Chiocchia G,Sautès-Fridman C,Tourneur L

更新日期：2012-06-05 00:00:00

abstract：:Data collected from lung cancer patients attending the Victoria Clinic of the British Columbia Cancer Agency are used to investigate how resources are rationed in the treatment of non-small-cell lung cancer (NSCLC). An ordered logit model is estimated to analyse empirically the relationship between treatment selection...

journal_title：British journal of cancer

authors： Arndt K,Coy P,Schaafsma J

更新日期：1996-03-01 00:00:00

abstract：:DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for o...

journal_title：British journal of cancer

authors： Jaeckle KA,Phuphanich S,Bent MJ,Aiken R,Batchelor T,Campbell T,Fulton D,Gilbert M,Heros D,Rogers L,O'Day SJ,Akerley W,Allen J,Baidas S,Gertler SZ,Greenberg HS,LaFollette S,Lesser G,Mason W,Recht L,Wong E,Chamber

更新日期：2001-01-01 00:00:00

abstract：:Many cancers express Fas ligand (FasL/CD95L) in vivo, and can kill lymphoid cells by Fas-mediated apoptosis in vitro. However, overexpression of recombinant FasL in murine tumour allografts revealed a potential antitumour effect of FasL, via recruitment of neutrophils. Transforming growth factor-beta1 (TGF-beta1) coul...

journal_title：British journal of cancer

authors： Houston A,Bennett MW,O'Sullivan GC,Shanahan F,O'Connell J

更新日期：2003-10-06 00:00:00

abstract：:Altered expression and activity of proteases is a key event in cancer, particularly in relation to invasion, modification of the extracellular matrix and metastasis. The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase. We review...

journal_title：British journal of cancer

authors： de Aberasturi AL,Calvo A

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...

journal_title：British journal of cancer

authors： Ming C,Viassolo V,Probst-Hensch N,Dinov ID,Chappuis PO,Katapodi MC

更新日期：2020-09-01 00:00:00

abstract：:Discrete masses are commonly detected during mammographic screening and most such lesions are benign. For lesions without pathognomonically benign imaging features that are still regarded likely to be non-malignant (Tabar grade 3) reliable biopsy results would be a clinically useful alternative to mammographic surveil...

journal_title：British journal of cancer

authors： Farshid G,Downey P,Gill P,Pieterse S

更新日期：2008-04-08 00:00:00

abstract：:Gap junctions provide a route for small molecules to pass directly between cells. Toxic species may spread through junctions into 'bystander' cells, which may be exploited in chemotherapy and radiotherapy. However, this may be prevented by junction closure, and therefore an understanding of the dose-dependency of inhi...

journal_title：British journal of cancer

authors： Edwards GO,Botchway SW,Hirst G,Wharton CW,Chipman JK,Meldrum RA

更新日期：2004-04-05 00:00:00