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Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine.

Abstract：

:DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for one month of induction therapy; responding patients were treated with an additional 3 months of consolidation therapy. All patients had metastatic breast cancer and a positive CSF cytology or neurologic findings characteristic of neoplastic meningitis. The median number of DepoCyte doses was 3, and 85% of patients completed the planned 1 month induction. Median follow up is currently 19 months. The primary endpoint was response, defined as conversion of the CSF cytology from positive to negative at all sites known to be positive, and the absence of neurologic progression at the time the cytologic conversion was documented. The response rate among the 43 evaluable patients was 28% (CI 95%: 14-41%); the intent-to-treat response rate was 21% (CI 95%: 12-34%). Median time to neurologic progression was 49 days (range 1-515(+)); median survival was 88 days (range 1-515(+)), and 1 year survival is projected to be 19%. The major adverse events were headache and arachnoiditis. When drug-related, these were largely of low grade, transient and reversible. Headache occurred on 11% of cycles; 90% were grade 1 or 2. Arachnoiditis occurred on 19% of cycles; 88% were grade 1 or 2. DepoCyte demonstrated activity in neoplastic meningitis due to breast cancer that is comparable to results reported with conventional intrathecal agents. However, this activity was achieved with one fourth as many intrathecal injections as typically required in conventional therapy. The every 2 week dose schedule is a major advantage for both patients and physicians.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Jaeckle KA,Phuphanich S,Bent MJ,Aiken R,Batchelor T,Campbell T,Fulton D,Gilbert M,Heros D,Rogers L,O'Day SJ,Akerley W,Allen J,Baidas S,Gertler SZ,Greenberg HS,LaFollette S,Lesser G,Mason W,Recht L,Wong E,Chamber

doi

10.1054/bjoc.2000.1574

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

157-63

issue

eissn

0007-0920

issn

1532-1827

pii

S000709200091574X

journal_volume

pub_type

临床试验,杂志文章,多中心研究

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Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine.