Abstract：
:Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of axillary nodes, have been related to survival.It was found that prognosis was worse in patients with a high grade tumour and in those with histological evidence of axillary node spread. Round cell infiltration of the primary tumour did not confer improved survival.The clinical state of the axillary nodes was associated with prognosis in so far that palpable nodes were twice as commonly the seat of metastatic spread as were impalpable nodes.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Champion HR,Wallace IW,Prescott RJdoi
10.1038/bjc.1972.19subject
Has Abstractpub_date
1972-04-01 00:00:00pages
129-38issue
2eissn
0007-0920issn
1532-1827journal_volume
26pub_type
杂志文章abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.379
更新日期：1993-09-01 00:00:00
abstract：:MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605901
更新日期：2010-10-12 00:00:00
abstract：:A prospective, consecutive study of the aetiology of treatment-associated diarrhoea was conducted in 25 patients with disseminated germ cell cancer treated with intensive chemotherapy. Clostridium difficile was isolated in 45% of the diarrhoea episodes, which makes this species the most important bacterial pathogen in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.334
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.184
更新日期：2011-07-12 00:00:00
abstract：:Ultrafiltrates from spleen inhibited both DNA synthesis and the proliferation of normal lymphocytes stimulated inculture from both mouse and man without apparent cytotoxicity. However, the same doses of this spleen ultrafiltrate will kill up to two-thirds of the leukaemic lymphoblasts from both mouse and man after 24 ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.280
更新日期：1975-12-01 00:00:00
abstract：:Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. Treatment was continued 3 times weekly for up to 110 weeks, by which time 509 of the 1428 treated mice had developed skin tumours. The dependence of tumour in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.126
更新日期：1974-08-01 00:00:00
abstract：:The orally administered tubulin-binding agent 1069C85 was developed with the hope of overcoming the multidrug resistance associated with existing anti-tubulin agents, such as the vinca alkaloids. A phase I study was performed using a single oral dose every 3 weeks, administered as a suspension reconstituted in 0.1% Tw...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1997.107
更新日期：1997-01-01 00:00:00
abstract：:Intra-tumoural heterogeneity of proliferation has been assessed by taking multiple biopsies from 30 colorectal cancers. Following in vivo IUDR labelling, dual parameter flow cytometry was used to measure tumour DNA index (DI) and labelling index (LI) and to derive DNA synthesis time (Ts) and potential doubling time (T...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.376
更新日期：1993-09-01 00:00:00
abstract：:We have analysed 174 gastric carcinomas from the United Kingdom and from Japan for the presence of Epstein-Barr virus (EBV) using in situ hybridisation for the small EBV-encoded nuclear RNAs (EBERs). EBV was detected in the tumour cells in all of six undifferentiated gastric carcinomas with prominent lymphoid stroma (...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.472
更新日期：1993-11-01 00:00:00
abstract：:To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Scotti...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6604155
更新日期：2008-02-26 00:00:00
abstract：BACKGROUND:BRCAness is defined as shared tumour characteristics between sporadic and BRCA-mutated cancers. However, how to exactly measure BRCAness and its frequency in breast cancer is not known. Assays to establish BRCAness would be extremely valuable for the clinical management of these tumours. We assessed BRCAness...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.144
更新日期：2013-05-28 00:00:00
abstract：:The function of the reticulo-endothelial system in mice bearing Lewis lung carcinomas has been measured by(1) the rate of clearance of carbon particles from the circulation in vivo and calculation of the phagocytic index K; (2) chemotactic locomotion of macrophages in vitro in the presence or absence of serum or tumou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.197
更新日期：1977-09-01 00:00:00
abstract：BACKGROUND:The role of further hormone therapy in castration-resistant prostate cancer (CRPC) remains unclear. We performed a multi-centre randomised phase III study comparing the use of Dexamethasone, Aspirin, and immediate addition of Diethylstilbestrol (DAiS) vs Dexamethasone, Aspirin, and deferred (until disease pr...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2011.7
更新日期：2011-02-15 00:00:00
abstract：:Male and female Swiss strain mice were put on a 0.03% thioacetamide diet at the age of 2 months. Control mice were kept on a stock diet. Control and treated mice were killed at the ages of 6, 9, 13 and 17 months. Progressive morphological, histological and biochemical alterations in the liver and tumour tissue of the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1970.60
更新日期：1970-09-01 00:00:00
abstract：:Chemical structures of the sugar chains of various human alpha-fetoprotein (AFP) species with different affinity for Concanavalin A (Con A) and Lens culinaris agglutinin (LCA) were examined by pyridylamination of their oligosaccharides and stepwise exoglycosidase digestion. Using reversed-phase and size-fractionation ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.91
更新日期：1993-03-01 00:00:00
abstract：:Tumour angiogenesis is a complex multistep process regulated by a number of angiogenic factors. One such factor, platelet-derived endothelial cell growth factor has recently been shown to be thymidine phosphorylase (TP). TP catalyses the reversible phosphorylation of thymidine to deoxyribose-1-phosphate and thymine. A...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.49
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Tumour heterogeneity is documented for many characters, including the production of growth factors, one of the hallmarks of cancer. What maintains heterogeneity remains an open question that has implications for diagnosis and treatment, as drugs that target growth factors are susceptible to the evolution of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.336
更新日期：2013-08-20 00:00:00
abstract：BACKGROUND:Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS:We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS:A high protein e...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.80
更新日期：2012-04-24 00:00:00
abstract：:Patient participation in medical consultations has been demonstrated to benefit their subsequent psychological well being. Question asking is one way in which patients can be active. We investigated 2 means of promoting cancer patient question asking. One was the provision of a question prompt sheet to patients prior ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1054/bjoc.2001.2073
更新日期：2001-11-02 00:00:00
abstract：:In this population-based Norwegian cohort study (2.1 million children), the impact of birth and parental characteristics on the risk of neuroblastoma (178 cases) was evaluated. In children below the age of 18 months, there was an increased neuroblastoma risk among those with congenital malformations and suggestion of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604646
更新日期：2008-10-07 00:00:00
abstract：INTRODUCTION:We investigated the association between socioeconomic position, stage at diagnosis, and length of period between referral and diagnosis in a nationwide cohort of lung cancer patients. METHODS:Through the Danish Lung Cancer Register, we identified 18,103 persons diagnosed with lung cancer (small cell and n...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.342
更新日期：2011-09-27 00:00:00
abstract：:We screened 145 HIV-infected non-pregnant women at a tertiary care centre in Lusaka, Zambia. Liquid-based cytology and human papillomavirus (HPV) genotyping with PGMY09/11 biotinylated primers (Roche Linear Array HPV genotyping test) maximised sensitivity of cytology and HPV assessments. Among high-risk (HR) types, HP...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603737
更新日期：2007-05-07 00:00:00
abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603589
更新日期：2007-02-12 00:00:00
abstract：:Adriamycin and cyclophosphamide are active agents in human and experimental tumours. Using the L1210 murine leukaemia, their effectiveness alone and in combination was studied. The combination is highly synergistic in this tumour, resulting in a greater than 50% survival rate when the agents used alone at optimal dose...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.150
更新日期：1975-08-01 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumour and has poor prognosis. Currently, systematic chemotherapy is the only approach to prolong survival. Thus the development of new treatment regimens is urgently needed to improve the therapeutic efficacy. Our study intended to ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.55
更新日期：2017-04-11 00:00:00
abstract：:In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602158
更新日期：2004-11-15 00:00:00
abstract：BACKGROUND:The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased. METHODS:Canc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0869-8
更新日期：2020-08-01 00:00:00
abstract：:The effect of acute carbon monoxide (CO) breathing on blood oxygenation and tumour hypoxia was related to the radiation response of the C3H/Tif mammary carcinoma. Blood gas analysis showed that CO breathing caused a time- and dose-dependent formation of carboxyhaemoglobin (HbCO), a significant left shift of the oxygen...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.8
更新日期：1994-01-01 00:00:00
abstract：:'de novo' carcinogenesis has been advocated besides 'adenoma carcinoma sequence' as another dominant pathway leading to colorectal carcinoma. Our recent study has demonstrated that the distribution of brain (fetal)-type glycogen phosphorylase (BGP) positive foci (BGP foci) has a close relationship with the location of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1824
更新日期：2001-06-01 00:00:00
abstract：:Mismatch repair (MMR) deficiency in tumours from patients with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome is mainly caused by mutations in the MLH1, MSH2, and MSH6 genes. A major challenge in the clinical management of patients with suspected HNPCC is the frequent occurrence of missense mutations i...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602129
更新日期：2004-10-04 00:00:00
