High prevalence of Clostridium difficile diarrhoea during intensive chemotherapy for disseminated germ cell cancer.

abstract：BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...

journal_title：British journal of cancer

authors： Pogoda JM,Nichols PW,Ross RK,Stram DO,Thomas DC,Preston-Martin S

更新日期：2011-04-26 00:00:00

abstract：:The duration of the DNA synthesis period in normal and malignant human tissues from the larynx, trachea bronchus and esophagus of 13 patient has been estimated by a tritiated thymidine, carbon-14 thymidine double-labeling method in vitro. The DNA synthesis times range from approximately 10 to 25 hours, are shortest in...

journal_title：British journal of cancer

authors： Fabrikant JI

更新日期：1970-03-01 00:00:00

abstract：:Doxorubicin- and paclitaxel-selected variants of an in vitro invasive clonal population of the human breast cancer cell line, MDA-MB-435S, were established by pulse selection, and exhibited a novel 'superinvasive' phenotype. This phenotype is characterised by an ability to relocate to another surface following invasio...

journal_title：British journal of cancer

authors： Glynn SA,Gammell P,Heenan M,O'Connor R,Liang Y,Keenan J,Clynes M

更新日期：2004-11-15 00:00:00

abstract：:Even though the majority of patients with bladder malignancies initially present with low stage disease, the clinical epidemiology of these so-called superficial bladder tumours is not well known. In this paper, disease characteristics at initial presentation and during follow-up are described in 1,745 primary cases d...

journal_title：British journal of cancer

authors： Kiemeney LA,Witjes JA,Verbeek AL,Heijbroek RP,Debruyne FM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Cervical cancer screening coverage remains insufficient in most countries. Our objective was to assess whether in-home vaginal self-sampling with a dry swab for high-risk human papillomavirus (HR-HPV) testing is effective and cost-effective in increasing participation in cervical cancer screening. METHODS:I...

journal_title：British journal of cancer

authors： Haguenoer K,Sengchanh S,Gaudy-Graffin C,Boyard J,Fontenay R,Marret H,Goudeau A,Pigneaux de Laroche N,Rusch E,Giraudeau B

更新日期：2014-11-25 00:00:00

abstract：:This study provides an analysis of the structure of the initial cancer consultation, the consultation styles of medical and radiation oncologists, and their effect on patient outcomes. One hundred and fifty-five cancer patients attending their first consultation with either a medical or radiation oncologist were audio...

journal_title：British journal of cancer

authors： Dimoska A,Butow PN,Dent E,Arnold B,Brown RF,Tattersall MH

更新日期：2008-05-06 00:00:00

abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...

journal_title：British journal of cancer

authors： O'Donnell A,Judson I,Dowsett M,Raynaud F,Dearnaley D,Mason M,Harland S,Robbins A,Halbert G,Nutley B,Jarman M

更新日期：2004-06-14 00:00:00

abstract：:Sera from patients with nasopharyngeal carcinoma (NPC), a disease associated with Epstein-Barr virus (EBV), were found to be cytotoxic at 15% degrees C in the presence of complement for a panel of human lymphocytes, with a higher frequency than those of matched controls. The cold lymphocytotoxic antibodies (LTA) respo...

journal_title：British journal of cancer

authors： Lamelin JP,Revillard JP,Chalopin JM,Ho JH,Souissi T,Schwaab G,De-Thé G

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS:Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates...

journal_title：British journal of cancer

authors： Genus TSE,Bouvier C,Wong KF,Srirajaskanthan R,Rous BA,Talbot DC,Valle JW,Khan M,Pearce N,Elshafie M,Reed NS,Morgan E,Deas A,White C,Huws D,Ramage J

更新日期：2019-11-01 00:00:00

abstract：:Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...

journal_title：British journal of cancer

authors： Fjeld JG,Benestad HB,Stigbrand T,Nustad K

更新日期：1992-07-01 00:00:00

abstract：:L-Glutamine is a requirement for many cells in tissue culture, an intermediate in many metabolic pathways, and an alternative substrate to glucose for energy metabolism. These properties suggest that glutamine concentration might be a determinant of cell viability in tumours, especially in regions that are deficient i...

journal_title：British journal of cancer

authors： Tannock IF,Steele D,Roberts J

更新日期：1986-11-01 00:00:00

abstract：:The limited prognosis of patients with castration-resistant prostate cancer (CRPC) on existing hormonal manipulation therapies calls out for the urgent need for new management strategies. The novel, orally available, small-molecule compound, abiraterone acetate, is undergoing evaluation in early clinical trials and em...

journal_title：British journal of cancer

authors： Ang JE,Olmos D,de Bono JS

更新日期：2009-03-10 00:00:00

abstract：BACKGROUND:Therapies targeting ERBB2 have shown success in the clinic. However, response is not determined solely by expression of ERBB2. Levels of ERBB3, its preferred heterodimerisation partner and ERBB ligands may also have a role. METHODS:We measured NRG1 expression by real-time quantitative RT-PCR and ERBB recept...

journal_title：British journal of cancer

authors： Forster JA,Paul AB,Harnden P,Knowles MA

更新日期：2011-03-29 00:00:00

abstract：:Cisplatin is one of the most active cytotoxic agents in the treatment of testicular cancer, but its clinical use is associated with side-effects such as ototoxicity, neurotoxicity and nephrotoxicity. Long-term kidney damage from cisplatin particularly affects the proximal tubular apparatus and can be detected by incre...

journal_title：British journal of cancer

authors： Bokemeyer C,Fels LM,Dunn T,Voigt W,Gaedeke J,Schmoll HJ,Stolte H,Lentzen H

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:We analysed critically the potential usefulness of RNA- and DNA-based biomarkers in supporting conventional histological diagnostic tests for prostate carcinoma (PCa) detection. METHODS:Microarray profiling of gene expression and DNA methylation was performed on 16 benign prostatic hyperplasia (BPH) and 32 ...

journal_title：British journal of cancer

authors： Paziewska A,Dabrowska M,Goryca K,Antoniewicz A,Dobruch J,Mikula M,Jarosz D,Zapala L,Borowka A,Ostrowski J

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:The association between gall bladder removal (cholecystectomy) and hepatocellular carcinoma warrants investigation. An increased intrahepatic bile duct pressure following cholecystectomy might cause chronic inflammation in the surrounding liver tissue, which might induce cancer development. METHODS:A nation...

journal_title：British journal of cancer

authors： Lagergren J,Mattsson F,El-Serag H,Nordenstedt H

更新日期：2011-06-28 00:00:00

abstract：BACKGROUND:The distinct expression pattern of tumour-associated antigens (TAAs) might be a critical reason for the inefficacy of immunity-based treatments and heterogeneous postsurgical recovery in patients with solid tumours, including hepatocellular carcinoma (HCC). However, little is known about the clinical value o...

journal_title：British journal of cancer

authors： Liang J,Ding T,Guo ZW,Yu XJ,Hu YZ,Zheng L,Xu J

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:This randomised controlled trial examined the impact of screening for distress followed by two different triage methods on clinically relevant outcomes over a 12-month period. METHODS:Newly diagnosed patients attending a large tertiary cancer centre were randomised to one of the two conditions: (1) screenin...

journal_title：British journal of cancer

authors： Carlson LE,Waller A,Groff SL,Zhong L,Bultz BD

更新日期：2012-08-07 00:00:00

abstract：:Basal cell carcinoma (BCC) is a common malignancy with a good prognosis in the majority of cases. However, some BCC patients develop a more advanced disease that poses significant management challenges. Such cases include locally advanced, recurrent or metastatic BCC, or tumours that occur in anatomical sites where su...

journal_title：British journal of cancer

authors： Lear JT,Corner C,Dziewulski P,Fife K,Ross GL,Varma S,Harwood CA

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:Neutropenia is a common adverse reaction of chemotherapy. We assessed whether chemotherapy-induced neutropenia could be a predictor of survival for patients with non-small-cell lung cancer (NSCLC). METHODS:A total of 387 chemotherapy-naïve patients who received chemotherapy (vinorelbine and gemcitabine foll...

journal_title：British journal of cancer

authors： Kishida Y,Kawahara M,Teramukai S,Kubota K,Komuta K,Minato K,Mio T,Fujita Y,Yonei T,Nakano K,Tsuboi M,Shibata K,Atagi S,Kawaguchi T,Furuse K,Fukushima M

更新日期：2009-11-03 00:00:00

abstract：:Screen-detected (SD) breast cancers are smaller and biologically more indolent than clinically presenting cancers. An often debated question is: if left undiagnosed during their preclinical phase, would they become more aggressive or would they only increase in size? This study considered a registry-based series (1988...

journal_title：British journal of cancer

authors： Bucchi L,Barchielli A,Ravaioli A,Federico M,De Lisi V,Ferretti S,Paci E,Vettorazzi M,Patriarca S,Frigerio A,Buiatti E,SCREENREG Working Group.

更新日期：2005-01-17 00:00:00

abstract：BACKGROUND:The National Comprehensive Cancer Network (NCCN) guidelines provide recommendations for staging of prostate cancer patients in the objective regarding presence of locoregional lymph node metastases (LNM) and bone metastases. We tested the performance characteristics of these recommendations in a community se...

journal_title：British journal of cancer

authors： Preisser F,Mazzone E,Nazzani S,Marchioni M,Bandini M,Tian Z,Saad F,Soulières D,Shariat SF,Montorsi F,Huland H,Graefen M,Tilki D,Karakiewicz PI

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Earlier studies have shown raised risks of leukaemia and non-Hodgkin lymphoma in children, teenagers and young adults resident either at birth or diagnosis in Seascale. Some increases in cancer risk in these age groups have also been noted among those living around Dounreay. We aimed to update previous analy...

journal_title：British journal of cancer

authors： Bunch KJ,Vincent TJ,Black RJ,Pearce MS,McNally RJ,McKinney PA,Parker L,Craft AW,Murphy MF

更新日期：2014-10-28 00:00:00

abstract：:The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed...

journal_title：British journal of cancer

authors： Korkeila E,Talvinen K,Jaakkola PM,Minn H,Syrjänen K,Sundström J,Pyrhönen S

更新日期：2009-03-24 00:00:00

abstract：BACKGROUND:Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. ME...

journal_title：British journal of cancer

authors： Cortes J,Tamura K,DeAngelo DJ,de Bono J,Lorente D,Minden M,Uy GL,Kantarjian H,Chen LS,Gandhi V,Godin R,Keating K,McEachern K,Vishwanathan K,Pease JE,Dean E

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. METHODS:A well characterised DCIS cohor...

journal_title：British journal of cancer

authors： Toss MS,Abidi A,Lesche D,Joseph C,Mahale S,Saunders H,Kader T,Miligy IM,Green AR,Gorringe KL,Rakha EA

更新日期：2020-05-01 00:00:00

abstract：:The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curativ...

journal_title：British journal of cancer

authors： Cooper R,Sarioğlu S,Sökmen S,Füzün M,Küpelioğlu A,Valentine H,Görken IB,Airley R,West C

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...

journal_title：British journal of cancer

authors： Wang LL,Teshiba R,Ikegaki N,Tang XX,Naranjo A,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Asgharzadeh S,Shimada H

更新日期：2015-06-30 00:00:00

abstract：:Telomerase, an enzyme related with cellular immortality, has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. Telomerase activity is mainly regulated by the expression of hTERT (human telomerase reverse transcriptase), which is a catalytic component of human ...

journal_title：British journal of cancer

authors： Hiyama E,Yamaoka H,Matsunaga T,Hayashi Y,Ando H,Suita S,Horie H,Kaneko M,Sasaki F,Hashizume K,Nakagawara A,Ohnuma N,Yokoyama T

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Gastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker. METHODS:Forty patients (17 palliative and 23 curative) were followed by serial plasma monitoring. Primary tumour DNA was analysed by tar...

journal_title：British journal of cancer

authors： Openshaw MR,Mohamed AA,Ottolini B,Fernandez-Garcia D,Richards CJ,Page K,Guttery DS,Thomas AL,Shaw JA

更新日期：2020-10-01 00:00:00