Expression of NRG1 and its receptors in human bladder cancer.


BACKGROUND:Therapies targeting ERBB2 have shown success in the clinic. However, response is not determined solely by expression of ERBB2. Levels of ERBB3, its preferred heterodimerisation partner and ERBB ligands may also have a role. METHODS:We measured NRG1 expression by real-time quantitative RT-PCR and ERBB receptors by western blotting and immunohistochemistry in bladder tumours and cell lines. RESULTS:NRG1α and NRG1β showed significant coordinate expression. NRG1β was upregulated in 78% of cell lines. In tumours, there was a greater range of expression with a trend towards increased NRG1α with higher stage and grade. Increased expression of ERBB proteins was detected in 15% (EGFR), 20% (ERBB2), 41% (ERBB3) and 0% (ERBB4) of cell lines. High EGFR expression was detected in 28% of tumours, associated with grade and stage (P=0.05; P=0.04). Moderate or high expression of ERBB2 was detected in 22% and was associated with stage (P=0.025). Cytoplasmic ERBB3 was associated with high tumour grade (P=0.01) and with ERBB2 positivity. In cell lines, NRG1β expression was significantly inversely related to ERBB3, but this was not confirmed in tumours. CONCLUSION:There is a wide spectrum of NRG1 and ERBB receptor expression in bladder cancer. In advanced tumours, EGFR, ERBB2 and ERBB3 upregulation is common and there is a relationship between expression of ERBB2 and ERBB3 but not the NRG1 ligand.


Br J Cancer


Forster JA,Paul AB,Harnden P,Knowles MA




Has Abstract


2011-03-29 00:00:00














  • Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma.

    abstract:BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

    更新日期:2014-08-12 00:00:00

  • Risk of cancer in patients with epistaxis and haemoptysis.

    abstract::This corrects the article DOI: 10.1038/bjc.2017.85. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ording AG,Veres K,Farkas DK,Adelborg K,Sørensen HT

    更新日期:2018-03-20 00:00:00

  • The impact of body mass index on complication and survival in resected oesophageal cancer: a clinical-based cohort and meta-analysis.

    abstract:BACKGROUND:Body mass index (BMI) has been associated with the risk of oesophageal cancer. But the influence of BMI on postoperative complication and prognosis has always been controversial. METHODS:In total, 2031 consecutive patients who underwent oesophagectomy between 1998 and 2008 were classified according to Asian...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Zhang SS,Yang H,Luo KJ,Huang QY,Chen JY,Yang F,Cai XL,Xie X,Liu QW,Bella AE,Hu RG,Wen J,Hu Y,Fu JH

    更新日期:2013-11-26 00:00:00

  • Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response.

    abstract::Recent studies have suggested a correlation between the rate and incidence of apoptosis and the radiation response of particular cell lines. However, we found that increasing the rate of induction of apoptosis in the fibroblast line 208F, by transfecting it with human c-myc, did not lead to a change in its clonogenic ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Aldridge DR,Arends MJ,Radford IR

    更新日期:1995-03-01 00:00:00

  • Molecular alterations in a patient with Turcot's syndrome.

    abstract::Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Rochlitz CF,Heide I,de Kant E,Neubauer A,Schmidt CA,Neuhaus P,Huhn D,Herrmann R

    更新日期:1993-09-01 00:00:00

  • Sensitivity of locally recurrent rat mammary tumour cell lines to syngeneic polymorphonuclear cell, macrophage and natural killer cell cytolysis.

    abstract::Using a recently developed model for studying the biology of locally recurrent (LR) mammary tumours in the 13762NF rat mammary adenocarcinoma system, we examined the sensitivity to polymorphonuclear cell, macrophage and natural killer cell cytolysis. The parental MTF7(T20) cell line; the 'primary' tumours which arose ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Aeed PA,Welch DR

    更新日期:1988-12-01 00:00:00

  • P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo.

    abstract::Overexpression of the MDR1 product, P-glycoprotein (Pgp), has been shown to be one of the mechanisms underlying the development of multidrug resistance (MDR). Recently, one mutant p53 has been shown to stimulate the MDR1 gene promoter in vitro, whereas wild-type p53 repressed this activity. We measured Pgp and p53 exp...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: De Angelis P,Stokke T,Smedshammer L,Lothe RA,Lehne G,Chen Y,Clausen OP

    更新日期:1995-08-01 00:00:00

  • Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers.

    abstract:BACKGROUND:Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. ME...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Cortes J,Tamura K,DeAngelo DJ,de Bono J,Lorente D,Minden M,Uy GL,Kantarjian H,Chen LS,Gandhi V,Godin R,Keating K,McEachern K,Vishwanathan K,Pease JE,Dean E

    更新日期:2018-05-01 00:00:00

  • Inhibition of cell-cycle progression by acute treatment with various degrees of hypoxia: modifications induced by low concentrations of misonidazole present during hypoxia.

    abstract::The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Pettersen EO,Lindmo T

    更新日期:1983-12-01 00:00:00

  • Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma.

    abstract::Germline anomalies of the INK4a-ARF and Cdk4 genes were sought in a series of 89 patients suspected of having a genetic predisposition to melanoma. Patients were selected based on the following criteria: (a) familial melanoma (23 cases), (b) multiple primary melanoma (MPM; 18 cases), (c) melanoma and additional unrela...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Soufir N,Lacapere JJ,Bertrand G,Matichard E,Meziani R,Mirebeau D,Descamps V,Gérard B,Archimbaud A,Ollivaud L,Bouscarat F,Baccard M,Lanternier G,Saïag P,Lebbé C,Basset-Seguin N,Crickx B,Cave H,Grandchamp B

    更新日期:2004-01-26 00:00:00

  • Incorporating multiparametric MRI staging and the new histological Grade Group system improves risk-stratified detection of bone metastasis in prostate cancer.

    abstract:BACKGROUND:There remains uncertainty on the need for bone staging in men with intermediate-risk prostate cancer. Current guidelines do not use mpMRI-staging information and rely on historic pathology grading. METHODS:We investigated the ability of mpMRI and the new Grade Group system to better predict bone metastasis ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Thurtle D,Hsu RC,Chetan M,Lophatananon A,Hubbard R,Gnanapragasam VJ,Barrett T

    更新日期:2016-11-22 00:00:00

  • Intra-tumoral heterogeneity of tumour potential doubling times (Tpot) in colorectal cancer.

    abstract::Intra-tumoural heterogeneity of proliferation has been assessed by taking multiple biopsies from 30 colorectal cancers. Following in vivo IUDR labelling, dual parameter flow cytometry was used to measure tumour DNA index (DI) and labelling index (LI) and to derive DNA synthesis time (Ts) and potential doubling time (T...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wilson MS,West CM,Wilson GD,Roberts SA,James RD,Schofield PF

    更新日期:1993-09-01 00:00:00

  • Correction: AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL.

    abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:British journal of cancer

    pub_type: 已发布勘误


    authors: Weisberg E,Manley P,Mestan J,Cowan-Jacob S,Ray A,Griffin JD

    更新日期:2019-07-01 00:00:00

  • Tumour-marker levels and prognosis in malignant teratoma of the testis.

    abstract::The effect of 6 putative prognostic factors on survival was studied in patients with Stages III and IV malignant teratoma of the testis. Differences between survival curves were tested for statistical significance. A diameter greater than 5 cm in the largest tumour mass, and greater than 8 pulmonary metastases were ad...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Germa-Lluch JR,Begent RH,Bagshawe KD

    更新日期:1980-12-01 00:00:00

  • The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468.

    abstract::Using the breast carcinoma cell line MDA-MB 468 as immunogen, we have produced six new rat monoclonal antibodies (mAbs) against the human EGF receptor (EGFR) and are investigating their use for diagnostic and therapeutic applications in cancer patients whose tumours overexpress these receptors. The mAbs (three IgG2b a...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Modjtahedi H,Styles JM,Dean CJ

    更新日期:1993-02-01 00:00:00

  • Epidemiology of carcinoid neoplasms in Vaud, Switzerland, 1974-97.

    abstract::In Vaud, Switzerland, the incidence of carcinoids based on 218 malignant and 215 benign cases rose from 19.6/10(6)in 1974-85 to 28. 2/10(6)in 1986-97, more so among males and malignant neoplasms. Lung was the commonest site for malignant and large intestine for benign carcinoids. Sixty-eight (16%) carcinoids had anoth...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Levi F,Te VC,Randimbison L,Rindi G,La Vecchia C

    更新日期:2000-10-01 00:00:00

  • Daunorubicin and doxorubicin but not BCNU have deleterious effects on organotypic multicellular spheroids of gliomas.

    abstract::In the present study organotypic multicellular spheroids (OMS) were used to study the effects of chemotherapeutic agents on malignant gliomas. Compared with the frequently used cell line models, OMS have several advantages with respect to the preservation of the cellular heterogeneity and the structure of the original...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kaaijk P,Troost D,de Boer OJ,Van Amstel P,Bakker PJ,Leenstra S,Bosch DA

    更新日期:1996-07-01 00:00:00

  • How should cancer presenting as a malignant pleural effusion be managed?

    abstract::The objective of the study was to review the natural history of patients with a malignant pleural effusion but without obvious evidence of a primary, to assess the value of investigations used to look for a primary and to assess the response to palliative chemotherapy. This was done by a retrospective study of patient...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bonnefoi H,Smith IE

    更新日期:1996-09-01 00:00:00

  • Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation.

    abstract::We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, named PTC, is a novel rearranged version of the ret proto-oncogene. In fact PTC is the product of the fusion of the tyrosine kinase domain of the ret proto-oncogene with the 5'-terminal region of another ge...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Fabien N,Paulin C,Santoro M,Berger N,Grieco M,Galvain D,Barbier Y,Dubois PM,Fusco A

    更新日期:1992-12-01 00:00:00

  • The prognostic significance of DNA flow cytometry in breast cancer: results from 881 patients treated in a single centre.

    abstract::In this single-centre study of 881 patients, S-phase fraction (SPF) was shown to be a significant prognostic marker in terms of overall survival (OS), relapse-free survival (RFS) and survival after relapse (SAR). Further, SPF had independent prognostic significance when considering a range of other clinicopathological...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Camplejohn RS,Ash CM,Gillett CE,Raikundalia B,Barnes DM,Gregory WM,Richards MA,Millis RR

    更新日期:1995-01-01 00:00:00

  • Modelling prognostic factors in advanced pancreatic cancer.

    abstract::Pancreatic cancer is the fifth most common cause of cancer death. Identification of defined patient groups based on a prognostic index may improve the prediction of survival and selection of therapy. Many prognostic factors have been identified often based on retrospective, underpowered studies with unclear analyses. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Stocken DD,Hassan AB,Altman DG,Billingham LJ,Bramhall SR,Johnson PJ,Freemantle N

    更新日期:2008-09-16 00:00:00

  • Comparisons of vaginal and abdominal radical trachelectomy for early-stage cervical cancer: preliminary results of a multi-center research in China.

    abstract:BACKGROUND:There are limited data comparing the prognosis and fertility outcomes of the patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal radical trachelectomy (ART).The objective of this study was to compare the surgical and pathologic characteristics, the prognosis ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Cao DY,Yang JX,Wu XH,Chen YL,Li L,Liu KJ,Cui MH,Xie X,Wu YM,Kong BH,Zhu GH,Xiang Y,Lang JH,Shen K,China Gynecologic Oncology Group.

    更新日期:2013-11-26 00:00:00

  • The impact of regulatory T cells on carcinogen-induced sarcogenesis.

    abstract::Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Betts G,Twohig J,Van den Broek M,Sierro S,Godkin A,Gallimore A

    更新日期:2007-06-18 00:00:00

  • Treatment with interleukin-2 in malignant pleural mesothelioma: immunological and angiogenetic assessment and prognostic impact.

    abstract:BACKGROUND:Administration of interleukin-2 (IL-2) has shown some effects on malignant pleural mesothelioma (MPM) tumour regression. The purpose of this study was to investigate the ability of IL-2 to modify immunological effector cells and angiogenesis in MPM patients and their prognostic value. METHODS:Tumour-infiltr...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Alì G,Boldrini L,Lucchi M,Picchi A,Dell'Omodarme M,Prati MC,Mussi A,Corsi V,Fontanini G

    更新日期:2009-12-01 00:00:00

  • Butyrate augments interferon-alpha-induced S phase accumulation and persistent tyrosine phosphorylation of cdc2 in K562 cells.

    abstract::Interferon-alpha (IFN-alpha) is a clinically useful cytokine for treatment of a variety of cancers, including chronic myelocytic leukaemia (CML). Most CML cells are sensitive to IFN-alpha; however, its biological effects on leukaemic cells are incompletely characterized. Here, we provide evidence that IFN-alpha induce...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Miyachi T,Adachi M,Hinoda Y,Imai K

    更新日期:1999-03-01 00:00:00

  • Do cell lines in vitro reflect the properties of the tumours of origin? A study of lines derived from human melanoma xenografts.

    abstract::The characteristics of 7 human melanoma cell lines were compared with those of the xenografts from which they were established. The ultrastructure, melanin content, isozyme pattern and chromosome numbers of the cell lines were closely similar to those of the corresponding xenografts. The different cell lines gave rise...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Tveit KM,Pihl A

    更新日期:1981-12-01 00:00:00

  • Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation-positive melanoma.

    abstract:BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

    更新日期:2018-03-20 00:00:00

  • Phase I dose-escalation studies of roniciclib, a pan-cyclin-dependent kinase inhibitor, in advanced malignancies.

    abstract:BACKGROUND:To evaluate safety, pharmacokinetics, and maximum tolerated dose of roniciclib in patients with advanced malignancies, with dose expansion to evaluate clinical benefit at the recommended phase II dose (RP2D). METHODS:Two phase I dose-escalation studies evaluated two roniciclib dosing schedules: 3 days on/4 ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Bahleda R,Grilley-Olson JE,Govindan R,Barlesi F,Greillier L,Perol M,Ray-Coquard I,Strumberg D,Schultheis B,Dy GK,Zalcman G,Weiss GJ,Walter AO,Kornacker M,Rajagopalan P,Henderson D,Nogai H,Ocker M,Soria JC

    更新日期:2017-06-06 00:00:00

  • Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer.

    abstract::The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only. Archival tumour samples from 166 patients were analysed...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Korkeila E,Talvinen K,Jaakkola PM,Minn H,Syrjänen K,Sundström J,Pyrhönen S

    更新日期:2009-03-24 00:00:00

  • Detection of micrometastasis by cytokeratin 20 RT-PCR is limited due to stable background transcription in granulocytes.

    abstract::The reverse transcription polymerase chain reaction (RT-PCR) amplification of cytokeratin 20 (CK20) mRNA is considered a promising candidate method for the detection of circulating tumour cells in bone marrow and peripheral blood of cancer patients. In this study we have investigated the diagnostic specificity of the ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Jung R,Petersen K,Krüger W,Wolf M,Wagener C,Zander A,Neumaier M

    更新日期:1999-11-01 00:00:00