当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Expression of NRG1 and its receptors in human bladder cancer.

Expression of NRG1 and its receptors in human bladder cancer.

Abstract：

BACKGROUND:Therapies targeting ERBB2 have shown success in the clinic. However, response is not determined solely by expression of ERBB2. Levels of ERBB3, its preferred heterodimerisation partner and ERBB ligands may also have a role. METHODS:We measured NRG1 expression by real-time quantitative RT-PCR and ERBB receptors by western blotting and immunohistochemistry in bladder tumours and cell lines. RESULTS:NRG1α and NRG1β showed significant coordinate expression. NRG1β was upregulated in 78% of cell lines. In tumours, there was a greater range of expression with a trend towards increased NRG1α with higher stage and grade. Increased expression of ERBB proteins was detected in 15% (EGFR), 20% (ERBB2), 41% (ERBB3) and 0% (ERBB4) of cell lines. High EGFR expression was detected in 28% of tumours, associated with grade and stage (P=0.05; P=0.04). Moderate or high expression of ERBB2 was detected in 22% and was associated with stage (P=0.025). Cytoplasmic ERBB3 was associated with high tumour grade (P=0.01) and with ERBB2 positivity. In cell lines, NRG1β expression was significantly inversely related to ERBB3, but this was not confirmed in tumours. CONCLUSION:There is a wide spectrum of NRG1 and ERBB receptor expression in bladder cancer. In advanced tumours, EGFR, ERBB2 and ERBB3 upregulation is common and there is a relationship between expression of ERBB2 and ERBB3 but not the NRG1 ligand.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Forster JA,Paul AB,Harnden P,Knowles MA

doi

10.1038/bjc.2011.39

subject

Has Abstract

pub_date

2011-03-29 00:00:00

pages

1135-43

issue

7

eissn

0007-0920

issn

1532-1827

pii

bjc201139

journal_volume

104

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Benign prostatic hyperplasia and subsequent risk of bladder cancer.

    abstract：:We evaluated the risk of bladder cancer in a cohort of 79,280 Swedish men hospitalised for benign prostatic hyperplasia (BPH), identified in the Swedish Inpatient Register between 1964 and 1983 and followed until 1989 via multiple record linkages with nationwide data on cancer registry, death and emigration. Standardi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603730

    authors： Kang D,Chokkalingam AP,Gridley G,Nyren O,Johansson JE,Adami HO,Silverman D,Hsing AW

    更新日期：2007-05-07 00:00:00

  • Peptide HER2(776-788) represents a naturally processed broad MHC class II-restricted T cell epitope.

    abstract：:HER2/neu-derived peptides inducing MHC class II-restricted CD4+ T helper lymphocyte (Th) responses, although critical for tumour rejection, are not thoroughly characterized. Here, we report the generation and characterization of CD4+ T cell clones specifically recognizing a HER-2/neu-derived peptide (776-788) [designa...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2001.2089

    authors： Sotiriadou R,Perez SA,Gritzapis AD,Sotiropoulou PA,Echner H,Heinzel S,Mamalaki A,Pawelec G,Voelter W,Baxevanis CN,Papamichail M

    更新日期：2001-11-16 00:00:00

  • Collaborative study of bronchial tumour-associated antigens.

    abstract：:Eleven groups of workers submitted a total of 21 bronchial tumour-associated antigen preparations and 19 antisera for comparative studies. Many of the antisera proved to be polyspecific despite absorption procedures. Most of the antigen preparations contained some material reactive towards a reference antiserum to nor...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.216

    authors： Gennings JN,Bagshawe KD,Axelsen NH,Sizaret P

    更新日期：1981-10-01 00:00:00

  • Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma.

    abstract：:Germline anomalies of the INK4a-ARF and Cdk4 genes were sought in a series of 89 patients suspected of having a genetic predisposition to melanoma. Patients were selected based on the following criteria: (a) familial melanoma (23 cases), (b) multiple primary melanoma (MPM; 18 cases), (c) melanoma and additional unrela...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601503

    authors： Soufir N,Lacapere JJ,Bertrand G,Matichard E,Meziani R,Mirebeau D,Descamps V,Gérard B,Archimbaud A,Ollivaud L,Bouscarat F,Baccard M,Lanternier G,Saïag P,Lebbé C,Basset-Seguin N,Crickx B,Cave H,Grandchamp B

    更新日期：2004-01-26 00:00:00

  • Predictors of complications in gynaecological oncological surgery: a prospective multicentre study (UKGOSOC-UK gynaecological oncology surgical outcomes and complications).

    abstract：BACKGROUND:There are limited data on surgical outcomes in gynaecological oncology. We report on predictors of complications in a multicentre prospective study. METHODS:Data on surgical procedures and resulting complications were contemporaneously recorded on consented patients in 10 participating UK gynaecological can...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2014.630

    authors： Iyer R,Gentry-Maharaj A,Nordin A,Burnell M,Liston R,Manchanda R,Das N,Desai R,Gornall R,Beardmore-Gray A,Nevin J,Hillaby K,Leeson S,Linder A,Lopes A,Meechan D,Mould T,Varkey S,Olaitan A,Rufford B,Ryan A,Shanbhag

    更新日期：2015-02-03 00:00:00

  • Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas.

    abstract：:Expression of CDX2, a caudal-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of C...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690068

    authors： Yagi OK,Akiyama Y,Yuasa Y

    更新日期：1999-02-01 00:00:00

  • Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments.

    abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605785

    authors： Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

    更新日期：2010-08-24 00:00:00

  • Modulation of tumour colony growth by irradiated accessory cells.

    abstract：:The ability of human tumour cells to form colonies in soft agar is enhanced by the presence of autologous phagocytic/adherent cells. We investigated the effect of irradiation on the ability of the adherent cells to support human tumour colony formation. Relatively low doses of irradiation significantly increased the g...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1983.249

    authors： Hamburger AW,White CP,Dunn FE

    更新日期：1983-11-01 00:00:00

  • Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion.

    abstract：BACKGROUND:Glioma stem-like cell (GSC) properties are responsible for gliomagenesis and recurrence. GSCs are invasive but its mechanism remains to be elucidated. Here, we attempted to identify the molecules that promote invasion in GSCs. METHODS:Neurospheres and CD133⁺ cells were collected from glioblastoma (GBM) spec...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.218

    authors： Nakada M,Nambu E,Furuyama N,Yoshida Y,Takino T,Hayashi Y,Sato H,Sai Y,Tsuji T,Miyamoto KI,Hirao A,Hamada JI

    更新日期：2013-06-25 00:00:00

  • Effect of hormone manipulation on oxidation, reduction and sulphurylation of dehydroepiandrosterone and oestrone in DMBA-induced rat mammary tumours.

    abstract：:Using the DMBA-induced mammary tumour as a model, the effect of hormone manipulation on steroid sulphurylation and on oxidative and reductive metabolism has been investigated. Oestradiol-17 beta, or oestradiol-17 beta + progesterone, administered to oophorectomized animals, had no effect on adenosine-3'-phosphate-5'-p...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1980.14

    authors： Li K,Chandra DP,Pewnim T,Foo T,Adams JB

    更新日期：1980-01-01 00:00:00

  • Mechanisms of adverse effects of anti-VEGF therapy for cancer.

    abstract：:Advances in understanding the role of vascular endothelial growth factor (VEGF) in normal physiology are giving insight into the basis of adverse effects attributed to the use of VEGF inhibitors in clinical oncology. These effects are typically downstream consequences of suppression of cellular signalling pathways imp...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6603813

    authors： Kamba T,McDonald DM

    更新日期：2007-06-18 00:00:00

  • No defect in G1/S cell cycle arrest in irradiated Li-Fraumeni lymphoblastoid cell lines.

    abstract：:The radiation response of Epstein-Barr virus (EBV)-immortalised lymphoblastoid cell lines derive from Li-Fraumeni syndrome (LFS) and LFS-like individuals was investigated. Cells from all LFS and LFS-like cases showed an accumulation of p53 protein following 137Cs gamma-irradiation, which was associated with cell cycle...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.424

    authors： Williams KJ,Heighway J,Birch JM,Norton JD,Scott D

    更新日期：1996-09-01 00:00:00

  • A functional bioassay to determine the activity of anti-VEGF antibody therapy in blood of patients with cancer.

    abstract：BACKGROUND:Only a small proportion of patients respond to anti-VEGF therapy, pressing the need for a reliable biomarker that can identify patients who will benefit. We studied the biological activity of anti-VEGF antibodies in patients' blood during anti-VEGF therapy by using the Ba/F3-VEGFR2 cell line, which is depend...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.275

    authors： Wentink MQ,Broxterman HJ,Lam SW,Boven E,Walraven M,Griffioen AW,Pili R,van der Vliet HJ,de Gruijl TD,Verheul HM

    更新日期：2016-10-11 00:00:00

  • Tobacco use and sinonasal cancer: a case-control study.

    abstract：:The risk for sinonasal cancer associated with tobacco use was examined in a case-control study in males diagnosed between 1978 and 1981 in the Netherlands. Of the 116 cases of sinonasal cancer and 259 controls identified, interviews were completed for 92 (79%) of the cases and 195 (75%) of the controls. Ever-users of ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.303

    authors： Hayes RB,Kardaun JW,de Bruyn A

    更新日期：1987-12-01 00:00:00

  • Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas.

    abstract：BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We ha...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.405

    authors： Shimwell NJ,Ward DG,Mohri Y,Mohri T,Pallan L,Teng M,Miki YC,Kusunoki M,Tucker O,Wei W,Morse J,Johnson PJ

    更新日期：2012-10-23 00:00:00

  • Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study.

    abstract：BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0523-5

    authors： Kim JW,Lee KH,Kim JW,Suh KJ,Nam AR,Bang JH,Bang YJ,Oh DY

    更新日期：2019-08-01 00:00:00

  • Anticancer effects of gemcitabine are enhanced by co-administered iRGD peptide in murine pancreatic cancer models that overexpressed neuropilin-1.

    abstract：BACKGROUND:Impaired drug transport is an important factor that reduces the efficacy of anticancer agents against pancreatic cancer. Here, we report a novel combination chemotherapy using gemcitabine (GEM) and internalised-RGD (iRGD) peptide, which enhances tumour-specific drug penetration by binding neuropilin-1 (NRP1)...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.49

    authors： Akashi Y,Oda T,Ohara Y,Miyamoto R,Kurokawa T,Hashimoto S,Enomoto T,Yamada K,Satake M,Ohkohchi N

    更新日期：2014-03-18 00:00:00

  • Parental educational attainment as an indicator of socioeconomic status and risk of childhood cancers.

    abstract：BACKGROUND:Little has been reported on socioeconomic (SES) patterns of risk for most forms of childhood cancer. METHODS:Population-based case-control data from epidemiological studies of childhood cancer conducted in five US states were pooled and associations of maternal, paternal and household educational attainment...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605732

    authors： Carozza SE,Puumala SE,Chow EJ,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Mueller BA,Spector LG

    更新日期：2010-06-29 00:00:00

  • Intrathecal chemotherapy. Selection of cytostatic agents.

    abstract：:Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of variou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1970.59

    authors： Hayakawa T,Yamada R,Kanai N,Kuroda R,Ushio Y,Higashi H,Mogami H

    更新日期：1970-09-01 00:00:00

  • Effects of nicotinamide and carbogen on tumour oxygenation, blood flow, energetics and blood glucose levels.

    abstract：:Both host carbogen (95% oxygen/5% carbon dioxide) breathing and nicotinamide administration enhance tumour radiotherapeutic response and are being re-evaluated in the clinic. Non-invasive magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) methods have been used to give information on the ef...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1144

    authors： Robinson SP,Howe FA,Stubbs M,Griffiths JR

    更新日期：2000-06-01 00:00:00

  • CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers.

    abstract：:Peutz-Jeghers syndrome (PJS) and juvenile polyposis (JPS) are both characterized by the presence of hamartomatous polyps and increased risk of malignancy in the gastrointestinal tract. Mutations of the LKB1 and SMAD4 genes have been shown recently to cause a number of PJS and JPS cases respectively, but there remains ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2001.1800

    authors： Woodford-Richens KL,Halford S,Rowan A,Bevan S,Aaltonen LA,Wasan H,Bicknell D,Bodmer WF,Houlston RS,Tomlinson IP

    更新日期：2001-05-18 00:00:00

  • Imaging tumour hypoxia with positron emission tomography.

    abstract：:Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variet...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2014.610

    authors： Fleming IN,Manavaki R,Blower PJ,West C,Williams KJ,Harris AL,Domarkas J,Lord S,Baldry C,Gilbert FJ

    更新日期：2015-01-20 00:00:00

  • Effects of the ACTH(4-9) analogue, ORG 2766, on vincristine cytotoxicity in two human lymphoma cell lines, U937 and U715.

    abstract：:The use of cytotoxic drug vincristine (VCR) is limited by the occurrence of peripheral neuropathy. A neurotrophic ACTH(4-9) analogue, ORG 2766, is being studied for its protective effect. Possible modulatory effects of ORG 2766 on tumour cell growth and interference with the cytotoxic efficacy of VCR were studied in t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.90

    authors： Kiburg B,van de Loosdrecht AA,Schweitzer KM,Ossenkoppele GJ,Müller LJ,Heimans JJ,Huijgens PC

    更新日期：1994-03-01 00:00:00

  • Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder.

    abstract：:Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic signifi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602593

    authors： Cheng HL,Liu HS,Lin YJ,Chen HH,Hsu PY,Chang TY,Ho CL,Tzai TS,Chow NH

    更新日期：2005-05-23 00:00:00

  • Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies.

    abstract：:Temozolomide, an oral cytotoxic agent with approximately 100% bioavailability after one administration, has demonstrated schedule-dependent clinical activity against highly resistant cancers. Thirty patients with minimal prior chemotherapy were enrolled in this phase I trial to characterize the drug's safety, pharmaco...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6690802

    authors： Brada M,Judson I,Beale P,Moore S,Reidenberg P,Statkevich P,Dugan M,Batra V,Cutler D

    更新日期：1999-11-01 00:00:00

  • Prognostic value of histological and biological markers in pharyngeal squamous cell carcinoma: a case-control study.

    abstract：:Between 1980 and 1985, 914 patients with head and neck squamous cell carcinoma underwent lymph node dissection in our institution. The prognostic value of clinical factors has already been reported (Mamelle et al, 1994, Am J Surg 168: 494-498). We present here a comparison of biological characteristics of pharyngeal t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.320

    authors： Guerry M,Vabre L,Talbot M,Mamelle G,Leridant AM,Hill C,Bosq J,Luboinski B,Janot F

    更新日期：1998-06-01 00:00:00

  • Determination of cell-free interleukin 2 receptor level in the serum of normal animals and of animals bearing IL-2 receptor positive tumours with high or low metastatic capacity.

    abstract：:Serum levels of cell-free interleukin-2 receptors were elevated above normal in mice bearing the IL-2R positive T-cell lymphoma Eb or its highly metastatic variant ESb. Although ESb cells expressed less IL-2R molecules than Eb cells on their cell surface, serum receptor levels were raised more quickly in ESb than in E...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.119

    authors： Schirrmacher V,Josimovic-Alasevic O,Osawa H,Diamantstein T

    更新日期：1987-06-01 00:00:00

  • Haemato-oncology and burnout: an Italian survey.

    abstract：:This cross-sectional survey aimed to evaluate the prevalence of burnout and estimated psychiatric disorders among haemato-oncology healthcare professionals in Italy. The aspects of work that respondents perceive as stressful and satisfying have also been examined. The assessments were made using the Maslach Burnout In...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/sj.bjc.6604270

    authors： Bressi C,Manenti S,Porcellana M,Cevales D,Farina L,Felicioni I,Meloni G,Milone G,Miccolis IR,Pavanetto M,Pescador L,Poddigue M,Scotti L,Zambon A,Corrao G,Lambertenghi-Deliliers G,Invernizzi G

    更新日期：2008-03-25 00:00:00

  • High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.

    abstract：BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2015.3

    authors： Wang M,Zhu X,Sha Z,Li N,Li D,Chen L

    更新日期：2015-03-03 00:00:00

  • Combination chemotherapy with epirubicin, docetaxel and cisplatin (EDP) in metastatic or recurrent, unresectable gastric cancer.

    abstract：:Based on single agent activities and the additive or synergistic effects of three individual drugs in gastric cancer, we performed a phase II study of a new regimen combining epirubicin, docetaxel and cisplatin (EDP) for unresectable gastric cancer. The patients with histologically confirmed metastatic or recurrent, u...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6601891

    authors： Lee SH,Kang WK,Park J,Kim HY,Kim JH,Lee SI,Park JO,Kim K,Jung CW,Park YS,Im YH,Lee MH,Park K

    更新日期：2004-07-05 00:00:00