Cold lymphocytotoxic antibodies in nasopharyngeal carcinoma.

abstract：:The integrin alpha(v)beta6 is not detectable on normal keratinocytes in vivo but expression is increased significantly in oral squamous cell carcinoma where this heterodimer has been shown to play a role in cell migration, invasion and protease expression. Although regarded initially as a fibronectin receptor, alpha(v...

journal_title：British journal of cancer

authors： Thomas GJ,Hart IR,Speight PM,Marshall JF

更新日期：2002-10-07 00:00:00

abstract：:The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period. The study was carried out to determine whether mitochondrial DNA abnormalities were ...

journal_title：British journal of cancer

authors： Wheelhouse NM,Lai PB,Wigmore SJ,Ross JA,Harrison DJ

更新日期：2005-04-11 00:00:00

abstract：:Telomerase, an enzyme related with cellular immortality, has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. Telomerase activity is mainly regulated by the expression of hTERT (human telomerase reverse transcriptase), which is a catalytic component of human ...

journal_title：British journal of cancer

authors： Hiyama E,Yamaoka H,Matsunaga T,Hayashi Y,Ando H,Suita S,Horie H,Kaneko M,Sasaki F,Hashizume K,Nakagawara A,Ohnuma N,Yokoyama T

更新日期：2004-08-31 00:00:00

abstract：:Many kallikrein genes were found to be differentially expressed in various malignancies, and prostate specific antigen (encoded by the KLK3 gene) is the best tumour marker for prostate cancer. Prostate specific antigen has recently been shown to be an independent favourable prognostic marker for breast cancer. KLK15 i...

journal_title：British journal of cancer

authors： Yousef GM,Scorilas A,Magklara A,Memari N,Ponzone R,Sismondi P,Biglia N,Abd Ellatif M,Diamandis EP

更新日期：2002-11-18 00:00:00

abstract：BACKGROUND:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CR...

journal_title：British journal of cancer

authors： Snoeren N,Emmink BL,Koerkamp MJ,van Hooff SR,Goos JA,van Houdt WJ,de Wit M,Prins AM,Piersma SR,Pham TV,Belt EJ,Bril H,Stockmann HB,Meijer GA,van Hillegersberg R,Holstege FC,Jimenez CR,Fijneman RJ,Kranenburg OW,Rinke

更新日期：2013-09-17 00:00:00

abstract：:The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...

journal_title：British journal of cancer

authors： Begleiter A,Leith MK,Thliveris JA,Digby T

更新日期：2004-10-18 00:00:00

abstract：:The acute toxicity, pharmacokinetics and hypoxic cytotoxicity of RSU-1069 were investigated using the subcutaneous (sc) rat 9L tumour model. The pharmacokinetics were studied after i.p. injection of RSU-1069 (20 mg kg-1 or 100 mg kg-1). For both doses, the elimination of RSU-1069 followed first-order kinetics in both ...

journal_title：British journal of cancer

authors： Wong KH,Koch CJ,Wallen CA,Wheeler KT

更新日期：1991-04-01 00:00:00

abstract：:We determined the prevalence of type-specific hrHPV infections in the Netherlands on cervical scrapes of 45 362 women aged 18-65 years. The overall hrHPV prevalence peaked at the age of 22 with peak prevalence of 24%. Each of the 14 hrHPV types decreased significantly with age (P-values between 0.0009 and 0.03). The p...

journal_title：British journal of cancer

authors： Coupé VM,Berkhof J,Bulkmans NW,Snijders PJ,Meijer CJ

更新日期：2008-02-12 00:00:00

abstract：:5'-nucleotidase activity, arachidonate metabolism and adenosine uptake were measured in P388 murine leukaemia cells and in a subline resistant to doxorubicin. These membranes related activities were found to be increased in the doxorubicin resistant cell line, compared to the drug sensitive cells. It is suggested that...

journal_title：British journal of cancer

authors： Ramu A,Glaubiger D,Soprey P,Reaman GH,Feuerstein N

更新日期：1984-04-01 00:00:00

abstract：:The present study was designed in order to evaluate the response rate and the toxicity of continuous infusion of Interleukin 2 (IL2) in patients over 65 with metastatic renal cell carcinoma. Twenty-five patients, median age 69 (range 65-77), without any prior systemic anticancer therapy received a continuous infusion ...

journal_title：British journal of cancer

authors： Négrier S,Mercatello A,Bret M,Thiesse P,Blay JY,Coronel B,Merrouche Y,Oskam R,Franks CR,Clavel M

更新日期：1992-05-01 00:00:00

abstract：:Periodate-treated, non-anticoagulant heparin-carrying polystyrene consists of about ten periodate-oxidized, alkaline-degraded low molecular weight-heparin chains linked to a polystyrene core and has a markedly lower anti-coagulant activity than heparin. In this study, we evaluated the effect of non-anticoagulant hepar...

journal_title：British journal of cancer

authors： Ono K,Ishihara M,Ishikawa K,Ozeki Y,Deguchi H,Sato M,Hashimoto H,Saito Y,Yura H,Kurita A,Maehara T

更新日期：2002-06-05 00:00:00

abstract：:Broad-spectrum neuropeptide growth factor antagonists, such as [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P (antagonist D) and [Arg6, D-Trp7,9, NmePhe8]substance P(6-11) (antagonist G), are currently being investigated as possible anti-tumour agents. These compounds are hoped to be effective against neuropeptide-drive...

journal_title：British journal of cancer

authors： Jones DA,Cummings J,Langdon SP,Maclellan AJ,Higgins T,Rozengurt E,Smyth JF

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Chemerin, a known chemoattractant, participates in multiple biological events. However, its role in cancer remains largely unknown. METHODS:Chemerin expression was evaluated by real-time PCR, western blot and immunohistochemistry. Forced expression, RNAi, immunoprecipitation, etc. were used in function and ...

journal_title：British journal of cancer

authors： Li JJ,Yin HK,Guan DX,Zhao JS,Feng YX,Deng YZ,Wang X,Li N,Wang XF,Cheng SQ,Bao Y,Xie D

更新日期：2018-05-01 00:00:00

abstract：:The serum CA125 level was determined by a one-step immunoradiometric assay method in patients with lung cancer. Increased serum CA125 levels were observed in 37.8% of patients with squamous cell cancer, in 30.0% of those with adenocarcinoma and in 60.0% of those with small call cancer. Most patients with increased ser...

journal_title：British journal of cancer

authors： Kimura Y,Fujii T,Hamamoto K,Miyagawa N,Kataoka M,Iio A

更新日期：1990-10-01 00:00:00

abstract：:Oesopharyngeal brush (OPB) sampling with cytological analysis can yield exfoliated cells from asymptomatic tumours of the upper aero-digestive tract and the oesophagus. In this study, we compared cytological evaluation and molecular analysis for the detection of exfoliated cancer cells sampled with an OPB. A total of ...

journal_title：British journal of cancer

authors： Temam S,Trassard M,Leroux G,Bosq J,Luboinski B,Lenoir G,Bénard J,Janot F

更新日期：2003-06-02 00:00:00

abstract：:This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...

journal_title：British journal of cancer

authors： Couteau C,Chouaki N,Leyvraz S,Oulid-Aissa D,Lebecq A,Domenge C,Groult V,Bordessoule S,Janot F,De Forni M,Armand JP

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:This open-label, phase 1 trial (NCT02316197) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (formerly M3814), a DNA-dependent protein kinase (DNA-PK) inhibitor in patients with advanced solid tumours. Secondary/exploratory objectives included safety/t...

journal_title：British journal of cancer

authors： van Bussel MTJ,Awada A,de Jonge MJA,Mau-Sørensen M,Nielsen D,Schöffski P,Verheul HMW,Sarholz B,Berghoff K,El Bawab S,Kuipers M,Damstrup L,Diaz-Padilla I,Schellens JHM

更新日期：2020-11-24 00:00:00

abstract：:We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro stud...

journal_title：British journal of cancer

authors： Hosokawa S,Tagawa T,Niki H,Hirakawa Y,Nohga K,Nagaike K

更新日期：2003-10-20 00:00:00

abstract：:Isomerisation to all-trans-retinoic acid (ATRA) is widely accepted as the key mechanism underlying the favourable clinical properties of 13-cis-retinoic acid (13cisRA). As intracellular metabolism of ATRA by CYP26 may result in clinical resistance to 13cisRA, an increase in efficacy may be achieved through modulation ...

journal_title：British journal of cancer

authors： Armstrong JL,Taylor GA,Thomas HD,Boddy AV,Redfern CP,Veal GJ

更新日期：2007-06-04 00:00:00

abstract：BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...

journal_title：British journal of cancer

authors： Wang LL,Teshiba R,Ikegaki N,Tang XX,Naranjo A,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Asgharzadeh S,Shimada H

更新日期：2015-06-30 00:00:00

abstract：:Several techniques are under development to diagnose oesophageal adenocarcinoma at an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical diagnostic technique, for the identification and classification of malignant changes. However, there is no clear recognition of the biochemical chang...

journal_title：British journal of cancer

authors： Shetty G,Kendall C,Shepherd N,Stone N,Barr H

更新日期：2006-05-22 00:00:00

abstract：:The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...

journal_title：British journal of cancer

authors： Sharrard RM,Maitland NJ

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...

journal_title：British journal of cancer

authors： Pinto R,De Summa S,Danza K,Popescu O,Paradiso A,Micale L,Merla G,Palumbo O,Carella M,Tommasi S

更新日期：2014-12-09 00:00:00

abstract：:Maturation of monocytes into macrophages in vitro has been assayed by a quantitative microtitre assay in patients with squamous-cell carcinoma of the lung. Monocyte maturation in autologous serum was significantly depressed in patients with both limited and extensive disease compared with normal controls, patients wit...

journal_title：British journal of cancer

authors： Dent RG,Cole P

更新日期：1981-04-01 00:00:00

abstract：:Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...

journal_title：British journal of cancer

authors： Selby PJ,Heyderman E,Gibbs J,Peckham MJ

更新日期：1979-05-01 00:00:00

abstract：:Several substances mark the course of lung cancer and may reliably help the clinician in decision-making. This is the first clinical study specifically designed to compare tissue polypeptide antigen and CA 125 tumour associated antigen. Three hundred and eighty-four new lung cancer patients (309 males) were studied at...

journal_title：British journal of cancer

authors： Buccheri G,Ferrigno D

更新日期：2002-11-04 00:00:00

abstract：BACKGROUND:Focal adhesion kinase (FAK) is overexpressed in a variety of cancers, such as breast, colon, prostate, ovary, and lung cancers. However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated. METHODS:The signalling p...

journal_title：British journal of cancer

authors： Meng XN,Jin Y,Yu Y,Bai J,Liu GY,Zhu J,Zhao YZ,Wang Z,Chen F,Lee KY,Fu SB

更新日期：2009-07-21 00:00:00

abstract：:The pharmacological interest in lonidamine is related to its ability to enhance the cytotoxic effects of several DNA-damaging anti-tumour agents. This study was undertaken to better understand the in vivo interaction between lonidamine and cisplatin in the treatment of human tumour xenografts, including three carcinom...

journal_title：British journal of cancer

authors： De Cesare M,Pratesi G,Giusti A,Polizzi D,Zunino F

更新日期：1998-01-01 00:00:00

abstract：:Immunoreactive and bioassayable plasma fibronectin (opsonic α(2) surface-binding (SB) glycoprotein) was measured during experimental Sarcoma-180 tumour growth in mice. Male C57BL/6 mice were challenged s.c. with 2 × 10(6) viable Sarcoma-180 tumour cells and evaluated sequentially in parallel with saline-injected contr...

journal_title：British journal of cancer

authors： Saba TM,Gregory TJ,Blumenstock FA

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND:Non-persistence and non-compliance are common in women prescribed hormonal therapy for breast cancer, but little is known about their influence on recurrence. METHODS:A nested case-control study of associations between hormonal therapy non-persistence and non-compliance and the risk of early recurrence in w...

journal_title：British journal of cancer

authors： Barron TI,Cahir C,Sharp L,Bennett K

更新日期：2013-09-17 00:00:00