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A nested case-control study of adjuvant hormonal therapy persistence and compliance, and early breast cancer recurrence in women with stage I-III breast cancer.

Abstract：

BACKGROUND:Non-persistence and non-compliance are common in women prescribed hormonal therapy for breast cancer, but little is known about their influence on recurrence. METHODS:A nested case-control study of associations between hormonal therapy non-persistence and non-compliance and the risk of early recurrence in women with stage I-III breast cancer was undertaken. Cases, defined as women with a breast cancer recurrence within 4 years of hormonal therapy initiation, were matched to controls (1 : 5) by tumour stage and age. Conditional logistic regression was used to examine associations between early recurrence and hormonal therapy non-persistence and non-compliance. RESULTS:Ninety-four women with breast cancer recurrence were matched to 458 controls. Women who were non-persistent (≥ 180 days without hormonal therapy) had a significantly increased adjusted recurrence odds ratio (OR) of 2.88 (95%CI 1.11, 7.46) compared with persistent women. There was no significant association between low compliance (OR 1.30; 95% CI 0.74, 2.30) and breast cancer recurrence. CONCLUSION:Hormonal therapy non-persistence is associated with a significantly higher risk of early recurrence in women with stage I-III oestrogen receptor (ER)-positive breast cancer. This finding is consistent with results from randomized studies of hormonal therapy treatment duration and suggests that interventions to target modifiable risk factors for non-persistence are required.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Barron TI,Cahir C,Sharp L,Bennett K

doi

10.1038/bjc.2013.518

subject

Has Abstract

pub_date

2013-09-17 00:00:00

pages

1513-21

issue

6

eissn

0007-0920

issn

1532-1827

pii

bjc2013518

journal_volume

109

pub_type

杂志文章

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