Effects of Cremophor EL on distribution of Taxol to serum lipoproteins.

abstract：BACKGROUND:Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observatio...

journal_title：British journal of cancer

authors： Witkowski L,Mattina J,Schönberger S,Murray MJ,Choong CS,Huntsman DG,Reis-Filho JS,McCluggage WG,Nicholson JC,Coleman N,Calaminus G,Schneider DT,Arseneau J,Stewart CJ,Foulkes WD

更新日期：2013-11-12 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) frequently complicates cancer. Data on tumour-specific VTE predictors are limited, but may inform strategies to prevent thrombosis. METHODS:We computed incidence rates (IRs) with 95% confidence intervals (CIs) for VTE hospitalisation in a cohort of cancer patients (n=57,591) and...

journal_title：British journal of cancer

authors： Cronin-Fenton DP,Søndergaard F,Pedersen LA,Fryzek JP,Cetin K,Acquavella J,Baron JA,Sørensen HT

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment options. PDAC cells shift their metabolism towards glycolysis, which fuels the plasma membrane calcium pump (PMCA), thereby preventing Ca2+-dependent cell death. The ATP-generating pyruvate kinase-M2 (PKM2) is oncogenic and overexpressed...

journal_title：British journal of cancer

authors： James AD,Richardson DA,Oh IW,Sritangos P,Attard T,Barrett L,Bruce JIE

更新日期：2020-01-01 00:00:00

abstract：:Electron spin resonance (ESR) spectroscopy was used to examine changes in the concentration of paramagnetic metal ions in Yoshida tumours carried by female Wistar rats. Blood, spleen and lymph nodes from these animals were also examined by ESR. A decrease in the concentration of a paramagnetic species associated with ...

journal_title：British journal of cancer

authors： Dodd NJ,Silcock JM

更新日期：1976-11-01 00:00:00

abstract：:Hepatic arterial floxuridine (HAI) in 35 patients with systemic fluorouracil/folinic acid-resistant colorectal liver metastases achieved a 14% partial response and 26% disease stabilization rate, with a median response duration of 7 months from onset of HAI. ...

journal_title：British journal of cancer

authors： Fordy C,Glover C,Davies MM,Allen-Mersh TG

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...

journal_title：British journal of cancer

authors： Crespo M,van Dalum G,Ferraldeschi R,Zafeiriou Z,Sideris S,Lorente D,Bianchini D,Rodrigues DN,Riisnaes R,Miranda S,Figueiredo I,Flohr P,Nowakowska K,de Bono JS,Terstappen LW,Attard G

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:A combination of S-1 and cisplatin has been shown to be effective with acceptable safety for the first-line treatment of far-advanced gastric cancer in Japan. This is the first randomised phase II trial to compare S-1+paclitaxel with S-1+cisplatin in this setting. METHODS:Patients with unresectable and/or r...

journal_title：British journal of cancer

authors： Mochiki E,Ogata K,Ohno T,Toyomasu Y,Haga N,Fukai Y,Aihara R,Ando H,Uchida N,Asao T,Kuwano H,North Kanto Gastric Cancer Study Group.

更新日期：2012-06-26 00:00:00

abstract：BACKGROUND:Cervical cancer screening coverage remains insufficient in most countries. Our objective was to assess whether in-home vaginal self-sampling with a dry swab for high-risk human papillomavirus (HR-HPV) testing is effective and cost-effective in increasing participation in cervical cancer screening. METHODS:I...

journal_title：British journal of cancer

authors： Haguenoer K,Sengchanh S,Gaudy-Graffin C,Boyard J,Fontenay R,Marret H,Goudeau A,Pigneaux de Laroche N,Rusch E,Giraudeau B

更新日期：2014-11-25 00:00:00

abstract：:Our recent genome-wide allelotyping analysis of gallbladder carcinoma identified 3p, 8p, 9q and 22q as chromosomal regions with frequent loss of heterozygosity. The present study was undertaken to more precisely identify the presence and location of regions of frequent allele loss involving those chromosomes in gallbl...

journal_title：British journal of cancer

authors： Wistuba II,Maitra A,Carrasco R,Tang M,Troncoso P,Minna JD,Gazdar AF

更新日期：2002-08-12 00:00:00

abstract：:A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) 1.70, 95% CI 1.23 - 2.35, P=0.001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The fo...

journal_title：British journal of cancer

authors： Forrest LM,McMillan DC,McArdle CS,Angerson WJ,Dunlop DJ

更新日期：2003-09-15 00:00:00

abstract：:In recent years, large discrepancies were described in the success rate of the tyrosinase reverse transcription polymerase chain reaction (RT-PCR) for detecting melanoma cells in the peripheral blood of melanoma patients. We present a quality control study in which we analysed the reproducibility of detection of tyros...

journal_title：British journal of cancer

authors： de Vries TJ,Fourkour A,Punt CJ,van de Locht LT,Wobbes T,van den Bosch S,de Rooij MJ,Mensink EJ,Ruiter DJ,van Muijen GN

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. ...

journal_title：British journal of cancer

authors： Zhou CK,Sutcliffe S,Welsh J,Mackinnon K,Kuh D,Hardy R,Cook MB

更新日期：2016-03-29 00:00:00

abstract：:It has recently been reported that a series of testis cancers shows a temporal cycle in birth dates with a peak in certain months. This observation has been tested by an examination of a larger series covering all testis cancers diagnosed in the years 1971-84 in England and Wales, in men born in 1940 or later. Limited...

journal_title：British journal of cancer

authors： Kinlen LJ,Willows AN

更新日期：1987-05-01 00:00:00

abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

journal_title：British journal of cancer

authors： Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...

journal_title：British journal of cancer

authors： Wang X,Zhao L,Liu H,Zhong D,Liu W,Shan G,Dong F,Gao W,Bai C,Li X

更新日期：2016-06-14 00:00:00

abstract：:To understand genetic events which play a role in the development and/or progression of human endometrial cancer, we studied allelotypes on all autosomal chromosomes, as well as chromosome X, with 42 microsatellite markers and 56 endometrial cancers. The most frequent loss of heterozygosity (LOH) was observed on the l...

journal_title：British journal of cancer

authors： Nagase S,Sato S,Tezuka F,Wada Y,Yajima A,Horii A

更新日期：1996-12-01 00:00:00

abstract：:Epidemiological, animal, and cell culture studies have identified boron as a chemopreventative agent in prostate cancer. The present objective was to identify boron-induced changes in the DU-145 human prostate cancer cell line. We show that prolonged exposure to pharmacologically-relevant levels of boric acid, the nat...

journal_title：British journal of cancer

authors： Barranco WT,Eckhert CD

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents. Patients who respond poorly to chemotherapy have a higher risk of metastatic disease and 5-year survival rates of only 10-20%. Therefore, identifying molecular targets that are specific for OS, or more specifically, metasta...

journal_title：British journal of cancer

authors： Endo-Munoz L,Cumming A,Sommerville S,Dickinson I,Saunders NA

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...

journal_title：British journal of cancer

authors： Basso M,Strippoli A,Orlandi A,Martini M,Calegari MA,Schinzari G,Di Salvatore M,Cenci T,Cassano A,Larocca LM,Barone C

更新日期：2013-01-15 00:00:00

abstract：:The incidence of adenocarcinoma of the oesophagus in British women is among the highest in the world. To investigate its aetiology, we conducted a multi-centre, population based case-control study in four regions in England and Scotland. We included 74 incident cases in women with histologically confirmed diagnoses of...

journal_title：British journal of cancer

authors： Cheng KK,Sharp L,McKinney PA,Logan RF,Chilvers CE,Cook-Mozaffari P,Ahmed A,Day NE

更新日期：2000-07-01 00:00:00

abstract：:The relationship between hormone replacement treatment (HRT) and breast cancer risk was analysed using data from a case-control study conducted between June 1991 and February 1994 in six Italian centres on 2569 patients aged below 75 with histologically confirmed breast cancer and 2588 controls admitted to hospital fo...

journal_title：British journal of cancer

authors： La Vecchia C,Negri E,Franceschi S,Favero A,Nanni O,Filiberti R,Conti E,Montella M,Veronesi A,Ferraroni M

更新日期：1995-07-01 00:00:00

abstract：:Combinations of dacarbazine (DTIC) and other cytotoxic agents or alpha-interferon were given to 136 patients in five different regimens. The total response rate was 32% (95% confidence interval 24-40%); 13% had a complete remission. Female patients had a significantly higher chance of response than male patients: 46% ...

journal_title：British journal of cancer

authors： Mulder NH,van der Graaf WT,Willemse PH,Koops HS,de Vries EG,Sleijfer DT

更新日期：1994-10-01 00:00:00

abstract：METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

journal_title：British journal of cancer

authors： Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

更新日期：2009-08-04 00:00:00

abstract：:Cancer incidence in the Falkland Islands, 1989-2000, was compared with rates in England and Wales, from which most Islanders originate. Colon and rectum cancer incidence was significantly raised 1989-93 but greatly reduced after 1994, when colonoscopic screening in high-risk families and sigmoidoscopic screening in th...

journal_title：British journal of cancer

authors： Swerdlow AJ,Elsby B,Qiao Z

更新日期：2001-11-02 00:00:00

abstract：:Women referred to a familial breast cancer clinic completed questionnaires before and after counselling and at annual follow-up to assess their risk estimate and psychological characteristics. The aims were to determine whether those who attended the clinic overestimated their risk or were highly anxious and whether c...

journal_title：British journal of cancer

authors： Cull A,Anderson ED,Campbell S,Mackay J,Smyth E,Steel M

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:High amplification of epiregulin (EREG) and amphireglin (AREG) in tumour tissues has been previously reported to be associated with better outcome in metastatic colorectal cancer (mCRC) patients who were treated with anti-EGFR antibodies. Here we investigated associations between the expression of other cand...

journal_title：British journal of cancer

authors： Takahashi N,Iwasa S,Taniguchi H,Sasaki Y,Shoji H,Honma Y,Takashima A,Okita N,Kato K,Hamaguchi T,Shimada Y,Yamada Y

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT). METHODS:The WHI study enrolled women aged 50-79 years from 1993 t...

journal_title：British journal of cancer

authors： Wang A,Aragaki AK,Tang JY,Kurian AW,Manson JE,Chlebowski RT,Simon M,Desai P,Wassertheil-Smoller S,Liu S,Kritchevsky S,Wakelee HA,Stefanick ML

更新日期：2016-06-28 00:00:00

abstract：:1,25(OH)2D3 promotes differentiation and has an antiproliferative effect in a variety of cell lines derived from the immunohaematopoetic system. alpha-Calcidol which is metabolised to 1,25(OH)2D3 has been shown to produce tumour regression in follicular low grade non-Hodgkin's lymphoma (NHL) and the dose limiting toxi...

journal_title：British journal of cancer

authors： Hickish T,Cunningham D,Colston K,Millar BC,Sandle J,Mackay AG,Soukop M,Sloane J

更新日期：1993-10-01 00:00:00

abstract：:The trimodality approach represented by concurrent chemoradiotherapy followed by surgical resection is a highly effective, but potentially toxic therapy for locally advanced non-small-cell lung cancer (NSCLC). In this review, we discuss the current status of this therapy in patients with mediastinal node-positive (N2)...

journal_title：British journal of cancer

authors： Kunitoh H,Suzuki K

更新日期：2007-05-21 00:00:00

abstract：BACKGROUND:Gender-associated epigenetic alterations are poorly investigated in male and female familial breast cancer (fBC). MicroRNAs may contribute to the different biology in men and women particularly related to RASSF1A pathways. METHODS:Microarray technology was used to evaluate miRNA profile in 24 male and 43 fe...

journal_title：British journal of cancer

authors： Pinto R,De Summa S,Danza K,Popescu O,Paradiso A,Micale L,Merla G,Palumbo O,Carella M,Tommasi S

更新日期：2014-12-09 00:00:00