Tumorigenic effect of thioacetamide in Swiss strain mice.

abstract：BACKGROUND:defective DNA repair has a causal role in hereditary colorectal cancer (CRC). Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated polyposis and CRC predisposition as an autosomal recessive trait. Numerous reports have suggested MUTYH mono-allelic variants to be low penetrance ...

journal_title：British journal of cancer

authors： Theodoratou E,Campbell H,Tenesa A,Houlston R,Webb E,Lubbe S,Broderick P,Gallinger S,Croitoru EM,Jenkins MA,Win AK,Cleary SP,Koessler T,Pharoah PD,Küry S,Bézieau S,Buecher B,Ellis NA,Peterlongo P,Offit K,Aaltonen L

更新日期：2010-12-07 00:00:00

abstract：:The association of endometrial thickness with the risk of developing endometrial cancer (EC) within 2 years was investigated in a consecutive cohort of 1205 breast cancer patients under tamoxifen treatment, undergoing transvaginal ultrasonography (TVUS) for follow-up purpose (asymptomatic, 1068) or for abnormal uterin...

journal_title：British journal of cancer

authors： Ciatto S,Cecchini S,Gervasi G,Landini A,Zappa M,Crocetti E

更新日期：2003-04-22 00:00:00

abstract：:ICI 182,780 (Fulvestrant) is the first in a new class of novel, steroidal, 'pure' antioestrogens--the oestrogen receptor (ER) down-regulators. Its unique mode of action and the absence of partial agonist activity make it a candidate for the treatment of advanced breast cancer in both pre- and postmenopausal women. Tam...

journal_title：British journal of cancer

authors： Robertson JF

更新日期：2001-11-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) was studied in ovarian tumours with immunohistochemical (IH) and ligand-binding assay (LBA). Two different monoclonal antibodies (MoAbs: 2E9, EGFR1) with respect to detecting EGFR with different ligand-binding affinities (low, high and low) were used. When comparing the IH data ...

journal_title：British journal of cancer

authors： Henzen-Logmans SC,Berns EM,Klijn JG,van der Burg ME,Foekens JA

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16INK4a...

journal_title：British journal of cancer

authors： Wagner S,Prigge ES,Wuerdemann N,Reder H,Bushnak A,Sharma SJ,Obermueller T,von Knebel Doeberitz M,Dreyer T,Gattenlöhner S,Wolf G,Pons-Kühnemann J,Wittekindt C,Klussmann JP

更新日期：2020-09-01 00:00:00

abstract：:The c-erbB-2 product is thought to be a unique and useful target for antibody therapy of cancers overexpressing the c-erbB-2 gene. In vitro and in vivo anti-tumour effects of a humanised antibody against the extracellular domain of the c-erbB-2 gene product, rhu4D5, were examined. Rhu4D5 was less effective than its mu...

journal_title：British journal of cancer

authors： Tokuda Y,Ohnishi Y,Shimamura K,Iwasawa M,Yoshimura M,Ueyama Y,Tamaoki N,Tajima T,Mitomi T

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:FOXA1 expression is a good prognostic marker for endocrine therapy in hormone-positive breast cancer. We retrospectively examined breast cancer patients with luminal human epidermal growth factor receptor 2 (HER2)-negative tumours, as defined by immunohistochemistry, who received neo-adjuvant chemotherapy (N...

journal_title：British journal of cancer

authors： Horimoto Y,Arakawa A,Harada-Shoji N,Sonoue H,Yoshida Y,Himuro T,Igari F,Tokuda E,Mamat O,Tanabe M,Hino O,Saito M

更新日期：2015-01-20 00:00:00

abstract：:Expression of both P-glycoprotein (P-gp) and mutant p53 have recently been reported to be associated with poor prognosis of breast cancer. The expression of P-gp is associated in vitro and in vivo with cross-resistance to several anti-cancer drugs. p53 plays a regulatory role in apoptosis, and mutant p53 has been sugg...

journal_title：British journal of cancer

authors： Linn SC,Honkoop AH,Hoekman K,van der Valk P,Pinedo HM,Giaccone G

更新日期：1996-07-01 00:00:00

abstract：:The influence on heat sensitivity of interactions between HT29 human colon adenocarcinoma cells grown in two- or three-dimensional contact was investigated. No evidence for intercellular cooperation affecting cellular sensitivity to hyperthermia was found. Cells grown in monolayer were found to be more heat sensitive ...

journal_title：British journal of cancer

authors： Dobrucki J,Bleehen NM

更新日期：1985-12-01 00:00:00

abstract：:High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorect...

journal_title：British journal of cancer

authors： Michel S,Benner A,Tariverdian M,Wentzensen N,Hoefler P,Pommerencke T,Grabe N,von Knebel Doeberitz M,Kloor M

更新日期：2008-12-02 00:00:00

abstract：:Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...

journal_title：British journal of cancer

authors： Bridgewater J,van Laar R,Floore A,Van'T Veer L

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND:Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. We conducted a la...

journal_title：British journal of cancer

authors： Köbel M,Madore J,Ramus SJ,Clarke BA,Pharoah PD,Deen S,Bowtell DD,Odunsi K,Menon U,Morrison C,Lele S,Bshara W,Sucheston L,Beckmann MW,Hein A,Thiel FC,Hartmann A,Wachter DL,Anglesio MS,Høgdall E,Jensen A,Høgdall C

更新日期：2014-12-09 00:00:00

abstract：:When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour siz...

journal_title：British journal of cancer

authors： Abid SH,Khoobyarian N

更新日期：1976-04-01 00:00:00

abstract：:Besides cytotoxicity, taxanes induce other biological effects, especially in the immune system. Taxanes have demonstrated immunostimulatory effects against neoplasms, supporting the idea that these agents suppress cancer through several mechanisms and not solely through inhibiting cell division. The purpose of the pre...

journal_title：British journal of cancer

authors： Tsavaris N,Kosmas C,Vadiaka M,Kanelopoulos P,Boulamatsis D

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...

journal_title：British journal of cancer

authors： Kunitoh H,Tamura T,Shibata T,Takeda K,Katakami N,Nakagawa K,Yokoyama A,Nishiwaki Y,Noda K,Watanabe K,Saijo N,JCOG Lung Cancer Study Group.

更新日期：2010-06-29 00:00:00

abstract：:Epidemiological, animal, and cell culture studies have identified boron as a chemopreventative agent in prostate cancer. The present objective was to identify boron-induced changes in the DU-145 human prostate cancer cell line. We show that prolonged exposure to pharmacologically-relevant levels of boric acid, the nat...

journal_title：British journal of cancer

authors： Barranco WT,Eckhert CD

更新日期：2006-03-27 00:00:00

abstract：:Recent evidence has demonstrated that endothelial-to-mesenchymal transition (EndMT) may have a significant role in a number of diseases. Although EndMT has been previously studied as a critical process in heart development, it is now clear that EndMT can also occur postnatally in various pathologic settings, including...

journal_title：British journal of cancer

authors： Potenta S,Zeisberg E,Kalluri R

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern ...

journal_title：British journal of cancer

authors： van Dam PJ,van der Stok EP,Teuwen LA,Van den Eynden GG,Illemann M,Frentzas S,Majeed AW,Eefsen RL,Coebergh van den Braak RRJ,Lazaris A,Fernandez MC,Galjart B,Laerum OD,Rayes R,Grünhagen DJ,Van de Paer M,Sucaet Y,Mudhar H

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Dysregulation of microRNAs (miRNAs) has been found in human epithelial ovarian cancer (EOC). However, the role and mechanism of action of miR-23a in EOC remain unclear. METHODS:The roles of miR-23a, IKKα, and ST7L in EOC were determined by MTT, colony formation, wounding healing, transwell, flow cytometry, ...

journal_title：British journal of cancer

authors： Yang Z,Wang XL,Bai R,Liu WY,Li X,Liu M,Tang H

更新日期：2016-09-06 00:00:00

abstract：:Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...

journal_title：British journal of cancer

authors： Kabingu E,Vaughan L,Owczarczak B,Ramsey KD,Gollnick SO

更新日期：2007-06-18 00:00:00

abstract：BACKGROUND:To describe the prescription patterns of analgesics during the last 3 months of life in lung cancer and to determine the associated factors. METHODS:Data on lung cancer patients (N=10,202) who died during 2000-2008 were extracted from the General Practice Research Database (GPRD). This database records pres...

journal_title：British journal of cancer

authors： Gao W,Gulliford M,Higginson IJ

更新日期：2011-05-24 00:00:00

abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Weisberg E,Manley P,Mestan J,Cowan-Jacob S,Ray A,Griffin JD

更新日期：2019-07-01 00:00:00

abstract：:To assist in the description of the cellular heterogeneity present in normal and neoplastic urothelium, a panel of monoclonal antibodies (MoAbs) was raised against human transitional cell carcinoma (TCC) of the urinary bladder. All immunizations were carried out using whole cells and membrane preparations from well di...

journal_title：British journal of cancer

authors： Dotsikas G,Konowalchuk T,Major PP,Kovac PE,Ward GK,Stewart SS,Price GB,Elhilali MM,Mackillop WJ

更新日期：1987-10-01 00:00:00

abstract：:We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, partic...

journal_title：British journal of cancer

authors： Gunnell D,Oliver SE,Peters TJ,Donovan JL,Persad R,Maynard M,Gillatt D,Pearce A,Hamdy FC,Neal DE,Holly JM

更新日期：2003-06-02 00:00:00

abstract：BACKGROUND:Sequence variations in coding and non-coding regions of the genome can affect gene expression and signalling pathways, which in turn may influence disease outcome. METHODS:In this study, we integrated somatic mutations, gene expression and clinical data from 930 breast cancer patients included in the TCGA d...

journal_title：British journal of cancer

authors： Győrffy B,Pongor L,Bottai G,Li X,Budczies J,Szabó A,Hatzis C,Pusztai L,Santarpia L

更新日期：2018-04-01 00:00:00

abstract：:We evaluated the therapeutic usefulness of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). We also examined the relation between DNA ploidy pattern and the response to chemotherapy. A total of 267 patients with NSCLC (pathologically documented stage I, II, or IIIA) underw...

journal_title：British journal of cancer

authors： Nakagawa K,Tada H,Akashi A,Yasumitsu T,Iuchi K,Taki T,Kodama K,Osaka Lung Cancer Study Group, Japan.

更新日期：2006-10-09 00:00:00

abstract：BACKGROUND:Non-persistence and non-compliance are common in women prescribed hormonal therapy for breast cancer, but little is known about their influence on recurrence. METHODS:A nested case-control study of associations between hormonal therapy non-persistence and non-compliance and the risk of early recurrence in w...

journal_title：British journal of cancer

authors： Barron TI,Cahir C,Sharp L,Bennett K

更新日期：2013-09-17 00:00:00

abstract：:In addition to cobalt, metallic nickel, cadmium and other metals (e.g. zinc and copper) dissolve when incubated with horse serum at 37°. The dissolving property of copper in serum resembles that of cobalt, its solubility being increased greatly in the presence of oxygen, whereas the solubilities of cadmium, zinc and m...

journal_title：British journal of cancer

authors： Weinzierl SM,Webb M

更新日期：1972-08-01 00:00:00

abstract：:The pp125 focal adhesion kinase (FAK) is involved in integrin-mediated cell signalling and overexpressed in a variety of solid tumours. Focal adhesion kinase expression has been correlated to invasion and metastasis, but the data on breast cancer are inconclusive. We analysed FAK mRNA, protein levels and expression pa...

journal_title：British journal of cancer

authors： Watermann DO,Gabriel B,Jäger M,Orlowska-Volk M,Hasenburg A,zur Hausen A,Gitsch G,Stickeler E

更新日期：2005-09-19 00:00:00

abstract：:During the period from 1950 to 1952, three patients were studied by electrophoresis according to Tiselius on account of anticomplementary activity at WR; the presence of an M-component was demonstrated. On several later occasions it was observed that this component at first seemed to remain unchanged, later it was sli...

journal_title：British journal of cancer

authors： Norgaard O

更新日期：1971-09-01 00:00:00