In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product.

abstract：:Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs,...

journal_title：British journal of cancer

authors： Volm M,Koomägi R,Mattern J,Stammler G

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...

journal_title：British journal of cancer

authors： Sahebjam S,Aloyz R,Pilavdzic D,Brisson ML,Ferrario C,Bouganim N,Cohen V,Miller WH Jr,Panasci LC

更新日期：2011-10-25 00:00:00

abstract：:Both host carbogen (95% oxygen/5% carbon dioxide) breathing and nicotinamide administration enhance tumour radiotherapeutic response and are being re-evaluated in the clinic. Non-invasive magnetic resonance imaging (MRI) and 31P magnetic resonance spectroscopy (MRS) methods have been used to give information on the ef...

journal_title：British journal of cancer

authors： Robinson SP,Howe FA,Stubbs M,Griffiths JR

更新日期：2000-06-01 00:00:00

abstract：:The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) co...

journal_title：British journal of cancer

authors： Adams SM,Sharp MG,Walker RA,Brammar WJ,Varley JM

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The association between gall bladder removal (cholecystectomy) and hepatocellular carcinoma warrants investigation. An increased intrahepatic bile duct pressure following cholecystectomy might cause chronic inflammation in the surrounding liver tissue, which might induce cancer development. METHODS:A nation...

journal_title：British journal of cancer

authors： Lagergren J,Mattsson F,El-Serag H,Nordenstedt H

更新日期：2011-06-28 00:00:00

abstract：:The cisplatin analogue 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) (DAP) is a DNA-damaging agent that will be entering clinical trials for its potent cytotoxic effects against cisplatin-resistant tumour cells. This cytotoxicity may reside in its ability to selectively activate G1-phase checkpoint r...

journal_title：British journal of cancer

authors： He G,Kuang J,Huang Z,Koomen J,Kobayashi R,Khokhar AR,Siddik ZH

更新日期：2006-12-04 00:00:00

abstract：:The influence of cyclooxygenase-2 (COX-2) overexpression on the development of tumours has been well documented. The underlying mechanism however has still not been completely elucidated. An escape of proliferating cells from the regulatory influence of TGF-beta for example in the intestine has been discussed as well ...

journal_title：British journal of cancer

authors： Enders GA

更新日期：2007-11-19 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) regulate colon cancer growth and metastasis. Previous studies utilizing antibodies against the VEGF receptor (DC101) or EGF receptor (C225) have demonstrated independently that these agents can inhibit tumour growth and induce apoptosis in col...

journal_title：British journal of cancer

authors： Shaheen RM,Ahmad SA,Liu W,Reinmuth N,Jung YD,Tseng WW,Drazan KE,Bucana CD,Hicklin DJ,Ellis LM

更新日期：2001-08-17 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer. Approximately 70% of patients with newly diagnosed NPC present with locally advanced disease. Phase III clinical trials support the addition of chemotherapy to radiotherapy for the initial treatment of these patients. Once metastatic disease de...

journal_title：British journal of cancer

authors： Agulnik M,Siu LL

更新日期：2005-03-14 00:00:00

abstract：:We report here a case of a patient affected by endometrial cancer and treated primarily with leuprolide, the surgical approach being unfeasible due to her compromised conditions. The therapy was continued for more than 6 years, and no progression of the disease was observed. During this period, some histological and i...

journal_title：British journal of cancer

authors： Noci I,Borri P,Bonfirraro G,Chieffi O,Arcangeli A,Cherubini A,Dabizzi S,Buccoliero AM,Paglierani M,Taddei GL

更新日期：2001-08-03 00:00:00

abstract：:Functionally active telomerase is affected at various steps including transcriptional and post-transcriptional levels of major telomerase components (hTR and human telomerase reverse transcriptase (hTERT)). We therefore developed a rapid and sensitive method to quantify hTERT and its splicing variants as well as the h...

journal_title：British journal of cancer

authors： Ohyashiki JH,Hisatomi H,Nagao K,Honda S,Takaku T,Zhang Y,Sashida G,Ohyashiki K

更新日期：2005-05-23 00:00:00

abstract：BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...

journal_title：British journal of cancer

authors： Farace F,Massard C,Vimond N,Drusch F,Jacques N,Billiot F,Laplanche A,Chauchereau A,Lacroix L,Planchard D,Le Moulec S,André F,Fizazi K,Soria JC,Vielh P

更新日期：2011-09-06 00:00:00

abstract：BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...

journal_title：British journal of cancer

authors： van der Bij S,Schaake E,Koffijberg H,Burgers JA,de Mol BA,Moons KG

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:Late effects of cisplatin-based chemotherapy in testicular cancer survivors (TCS) include cardiovascular morbidity, but little data is available beyond 20 years. The objective was to assess vascular damage in very long-term TCS. METHODS:TCS (treated with chemotherapy or orchiectomy only) and age-matched hea...

journal_title：British journal of cancer

authors： Stelwagen J,Lubberts S,Steggink LC,Steursma G,Kruyt LM,Donkerbroek JW,van Roon AM,van Gessel AI,van de Zande SC,Meijer C,Gräfin Zu Eulenburg CH,Oosting SF,Nuver J,Walenkamp AME,Jan de Jong I,Lefrandt JD,Gietema JA

更新日期：2020-11-01 00:00:00

abstract：:Cultured H35 hepatoma cells release a cytotoxic factor in response to irradiation with X-rays. When the conditioned medium from irradiated cells is given to nonirradiated cells, growth is inhibited and followed by cell death, possibly apoptosis, Analysis of the conditioned medium reveals a dramatic change in the ornit...

journal_title：British journal of cancer

authors： van Rijn J,van den Berg J,Teerlink T,Kruyt FA,Schor DS,Renardel de Lavalette AC,van den Berg TK,Jakobs C,Slotman BJ

更新日期：2003-02-10 00:00:00

abstract：:Elderly patients are recommended to have a reduced starting dose (300 mg m(-2) once every 3 weeks) of irinotecan monotherapy. The aims of this analysis are to compare toxicity and survival according to age, performance status (PS), gender and prior radical pelvic radiotherapy (RT). The primary end points were overall ...

journal_title：British journal of cancer

authors： Chau I,Norman AR,Cunningham D,Waters JS,Topham C,Middleton G,Hill M,Ross PJ,Katopodis R,Stewart G,Oates JR

更新日期：2004-10-18 00:00:00

abstract：BACKGROUND:The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact. METHODS:Using immunohistochemistry, we examined tumour-infiltrat...

journal_title：British journal of cancer

authors： Ino Y,Yamazaki-Itoh R,Shimada K,Iwasaki M,Kosuge T,Kanai Y,Hiraoka N

更新日期：2013-03-05 00:00:00

abstract：:The goal of the study was to identify any normal genes that may become inactivated in malignant cells, with associated modifications or loss of gene products. Consequently, attempts were made to identify such products by generating monoclonal antibodies using an immune tolerisation-immunisation procedure. Using such a...

journal_title：British journal of cancer

authors： Imam SA,Stampfer MR,Yilmaz A,Taylor CR

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:To evaluate the anticancer activity of erlotinib in patients with previously treated, advanced non-small cell lung cancer (NSCLC) whose dose is increased to that associated with a maximal level of tolerable skin toxicity (i.e., target rash (TR)); to characterise the pharmacokinetics (PK) and pharmacodynamics...

journal_title：British journal of cancer

authors： Mita AC,Papadopoulos K,de Jonge MJ,Schwartz G,Verweij J,Mita MM,Ricart A,Chu QS,Tolcher AW,Wood L,McCarthy S,Hamilton M,Iwata K,Wacker B,Witt K,Rowinsky EK

更新日期：2011-09-27 00:00:00

abstract：:This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...

journal_title：British journal of cancer

authors： Couteau C,Chouaki N,Leyvraz S,Oulid-Aissa D,Lebecq A,Domenge C,Groult V,Bordessoule S,Janot F,De Forni M,Armand JP

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. ME...

journal_title：British journal of cancer

authors： Cortes J,Tamura K,DeAngelo DJ,de Bono J,Lorente D,Minden M,Uy GL,Kantarjian H,Chen LS,Gandhi V,Godin R,Keating K,McEachern K,Vishwanathan K,Pease JE,Dean E

更新日期：2018-05-01 00:00:00

abstract：:Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...

journal_title：British journal of cancer

authors： Hartley AL,Blair V,Harris M,Birch JM,Banerjee SS,Freemont AJ,McClure J,McWilliam LJ

更新日期：1993-12-01 00:00:00

abstract：:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...

journal_title：British journal of cancer

authors： Naito M,Komohara Y,Ishihara Y,Noguchi M,Yamashita Y,Shirakusa T,Yamada A,Itoh K,Harada M

更新日期：2007-12-17 00:00:00

abstract：BACKGROUND:We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obes...

journal_title：British journal of cancer

authors： Freisling H,Arnold M,Soerjomataram I,O'Doherty MG,Ordóñez-Mena JM,Bamia C,Kampman E,Leitzmann M,Romieu I,Kee F,Tsilidis K,Tjønneland A,Trichopoulou A,Boffetta P,Benetou V,Bueno-de-Mesquita HBA,Huerta JM,Brenner H,Wils

更新日期：2017-05-23 00:00:00

abstract：:The effects of X-radiation on the Nembutal-induced redistribution of the cardiac output in two types of transplanted mouse tumours and some normal mouse tissues have been investigated, using rubidium-86 and 125I-human serum albumin. Irradiation causes an increase in 86Rb uptake (relative blood perfusion) by the tumour...

journal_title：British journal of cancer

authors： Zanelli GD,Lucas PB

更新日期：1976-10-01 00:00:00

abstract：:To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...

journal_title：British journal of cancer

authors： Tsutsumi Y,Tsunoda S,Kamada H,Kihira T,Nakagawa S,Kaneda Y,Kanamori T,Mayumi T

更新日期：1996-10-01 00:00:00

abstract：:Eleven patients suffering from intra-abdominal malignancy were treated with various doses of intraperitoneal mitomycin C adsorbed onto activated carbon particles. Seven of the patients underwent resection of their primary gastric tumour and all developed potentially life-threatening severe complications that proved to...

journal_title：British journal of cancer

authors： Ubhi SS,McCulloch P,Veitch PS

更新日期：1997-01-01 00:00:00

abstract：:The effects of polymorphisms in genes coding for key folate metabolism enzymes such as thymidylate synthetase (TS) on colorectal neoplasia risk are likely to be influenced by gene-gene and gene-nutrient interactions. We investigated the combined effects of three polymorphisms in the TS gene region, TSER, TS 3R G>C, an...

journal_title：British journal of cancer

authors： Hubner RA,Liu JF,Sellick GS,Logan RF,Houlston RS,Muir KR

更新日期：2007-11-19 00:00:00

abstract：:We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA ...

journal_title：British journal of cancer

authors： Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJ

更新日期：2006-06-19 00:00:00

abstract：:To evaluate whether green tea consumption provides protection against stomach cancer death, relative risks were calculated using Cox proportional hazards regression analysis in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based...

journal_title：British journal of cancer

authors： Hoshiyama Y,Kawaguchi T,Miura Y,Mizoue T,Tokui N,Yatsuya H,Sakata K,Kondo T,Kikuchi S,Toyoshima H,Hayakawa N,Tamakoshi A,Ohno Y,Yoshimura T,Japan Collaborative Cohort Study Group.

更新日期：2002-07-29 00:00:00