Differential expression of translation-associated genes in benign and malignant human breast tumours.

abstract：:Selection of patients for randomised clinical trials may have a large impact on the applicability of the study results to the general population presenting the same disorder. However, clinical characteristics and outcome data on non-entered patients are usually not available. The effects of patient selection for the E...

journal_title：British journal of cancer

authors： Bijker N,Peterse JL,Fentiman IS,Julien JP,Hart AA,Avril A,Cataliotti L,Rutgers EJ

更新日期：2002-09-09 00:00:00

abstract：BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

journal_title：British journal of cancer

authors： Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

更新日期：2014-11-25 00:00:00

abstract：:Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and d...

journal_title：British journal of cancer

authors： Fukatsu T,Sobue M,Nagasaka T,Ohiwa N,Fukata S,Nakashima N,Takeuchi J

更新日期：1988-01-01 00:00:00

abstract：:Pamidronate belongs to the class of nitrogen-containing bisphosphonates that are potent inhibitors of bone resorption frequently used for the treatment of osteoporosis and cancer-induced osteolysis. The inhibition of osteoclasts' growth has been suggested as the main mechanism of the inhibitory effect of pamidronate o...

journal_title：British journal of cancer

authors： Riebeling C,Forsea AM,Raisova M,Orfanos CE,Geilen CC

更新日期：2002-07-29 00:00:00

abstract：BACKGROUND:Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. METHODS:We performed a nested cas...

journal_title：British journal of cancer

authors： Yang B,Hagberg KW,Chen J,Sahasrabuddhe VV,Graubard BI,Jick S,McGlynn KA

更新日期：2016-06-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant human tumours because of its high incidence of metastasis. The mechanisms underlying the metastasis of HCC, however, remain poorly understood. In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, sol...

journal_title：British journal of cancer

authors： Wang W,Yang LY,Huang GW,Lu WQ,Yang ZL,Yang JQ,Liu HL

更新日期：2004-06-14 00:00:00

abstract：:The influence of anthracyclines on membrane permeability functions has been investigated in HeLa cells by monitoring the efflux of fluorescein. Release of the fluorescent dye, dependent on the metabolic energy supply, occurs after the intracellular accumulation and enzymatic hydrolysis of the non-fluorescent substrate...

journal_title：British journal of cancer

authors： Croce AC,Prosperi E,Supino R,Bottiroli G

更新日期：1986-12-01 00:00:00

abstract：:Forty-two patients with clinical stage IIIA or IIIB breast cancer were treated with neoadjuvant chemotherapy followed by mastectomy and radiotherapy. The median follow-up was 32 months (range 10-72 months) and the median time to progression was 17 months (range 10-30 months). A multivariate analysis showed that a long...

journal_title：British journal of cancer

authors： Honkoop AH,van Diest PJ,de Jong JS,Linn SC,Giaccone G,Hoekman K,Wagstaff J,Pinedo HM

更新日期：1998-02-01 00:00:00

abstract：:Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. We report lymphocytic DPD data concerning a group of 53 patients (23 men, 30 women, mean age 58, range 36-73), treated by 5-FU-based chemotherapy in different French institutions and who developed unantic...

journal_title：British journal of cancer

authors： Milano G,Etienne MC,Pierrefite V,Barberi-Heyob M,Deporte-Fety R,Renée N

更新日期：1999-02-01 00:00:00

abstract：:The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...

journal_title：British journal of cancer

authors： García-Rocha M,García-Gravalos MD,Avila J

更新日期：1996-04-01 00:00:00

abstract：:The registered incidence rate of childhood central nervous system (CNS) tumours has increased in several countries. It is uncertain whether these increases are biologically real or owing to improved diagnostic methods. We explored the medical records of 626 CNS tumours diagnosed in Danish children between 1980 and 199...

journal_title：British journal of cancer

authors： Raaschou-Nielsen O,Sørensen M,Carstensen H,Jensen T,Bernhardtsen T,Gjerris F,Schmiegelow K

更新日期：2006-08-07 00:00:00

abstract：:An attempt has been made to develop tritiated derivatives of Synkavit (menadiol sodium diphosphate, MNDP) of high specific activity as a radioactive drug.This paper summarizes the preliminary biological and physical studies, with emphasis on approximate radiation dosimetry and the necessary preliminary testing, and th...

journal_title：British journal of cancer

authors： Mitchell JS

更新日期：1974-05-01 00:00:00

abstract：BACKGROUND:A decade ago it was reported that childhood cancer incidence was higher in boys than girls in many countries, particularly those with low gross domestic product (GDP) and high infant mortality rate. Research suggests that socio-economic and cultural factors are likely to be responsible. This study aimed to i...

journal_title：British journal of cancer

authors： Bhopal SS,Mann KD,Pearce MS

更新日期：2012-06-26 00:00:00

abstract：BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...

journal_title：British journal of cancer

authors： Liu WR,Tian MX,Tang Z,Fang Y,Zhou YF,Song SS,Jiang XF,Wang H,Tao CY,Zhou PY,Qu WF,Ding ZB,Peng YF,Zhou J,Fan J,Shi YH

更新日期：2020-07-01 00:00:00

abstract：:Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This st...

journal_title：British journal of cancer

authors： De Cicco C,Sideri M,Bartolomei M,Grana C,Cremonesi M,Fiorenza M,Maggioni A,Bocciolone L,Mangioni C,Colombo N,Paganelli G

更新日期：2000-01-01 00:00:00

abstract：:Thermosensitisation by step-down heating (SDH) has previously been demonstrated in experimental rodent tumours. The purpose of the study reported here was to investigate whether the SDH effect in tumours in part may be attributed to heat-induced alterations in the capillary network and/or the microenvironment. Two hum...

journal_title：British journal of cancer

authors： Rofstad EK

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. ME...

journal_title：British journal of cancer

authors： Sgaramella N,Coates PJ,Strindlund K,Loljung L,Colella G,Laurell G,Rossiello R,Muzio LL,Loizou C,Tartaro G,Olofsson K,Danielsson K,Fåhraeus R,Nylander K

更新日期：2015-07-14 00:00:00

abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...

journal_title：British journal of cancer

authors： Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le N

更新日期：2017-01-17 00:00:00

abstract：:Associations between work in the electrical and electronic industry and cancer incidence were assessed using data for 371 890 cancers registered in England between 1981 and 1987, of which 7981 were in electrical workers. Proportional registration ratios (PRRs) were calculated, both with and without the commonest cance...

journal_title：British journal of cancer

authors： Fear NT,Roman E,Carpenter LM,Newton R,Bull D

更新日期：1996-04-01 00:00:00

abstract：:Between 1971 and 1988, 20 patients with previously undiagnosed non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery. The first treatment after surgery was chemotherapy in nine and radiotherapy in 11 patients. At presentat...

journal_title：British journal of cancer

authors： Eeles RA,O'Brien P,Horwich A,Brada M

更新日期：1991-01-01 00:00:00

abstract：:We examined polymorphisms in exons 3 and 4 of microsomal epoxide hydrolase in 101 patients with colon cancer and compared the results with 203 control samples. The frequency of the exon 3 T to C mutation was higher in cancer patients than in controls (odds ratio 3.8; 95% confidence intervals 1.8-8.0). This sequence al...

journal_title：British journal of cancer

authors： Harrison DJ,Hubbard AL,MacMillan J,Wyllie AH,Smith CA

更新日期：1999-01-01 00:00:00

abstract：:Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...

journal_title：British journal of cancer

authors： Mertens F,Jonsson K,Willén H,Rydholm A,Kreicbergs A,Eriksson L,Olsson-Sandin G,Mitelman F,Mandahl N

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...

journal_title：British journal of cancer

authors： Cordani M,Butera G,Dando I,Torrens-Mas M,Butturini E,Pacchiana R,Oppici E,Cavallini C,Gasperini S,Tamassia N,Nadal-Serrano M,Coan M,Rossi D,Gaidano G,Caraglia M,Mariotto S,Spizzo R,Roca P,Oliver J,Scupoli MT,Donad

更新日期：2018-10-01 00:00:00

abstract：:Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven e...

journal_title：British journal of cancer

authors： Rand V,Prebble E,Ridley L,Howard M,Wei W,Brundler MA,Fee BE,Riggins GJ,Coyle B,Grundy RG,Children's Cancer and Leukaemia Group Biological Studies Committee.

更新日期：2008-10-07 00:00:00

abstract：:Methotrexate (MTX)-based chemotherapy extends survival in patients with primary brain lymphomas, but it is not clear whether multiagent chemotherapy is superior to MTX alone. Treatment options for patients with recurrent primary brain lymphoma are limited; there is no standard second-line chemotherapy. New chemotherap...

journal_title：British journal of cancer

authors： Reni M,Zaja F,Mason W,Perry J,Mazza E,Spina M,Bordonaro R,Ilariucci F,Faedi M,Corazzelli G,Manno P,Franceschi E,Pace A,Candela M,Abbadessa A,Stelitano C,Latte G,Ferreri AJ

更新日期：2007-03-26 00:00:00

abstract：:The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler wavef...

journal_title：British journal of cancer

authors： Long MG,Boultbee JE,Langley R,Newlands ES,Begent RH,Bagshawe KD

更新日期：1992-11-01 00:00:00

abstract：:We analysed the molecular genetic profiles of breast cancer samples before and after neoadjuvant chemotherapy with combination doxorubicin and cyclophosphamide (AC). DNA was obtained from microdissected frozen breast core biopsies from 44 patients before chemotherapy. Additional samples were obtained before the second...

journal_title：British journal of cancer

authors： Pierga JY,Reis-Filho JS,Cleator SJ,Dexter T,Mackay A,Simpson P,Fenwick K,Iravani M,Salter J,Hills M,Jones C,Ashworth A,Smith IE,Powles T,Dowsett M

更新日期：2007-01-29 00:00:00

abstract：:Mediastinal masses include a wide variety of tumours and remain an interesting diagnostic challenge for radiologist. We performed positron emission tomography (PET) studies of primary mediastinal tumours in order to predict the malignancy of these tumours preoperatively. Twenty-two patients with primary mediastinal tu...

journal_title：British journal of cancer

authors： Kubota K,Yamada S,Kondo T,Yamada K,Fukuda H,Fujiwara T,Ito M,Ido T

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

journal_title：British journal of cancer

authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

更新日期：2013-07-23 00:00:00

abstract：:Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...

journal_title：British journal of cancer

authors： Masson P,Pålsson B,Andrén-Sandberg A

更新日期：1990-07-01 00:00:00