Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.


:We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA stability in a cohort, which is not folate deficient. Preintervention, there was a significant inverse association between uracil misincorporation in lymphocyte DNA and red cell folate (P < 0.05). In contrast, there were no associations between folate status and DNA strand breakage, global DNA methylation or DNA base excision repair (measured as the capacity of the lymphocyte extract to repair 8-oxoGua ex vivo). Folate supplementation elicited a significant reduction in uracil misincorporation (P < 0.05), while DNA strand breakage and global DNA methylation remained unchanged. Increasing folate status significantly decreased the base excision repair capacity in those volunteers with the lowest preintervention folate status (P < 0.05). Uracil misincorporation was more sensitive to changes in folate status than other measures of DNA stability and therefore could be considered a specific and functional marker of folate status, which may also be relevant to cancer risk in healthy people.


Br J Cancer


Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJ




Has Abstract


2006-06-19 00:00:00














  • Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans in tumour tissues.

    abstract::Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and d...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Fukatsu T,Sobue M,Nagasaka T,Ohiwa N,Fukata S,Nakashima N,Takeuchi J

    更新日期:1988-01-01 00:00:00

  • A pilot study of mitomycin, cisplatin and continuous infusion 5-fluorouracil (MCF) in advanced non-small-cell lung cancer.

    abstract::A pilot study of continuous infusional 5-fluorouracil 200 mg m-2 per 24 h by ambulatory pump and Hickman line for the entire treatment cycle with mitomycin C 8 mg m-2 i.v. on day 1 and cisplatin 75 mg m-2 i.v. on day 1, both repeated every 28 days, was carried out in 31 previously untreated patients with advanced non-...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Ellis PA,Talbot DC,Nicolson MC,Priest K,Ashley S,Smith IE

    更新日期:1995-06-01 00:00:00

  • Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium.

    abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS:Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosi...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Dixon SC,Nagle CM,Wentzensen N,Trabert B,Beeghly-Fadiel A,Schildkraut JM,Moysich KB,deFazio A,Australian Ovarian Cancer Study Group.,Risch HA,Rossing MA,Doherty JA,Wicklund KG,Goodman MT,Modugno F,Ness RB,Edwards RP,Jen

    更新日期:2017-04-25 00:00:00

  • Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians.

    abstract:BACKGROUND:Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS:We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 200...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Nam GE,Cho KH,Han K,Kim CM,Han B,Cho SJ,Jung SJ,Kwon Y,Kim YH,Kim DH,Kim SM,Choi YS,Roh YK,Park YG

    更新日期:2019-07-01 00:00:00

  • Collaborative study of bronchial tumour-associated antigens.

    abstract::Eleven groups of workers submitted a total of 21 bronchial tumour-associated antigen preparations and 19 antisera for comparative studies. Many of the antisera proved to be polyspecific despite absorption procedures. Most of the antigen preparations contained some material reactive towards a reference antiserum to nor...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Gennings JN,Bagshawe KD,Axelsen NH,Sizaret P

    更新日期:1981-10-01 00:00:00

  • Patient-reporting improves estimates of postoperative complication rates: a prospective cohort study in gynaecological oncology.

    abstract:BACKGROUND:Most studies use hospital data to calculate postoperative complication rates (PCRs). We report on improving PCR estimates through use of patient-reporting. METHODS:A prospective cohort study of major surgery performed at 10 UK gynaecological cancer centres was undertaken. Hospitals entered the data contempo...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Iyer R,Gentry-Maharaj A,Nordin A,Liston R,Burnell M,Das N,Desai R,Gornall R,Beardmore-Gray A,Hillaby K,Leeson S,Linder A,Lopes A,Meechan D,Mould T,Nevin J,Olaitan A,Rufford B,Ryan A,Shanbhag S,Thackeray A,Wood N

    更新日期:2013-08-06 00:00:00

  • Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.

    abstract::We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Burt EC,McGown G,Thorncroft M,James LA,Birch JM,Varley JM

    更新日期:1999-04-01 00:00:00

  • Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force.

    abstract::Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究,实务指引


    authors: Beiske K,Burchill SA,Cheung IY,Hiyama E,Seeger RC,Cohn SL,Pearson AD,Matthay KK,International neuroblastoma Risk Group Task Force.

    更新日期:2009-05-19 00:00:00

  • Correction: AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL.

    abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:British journal of cancer

    pub_type: 已发布勘误


    authors: Weisberg E,Manley P,Mestan J,Cowan-Jacob S,Ray A,Griffin JD

    更新日期:2019-07-01 00:00:00

  • Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?

    abstract::To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expre...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Verburg FA,Lips CJ,Lentjes EG,de Klerk JM

    更新日期:2004-07-19 00:00:00

  • Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer.

    abstract:BACKGROUND:The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer. METHODS:A tissue microarray of 1420 primary colorectal cancers and 57 normal mucosa samples was immunostained for CD133, CD...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Lugli A,Iezzi G,Hostettler I,Muraro MG,Mele V,Tornillo L,Carafa V,Spagnoli G,Terracciano L,Zlobec I

    更新日期:2010-07-27 00:00:00

  • Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells.

    abstract::The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sharrard RM,Maitland NJ

    更新日期:2000-10-01 00:00:00

  • Microsatellite instability in squamous cell carcinomas of the head and neck related to field cancerization phenomena.

    abstract::Patients affected by squamous cell carcinoma of the head and neck (HNSCC) show frequent occurrence of multiple cancers and widespread precancerous lesions in the mucosa of the upper respiratory tract, a phenomenon known as field cancerization. In this study, we investigated the role of genetic instability in the devel...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Piccinin S,Gasparotto D,Vukosavljevic T,Barzan L,Sulfaro S,Maestro R,Boiocchi M

    更新日期:1998-11-01 00:00:00

  • Autoradiographic analysis of the cell cycle of five solid human tumours in vitro.

    abstract::Reports are available on the studies of the cell cycle of several normal cell populations and of neoplastic effusions in man and experimental animals in vitro and in vivo at various stages of the growth. In the present work the cell cycle of 5 solid human tumours in vitro and the duration of their various intermitotic...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kucheria K

    更新日期:1970-06-01 00:00:00

  • Elevated levels of prolactin in nulliparous women.

    abstract::Follicular-phase (Day 11) plasma prolactin, and plasma and urinary oestrogen levels of 70 nulliparous nuns were compared with those of 80 of their sisters, of whom 62 were parous. The nuns and their nulliparous sisters did not differ significantly in their prolactin and oestrogen levels. No differences in plasma oestr...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Yu MC,Gerkins VR,Henderson BE,Brown JB,Pike MC

    更新日期:1981-06-01 00:00:00

  • External multicentre validation of a nomogram predicting the risk of relapse in patients with borderline ovarian tumours.

    abstract:BACKGROUND:The Obermair nomogram was recently developed to predict the risk of relapse in patients with borderline ovarian tumours (BOTs) based on five readily available clinical, biological, and pathological characteristics. We set out to externally validate and assess its robustness using a multi-institutional BOT da...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Bendifallah S,Uzan C,Fauvet R,Morice P,Darai E

    更新日期:2013-11-26 00:00:00

  • Modulation of cisplatin cytotoxicity by sulphasalazine.

    abstract::The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Awasthi S,Sharma R,Singhal SS,Herzog NK,Chaubey M,Awasthi YC

    更新日期:1994-08-01 00:00:00

  • Risk factors for oral and pharyngeal cancer in women: a study from Italy and Switzerland.

    abstract::We analysed two case-control studies of women from Italy and Switzerland, including 195 cases of oral and pharyngeal cancers and 1113 controls. The multivariate odds ratio was 4.6 for heavy smokers and 2.7 for high alcohol intake. Vegetables, fruit, beta-carotene and wholegrain foods were inversely, butter and retinol...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bosetti C,Negri E,Franceschi S,Conti E,Levi F,Tomei F,La Vecchia C

    更新日期:2000-01-01 00:00:00

  • Generation of metastatic variants by transfection of a rat non-metastatic epithelial cell line with genomic DNA from rat prostatic carcinoma cells.

    abstract::Prostate cancer is the second leading cause of male death from malignant disease in Europe and in the USA. Failure to prevent or eliminate metastatic dissemination is a fundamental problem underlying the current inadequate treatment of prostate cancer, and novel therapeutic strategies are required if this disease is t...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ke Y,Beesley C,Smith P,Barraclough R,Rudland P,Foster CS

    更新日期:1998-01-01 00:00:00

  • Evaluation of Angiopoietin-2 as a biomarker in gastric cancer: results from the randomised phase III AVAGAST trial.

    abstract:BACKGROUND:In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and resistance to antiang...

    journal_title:British journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Hacker UT,Escalona-Espinosa L,Consalvo N,Goede V,Schiffmann L,Scherer SJ,Hedge P,Van Cutsem E,Coutelle O,Büning H

    更新日期:2016-04-12 00:00:00

  • Pre- and post-operative anti-PD-L1 plus anti-angiogenic therapies in mouse breast or renal cancer models of micro- or macro-metastatic disease.

    abstract:BACKGROUND:There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wu FTH,Xu P,Chow A,Man S,Krüger J,Khan KA,Paez-Ribes M,Pham E,Kerbel RS

    更新日期:2019-01-01 00:00:00

  • A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence.

    abstract:BACKGROUND:Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Surakhy M,Wallace M,Bond E,Grochola LF,Perez H,Di Giovannantonio M,Zhang P,Malkin D,Carter H,Parise IZS,Zambetti G,Komechen H,Paraizo MM,Pagadala MS,Pinto EM,Lalli E,Figueiredo BC,Bond GL

    更新日期:2020-04-01 00:00:00

  • Number of apoptotic cells as a prognostic marker in invasive breast cancer.

    abstract::Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: de Jong JS,van Diest PJ,Baak JP

    更新日期:2000-01-01 00:00:00

  • Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines.

    abstract::Manganese superoxide dismutase (SOD2) is an enzyme that catalyses the dismutation of superoxide in the mitochondria, leading to reduced levels of reactive oxygen species. Reduced expression levels of SOD2 have been shown to result in increased DNA damage and sod2 heterozygous mice have increased incidences of cancer. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hurt EM,Thomas SB,Peng B,Farrar WL

    更新日期:2007-10-22 00:00:00

  • Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers.

    abstract::We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Clarke CL,Sandle J,Jones AA,Sofronis A,Patani NR,Lakhani SR

    更新日期:2006-08-21 00:00:00

  • Screening and the costs of treating colorectal cancer.

    abstract::The objective of this paper is to compare the hospital costs of treating patients with colorectal cancers detected as a result of a faecal occult blood screening programme with those of patients whose cancers present symptomatically (control group). Patient-specific cost estimates are made, using case records and hosp...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Whynes DK,Walker AR,Chamberlain JO,Hardcastle JD

    更新日期:1993-11-01 00:00:00

  • Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.

    abstract::Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressi...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Brodowicz T,Kandioler D,Tomek S,Ludwig C,Rudas M,Kunstfeld R,Koestler W,Hejna M,Budinsky A,Wiltschke C,Zielinski CC

    更新日期:2001-11-30 00:00:00

  • Bosutinib plus capecitabine for selected advanced solid tumours: results of a phase 1 dose-escalation study.

    abstract:BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

    更新日期:2014-11-25 00:00:00

  • Mammographic density and its interaction with other breast cancer risk factors in an Asian population.

    abstract:BACKGROUND:Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. METHODS:From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression. RESULTS:Den...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wong CS,Lim GH,Gao F,Jakes RW,Offman J,Chia KS,Duffy SW

    更新日期:2011-03-01 00:00:00

  • ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer.

    abstract:BACKGROUND:In colorectal cancer (CRC), BRAF mutations influence tumour progression. In mismatch repair-deficient (dMMR) tumours, BRAF mutations are associated with a good prognosis, whereas in MMR-competent tumours, they are detrimental. The differential expression of the downstream MAPK pathway members, which are cons...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Roseweir AK,Halcrow ES,Chichilo S,Powell AG,McMillan DC,Horgan PG,Edwards J

    更新日期:2018-08-01 00:00:00