Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.

Abstract:

:We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA stability in a cohort, which is not folate deficient. Preintervention, there was a significant inverse association between uracil misincorporation in lymphocyte DNA and red cell folate (P < 0.05). In contrast, there were no associations between folate status and DNA strand breakage, global DNA methylation or DNA base excision repair (measured as the capacity of the lymphocyte extract to repair 8-oxoGua ex vivo). Folate supplementation elicited a significant reduction in uracil misincorporation (P < 0.05), while DNA strand breakage and global DNA methylation remained unchanged. Increasing folate status significantly decreased the base excision repair capacity in those volunteers with the lowest preintervention folate status (P < 0.05). Uracil misincorporation was more sensitive to changes in folate status than other measures of DNA stability and therefore could be considered a specific and functional marker of folate status, which may also be relevant to cancer risk in healthy people.

journal_name

Br J Cancer

authors

Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJ

doi

10.1038/sj.bjc.6603197

subject

Has Abstract

pub_date

2006-06-19 00:00:00

pages

1942-7

issue

12

eissn

0007-0920

issn

1532-1827

pii

6603197

journal_volume

94

pub_type

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