Abstract:
:We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA stability in a cohort, which is not folate deficient. Preintervention, there was a significant inverse association between uracil misincorporation in lymphocyte DNA and red cell folate (P < 0.05). In contrast, there were no associations between folate status and DNA strand breakage, global DNA methylation or DNA base excision repair (measured as the capacity of the lymphocyte extract to repair 8-oxoGua ex vivo). Folate supplementation elicited a significant reduction in uracil misincorporation (P < 0.05), while DNA strand breakage and global DNA methylation remained unchanged. Increasing folate status significantly decreased the base excision repair capacity in those volunteers with the lowest preintervention folate status (P < 0.05). Uracil misincorporation was more sensitive to changes in folate status than other measures of DNA stability and therefore could be considered a specific and functional marker of folate status, which may also be relevant to cancer risk in healthy people.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJdoi
10.1038/sj.bjc.6603197subject
Has Abstractpub_date
2006-06-19 00:00:00pages
1942-7issue
12eissn
0007-0920issn
1532-1827pii
6603197journal_volume
94pub_type
杂志文章,随机对照试验abstract::The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1899
更新日期:2001-09-01 00:00:00
abstract::In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cance...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603214
更新日期:2006-07-03 00:00:00
abstract::Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication an...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6605126
更新日期:2009-07-07 00:00:00
abstract:BACKGROUND:There have been controversies in prognostic impact of mucinous histology on colorectal cancer, and its implication in patients treated with adjuvant 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is unclear. METHODS:Stage II and III colorectal cancer patients who underwent curative resection followed ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.232
更新日期:2013-05-28 00:00:00
abstract::This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,评审
doi:10.1038/sj.bjc.6690715
更新日期:1999-10-01 00:00:00
abstract::Magnetic resonance spectroscopy was used to study intracellular pH and compounds which contain phosphorus in normal human brain and primary brain tumours non-invasively. In normal subjects (n = 7) intracellular pH (pHi) of the brain was 7.03 +/- 0.02 (mean +/- s.e.m.). The pHi did not vary between superficial (2 cm, m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.300
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:The percentage of tumour stroma (TSP) has recently been reported to be a novel independent predictor of outcome in patients with a variety of common solid organ tumours. The aim of this study was to examine the relationship between TSP, clinicopathological characteristics and outcome in patients with invasiv...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.279
更新日期:2014-07-08 00:00:00
abstract::Doxorubicin- and paclitaxel-selected variants of an in vitro invasive clonal population of the human breast cancer cell line, MDA-MB-435S, were established by pulse selection, and exhibited a novel 'superinvasive' phenotype. This phenotype is characterised by an ability to relocate to another surface following invasio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602221
更新日期:2004-11-15 00:00:00
abstract::DNA flow cytometry was performed on formalin fixed, paraffin embedded melanocytic naevi. DNA aneuploidy was detected in all three types of naevus but was significantly more frequent in those naevi accepted as precursors of malignancy: that is, dysplastic and congenital pigmented hairy naevi. It may be that the presenc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.268
更新日期:1988-11-01 00:00:00
abstract::The radiosensitizing activity of S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, was assessed in a model of non-metabolic hypoxia achieved in an atmosphere of 95% nitrogen-5% carbon dioxide. A 10 min preincubation of hypoxic EMT-6 cells (10 x 10(6) ml(-1)) with 0.1 and 1 mM SNAP before radiation res...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690173
更新日期:1999-03-01 00:00:00
abstract::Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1972.19
更新日期:1972-04-01 00:00:00
abstract::PEP005 is a novel ingenol angelate that modulates protein kinases C (PKC) functions by activating PKC delta and inhibiting PKC alpha. This study assessed the antiproliferative effects of PEP005 alone and in combination with several other anticancer agents in a panel of 10 human cancer cell lines characterised for expr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604642
更新日期:2008-12-02 00:00:00
abstract:BACKGROUND:Random error in the numbers of avoidable deaths among cancer patients has not been considered in earlier studies. METHODS:Methods to obtain valid confidence intervals (CIs) for numbers of avoidable deaths were developed. The excess mortality rates were estimated for patients diagnosed with colon cancer in f...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.169
更新日期:2012-05-22 00:00:00
abstract:BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2014.384
更新日期:2014-08-26 00:00:00
abstract:BACKGROUND:Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the 'Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it can be potentially targete...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.120
更新日期:2013-04-30 00:00:00
abstract:BACKGROUND:Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS:Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comp...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.392
更新日期:2017-01-03 00:00:00
abstract::Tumour markers are important in the diagnosis and monitoring of many tumours. This study tested the hypothesis that an oncofoetal protein, foetal haemoglobin (HbF) is a potential tumour marker in embryonic tumours, useful for management. An immunohistochemical investigation of HbF blood cell (Fc) distribution was carr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603867
更新日期:2007-08-06 00:00:00
abstract:BACKGROUND:Gemcitabine-based chemotherapy is the standard treatment for pancreatic cancer. However, the issue of resistance remains unresolved. The aim of this study was to identify microRNAs (miRNAs) that govern the resistance to gemcitabine in pancreatic cancer. METHODS:miRNA microarray analysis using gemcitabine-re...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.320
更新日期:2013-07-23 00:00:00
abstract::P-glycoprotein (P-gp) pumps multiple types of drugs out of the cell, using energy generated from ATP, and confers multidrug resistance (MDR) on cancer cells. ZD6474 is an orally active, selective inhibitor of the vascular endothelial growth factor receptor, epidermal growth factor receptor, and rearranged during trans...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603985
更新日期:2007-10-08 00:00:00
abstract::5'-nucleotidase activity, arachidonate metabolism and adenosine uptake were measured in P388 murine leukaemia cells and in a subline resistant to doxorubicin. These membranes related activities were found to be increased in the doxorubicin resistant cell line, compared to the drug sensitive cells. It is suggested that...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1984.71
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:This Phase Ib dose-escalating study investigated safety, maximum tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics (PK) and clinical antitumour activity of tosedostat (CHR-2797), an orally bioavailable aminopeptidase inhibitor, in combination with paclitaxel. METHODS:A total of 22 patient...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605917
更新日期:2010-10-26 00:00:00
abstract::The incidence of oncofoetal antigens has been reported to be increased in patients with gynaecological cancers. In this study the incidence of CEA, AFP, and hCG (beta subunit) were studied in patients with adenocarcinoma of the ovary, adenocarcinoma of the cervix, and squamous-cell carcinoma of the cervix. Using a low...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.198
更新日期:1981-09-01 00:00:00
abstract::In adults, the haemolytic-uraemic syndrome (HUS) is associated with probable causative factors in the minority of all cases. Cytotoxic drugs are one of these potential causative agents. Although metastatic cancer by itself is a recognized risk-factor for the development of HUS, therapy with mitomycin-C, with cis-plati...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690242
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.192
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS:We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Appl...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.438
更新日期:2017-01-01 00:00:00
abstract::This study aimed to evaluate the clinical and economic implications of integrating human papilloma virus (HPV) load testing into the follow-up and management protocol of women postconisation for high-grade cervical intraepithelial neoplasia (CIN2-3). We evaluated 130 suitable women: 63 were screened biannually by Pap ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601032
更新日期:2003-07-07 00:00:00
abstract::Although osteosclerotic bone metastases are characteristic of prostate cancer, mixed metastases with a lytic component are not uncommon. Type I collagen is synthesised by osteoblasts and accounts for about 90% of the organic matrix of bone. We have used new specific immunoassays for PICP (carboxy-terminal propeptide o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.204
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Dysplasia is a marker of cancer risk in Barrett's oesophagus (BO), but this risk is variable and diagnosis is subject to inter-observer variability. Cancer risk in BO is increased when chromosomal instability is present. Nucleotyping (NT) is a new method that uses high-resolution digital images of nuclei to ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.353
更新日期:2011-10-11 00:00:00
abstract::It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.23
更新日期:1998-01-01 00:00:00
abstract::The tolerability, anti-tumour activity and pharmacokinetic interaction of high-dose intravenous cyclosporin combined with intravenous etoposide was evaluated in children. Eighteen patients with recurrent or refractory tumours, all of whom had previously received etoposide, were treated with a combination of high-dose ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1998.383
更新日期:1998-06-01 00:00:00