Abstract：
BACKGROUND:To evaluate the anticancer activity of erlotinib in patients with previously treated, advanced non-small cell lung cancer (NSCLC) whose dose is increased to that associated with a maximal level of tolerable skin toxicity (i.e., target rash (TR)); to characterise the pharmacokinetics (PK) and pharmacodynamics (PD) of higher doses of erlotinib. METHODS:Patients initially received erlotinib 150 mg per day. The dose was successively increased in each patient to that associated with a TR. Anticancer activity was evaluated. Plasma, skin, and hair were sampled for PK and PD studies. RESULTS:Erlotinib dose escalation to 200-475 mg per day was feasible in 38 (90%) of 42 patients. Twenty-four (57%) patients developed a TR, but 19 (79%) did so at 150 mg per day. Five (12%) patients, all of whom developed a TR, had a partial response. Median progression-free survival (PFS) was 2.3 months (95% CI: 1.61, 4.14); median PFS was 3.5 months and 1.9 months, respectively, for patients who did and did not experience a TR (hazard ratio, 0.51; P=0.051). Neither rash severity nor response correlated with erlotinib exposure. CONCLUSION:Intrapatient dose escalation of erlotinib does not appreciably increase the propensity to experience a maximal level of tolerable skin toxicity, or appear to increase the anticancer activity of erlotinib in NSCLC.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Mita AC,Papadopoulos K,de Jonge MJ,Schwartz G,Verweij J,Mita MM,Ricart A,Chu QS,Tolcher AW,Wood L,McCarthy S,Hamilton M,Iwata K,Wacker B,Witt K,Rowinsky EKdoi
10.1038/bjc.2011.332subject
Has Abstractpub_date
2011-09-27 00:00:00pages
938-44issue
7eissn
0007-0920issn
1532-1827pii
bjc2011332journal_volume
105pub_type
杂志文章abstract：:We evaluated animal food intake and cooking methods in relation to endometrial cancer risk in a population-based case-control study in Shanghai, China. A validated food frequency questionnaire was used to collect the usual dietary habits of 1204 cases and 1212 controls aged 30-69 years between 1997 and 2003. Statistic...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603458
更新日期：2006-12-04 00:00:00
abstract：:There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690611
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:Activins and inhibins belong to the TGFβ-superfamily, which controls cell proliferation and differentiation in many organs. Activin A, the dimer of inhibin βA subunit, acts strongly anti-proliferative in hepatocytes. Little is known on the other activin/inhibin subunits in human liver and hepatocellular carc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.53
更新日期：2011-04-12 00:00:00
abstract：:People affected by cancer want information about their prognosis but clinicians have trouble estimating and talking about it. We sought to determine the nature and accuracy of medical oncologists' estimates of life expectancy in newly referred patients with incurable cancer. With reference to each patient, medical onc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602908
更新日期：2006-01-30 00:00:00
abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...
journal_title：British journal of cancer
pub_type： 共识发展会议,杂志文章,评审
doi：10.1038/s41416-019-0653-9
更新日期：2020-02-01 00:00:00
abstract：:We have purified epithelial cells from human colonic tumours by velocity sedimentation in an isokinetic density gradient of Ficoll in tissue culture medium. In frozen sections of colonic carcinoma, histochemically demonstrable N-acetyl-beta-D-glucosaminidase (HDAG) was observed primarily in epithelial cells. We used t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.128
更新日期：1977-06-01 00:00:00
abstract：BACKGROUND:Neuroblastoma is the most common malignancy of infancy but little is known about the aetiological factors associated with the development of this tumour. A number of epidemiological studies have previously examined the risk associated with paternal occupational exposures but most have involved small numbers ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605504
更新日期：2010-02-02 00:00:00
abstract：:Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.434
更新日期：1997-01-01 00:00:00
abstract：:To investigate the efficacy and safety of combining weekly oxaliplatin with weekly 24-h infusion of high-dose 5-fluorouracil (5-FU) and folinic acid (FA) in treatment of patients with advanced gastric cancer. Patients with histologically confirmed, locally advanced or recurrent/metastatic gastric cancer were studied. ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6601985
更新日期：2004-08-02 00:00:00
abstract：:A partially purified fraction of the water soluble photosensitive dye sulphonated aluminium phthalocyanine (AlSPc) was encapsulated in liposomes which were then linked to a targeting monoclonal antibody 791T/36 using a heterobifunctional linking agent. The photocytotoxic effects of the liposomes were determined on two...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.73
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605731
更新日期：2010-06-29 00:00:00
abstract：:Bilateral kidney ligation of mice immediately before injection of misonidazole (MIS) prolongs the plasma half-life of this radiosensitizer from about 2 h (in normal mice) to 10-11 h, similar to that in man. Kidney ligation does not, however, change the relative proportions of MIS and its O-demethylated metabolite, Ro-...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.55
更新日期：1979-03-01 00:00:00
abstract：:We analysed antibodies specific for human p53 in sera from primary breast cancer patients using three different immunoassays and we related these results to the p53 level in tumour tissue detected by immunohistochemistry. Only 44% (11/25) of apparently enzyme-linked immunosorbent assay (ELISA)-positive sera were from ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.242
更新日期：1995-06-01 00:00:00
abstract：:In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690136
更新日期：1999-02-01 00:00:00
abstract：:HER-2/neu is a tumour antigen that is overexpressed in human breast tumours. Among the vaccine strategies developed to overcome immune tolerance to self-proteins, vaccination with anti-idiotypic (anti-Id) antibodies has been described as a promising approach for treatment of several malignant diseases. To develop an a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601825
更新日期：2004-05-17 00:00:00
abstract：:Protein kinase C (PKC) has a critical role in several signal transduction pathways, and is involved in renal cancer pathogenesis. Bryostatin-1 modulates PKC activity and has antitumour effects in preclinical studies. We conducted a multicentre phase II clinical trial in patients with advanced renal cancer to determine...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6601321
更新日期：2003-10-20 00:00:00
abstract：:An economic sub-study was run alongside a large multi-centre randomised trial (MRC-CR06) comparing three chemotherapy regimens; de Gramont, Lokich and raltitrexed in patients with metastatic colorectal cancer. Patients in six of 45 centres in the main trial were approached to take part in the sub-study. Chemotherapy d...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6600273
更新日期：2002-06-05 00:00:00
abstract：:Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N=182), gastric cardia (N=178), and oesophageal a...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/sj.bjc.6604880
更新日期：2009-02-10 00:00:00
abstract：:Magnetic resonance spectroscopy is increasingly used as a non-invasive method to investigate apoptosis. Apoptosis was induced in Jurkat T-cells by Fas mAb. (1)H magnetic resonance spectra of live cells showed an increase in methylene signal as well as methylene/methyl ratio of fatty acid side chains at 5 and 24 h foll...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600188
更新日期：2002-03-18 00:00:00
abstract：BACKGROUND:Cutaneous melanoma is the most serious skin malignancy and new therapeutic strategies are needed for advanced melanoma. TP53 mutations are rare in cutaneous melanoma and hence activation of wild-type p53 is a potential therapeutic strategy in cutaneous melanoma. Here, we investigated the WIP1 inhibitor, GSK2...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.433
更新日期：2018-02-20 00:00:00
abstract：:Fine needle aspiration (FNA) biopsy is the least invasive method of sampling breast cancer in vivo and provides material for breast cancer diagnosis. FNA has also been used to examine cellular markers to predict and monitor the effects of therapy. The aim of this study was to assess the accuracy of using FNA material ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2064
更新日期：2001-10-19 00:00:00
abstract：:Somatostatin analogues may be useful novel agents in the systemic treatment of advanced colorectal cancer, as somatostatin inhibits proliferation in a wide variety of cell types. Here, we report the expression profiles of somatostatin receptor mRNAs in 32 pairs of malignant and normal colonic epithelia. Receptor subty...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.59
更新日期：1997-01-01 00:00:00
abstract：:Cardiotoxicity is the main dose-limiting side effect of doxorubicin in the clinic. Being a free radical producer, doxorubicin affects the heart specifically because of its low antioxidant capacity. Among those antioxidants, catalase is present in very low levels in the heart compared to other organs. Since catalase is...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601430
更新日期：2003-12-01 00:00:00
abstract：:Thirty-eight patients with previously treated Hodgkin's disease were given high dose combination chemotherapy using melphalan and BCNU and autologous bone marrow transplantation. In 25 patients etoposide was added in conventional dosage. During the course of the study the dose of melphalan was increased from 80 to 140...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.128
更新日期：1989-04-01 00:00:00
abstract：:To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2037
更新日期：2001-09-28 00:00:00
abstract：:Wistar rats were sensitized to rat embryonic tissue by immunization with irradiated (5000 rad) rat embryo cells (2 X 10(6) s.c. + 1 X 10(6) i.p.) derived from embryos aged 14-15 days, or by implantation of irradiated (5000 rad) tissue grafts from these embryos. Three to five immunizations were given at weekly interval...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.94
更新日期：1976-06-01 00:00:00
abstract：:Recent studies involving animal models of cancer and clinicopathological analyses of human tumours suggest that the growth of lymphatic vessels (lymphangiogenesis) in or nearby tumours is associated with the metastatic spread of cancer. The best validated molecular signalling system for tumour lymphangiogenesis involv...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6603120
更新日期：2006-05-22 00:00:00
abstract：BACKGROUND:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. METHODS:We report the screening of an in-house drug library to id...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.83
更新日期：2014-03-18 00:00:00
abstract：BACKGROUND:Low cancer awareness contributes to delay in presentation for cancer symptoms and may lead to delay in cancer diagnosis. The aim of this study was to review the evidence for the effectiveness of interventions to raise cancer awareness and promote early presentation in cancer to inform policy and future resea...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605388
更新日期：2009-12-03 00:00:00
abstract：:The brain-specific angiogenesis inhibitor 1 gene has been isolated in an attempt to find fragments with p53 "functional" binding sites. As reported herein and by others, brain-specific angiogenesis inhibitor 1 expression is present in some normal tissues, but is reduced or lost in tumour tissues. Such data and its par...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600067
更新日期：2002-02-01 00:00:00
