Targeting lymphangiogenesis to prevent tumour metastasis.

abstract：:Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks...

journal_title：British journal of cancer

authors： Safi N,Anazodo A,Dickinson JE,Lui K,Wang AY,Li Z,Sullivan EA

更新日期：2019-10-01 00:00:00

abstract：:The death certificate only (DCO) index, which quantifies the proportion of patients for whom the death certificate provides the only notification to the registry, is a widely used measure of incompleteness of population-based cancer registration. This paper provides an algebraic assessment and a quantitative illustrat...

journal_title：British journal of cancer

authors： Brenner H

更新日期：1995-08-01 00:00:00

abstract：:Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but...

journal_title：British journal of cancer

authors： Rubens RD,Knight RK,Hayward JL

更新日期：1975-12-01 00:00:00

abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...

journal_title：British journal of cancer

authors： Bauernhofer T,Kuss I,Friebe-Hoffmann U,Baum AS,Dworacki G,Vonderhaar BK,Whiteside TL

更新日期：2003-04-22 00:00:00

abstract：:We retrospectively analysed neuromuscular toxicity associated with paclitaxel 210 mg m(-2) given by 3-h infusion in 247 patients. The severity correlated significantly with total cumulative dose, but could not be predicted by the pretreatment clinical variables or by pharmacokinetic parameters. The toxicity tended to ...

journal_title：British journal of cancer

authors： Kunitoh H,Saijo N,Furuse K,Noda K,Ogawa M

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...

journal_title：British journal of cancer

authors： De Silva N,Schulz L,Paterson A,Qain W,Secrier M,Godfrey E,Cheow H,O'Donovan M,Lao-Sirieix P,Jobanputra M,Hochhauser D,Fitzgerald R,Ford H

更新日期：2015-11-03 00:00:00

abstract：:Erbicin is a human anti-ErbB2 single-chain antibody fragment with high affinity and selectivity for ErbB2-positive cancer cells. Two anti-ErbB2 immunoconjugates, called Erb-hRNase and Erb-hcAb, have been prepared and found to be selectively cytotoxic on ErbB2-positive cancer cells in vitro and vivo. In Erb-hRNase, Erb...

journal_title：British journal of cancer

authors： De Lorenzo C,Troise F,Cafaro V,D'Alessio G

更新日期：2007-11-19 00:00:00

abstract：BACKGROUND:Tumoural interstitial hypertension, possibly modulated by platelet-derived and vascular endothelial growth factor receptors (PDGFR and VEGFR), may mediate resistance to chemotherapy. METHODS:Forty-eight patients with advanced solid tumours received oral PDGFR inhibitor CP-868,596 (60-100 mg twice daily (BID...

journal_title：British journal of cancer

authors： Michael M,Vlahovic G,Khamly K,Pierce KJ,Guo F,Olszanski AJ

更新日期：2010-11-09 00:00:00

abstract：:Caffeine has for many years been known to be involved in the sensitization of DNA to damage. One potential mechanism recently put forward is an override of the G2/M block induced by irradiation, which would leave the cells less time for DNA repair prior to mitosis. However, different cell types display a variety of re...

journal_title：British journal of cancer

authors： Deplanque G,Vincent F,Mah-Becherel MC,Cazenave JP,Bergerat JP,Klein-Soyer C

更新日期：2000-08-01 00:00:00

abstract：:We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse transcription-polymerase chain reaction (RT-PCR) in 104 non-small-cell lung cancer (NSCLC) specimens [59 adenocarcinoma (Ad...

journal_title：British journal of cancer

authors： Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

更新日期：1995-09-01 00:00:00

abstract：:An increase in the number of identified therapeutic cancer targets achieved through recent biomedical research has resulted in the generation of a large number of molecules that need to be tested further. Current development of (anticancer) drugs is a rather inefficient process that for an average new molecule takes a...

journal_title：British journal of cancer

authors： Marchetti S,Schellens JH

更新日期：2007-09-03 00:00:00

abstract：:The nature of the invasive growth pattern and microvessel density (MVD) have been suggested to be predictors of prognosis in primary colorectal cancer (CRC) and colorectal liver metastases. The purpose of the present study was to determine whether these two histological features were interrelated and to assess their r...

journal_title：British journal of cancer

authors： Rajaganeshan R,Prasad R,Guillou PJ,Chalmers CR,Scott N,Sarkar R,Poston G,Jayne DG

更新日期：2007-04-10 00:00:00

abstract：:Fine needle aspiration (FNA) biopsy is the least invasive method of sampling breast cancer in vivo and provides material for breast cancer diagnosis. FNA has also been used to examine cellular markers to predict and monitor the effects of therapy. The aim of this study was to assess the accuracy of using FNA material ...

journal_title：British journal of cancer

authors： Ball HM,Hupp TR,Ziyaie D,Purdie CA,Kernohan NM,Thompson AM

更新日期：2001-10-19 00:00:00

abstract：:In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into func...

journal_title：British journal of cancer

authors： Coukos G,Benencia F,Buckanovich RJ,Conejo-Garcia JR

更新日期：2005-04-11 00:00:00

abstract：:The fluorometric microculture cytotoxicity assay (FMCA) was employed for analysing the effect of different chemotherapeutic drug combinations and their single constituents in 44 cases of acute myelocytic leukaemia (AML). A large heterogeneity with respect to cell kill was observed for all combinations tested, the inte...

journal_title：British journal of cancer

authors： Larsson R,Fridborg H,Kristensen J,Sundström C,Nygren P

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:We studied the biological significance of genes involved in a novel t(8;12)(p21.3;p13.31) reciprocal translocation identified in cervical squamous cell carcinoma (SCC) cells. METHODS:The rearranged genes were identified by breakpoint mapping, long-range PCR and sequencing. We investigated gene expression in...

journal_title：British journal of cancer

authors： Carter SA,Foster NA,Scarpini CG,Chattopadhyay A,Pett MR,Roberts I,Coleman N

更新日期：2012-08-07 00:00:00

abstract：:Treatment failure in AML is often attributed to P-glycoprotein-associated multidrug resistance. However, the importance of increased DNA repair in resistant cells is becoming more apparent. In order to investigate the ability of the DNA repair inhibitor aphidicolin to modulate drug resistance, we continually exposed b...

journal_title：British journal of cancer

authors： Sargent JM,Elgie AW,Williamson CJ,Lewandowicz GM,Taylor CG

更新日期：2001-03-02 00:00:00

abstract：:The author Sara Lonardi was incorrectly listed as Sara Leonardi. The correct name is listed above. ...

journal_title：British journal of cancer

authors： Rampazzo E,Del Bianco P,Bertorelle R,Boso C,Perin A,Spiro G,Bergamo F,Belluco C,Buonadonna A,Palazzari E,Lonardi S,De Paoli A,Pucciarelli S,De Rossi A

更新日期：2018-06-01 00:00:00

abstract：:In a blind study, 518 serum samples were assayed for serum levels of mammary serum antigen (MSA) by an enzyme immunoassay (EIA) using the 3E1.2 monoclonal antibody. Using 300 IU as the arbitrary cut off to distinguish normal from abnormal individuals, 75% of patients with primary Stage I carcinoma of the breast (n = 1...

journal_title：British journal of cancer

authors： Stacker SA,Sacks NP,Golder J,Tjandra JJ,Thompson CH,Smithyman A,McKenzie IF

更新日期：1988-03-01 00:00:00

abstract：:Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Resea...

journal_title：British journal of cancer

authors： Franceschi S,Castellsagué X,Dal Maso L,Smith JS,Plummer M,Ngelangel C,Chichareon S,Eluf-Neto J,Shah KV,Snijders PJ,Meijer CJ,Bosch FX,Muñoz N

更新日期：2002-03-04 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

journal_title：British journal of cancer

authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Pancreaticoduodenectomy remains a major undertaking. A preoperative blood test, which could confidently predict the benefits of surgery would improve the selection of pancreatic cancer patients for surgery. This study aimed to identify protein biomarkers prognostic for long-term survival and to validate them...

journal_title：British journal of cancer

authors： Xue A,Chang JW,Chung L,Samra J,Hugh T,Gill A,Butturini G,Baxter RC,Smith RC

更新日期：2012-11-20 00:00:00

abstract：:Variants of the melanocortin-1 receptor (MC1R) gene have been linked to sun-sensitive skin types and hair colour, and may independently play a role in susceptibility to cutaneous melanoma. To assess the role of MC1R variants in uveal melanoma, we have analysed a cohort of 350 patients for the changes within the major ...

journal_title：British journal of cancer

authors： Hearle N,Humphreys J,Damato BE,Wort R,Talaban R,Wixey J,Green H,Easton DF,Houlston RS

更新日期：2003-11-17 00:00:00

abstract：:For the first time in a clinical study oral Ifosfamide was used: 65 elderly or unfit patients with small cell lung cancer (SCLC) were treated as outpatients with fractionated oral Ifosfamide and Etoposide. Forty patients (62%) had extensive stage (ED) disease. The median age of the patients was 66 years. In the 60 pat...

journal_title：British journal of cancer

authors： Cerny T,Lind M,Thatcher N,Swindell R,Stout R

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS:Two cohorts were compared: one was a group with young-onset PrCa, t...

journal_title：British journal of cancer

authors： Edwards SM,Evans DG,Hope Q,Norman AR,Barbachano Y,Bullock S,Kote-Jarai Z,Meitz J,Falconer A,Osin P,Fisher C,Guy M,Jhavar SG,Hall AL,O'Brien LT,Gehr-Swain BN,Wilkinson RA,Forrest MS,Dearnaley DP,Ardern-Jones AT,Pag

更新日期：2010-09-07 00:00:00

abstract：:A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) 1.70, 95% CI 1.23 - 2.35, P=0.001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The fo...

journal_title：British journal of cancer

authors： Forrest LM,McMillan DC,McArdle CS,Angerson WJ,Dunlop DJ

更新日期：2003-09-15 00:00:00

abstract：BACKGROUND:Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC). METHODS:The number of CD8+ tumour-infiltrating immune cells (TIICs) and PD-1+ TII...

journal_title：British journal of cancer

authors： Hatogai K,Fujii S,Kitano S,Kojima T,Daiko H,Yoshino T,Ohtsu A,Takiguchi Y,Doi T,Ochiai A

更新日期：2020-02-01 00:00:00

abstract：:One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Eleven patients have been excluded from detailed analysis because they either received involved field radiotherapy (R...

journal_title：British journal of cancer

authors： Ganesan TS,Wrigley PF,Murray PA,Stansfeld AG,d'Ardenne AJ,Arnott S,Jones A,Shand WS,Malpas JS,Lister TA

更新日期：1990-08-01 00:00:00

abstract：:DT-diaphorase (DTD) is an important enzyme for the bioreductive activation of the new alkylating indoloquinone EO9. In preclinical studies, EO9 has shown selective anti-tumour activity against solid tumours and under hypoxic conditions. The levels of three reductive enzymes have been determined in three types of human...

journal_title：British journal of cancer

authors： Smitskamp-Wilms E,Giaccone G,Pinedo HM,van der Laan BF,Peters GJ

更新日期：1995-10-01 00:00:00

abstract：:Tumour angiogenesis is essential for progression of solid tumours and constitutes an interesting target for therapy. However, impaired tumour blood supply may also be an important obstacle for treatment by radiotherapy and chemotherapy. Estramustine has been shown to increase tumour blood flow and potentiate the effec...

journal_title：British journal of cancer

authors： Johansson M,Bergenheim AT,Widmark A,Henriksson R

更新日期：1999-04-01 00:00:00