Isolation and characterisation of a human anti-idiotypic scFv used as a surrogate tumour antigen to elicit an anti-HER-2/neu humoral response in mice.

abstract：BACKGROUND:Although the anti-tumour effect of cyclooxygenase-2 (Cox-2) inhibitors in invasive bladder cancer has been confirmed, its mechanisms of action are unclear. Recently, the concept of an epithelial-to-mesenchymal transition (EMT) promoting carcinoma progression has been suggested, and a key feature of the EMT i...

journal_title：British journal of cancer

authors： Adhim Z,Matsuoka T,Bito T,Shigemura K,Lee KM,Kawabata M,Fujisawa M,Nibu K,Shirakawa T

更新日期：2011-07-26 00:00:00

abstract：:Insoluble conanavalin A and wheat germ agglutinin (WGA) were found to bind to carbohydrates on radio-labelled carcinoembryonic antigen (CEA). Binding by WGA was inhibited both by N-acetyl D-glucosamine and fragments of antibody to CEA, but was increased by intact antibody to CEA. This suggests that WGA binds to expose...

journal_title：British journal of cancer

authors： Macsween JM,Fox RA

更新日期：1975-03-01 00:00:00

abstract：:Counter-irritation (CI) triggered by different non-specific irritant stimuli delayed the growth of a murine tumour of non-detected immunogenicity. The syngeneic LB tumour transplant by itself also induced CI and decreased the number of leukocytes migrating to a secondary s.c. irritant stimulus, e.g. sponge or carragee...

journal_title：British journal of cancer

authors： Sordelli DO,Fontán PA,Meiss RP,Ruggiero RA,Bustuoabad OD

更新日期：1989-11-01 00:00:00

abstract：:P450 reductase (NADPH:cytochrome P450 reductase, EC 1.6.2.4) is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine (SR 4233). Using a panel of six human breast adenocarcinoma cell lines we have examined the relationship between P450 reductase activity and sensitivity to tira...

journal_title：British journal of cancer

authors： Patterson AV,Barham HM,Chinje EC,Adams GE,Harris AL,Stratford IJ

更新日期：1995-11-01 00:00:00

abstract：:In an Italian case-control study of oral cancer, number of missing teeth and other aspects of dental care were similar, but the general condition of the mouth, as indicated by gum bleeding, tartar deposits and mucosal irritation, was worse among oral cancer cases than controls. No differences were detected in sexual p...

journal_title：British journal of cancer

authors： Talamini R,Vaccarella S,Barbone F,Tavani A,La Vecchia C,Herrero R,Muñoz N,Franceschi S

更新日期：2000-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) expression was investigated by immunohistochemistry (latent membrane protein 1 [LMP-1]) and in situ hybridization (EBV encoded RNA [EBER]) in biopsies from 95 patients with untreated Hodgkin's disease (HD). Tumour EBV status was related to EBV antibody titres, spontaneous and concanavalin A in...

journal_title：British journal of cancer

authors： Axdorph U,Porwit-MacDonald A,Sjöberg J,Grimfors G,Ekman M,Wang W,Biberfeld P,Björkholm M

更新日期：1999-12-01 00:00:00

abstract：:High levels of loss of distal markers on 17p13.3 in breast cancer suggested the presence within the region of at least one tumour-suppressor gene. Here we describe the derivation of two biallelic polymorphisms from the 17p telomeric yeast artificial chromosome (YAC) TYAC98. Polymerase chain reaction-restriction fragme...

journal_title：British journal of cancer

authors： White GR,Stack M,Santibáñez-Koref M,Liscia DS,Venesio T,Wang JC,Helms C,Donis-Keller H,Betticher DC,Altermatt HJ,Hoban PR,Heighway J

更新日期：1996-09-01 00:00:00

abstract：:Hyperthermia (42° C.) exerted an inhibitory effect on the O(2) uptake of rabbit VX2 carcinoma cells in vitro, and led to a decrease in viability and growth potential of the cells, as measured by their ability to produce tumours in rabbits. Anaerobic glycolysis of the tumour cells was unaltered by hyperthermia. Respira...

journal_title：British journal of cancer

authors： Muckle DS,Dickson JA

更新日期：1971-12-01 00:00:00

abstract：:Two hundred and thirteen lung tumours of primary site and 42 metastases were heterotransplanted into nude mice with an overall success rate of 44%. There were differences in success between the histological types. Squamous cell and adenocarcinoma had the highest success rate (51% and 43%, respectively) whereas large c...

journal_title：British journal of cancer

authors： Mattern J,Jäger S,Sonka J,Wayss K,Volm M

更新日期：1985-02-01 00:00:00

abstract：:Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, plays a role. We studied drug sensitivity to vincristine (VCR), doxorubicin (DOX) and nimustine (ACNU) in both int...

journal_title：British journal of cancer

authors： Takamiya Y,Abe Y,Tanaka Y,Tsugu A,Kazuno M,Oshika Y,Maruo K,Ohnishi Y,Sato O,Yamazaki H,Kijima H,Ueyama Y,Tamaoki N,Nakamura M

更新日期：1997-01-01 00:00:00

abstract：:The tissue-specific translation elongation factor eEF1A2 is a potential oncogene that is overexpressed in human ovarian cancer. eEF1A2 is highly similar (98%) to the near-ubiquitously expressed eEF1A1 (formerly known as EF1-alpha) making analysis with commercial antibodies difficult. We wanted to establish the express...

journal_title：British journal of cancer

authors： Tomlinson VA,Newbery HJ,Bergmann JH,Boyd J,Scott D,Wray NR,Sellar GC,Gabra H,Graham A,Williams AR,Abbott CM

更新日期：2007-05-21 00:00:00

abstract：:Vascular endothelial growth factor is an important angiogenic factor for tumour progression because it increases endothelial-cell proliferation and remodels extracellular matrix in blood vessels. We demonstrated that hyperthermia at 42 degrees C, termed heat shock, suppressed the gene expression and production of vasc...

journal_title：British journal of cancer

authors： Sawaji Y,Sato T,Takeuchi A,Hirata M,Ito A

更新日期：2002-05-20 00:00:00

abstract：:Common warts could indicate cervical cancer susceptibility, as both are caused by human papillomavirus (HPV). Eczema was also investigated, as atopic eczema has been negatively associated with warts, but non-atopic eczema may be associated with compromised host defences, as observed in patients with HIV, suggesting in...

journal_title：British journal of cancer

authors： Montgomery SM,Ehlin AG,Sparén P,Björkstén B,Ekbom A

更新日期：2002-10-21 00:00:00

abstract：BACKGROUND:Emergence of drug-resistant cancer phenotypes is a challenge for anti-cancer therapy. Cancer stem cells are identified as one of the ways by which chemoresistance develops. METHOD:We investigated the anti-inflammatory combinatorial treatment (DA) of doxorubicin and aspirin using a preclinical microfluidic m...

journal_title：British journal of cancer

authors： Khoo BL,Grenci G,Lim JSY,Lim YP,Fong J,Yeap WH,Bin Lim S,Chua SL,Wong SC,Yap YS,Lee SC,Lim CT,Han J

更新日期：2019-02-01 00:00:00

abstract：:The aim of this study was to investigate the expression of the protein tyrosine phosphatases (PTP) PRL-1, PRL-2, and PRL-3 in human breast cancer and to evaluate its clinical and prognostic significance. PRL-PTP mRNA expression was examined in malignant (n = 7) and nonmalignant (n = 7) cryoconserved breast tissue samp...

journal_title：British journal of cancer

authors： Radke I,Götte M,Kersting C,Mattsson B,Kiesel L,Wülfing P

更新日期：2006-08-07 00:00:00

abstract：:It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...

journal_title：British journal of cancer

authors： Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto M

更新日期：1998-01-01 00:00:00

abstract：:The utility of external beam radiotherapy for the treatment of malignant brain tumours is compromised by the need to avoid excessive radiation damage to normal CNS tissues. This review describes the current status of targeted radiotherapy, an alternative strategy for brain tumour treatment that offers the exciting pro...

journal_title：British journal of cancer

authors： Zalutsky MR

更新日期：2004-04-19 00:00:00

abstract：:Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after CC1(4), tumours for...

journal_title：British journal of cancer

authors： Pound AW,Lawson TA,Horn L

更新日期：1973-06-01 00:00:00

abstract：:The aim of this study was to find a procedure allowing estimation of individual pharmacokinetic parameters for adriamycin with minimal cost and disturbance for the patient. Twenty-five patients with breast cancer were treated by short infusion of adriamycin at a dose of 12 mg m-2 week-1 (41 courses). Population charac...

journal_title：British journal of cancer

authors： Launay MC,Milano G,Iliadis A,Frenay M,Namer N

更新日期：1989-07-01 00:00:00

abstract：:The incidence of nodal metastasis in early gastric carcinoma (EGC) is 10-20%. However, the optimal nodal dissection for early gastric carcinoma has not been established. A retrospective study was conducted in 392 consecutive patients who underwent potentially curative distal gastrectomy for EGC between 1962 and 1990. ...

journal_title：British journal of cancer

authors： Miwa K,Miyazaki I,Sahara H,Fujimura T,Yonemura Y,Noguchi M,Falla R

更新日期：1995-12-01 00:00:00

abstract：:Various procedures for immunoprotection in the A-SW mouse SEWA tumour system were compared. Four types of protector agents were used: polyoma virus, allogeneic S724 cells, A9/SEWA hybrid cells and xenogeneic ST(py) cells. Several injection schedules were also employed. On the whole, reasonable immunoprotection was obt...

journal_title：British journal of cancer

authors： Favre R,Carcassonne Y,Meyer G

更新日期：1974-04-01 00:00:00

abstract：BACKGROUND:The potential for cancer-testis (CT) antigens as targets for immunotherapy in cancer patients has been heavily investigated, and currently cancer vaccine trials based on the CT antigens, MAGE-A3 and NY-ESO-1, are being carried out. METHODS:We used specific q-RT-PCR assays to analyse the expression of the CT...

journal_title：British journal of cancer

authors： Dyrskjøt L,Zieger K,Kissow Lildal T,Reinert T,Gruselle O,Coche T,Borre M,Ørntoft TF

更新日期：2012-06-26 00:00:00

abstract：:Recently, we have found a high frequency of p53 gene mutations in human functional adrenal tumours. As the tumorigenesis is a multigene defect, we believe that other oncogenes may also be involved in the initiation or progression of adrenal tumours. Using the single-strand conformational polymorphism (SSCP) method, we...

journal_title：British journal of cancer

authors： Lin SR,Tsai JH,Yang YC,Lee SC

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...

journal_title：British journal of cancer

authors： Plummer R,Dua D,Cresti N,Drew Y,Stephens P,Foegh M,Knudsen S,Sachdev P,Mistry BM,Dixit V,McGonigle S,Hall N,Matijevic M,McGrath S,Sarker D

更新日期：2020-08-01 00:00:00

abstract：:Peutz-Jeghers syndrome (PJS) and juvenile polyposis (JPS) are both characterized by the presence of hamartomatous polyps and increased risk of malignancy in the gastrointestinal tract. Mutations of the LKB1 and SMAD4 genes have been shown recently to cause a number of PJS and JPS cases respectively, but there remains ...

journal_title：British journal of cancer

authors： Woodford-Richens KL,Halford S,Rowan A,Bevan S,Aaltonen LA,Wasan H,Bicknell D,Bodmer WF,Houlston RS,Tomlinson IP

更新日期：2001-05-18 00:00:00

abstract：:Carcinoma of the pancreas is an aggressive tumour with an extremely poor prognosis. Recent studies have shown that chemotherapy can improve survival as well as quality of life. Since the prognosis is generally poor, the identification of early responders to chemotherapy is important to avoid unnecessary toxicity in pa...

journal_title：British journal of cancer

authors： Maisey NR,Webb A,Flux GD,Padhani A,Cunningham DC,Ott RJ,Norman A

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Congenital anomalies have been found more often in children with cancer than in those without. Rib abnormalities (RAs) have been associated with childhood cancer; however, studies have differed in the type of RAs and cancers implicated. METHODS:Rib abnormalities were assessed predominantly by X-ray in a hos...

journal_title：British journal of cancer

authors： Zierhut H,Murati M,Holm T,Hoggard E,Spector LG

更新日期：2011-10-25 00:00:00

abstract：:The accurate determination of exposure to environmental tobacco smoke is notoriously difficult. There have been to date two approaches to determining this exposure in the study of association of passive smoking and lung cancer: the biochemical approach, using cotinine in the main as a marker, and the epidemiological a...

journal_title：British journal of cancer

authors： Tweedie RL,Mengersen KL

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Older women have lower breast cancer surgery rates than younger women. UK policy states that differences in cancer treatment by age can only be justified by patient choice or poor health. METHODS:We investigate whether lack of surgery for older patients is explained by patient choice/poor health in a prospe...

journal_title：British journal of cancer

authors： Lavelle K,Sowerbutts AM,Bundred N,Pilling M,Degner L,Stockton C,Todd C

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:Biomarkers for metastatic castration-resistant prostatic cancer (mCRPC) are an unmet medical need. METHODS:The prognostic and predictive value for survival and response to salvage hormonal therapy (SHT) of baseline testosterone level (TL) was analysed in a cohort of 101 mCRPC patients participating in 9 non...

journal_title：British journal of cancer

authors： de Liaño AG,Reig O,Mellado B,Martin C,Rull EU,Maroto JP

更新日期：2014-04-29 00:00:00