Association of rib anomalies and childhood cancers.

abstract：:Two aspects of the aerobic metabolism of nitroimidazole markers for hypoxia were investigated. Several normal murine tissues which are likely to be well oxygenated bind misonidazole at rates comparable to those of hypoxic regions in tumours. The possibility that this aerobic activation occurs via an oxygen independent...

journal_title：British journal of cancer

authors： Parliament MB,Wiebe LI,Franko AJ

更新日期：1992-12-01 00:00:00

abstract：:While statins have been highly effective for lowering serum cholesterol and reducing the incidence of coronary events, they have multiple other effects. Certain statins block the interaction of adhesion molecules that are important for cell-cell interactions including those between EBV-transformed B cells. These same ...

journal_title：British journal of cancer

authors： Cohen JI

更新日期：2005-05-09 00:00:00

abstract：:The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 chaperone dependence. In non-small cell lung cancer (NSCLC), these mutations are associated with enhanced sensitivity to EGF...

journal_title：British journal of cancer

authors： Xu W,Soga S,Beebe K,Lee MJ,Kim YS,Trepel J,Neckers L

更新日期：2007-09-17 00:00:00

abstract：:An attempt has been made to develop tritiated derivatives of Synkavit (menadiol sodium diphosphate, MNDP) of high specific activity as a radioactive drug.This paper summarizes the preliminary biological and physical studies, with emphasis on approximate radiation dosimetry and the necessary preliminary testing, and th...

journal_title：British journal of cancer

authors： Mitchell JS

更新日期：1974-05-01 00:00:00

abstract：:Pancreatic tumours are scirrhous, avascular tumours, suggesting that they may produce angiogenesis inhibitors that suppress the growth of the vasculature to the tumour and metastases. We have sought evidence for the angiogenesis inhibitor, endostatin, in normal and cancerous pancreatic tissue. Using Western blotting, ...

journal_title：British journal of cancer

authors： Brammer RD,Bramhall SR,Eggo MC

更新日期：2005-01-17 00:00:00

abstract：:Advanced or metastatic disease is common in both oesophagogastric and colorectal cancers, with poor 5-year survival despite palliative chemotherapy. We have investigated the sensitivity of gastrointestinal tumours to gemcitabine in combination with mitomycin C (GeM), using a modified ex vivo ATP-based tumour chemosens...

journal_title：British journal of cancer

authors： Whitehouse PA,Mercer SJ,Knight LA,Di Nicolantonio F,O'Callaghan A,Cree IA,Portsmouth Upper GI and Colorectal Cancer Multidisciplinary Teams.

更新日期：2003-12-15 00:00:00

abstract：:Regional chemotherapy is commonly used to treat patients with colorectal liver metastases. However, improvement in survival has still not been demonstrated. Cytotoxic loaded albumin microspheres for arterial administration have been described as a means of improving the the therapeutic index, but their distribution de...

journal_title：British journal of cancer

authors： Goldberg JA,Thomson JA,Bradnam MS,Fenner J,Bessent RG,McKillop JH,Kerr DJ,McArdle CS

更新日期：1991-07-01 00:00:00

abstract：:In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene, which encodes a p53-associated protein. SSCP (single-strand conformation polymorphism) analysis and direct sequencing of polymerase chain reaction (PCR)-amplified DNA were used to establish t...

journal_title：British journal of cancer

authors： Patterson H,Gill S,Fisher C,Law MG,Jayatilake H,Fletcher CD,Thomas M,Grimer R,Gusterson BA,Cooper CS

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Doxorubicin and cyclophosphamide (AC) therapy is an effective treatment for early-stage breast cancer. Doxorubicin is a substrate for ABCB1 and SLC22A16 transporters. Cyclophosphamide is a prodrug that requires oxidation to 4-hydroxycyclophosphamide, which yields a cytotoxic alkylating agent. The initial oxi...

journal_title：British journal of cancer

authors： Bray J,Sludden J,Griffin MJ,Cole M,Verrill M,Jamieson D,Boddy AV

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

journal_title：British journal of cancer

authors： Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

更新日期：2014-08-12 00:00:00

abstract：:We cytogenetically investigated six osteoid osteomas, one osteoblastoma and one aggressive osteoblastoma, and observed clonal structural changes in one osteoid osteoma and in the aggressive osteoblastoma. Clonal chromosome changes had not been reported previously in osteoid osteoma, whereas the only reported chromosom...

journal_title：British journal of cancer

authors： Dal Cin P,Sciot R,Samson I,De Wever I,Van den Berghe H

更新日期：1998-08-01 00:00:00

abstract：:Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...

journal_title：British journal of cancer

authors： Barnes TA,Amir E

更新日期：2017-08-08 00:00:00

abstract：:New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...

journal_title：British journal of cancer

authors： Allal C,Sixou S,Kravtzoff R,Soulet N,Soula G,Favre G

更新日期：1998-05-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL, also known as Apo-2L) is a promising novel anticancer agent that selectively induces apoptosis in tumour cells and the activity of which can be enhanced by combined treatment with chemo- or radiotherapy. For therapeutic purposes, the use of full-length TRAIL may be favoura...

journal_title：British journal of cancer

authors： Abou El Hassan MA,Mastenbroek DC,Gerritsen WR,Giaccone G,Kruyt FA

更新日期：2004-07-05 00:00:00

abstract：BACKGROUND:Gastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker. METHODS:Forty patients (17 palliative and 23 curative) were followed by serial plasma monitoring. Primary tumour DNA was analysed by tar...

journal_title：British journal of cancer

authors： Openshaw MR,Mohamed AA,Ottolini B,Fernandez-Garcia D,Richards CJ,Page K,Guttery DS,Thomas AL,Shaw JA

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The recently described navigator proteins have a multifaceted role in cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC). METHODS:We analysed changes in chromosome 12 and NAV3 copy number in CRC/adenoma samples of 59 patients and in 6 CRC ce...

journal_title：British journal of cancer

authors： Carlsson E,Ranki A,Sipilä L,Karenko L,Abdel-Rahman WM,Ovaska K,Siggberg L,Aapola U,Ässämäki R,Häyry V,Niiranen K,Helle M,Knuutila S,Hautaniemi S,Peltomäki P,Krohn K

更新日期：2012-01-31 00:00:00

abstract：:HER2/neu-derived peptides inducing MHC class II-restricted CD4+ T helper lymphocyte (Th) responses, although critical for tumour rejection, are not thoroughly characterized. Here, we report the generation and characterization of CD4+ T cell clones specifically recognizing a HER-2/neu-derived peptide (776-788) [designa...

journal_title：British journal of cancer

authors： Sotiriadou R,Perez SA,Gritzapis AD,Sotiropoulou PA,Echner H,Heinzel S,Mamalaki A,Pawelec G,Voelter W,Baxevanis CN,Papamichail M

更新日期：2001-11-16 00:00:00

abstract：:Rhizoxin is a tubulin-binding anti-neoplastic agent which is active in a range of murine tumour models. The recommended schedule, of intravenous (i.v.) bolus administration at a dose of 2 mg m-2 every 3 weeks, has been assessed in three phase II trials of ovarian, renal and colorectal cancer. In general terms the drug...

journal_title：British journal of cancer

authors： Kerr DJ,Rustin GJ,Kaye SB,Selby P,Bleehen NM,Harper P,Brampton MH

更新日期：1995-11-01 00:00:00

abstract：:To find out whether ultrasound-guided fine-needle aspiration (FNA) and ultrasound and stereotactic-guided large core needle biopsy (LCNB) are reliable alternatives to needle-localised open breast biopsy (NLBB) in daily practice, we performed a retrospective study and evaluated the validity of these methods. In all, 71...

journal_title：British journal of cancer

authors： Pijnappel RM,van den Donk M,Holland R,Mali WP,Peterse JL,Hendriks JH,Peeters PH

更新日期：2004-02-09 00:00:00

abstract：BACKGROUND:LGR5 is an important marker of intestinal stem cells and performs its vital functions at the cell membrane. Despite the importance of LGR5 to both normal and cancer stem cell biology, it is not known how microenvironmental stress affects the expression and subcellular distribution of the protein. METHODS:Nu...

journal_title：British journal of cancer

authors： Morgan RG,Molnár E,Jones RF,Collard TJ,Lane JD,Greenhough A,Paraskeva C,Williams AC

更新日期：2015-02-17 00:00:00

abstract：:Serum concentrations of oestradiol-17β were measured by radio-immunoassay during 40 menstrual cycles from 38 normal premenopausal women. Repeated samples were studied from 25 normal postmenopausal women. The method was highly specific and extremely sensitive. In premenopausal women the pattern of serum oestradiol-17β ...

journal_title：British journal of cancer

authors： England PC,Skinner LG,Cottrell KM,Sellwood RA

更新日期：1974-06-01 00:00:00

abstract：:A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...

journal_title：British journal of cancer

authors： Lindahl T

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...

journal_title：British journal of cancer

authors： Hurt CN,Falk S,Crosby T,McDonald A,Ray R,Joseph G,Staffurth J,Abrams RA,Griffiths G,Maughan T,Mukherjee S

更新日期：2017-05-09 00:00:00

abstract：BACKGROUND:Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. We conducted a la...

journal_title：British journal of cancer

authors： Köbel M,Madore J,Ramus SJ,Clarke BA,Pharoah PD,Deen S,Bowtell DD,Odunsi K,Menon U,Morrison C,Lele S,Bshara W,Sucheston L,Beckmann MW,Hein A,Thiel FC,Hartmann A,Wachter DL,Anglesio MS,Høgdall E,Jensen A,Høgdall C

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:To document the effect of bivalent HPV immunisation on cervical cytology as a screening test and assess the implications of any change, using a retrospective analysis of routinely collected data from the Scottish Cervical Screening Programme (SCSP). METHODS:Data were extracted from the Scottish Cervical Cal...

journal_title：British journal of cancer

authors： Palmer TJ,McFadden M,Pollock KG,Kavanagh K,Cuschieri K,Cruickshank M,Cotton S,Nicoll S,Robertson C

更新日期：2016-03-01 00:00:00

abstract：:Tumour-associated cell-surface glycoprotein is associated with tumour progression in gastric cancer. We investigated the biological significance of tumour-associated cell-surface glycoprotein, determined by the binding of Helix pomatia agglutinin (HPA), with regard to survival time and to the malignant potential of ca...

journal_title：British journal of cancer

authors： Maehara Y,Okuyama T,Kakeji Y,Endo K,Yamamoto M,Sugimachi K

更新日期：1995-05-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) have been increasingly recognized to play an important role in the pathobiology of pancreatic malignancy. We have investigated the effects of FGF-1 and FGF-2 on the behaviour and adhesion properties of human pancreatic adenocarcinoma cell ...

journal_title：British journal of cancer

authors： El-Hariry I,Pignatelli M,Lemoine NR

更新日期：2001-06-15 00:00:00

abstract：BACKGROUND:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. METHODS:Participant...

journal_title：British journal of cancer

authors： Kapidzic A,Korfage IJ,van Dam L,van Roon AH,Reijerink JC,Zauber AG,van Ballegooijen M,Kuipers EJ,van Leerdam ME

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO2 to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo. METHODS:We used 1H magnetic resonance spe...

journal_title：British journal of cancer

authors： Lee SH,McIntyre D,Honess D,Hulikova A,Pacheco-Torres J,Cerdán S,Swietach P,Harris AL,Griffiths JR

更新日期：2018-08-01 00:00:00

abstract：:Mutation and overexpression are the main activating mechanisms for the ras family of genes in human cancer and the variable tandem repeat (VTR) located at the 3' end of H-ras has been associated with this risk. In the present study, we have analysed the relative levels of expression of H-ras mRNA in 26 samples of squa...

journal_title：British journal of cancer

authors： Kiaris H,Spandidos DA,Jones AS,Vaughan ED,Field JK

更新日期：1995-07-01 00:00:00