Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.

abstract：:Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...

journal_title：British journal of cancer

authors： Mertens F,Jonsson K,Willén H,Rydholm A,Kreicbergs A,Eriksson L,Olsson-Sandin G,Mitelman F,Mandahl N

更新日期：1996-07-01 00:00:00

abstract：:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < o...

journal_title：British journal of cancer

authors： Verweij J,Wanders J,Gil T,Schöffski P,Catimel G,te Velde A,de Mulder PH

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:The small stress heat shock protein 27 (Hsp27) has recently turned as a promising target for cancer treatment. Hsp27 upregulation is associated with tumour growth and resistance to chemo- and radio-therapeutic treatments, and several ongoing drugs inhibiting Hsp27 expression are under clinical trial. Hsp27 i...

journal_title：British journal of cancer

authors： Gibert B,Eckel B,Gonin V,Goldschneider D,Fombonne J,Deux B,Mehlen P,Arrigo AP,Clézardin P,Diaz-Latoud C

更新日期：2012-06-26 00:00:00

abstract：:Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes selected for resistance against doxorubicin, melphalan, teniposide and vincristine, were profiled for mRNA expre...

journal_title：British journal of cancer

authors： Rickardson L,Fryknäs M,Dhar S,Lövborg H,Gullbo J,Rydåker M,Nygren P,Gustafsson MG,Larsson R,Isaksson A

更新日期：2005-08-22 00:00:00

abstract：:The aim of this phase I study was to determine the maximum tolerated dose of a 3-h infusion of paclitaxel, combined with carboplatin at a fixed AUC of 7 mg ml-1 min every 4 weeks for up to six cycles and to evaluate any possible pharmacokinetic interaction. Twelve chemonaive patients with ovarian cancer were treated w...

journal_title：British journal of cancer

authors： Siddiqui N,Boddy AV,Thomas HD,Bailey NP,Robson L,Lind MJ,Calvert AH

更新日期：1997-01-01 00:00:00

abstract：:C57BL mice were given local irradiation to 2 cm2 of the lower abdomen in the dose range 16--24 Gy. There were some early deaths, but mice dying between 50--240 days predominantly developed invasive adenocarcinomas of the intestine. When the radiosensitizer misonidazole was given in a single dose shortly before irradia...

journal_title：British journal of cancer

authors： Rostom AY,Kauffman SL,Steel GG

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant condition caused by germline FLCN mutations, and characterised by fibrofolliculomas, pneumothorax and renal cancer. The renal cancer risk, cancer phenotype and pneumothorax risk of BHD have not yet been fully clarified. The main focus of this study was t...

journal_title：British journal of cancer

authors： Houweling AC,Gijezen LM,Jonker MA,van Doorn MB,Oldenburg RA,van Spaendonck-Zwarts KY,Leter EM,van Os TA,van Grieken NC,Jaspars EH,de Jong MM,Bongers EM,Johannesma PC,Postmus PE,van Moorselaar RJ,van Waesberghe JH,Starink

更新日期：2011-12-06 00:00:00

abstract：BACKGROUND:This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT). METHODS:The WHI study enrolled women aged 50-79 years from 1993 t...

journal_title：British journal of cancer

authors： Wang A,Aragaki AK,Tang JY,Kurian AW,Manson JE,Chlebowski RT,Simon M,Desai P,Wassertheil-Smoller S,Liu S,Kritchevsky S,Wakelee HA,Stefanick ML

更新日期：2016-06-28 00:00:00

abstract：:We examined polymorphisms in exons 3 and 4 of microsomal epoxide hydrolase in 101 patients with colon cancer and compared the results with 203 control samples. The frequency of the exon 3 T to C mutation was higher in cancer patients than in controls (odds ratio 3.8; 95% confidence intervals 1.8-8.0). This sequence al...

journal_title：British journal of cancer

authors： Harrison DJ,Hubbard AL,MacMillan J,Wyllie AH,Smith CA

更新日期：1999-01-01 00:00:00

abstract：:The ribosome-inactivating proteins, bryodin, from Bryonia dioica, and momordin, from Momordica charantia, were coupled by a disulphide bond to a monoclonal anti-Thy 1.1 antibody (OX7). Both immunotoxins were specifically cytotoxic to the Thy 1.1-expressing mouse lymphoma cell line AKR-A in vitro. The OX7-bryodin immun...

journal_title：British journal of cancer

authors： Stirpe F,Wawrzynczak EJ,Brown AN,Knyba RE,Watson GJ,Barbieri L,Thorpe PE

更新日期：1988-11-01 00:00:00

abstract：:The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after injecting specimens with c...

journal_title：British journal of cancer

authors： Martin L,Holcombe C,Green B,Leinster SJ,Winstanley J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Few studies have investigated the relationship between physician and patient-assessed performance status (PS) in blood cancers. METHODS:Retrospective analysis among 1418 patients with haematologic malignancies seen at Dana-Farber Cancer Institute between 2007 and 2014. We analysed physician-patient agreemen...

journal_title：British journal of cancer

authors： Liu MA,Hshieh T,Condron N,Wadleigh M,Abel GA,Driver JA

更新日期：2016-09-27 00:00:00

abstract：:In a population-based prospective study of 19,998 Japanese individuals, consumption of vegetables, green-yellow and green leafy vegetables was inversely associated with the risk of hepatocellular carcinoma (101 cases), with multivariable hazard ratios for the highest vs lowest tertile of 0.61 (95% confidence interval ...

journal_title：British journal of cancer

authors： Kurahashi N,Inoue M,Iwasaki M,Tanaka Y,Mizokami M,Tsugane S,JPHC Study Group.

更新日期：2009-01-13 00:00:00

abstract：BACKGROUND:Risk factors for the development of myelodysplastic syndromes (MDS) include age, exposure to ionising radiation, and cytotoxic drug treatment. Recently, asthma also has been suggested as a risk factor for MDS. METHODS:We undertook this nationwide population-based cohort study on patients with a first-time h...

journal_title：British journal of cancer

authors： Frederiksen H,Farkas DK,Horváth-Puhó E,Nørgaard JM,Nørgaard M,Sørensen HT

更新日期：2017-01-03 00:00:00

abstract：:The survival and clonogenic growth (measured in terms of colony forming efficiency (CFE) of intravenously injected (i.v.) Walker (W256) tumour cells in the lungs of rats was greatly enhanced by states of topical and systemic stress induced by the intraperitoneal (i.p.) injection of rats with a single dose of 10(-5)-10...

journal_title：British journal of cancer

authors： Van Den Brenk HA,Stone MG,Kelly H,Sharpington C

更新日期：1976-01-01 00:00:00

abstract：:Cytogenetic investigation was performed on direct preparations of 15 endometrial cancers showing different histotypes. Clonal abnormalities were found in 11 out of 13 analysable cases. The modal chromosome number was near diploid in all cases. The abnormal karyotypes contained relatively simple numerical or structural...

journal_title：British journal of cancer

authors： Tibiletti MG,Bernasconi B,Taborelli M,Furlan D,Fabbri A,Franchi M,Taramelli R,Trubia M,Capella C

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Appreciating variation in the length of pre- or post-presentation diagnostic intervals can help prioritise early diagnosis interventions with either a community or a primary care focus. METHODS:We analysed data from the first English National Audit of Cancer Diagnosis in Primary Care on 10 953 patients with...

journal_title：British journal of cancer

authors： Lyratzopoulos G,Saunders CL,Abel GA,McPhail S,Neal RD,Wardle J,Rubin GP

更新日期：2015-03-31 00:00:00

abstract：:The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion...

journal_title：British journal of cancer

authors： Brown JS,Sundar R,Lopez J

更新日期：2018-02-06 00:00:00

abstract：:The clinical formulation of the anti-tumour agent Taxol involves the use of a mixture of ethanol and Cremophor EL. Gel electrophoresis and density-gradient ultracentrifugation were used to detect effects of Taxol infusions on serum lipoproteins. Use of the Cremophor vehicle results in a decrease in the electrophoretic...

journal_title：British journal of cancer

authors： Sykes E,Woodburn K,Decker D,Kessel D

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Currently, none of the available colorectal adenocarcinoma (CAC) testing has been established as a well-accepted diagnosis tool, particularly for the early stage of CAC. The recent discovery of serum microRNA (miRNA) profile has provided a new auxiliary approach for tumour diagnosis. Our study is involved in...

journal_title：British journal of cancer

authors： Zheng G,Du L,Yang X,Zhang X,Wang L,Yang Y,Li J,Wang C

更新日期：2014-11-11 00:00:00

abstract：:Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of th...

journal_title：British journal of cancer

authors： Avril MF,Auperin A,Margulis A,Gerbaulet A,Duvillard P,Benhamou E,Guillaume JC,Chalon R,Petit JY,Sancho-Garnier H,Prade M,Bouzy J,Chassagne D

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Patients with high-grade gliomas are treated with surgery followed by chemoradiation. The risk factors and implications of neurological side effects are not known. METHODS:Acute and late ≥ grade 3 neurological toxicities (NTs) were analysed among 2761 patients from 14 RTOG trials accrued from 1983 to 2003. ...

journal_title：British journal of cancer

authors： Lawrence YR,Wang M,Dicker AP,Andrews D,Curran WJ Jr,Michalski JM,Souhami L,Yung WK,Mehta M

更新日期：2011-04-26 00:00:00

abstract：BACKGROUND:RECORD-3 assessed non-inferiority of progression-free survival (PFS) with everolimus vs sunitinib in previously untreated patients with metastatic renal cell carcinoma. Baseline plasma sample collection and randomised design enabled correlation of circulating biomarkers with efficacy. METHODS:Samples were a...

journal_title：British journal of cancer

authors： Voss MH,Chen D,Marker M,Hakimi AA,Lee CH,Hsieh JJ,Knox JJ,Voi M,Motzer RJ

更新日期：2016-03-15 00:00:00

abstract：:Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs,...

journal_title：British journal of cancer

authors： Volm M,Koomägi R,Mattern J,Stammler G

更新日期：1997-01-01 00:00:00

abstract：:There are two main histological groups of testicular germ cell tumours, which may have different risk factors. Some authors have analysed potential risk factors by histological group but few consistent differences have been identified. In this paper we examine risk factors for pure seminoma and other tumours using dat...

journal_title：British journal of cancer

authors： Coupland CA,Chilvers CE,Davey G,Pike MC,Oliver RT,Forman D

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...

journal_title：British journal of cancer

authors： Niho S,Ikeda N,Michimae H,Suzuki K,Sakai H,Kaburagi T,Minato K,Kato T,Okamoto H,Seto T,Hosomi Y,Shimizu K,Oshita F,Kunitoh H,Tsuboi M,Takeuchi M,Watanabe K

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:This study is to investigate the effects of geserelin+tamoxifen (TAM) on estradiol level, breast density (BD), endometrial thickness (ET), and blood lipids in premenopausal and perimenopausal women with hormone receptor-positive early-stage breast cancer. METHODS:This study recruited 110 premenopausal and p...

journal_title：British journal of cancer

authors： Yang H,Zong X,Yu Y,Shao G,Zhang L,Qian C,Bian Y,Xu X,Sun W,Meng X,Ding X,Chen D,Zou D,Xie S,Zheng Y,Zhang J,He X,Sun C,Yu X,Ni J

更新日期：2013-08-06 00:00:00

abstract：:Serum samples taken between 6 and 20 weeks of gestation were obtained from 28 mothers who gave birth to cryptorchid sons (cases) and from 108 control mothers. In comparison with controls the cases had 10% higher geometric mean oestradiol (95% CI -13% to +39%: P=0.42) and 10% lower geometric mean testosterone (95% CI -...

journal_title：British journal of cancer

authors： Key TJ,Bull D,Ansell P,Brett AR,Clark GM,Moore JW,Chilvers CE,Pike MC

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:This open-label, phase 1 trial (NCT02316197) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (formerly M3814), a DNA-dependent protein kinase (DNA-PK) inhibitor in patients with advanced solid tumours. Secondary/exploratory objectives included safety/t...

journal_title：British journal of cancer

authors： van Bussel MTJ,Awada A,de Jonge MJA,Mau-Sørensen M,Nielsen D,Schöffski P,Verheul HMW,Sarholz B,Berghoff K,El Bawab S,Kuipers M,Damstrup L,Diaz-Padilla I,Schellens JHM

更新日期：2020-11-24 00:00:00

abstract：:Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...

journal_title：British journal of cancer

authors： Bridgewater J,van Laar R,Floore A,Van'T Veer L

更新日期：2008-04-22 00:00:00