Abstract：
BACKGROUND:The small stress heat shock protein 27 (Hsp27) has recently turned as a promising target for cancer treatment. Hsp27 upregulation is associated with tumour growth and resistance to chemo- and radio-therapeutic treatments, and several ongoing drugs inhibiting Hsp27 expression are under clinical trial. Hsp27 is now well described to counteract apoptosis and its elevated expression is associated with increased aggressiveness of several primary tumours. However, its role in the later stage of tumour progression and, more specifically, in the later and most deadly stage of tumour metastasis is still unclear. METHODS/RESULTS:In the present study, we showed by qRT-PCR that Hsp27 gene is overexpressed in a large fraction of the metastatic breast cancer area in 53 patients. We further analysed the role of this protein in mice during bone metastasis invasion and establishment by using Hsp27 genetically depleted MDA-MB231/B02 human breast cancer cell line as a model. We demonstrate that Hsp27 silencing led to reduced cell migration and invasion in vitro and that in vivo it correlated with a decreased ability of breast cancer cells to metastasise and grow in the skeleton. CONCLUSION:Altogether, these data characterised Hsp27 as a potent therapeutic target in breast cancer bone metastasis and skeletal tumour growth.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Gibert B,Eckel B,Gonin V,Goldschneider D,Fombonne J,Deux B,Mehlen P,Arrigo AP,Clézardin P,Diaz-Latoud Cdoi
10.1038/bjc.2012.188subject
Has Abstractpub_date
2012-06-26 00:00:00pages
63-70issue
1eissn
0007-0920issn
1532-1827pii
bjc2012188journal_volume
107pub_type
杂志文章abstract：BACKGROUND:Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. METHODS:We performed a nested cas...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.148
更新日期：2016-06-28 00:00:00
abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0892-9
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abstract：:To evaluate current guidelines criteria for inclusion of women in special 'breast cancer family history' surveillance programmes, records were reviewed of women referred to Scottish breast cancer family clinics between January 1994 and December 2003 but discharged as at 'less than 'moderate' familial risk'. The Scotti...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6604155
更新日期：2008-02-26 00:00:00
abstract：:Fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) have been increasingly recognized to play an important role in the pathobiology of pancreatic malignancy. We have investigated the effects of FGF-1 and FGF-2 on the behaviour and adhesion properties of human pancreatic adenocarcinoma cell ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1813
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abstract：:In this population-based Norwegian cohort study (2.1 million children), the impact of birth and parental characteristics on the risk of neuroblastoma (178 cases) was evaluated. In children below the age of 18 months, there was an increased neuroblastoma risk among those with congenital malformations and suggestion of ...
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6604646
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pub_type： 杂志文章,多中心研究,随机对照试验
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abstract：:The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.173
更新日期：1994-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.2015.53
更新日期：2015-03-17 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
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doi：10.1038/sj.bjc.6603471
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.402
更新日期：1994-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-11-26 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6602392
更新日期：2005-04-11 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1981.205
更新日期：1981-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1993.5
更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章,评审
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doi：10.1038/sj.bjc.6602991
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更新日期：2007-05-07 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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journal_title：British journal of cancer
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1986-08-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-020-0879-6
更新日期：2020-08-01 00:00:00
