Abstract：
:Large-scale genomic analyses of cutaneous melanoma have revealed insights into the aetiology and heterogeneity of this disease, as well as opportunities to further personalise treatment for patients with targeted and immune therapies. Herein, we review the proposed genomic classification of cutaneous melanoma from large-scale next-generation sequencing studies, including the largest integrative analysis of melanoma from The Cancer Genome Atlas (TCGA) Network. We examine studies that have identified molecular features of melanomas linked to immune checkpoint inhibitor response. In addition, we draw attention to low-frequency actionable mutations and highlight frequent non-coding mutations in melanoma where little is known about their biological function that may provide novel avenues for the development of treatment strategies for melanoma patients.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Rajkumar S,Watson IRdoi
10.1038/bjc.2016.195subject
Has Abstractpub_date
2016-07-12 00:00:00pages
145-55issue
2eissn
0007-0920issn
1532-1827pii
bjc2016195journal_volume
115pub_type
杂志文章,评审abstract：:The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts of cultured WEHI-11 ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.106
更新日期：1975-06-01 00:00:00
abstract：BACKGROUND:Gold(III) porphyrin 1a is a new class of anticancer drug, which inhibits cell proliferation of wide range of human cancer cell lines and induces apoptosis in human nasopharyngeal carcinoma cells. However, the underlying signalling mechanism by which gold(III) porphyrin 1a modifies the intracellular apoptosis...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605147
更新日期：2009-07-21 00:00:00
abstract：BACKGROUND:Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer (PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway that may mediate this interaction is the HGF-c-MET pathway. METHODS:Effects of HGF inhibition (using a neutralising antibody AMG102) alon...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.478
更新日期：2016-02-02 00:00:00
abstract：BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2011.104
更新日期：2011-04-12 00:00:00
abstract：:The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.278
更新日期：1994-08-01 00:00:00
abstract：:Until recently, endocrine therapy for breast cancer was relatively simple. If the tumour expressed hormone receptors, regardless of stage and age, tamoxifen was indicated. While this largely remains the case for premenopausal women, clinical trials in postmenopausal women have broadened our choice to include one of th...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6601508
更新日期：2004-01-12 00:00:00
abstract：:Based on the assumption that an accelerated proliferation process prevails in tumour cell residues after surgery, the possibility that treatment acceleration would offer a therapeutic advantage in postoperative radiotherapy of locally advanced head and neck cancer was investigated. The value of T(pot) in predicting th...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.bjc.6600119
更新日期：2002-02-12 00:00:00
abstract：:In a population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma and 913 healthy controls aged 16-80 years, the association between sunbed use and malignant melanoma was evaluated. A total of 250 (44%) cases and 372 (41%) controls reported e...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1181
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the safety of neoadjuvant chemoradiation using radiotherapy (RT) combined with concurrent capecitabine and irinotecan for locally advanced rectal cancer before surgery. METHODS:Forty-six patients were recruited and treated on the basis that MRI scanning had shown poo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605258
更新日期：2009-09-15 00:00:00
abstract：:Clinical data were reviewed in 325 patients with prostatic adenocarcinoma followed up for a mean of 13 years. Paraffin-embedded tumour biopsy specimens from the primary tumours were available for flow cytometry (FCM) in 273 cases. Intra-tumour heterogeneity in DNA index (DI) was found in 4% of the tumours (54 cases we...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.298
更新日期：1994-08-01 00:00:00
abstract：BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.453
更新日期：2011-11-22 00:00:00
abstract：:Serum laminin P1 was studied in patients with small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), respiratory infections, pulmonary fibrosis, and in normal subjects. The level of serum laminin P1 was elevated (greater than 1.27 U ml-1) in 58.9% of SCLC and in 11.5% of NSCLC patients. Median value in SCL...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.123
更新日期：1992-04-01 00:00:00
abstract：:Cimetidine has been shown to have beneficial effects in colorectal cancer patients. In this study, a total of 64 colorectal cancer patients who received curative operation were examined for the effects of cimetidine treatment on survival and recurrence. The cimetidine group was given 800 mg day(-1) of cimetidine orall...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6600048
更新日期：2002-01-21 00:00:00
abstract：:Combinations of dacarbazine (DTIC) and other cytotoxic agents or alpha-interferon were given to 136 patients in five different regimens. The total response rate was 32% (95% confidence interval 24-40%); 13% had a complete remission. Female patients had a significantly higher chance of response than male patients: 46% ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.372
更新日期：1994-10-01 00:00:00
abstract：:Survival and proliferation of cell cultures from human anaplastic astrocytomas were shown to be enhanced by glucocorticoids with an optimal concentration of approximately 2.5 x 10(-5)M (10 micrograms/ml). The stimulation of proliferation was only observed in a clonal growth assay and was reversed as the size of indivi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.161
更新日期：1980-06-01 00:00:00
abstract：:In advanced pancreatic cancer, level one evidence has established a significant survival advantage with chemotherapy, compared to best supportive care. The treatment-associated toxicity needs to be evaluated. This study examines the secondary outcome measures for chemotherapy in advanced pancreatic cancer using meta-a...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/sj.bjc.6604436
更新日期：2008-07-08 00:00:00
abstract：:Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603140
更新日期：2006-05-22 00:00:00
abstract：:The UK National Case-Control Study Group has examined the relationship between smoking (both own smoking and passive), alcohol consumption and caffeine consumption and the risk of breast cancer. A total of 755 women with breast cancer diagnosed before the age of 36, each with an age-matched general population control,...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.258
更新日期：1994-07-01 00:00:00
abstract：:Patients affected by squamous cell carcinoma of the head and neck (HNSCC) show frequent occurrence of multiple cancers and widespread precancerous lesions in the mucosa of the upper respiratory tract, a phenomenon known as field cancerization. In this study, we investigated the role of genetic instability in the devel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.644
更新日期：1998-11-01 00:00:00
abstract：:This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,评审
doi：10.1038/sj.bjc.6690715
更新日期：1999-10-01 00:00:00
abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600780
更新日期：2003-02-24 00:00:00
abstract：:Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 solub...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.196
更新日期：1986-09-01 00:00:00
abstract：:BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.143
更新日期：1973-09-01 00:00:00
abstract：:Studies in animal tumour models of colorectal cancer suggest that F(ab')2 antibody fragments to carcinoembryonic antigen (CEA) labelled with iodine-131 give superior therapy compared with intact anti-CEA antibody. The purpose of this study was to investigate this hypothesis in patients. Ten patients received intact A5...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.338
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:The natural history of prostate cancer is highly variable and difficult to predict accurately. Better markers are needed to guide management and avoid unnecessary treatment. In this study, we validate the prognostic value of a cell cycle progression score (CCP score) independently and in a prespecified linea...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.223
更新日期：2015-07-28 00:00:00
abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.122
更新日期：1992-04-01 00:00:00
abstract：:HER2 / neu is a potential antigen candidate for immunotherapy because of its correlation to a poor prognosis and high expressions in many kinds of epithelial tumours. Especially in the colorectal carcinomas, the higher expression of HER2 / neu is recognized in metastatic regions as well as in primary sites. Several CT...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1547
更新日期：2001-01-05 00:00:00
abstract：:Small-cell lung cancers (SCLCs) initially respond to chemotherapy, but are often resistant at recurrence. The non-steroidal anti-inflammatory drug indomethacin is an inhibitor of multidrug resistance protein 1 (MRP1) function. The doxorubicin-resistant MRP1-overexpressing human SCLC cell line GLC(4)-Adr was highly sen...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604010
更新日期：2007-10-22 00:00:00
abstract：:Somatostatin receptor (sstr)-mediated radiation therapy is a new therapeutic modality for neuroendocrine (NE) tumours. High expression of sstr in NE tumours leads to tumour-specific uptake of radiolabelled somatostatin analogues and high absorbed doses. In this study, we present the first optimised radiation therapy v...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602845
更新日期：2005-11-14 00:00:00
abstract：:A regional cancer network has been set up in the Rhône-Alpes region in France. The aim of the project is to improve the quality of care and to rationalize prescriptions in the network. In this network, we assessed the impact of the implementation of a clinical practice guidelines project by assessing the conformity of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600057
更新日期：2002-02-01 00:00:00
