Serum laminin P1 in small cell lung cancer: a valuable indicator of distant metastasis?

abstract：BACKGROUND:Non-persistence and non-compliance are common in women prescribed hormonal therapy for breast cancer, but little is known about their influence on recurrence. METHODS:A nested case-control study of associations between hormonal therapy non-persistence and non-compliance and the risk of early recurrence in w...

journal_title：British journal of cancer

authors： Barron TI,Cahir C,Sharp L,Bennett K

更新日期：2013-09-17 00:00:00

abstract：BACKGROUND:To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. METHODS:A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and ...

journal_title：British journal of cancer

authors： Feng X,Song M,Preston MA,Ma W,Hu Y,Pernar CH,Stopsack KH,Ebot EM,Fu BC,Zhang Y,Li N,Dai M,Liu L,Giovannucci EL,Mucci LA

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:There is clinical evidence to suggest that tumour necrosis factor-α (TNF-α) may be a therapeutic target in renal cell carcinoma (RCC). Multi-targeted kinase inhibitors, such as sorafenib and sunitinib, have become standard of care in advanced RCC. The anti-TNF-α monoclonal antibody infliximab and sorafenib h...

journal_title：British journal of cancer

authors： Larkin JM,Ferguson TR,Pickering LM,Edmonds K,James MG,Thomas K,Banerji U,Berns B,de Boer C,Gore ME

更新日期：2010-10-12 00:00:00

abstract：:Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time th...

journal_title：British journal of cancer

authors： Igarashi K,Masaki T,Shiratori Y,Rengifo W,Nagata T,Hara K,Oka T,Nakajima J,Hisada T,Hata E,Omata M

更新日期：1999-10-01 00:00:00

abstract：:Anti-inflammatory corticosteroids administered to rats in high dosages before intravenous injection of allogeneic tumour cells caused 5-10 fold reductions in "take" and clonogenic growth of the cells in lung and kidney and decreased growth and spread of the cells transplanted to leg muscle. Steroid therapy also reduce...

journal_title：British journal of cancer

authors： Van Den Brenk HA,Kelly H,Orton C

更新日期：1974-05-01 00:00:00

abstract：:Cultured H35 hepatoma cells release a cytotoxic factor in response to irradiation with X-rays. When the conditioned medium from irradiated cells is given to nonirradiated cells, growth is inhibited and followed by cell death, possibly apoptosis, Analysis of the conditioned medium reveals a dramatic change in the ornit...

journal_title：British journal of cancer

authors： van Rijn J,van den Berg J,Teerlink T,Kruyt FA,Schor DS,Renardel de Lavalette AC,van den Berg TK,Jakobs C,Slotman BJ

更新日期：2003-02-10 00:00:00

abstract：:Patient participation in medical consultations has been demonstrated to benefit their subsequent psychological well being. Question asking is one way in which patients can be active. We investigated 2 means of promoting cancer patient question asking. One was the provision of a question prompt sheet to patients prior ...

journal_title：British journal of cancer

authors： Brown RF,Butow PN,Dunn SM,Tattersall MH

更新日期：2001-11-02 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes assoc...

journal_title：British journal of cancer

authors： Kurozumi S,Joseph C,Sonbul S,Alsaeed S,Kariri Y,Aljohani A,Raafat S,Alsaleem M,Ogden A,Johnston SJ,Aleskandarany MA,Fujii T,Shirabe K,Caldas C,Ashankyty I,Dalton L,Ellis IO,Desmedt C,Green AR,Mongan NP,Rakha EA

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to that of standard chemotherapy, has not been evaluated. METHODS:Patients were randomly assigned to the control arm or the Ki-67 response-guided arm (Ki-67 arm). Primary ...

journal_title：British journal of cancer

authors： Mukai H,Yamaguchi T,Takahashi M,Hozumi Y,Fujisawa T,Ohsumi S,Akabane H,Nishimura R,Takashima T,Park Y,Sagara Y,Toyama T,Imoto S,Mizuno T,Yamashita S,Fujii S,Uemura Y

更新日期：2020-06-01 00:00:00

abstract：:The relation between pretreatment night-time urinary catecholamine excretion and chemotherapy-induced nausea and vomiting was studied. The first cohort included 17 women and three men with various cancer forms receiving low or moderately emetogenic chemotherapy. The second cohort included 42 women receiving cisplatinu...

journal_title：British journal of cancer

authors： Fredrikson M,Hursti TJ,Steineck G,Fürst CJ,Börjesson S,Peterson C

更新日期：1994-10-01 00:00:00

abstract：INTRODUCTION:We investigated the association between socioeconomic position, stage at diagnosis, and length of period between referral and diagnosis in a nationwide cohort of lung cancer patients. METHODS:Through the Danish Lung Cancer Register, we identified 18,103 persons diagnosed with lung cancer (small cell and n...

journal_title：British journal of cancer

authors： Dalton SO,Frederiksen BL,Jacobsen E,Steding-Jessen M,Østerlind K,Schüz J,Osler M,Johansen C

更新日期：2011-09-27 00:00:00

abstract：:By using a quantitative RNA-RNA solution hybridisation method, the average number of mdr1 RNA transcripts per cell was measured in total nucleic acid extracts of leukaemic cells from patients with acute leukaemia. The results in different types of leukaemia were (number of patients with detectable mdr1 RNA/total numbe...

journal_title：British journal of cancer

authors： Gruber A,Vitols S,Norgren S,Areström I,Peterson C,Björkholm M,Reizenstein P,Luthman H

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Therapies targeting ERBB2 have shown success in the clinic. However, response is not determined solely by expression of ERBB2. Levels of ERBB3, its preferred heterodimerisation partner and ERBB ligands may also have a role. METHODS:We measured NRG1 expression by real-time quantitative RT-PCR and ERBB recept...

journal_title：British journal of cancer

authors： Forster JA,Paul AB,Harnden P,Knowles MA

更新日期：2011-03-29 00:00:00

abstract：:In the present study the putative chemopreventive effect of dietary fish oil (MaxEPA) on azaserine-induced pancreatic carcinogenesis in rats was investigated. Groups of rats were maintained on a semipurified low-fat (LF; 5 wt%) diet or on semipurified high-fat (HF; 25 wt%) diets containing 5 wt% linoleic acid (LA) and...

journal_title：British journal of cancer

authors： Appel MJ,Woutersen RA

更新日期：1996-01-01 00:00:00

abstract：:Immunofluorescent assessment of hormone receptors in melanocytic tumours is quite feasible without loss of diagnostic material, in contrast to the impracticability of quantitative biochemical assays. Using this method, oestrogen receptors were demonstrated in 4/6, and progesterone receptors in 3/5 patients with metast...

journal_title：British journal of cancer

authors： Thompson AJ,Cook MG,Gill PG

更新日期：1981-05-01 00:00:00

abstract：:We investigated the predictors of the risk of developing a second primary cancer after breast cancer, this occurring in about 12% of affected women. The analysis included 335 191 females, registered in the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) database, who had been diagnosed wit...

journal_title：British journal of cancer

authors： Raymond JS,Hogue CJ

更新日期：2006-06-05 00:00:00

abstract：:The response of a transplantable rat fibrosarcoma, RIB(5), to a single injection of 100 mg/kg body weight of cyclophosphamide, 0·5, 1, 2 and 3 days after treatment, has been studied by means of a morphometric analysis of tumour sections and has been compared to the changes occurring in untreated tumours. The results s...

journal_title：British journal of cancer

authors： Peel S,Cowen DM

更新日期：1973-01-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...

journal_title：British journal of cancer

authors： Ording AG,Veres K,Farkas DK,Adelborg K,Sørensen HT

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Activated anaplastic lymphoma kinase (ALK) gene fusions are recurrent events in a small fraction of colorectal cancers (CRCs), although these events have not yet been exploited as in other malignancies. METHODS:We detected ALK protein expression by immunohistochemistry and gene rearrangements by fluorescenc...

journal_title：British journal of cancer

authors： Amatu A,Somaschini A,Cerea G,Bosotti R,Valtorta E,Buonandi P,Marrapese G,Veronese S,Luo D,Hornby Z,Multani P,Murphy D,Shoemaker R,Lauricella C,Giannetta L,Maiolani M,Vanzulli A,Ardini E,Galvani A,Isacchi A,Sartore

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) has been proposed to guide breast cancer surgery by measuring residual tumour after neoadjuvant chemotherapy. This study-level meta-analysis examines MRI's agreement with pathology, compares MRI with alternative tests and investigates consistency between different measures of...

journal_title：British journal of cancer

authors： Marinovich ML,Macaskill P,Irwig L,Sardanelli F,von Minckwitz G,Mamounas E,Brennan M,Ciatto S,Houssami N

更新日期：2013-09-17 00:00:00

abstract：:A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu. MDX-H210, constructed by crosslinking antigen binding fragments (F(ab') fragments) of monoclonal antibody (mAb) H22 to Fc ...

journal_title：British journal of cancer

authors： Repp R,van Ojik HH,Valerius T,Groenewegen G,Wieland G,Oetzel C,Stockmeyer B,Becker W,Eisenhut M,Steininger H,Deo YM,Blijham GH,Kalden JR,van de Winkel JG,Gramatzki M

更新日期：2003-12-15 00:00:00

abstract：:High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with neoadjuvant S-1/cisplatin chemotherapy. Paraffin sections of pretreatment biopsy and surgical specimens from 41 gastric cancers ...

journal_title：British journal of cancer

authors： Kamoshida S,Suzuki M,Shimomura R,Sakurai Y,Komori Y,Uyama I,Tsutsumi Y

更新日期：2007-01-29 00:00:00

abstract：:Oestrogen receptor (ER) is used routinely to predict endocrine responsiveness in patients with breast cancer. A second ER, ERbeta has been described but its significance remains undefined; most studies have described mRNA levels rather than protein expression. Here, we demonstrate for the first time, immunohistochemic...

journal_title：British journal of cancer

authors： Skliris GP,Carder PJ,Lansdown MR,Speirs V

更新日期：2001-04-20 00:00:00

abstract：:Thirty patients with previously treated metastatic breast cancer were entered in a phase II study with oral lonidamine. Twenty-eight patients are evaluable for toxicity and 25 for response. A partial remission was obtained in four patients (16%) and disease stability in 11 (44%): 10 patients progressed (40%). Toxicity...

journal_title：British journal of cancer

authors： Pronzato P,Amoroso D,Bertelli G,Conte PF,Cusimano MP,Ciottoli GB,Gulisano M,Lionetto R,Rosso R

更新日期：1989-02-01 00:00:00

abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...

journal_title：British journal of cancer

authors： Morrison AS,Verhoek WG,Leck I,Aoki K,Ohno Y,Obata K

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...

journal_title：British journal of cancer

authors： Sahebjam S,Aloyz R,Pilavdzic D,Brisson ML,Ferrario C,Bouganim N,Cohen V,Miller WH Jr,Panasci LC

更新日期：2011-10-25 00:00:00

abstract：BACKGROUND:The PI3K/Akt signalling pathway, induced by epidermal growth factor receptor (EGFR) and Her-2, is involved in the constitutive activation of NF-kappaB in prostate cancer cell lines. In this study, we extended the in vitro observation using an ex vivo model of prostate cancer tissues and assessed the prognost...

journal_title：British journal of cancer

authors： Koumakpayi IH,Le Page C,Mes-Masson AM,Saad F

更新日期：2010-03-30 00:00:00

abstract：:Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERc) in malignant breast were 21-1102 fmol mg-1 soluble protein (Kd 1.8 X 10(-9)-3.1 X 10(-8) mol l-1) and those of nucleosolic ER (ERn), 13-526 fmol mg-1 solub...

journal_title：British journal of cancer

authors： Iqbal MJ,Colletta AA,Houmayoun-Valyani SD,Baum M

更新日期：1986-09-01 00:00:00

abstract：:We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tu...

journal_title：British journal of cancer

authors： Harbeck N,Untch M,Pache L,Eiermann W

更新日期：1994-03-01 00:00:00

abstract：:We have established a highly sensitive and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect axillary lymph node metastases of breast cancer. Amplifying cytokeratin 19 (CK19) mRNA transcripts using real-time TaqMan PCR made it possible to quantify axillary metastatic burden. Metast...

journal_title：British journal of cancer

authors： Inokuchi M,Ninomiya I,Tsugawa K,Terada I,Miwa K

更新日期：2003-11-03 00:00:00