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A key genomic subtype associated with lymphovascular invasion in invasive breast cancer.

Abstract：

BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes associated with LVI in early-stage BC patients. METHODS:Gene expression data from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort (n = 1565) was used as a discovery dataset, and The Cancer Genome Atlas (TCGA; n = 854) cohort was used as a validation dataset. Key genes were identified on the basis of differential mRNA expression with respect to LVI status as characterised by histological review. The relationships among LVI-associated genomic subtype, clinicopathological features and patient outcomes were explored. RESULTS:A 99-gene set was identified that demonstrated significantly different expression between LVI-positive and LVI-negative cases. Clustering analysis with this gene set further divided cases into two molecular subtypes (subtypes 1 and 2), which were significantly associated with pathology-determined LVI status in both cohorts. The 10-year overall survival of subtype 2 was significantly worse than that of subtype 1. CONCLUSION:This study demonstrates that LVI in BC is associated with a specific transcriptomic profile with potential prognostic value.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Kurozumi S,Joseph C,Sonbul S,Alsaeed S,Kariri Y,Aljohani A,Raafat S,Alsaleem M,Ogden A,Johnston SJ,Aleskandarany MA,Fujii T,Shirabe K,Caldas C,Ashankyty I,Dalton L,Ellis IO,Desmedt C,Green AR,Mongan NP,Rakha EA

doi

10.1038/s41416-019-0486-6

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1129-1136

issue

12

eissn

0007-0920

issn

1532-1827

pii

10.1038/s41416-019-0486-6

journal_volume

120

pub_type

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