Abstract:
BACKGROUND:The PI3K/Akt signalling pathway, induced by epidermal growth factor receptor (EGFR) and Her-2, is involved in the constitutive activation of NF-kappaB in prostate cancer cell lines. In this study, we extended the in vitro observation using an ex vivo model of prostate cancer tissues and assessed the prognostic significance of the PI3K/Ak/NF-kappaB signalling determinants. METHODS:We analysed a prostate cancer tissue microarray of 63 patients for the expression of total and activated EGFR, Her-2 receptors and the signalling molecules PTEN, phospho-PTEN, Akt, phospho-Akt and the NF-kappaB subunit p65. Data were analysed using Spearman's rho test, Kaplan-Meier curves and multivariate Cox regression analysis. In addition, a non-supervised hierarchical clustering analysis was applied to stratify patients according to prognostic groups in terms of risk of recurrence. RESULTS:The concomitant overexpression of activated EGFR and Her-2 was correlated with the nuclear expression of NF-kappaB. EGFR, phospho-EGFR, phospho-Her-2, ErbB3 and nuclear NF-kappaB were associated with the overall biochemical recurrence (BCR) of patients. The non-supervised hierarchical clustering analysis resulted in the separation of patients into five groups according to BCR. CONCLUSIONS:These results validate the previous in vitro data on ErbB involvement in NF-kappaB activation and shows evidence for a significant role of ErbB/PI3K/Akt/NF-kappaB signalling in the progression of prostate cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Koumakpayi IH,Le Page C,Mes-Masson AM,Saad Fdoi
10.1038/sj.bjc.6605571subject
Has Abstractpub_date
2010-03-30 00:00:00pages
1163-73issue
7eissn
0007-0920issn
1532-1827pii
6605571journal_volume
102pub_type
杂志文章abstract:BACKGROUND:Previous studies showed an increased risk of thyroid cancer among children and adolescents exposed to radioactive iodines released after the Chornobyl (Chernobyl) accident, but the effects of screening, iodine deficiency, age at exposure and other factors on the dose-response are poorly understood. METHODS:...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605967
更新日期:2011-01-04 00:00:00
abstract::Four human melanoma xenograft lines (A-07, D-12, R-18, U-25) grown orthotopically in Balb/c nu/nu mice were characterized with respect to the fraction of radiobiologically hypoxic cells. The purpose of the study was to establish a firm radiobiological basis for future use of the lines in the development and evaluation...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.598
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Panobinostat, a pan-deacetylase inhibitor, overcomes imatinib resistance in preclinical models of gastrointestinal stromal tumours (GIST). Here we determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of panobinostat in combination with imatinib (IM) for treatment of patients with re...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.826
更新日期:2014-03-04 00:00:00
abstract::Mutation and overexpression are the main activating mechanisms for the ras family of genes in human cancer and the variable tandem repeat (VTR) located at the 3' end of H-ras has been associated with this risk. In the present study, we have analysed the relative levels of expression of H-ras mRNA in 26 samples of squa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.287
更新日期:1995-07-01 00:00:00
abstract::In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.5
更新日期:1993-01-01 00:00:00
abstract::The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curativ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601202
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.223
更新日期:2014-05-27 00:00:00
abstract::In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1994.385
更新日期:1994-10-01 00:00:00
abstract::The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with advanced breast cancer, respectively. The patients in each group were drawn from two separate populations, but the mean a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.223
更新日期:1985-10-01 00:00:00
abstract::Growth of the transplantable EMR-86 rat mammary carcinoma depends on elevated prolactin levels which are induced by oestrogenic stimulation of the pituitary. We investigated histological and cell kinetic changes during tumour regression after removal of implanted oestrogen pellets (EP), and we especially focused on th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.232
更新日期:1996-05-01 00:00:00
abstract::We have investigated both the effects of X-rays on angiogenesis and the possible role of nitric oxide (NO) on the observed antiangiogenic effect of X-rays, using as an in vivo model the chick embryo chorioallantoic membrane (CAM). These effects were assessed both morphologically and biochemically, by measuring vascula...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.653
更新日期:1996-12-01 00:00:00
abstract::Thirty patients with previously treated metastatic breast cancer were entered in a phase II study with oral lonidamine. Twenty-eight patients are evaluable for toxicity and 25 for response. A partial remission was obtained in four patients (16%) and disease stability in 11 (44%): 10 patients progressed (40%). Toxicity...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.51
更新日期:1989-02-01 00:00:00
abstract::The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6600780
更新日期:2003-02-24 00:00:00
abstract::The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.45
更新日期:1981-03-01 00:00:00
abstract::The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between Ja...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.466
更新日期:1997-01-01 00:00:00
abstract::Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1975.284
更新日期:1975-12-01 00:00:00
abstract::Fifty patients affected by histologically confirmed gastrointestinal tract cancer (GTC) were treated with oral tegafur (TG) 1,000 mg m-2 p.o. on days 1-14 repeated after a 14 day interval. Out of 42 evaluable patients seven patients had a partial response (PR. 17%) with a median duration of 20.5 weeks, three had a min...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.105
更新日期:1990-03-01 00:00:00
abstract::We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690313
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND:Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS:We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Appl...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.438
更新日期:2017-01-01 00:00:00
abstract::In vitro cloned lines derived from a primary nickel-induced rat rhabdomyosarcoma exhibited diverse levels of susceptibility to spontaneous NK activity. The presence of NK target structures was revealed by competition assays on all cloned cell lines, and the NK susceptibility of the tumour lines varied according to the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1983.159
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:We used bleomycin, etoposide, cisplatin (BEP), the most effective regimen in the treatment of germ cell tumours (GCTs) and increased dose-density by using pegfilgrastim to shorten cycle length. Our aim was to assess safety and tolerability. METHODS:Sixteen male patients with intermediate or poor prognosis m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.309
更新日期:2011-09-06 00:00:00
abstract::Recent studies indicate that cancer antigen 125 (CA125) response criteria tend to overestimate a tumour reduction measured by standard WHO response criteria in recurrent epithelial ovarian carcinoma. The aim of the study was to validate the recently introduced GCIG (The Gynaecological Cancer Intergroup) CA125 response...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6601501
更新日期:2004-01-26 00:00:00
abstract::The ability of the sister chromatid exchange (SCE) assay to detect heterogeneity in intrinsic radiation sensitivity was investigated. In order to identify tumour cell subpopulations, frequency histograms of cis-diamminedichloroplatinum (II) (cPt)-induced SCEs were generated and compared to those from cultures that had...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.11
更新日期:1989-01-01 00:00:00
abstract::In the past decade, an increasing number of frequently positive randomised clinical trials have been completed, allowing new consideration of the present therapeutic armamentarium for advanced renal cell carcinoma. These studies were predominantly designed to compare the experimental drugs with 1 of 2 active control a...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2014.240
更新日期:2015-01-06 00:00:00
abstract:BACKGROUND:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. METHODS:Participant...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.386
更新日期:2012-10-09 00:00:00
abstract::The combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha) has reported activity in the treatment of advanced colorectal carcinoma. Laboratory studies of IFN-beta suggest that this agent may offer theoretical advantages over IFN-alpha in combination with 5-FU. A total of 27 patients with advanced or rec...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1997.69
更新日期:1997-01-01 00:00:00
abstract::We assayed methyl-p-hydroxyphenyllactate esterase (MeHPLAase) activity in 63 cases of primary laryngeal squamous cell carcinoma. MeHPLAase activity did not show any correlation with oestrogen, progesterone and epidermal growth factor (EGF) receptor levels. No significant relationship was found between MeHPLAase activi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.210
更新日期:1998-04-01 00:00:00
abstract::A central role in anal carcinogenesis of high-risk types of human papillomaviruses (hrHPV) was recently established, but the possible role of benign anal lesions has not been addressed in hrHPV-positive and -negative anal cancers. As part of a population-based case-control study in Denmark and Sweden, we interviewed 4...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.719
更新日期:1998-12-01 00:00:00
abstract::A population-based, case-control study was conducted in Los Angeles County, California, to investigate the inter-relationships of obesity, hypertension and medications in relation to renal cell carcinoma (RCC) risk. A total of 1204 RCC patients and an equal number of neighbourhood controls were included. Obesity was a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.248
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS:The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clonogenic survival assays. Expression of DNA repair genes and enzymes...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.403
更新日期:2012-10-09 00:00:00