Abstract：
:The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between January 1987 and November 1990 were investigated. Three mouse monoclonal antibodies--T2-101 against TIMP-2, CA-4001 against MMP-2 and GE-213 against MMP-9--were used. Positive expression of TIMP-2 (a) in basement membranes and (b) diffusely in stroma with (c) subglandular enhancement was found significantly (P < 0.01, P < 0.05, P < 0.05) more often in localized tumours than in tumours with regional or distant metastases. Neither pattern correlated with tumour differentiation. Patterns (a) and (c) correlated with longer survival time (P < 0.05); (b) reached near significance (P < 0.07). When the survival analyses were restricted to potentially cured patients, neither pattern could foretell death from cancer. Positive expression of MMP-2 in tumour epithelium and of MMP-9 in tumour-infiltrating macrophages were both independent of tumour stage and were without correlation with survival time. A large number of MMP-9-positive macrophages correlated (P < 0.05) with poor tumour differentiation, whereas weak or absent epithelial MMP-2 staining reached near significance (P < 0.08). Exploration of TIMP-2 expression is valuable for the discrimination between macroscopically localized and metastatic colorectal cancer, but it cannot predict which of the potentially cured patients are likely to have micrometastases. MMP-2 and MMP-9 stainings are of minor value in staging and prognostic prediction.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Ring P,Johansson K,Höyhtyä M,Rubin K,Lindmark Gdoi
10.1038/bjc.1997.466subject
Has Abstractpub_date
1997-01-01 00:00:00pages
805-11issue
6eissn
0007-0920issn
1532-1827journal_volume
76pub_type
杂志文章abstract：:Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antige...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600507
更新日期：2002-09-23 00:00:00
abstract：:Between 1946 and 1976 over 9,000 women with breast cancer were seen within one year of diagnosis at the A. Maxwell Evans Clinic (AMEC) in Vancouver, British Columbia. By 1978, 275 had a subsequent diagnosis of a second primary in the contralateral breast: 100 were diagnosed within 1 year, and 175 after 1 year of the f...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.12
更新日期：1984-01-01 00:00:00
abstract：:The objective of this study was to examine the relationship between educational level and mortality from cancer in the city of Barcelona. The data were derived from a record linkage between the Barcelona Mortality Registry and the Municipal Census. The relative risks (RR) of death and 95% confidence intervals (CIs) ac...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690108
更新日期：1999-02-01 00:00:00
abstract：:The presence or absence of lymphocytic mucopolysaccharides (MPS) is studied in 223 subjects: 100 normals (controls); 8 cancer patients cured for more than 6 years; 30 cancer patients at the start of their treatment; and 85 relatives of first degree consanguinity of these last patients. The data are studied by statisti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.147
更新日期：1973-09-01 00:00:00
abstract：:Fine needle aspiration (FNA) biopsy is the least invasive method of sampling breast cancer in vivo and provides material for breast cancer diagnosis. FNA has also been used to examine cellular markers to predict and monitor the effects of therapy. The aim of this study was to assess the accuracy of using FNA material ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2064
更新日期：2001-10-19 00:00:00
abstract：:Window of opportunity trials exploit the 'window' of time after cancer diagnosis, typically prior to initiation of cancer therapy. In recent years this study design has become a more regular feature of drug development, as this 'window' provides an opportunity to carry out a thorough pharmacodynamic assessment of a th...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/s41416-019-0621-4
更新日期：2020-01-01 00:00:00
abstract：:To assist in the description of the cellular heterogeneity present in normal and neoplastic urothelium, a panel of monoclonal antibodies (MoAbs) was raised against human transitional cell carcinoma (TCC) of the urinary bladder. All immunizations were carried out using whole cells and membrane preparations from well di...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.220
更新日期：1987-10-01 00:00:00
abstract：:The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1400
更新日期：2000-10-01 00:00:00
abstract：:The purpose of the study was to determine the response rates (RR) and duration to second- and third-line chemotherapy programmes in patients with anthracycline-resistant breast cancer, utilizing various definitions of anthracycline resistance. This was a retrospective analysis performed on 1335 patients with metastati...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.0958
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:The vascular disrupting agent combretastatin A4 phosphate (CA4P) causes major regression of animal tumours when given as combination therapy. METHODS:Patients with advanced cancer refractory to standard therapy were treated with CA4P as a 10-min infusion, 20 h before carboplatin, paclitaxel, or paclitaxel, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605650
更新日期：2010-04-27 00:00:00
abstract：:In the early period following radical hepatectomy for hepatoma, recurrences in the remaining liver are frequently found. In regenerating liver, implantation and growth of tumour cells released into the portal system during surgical treatment might be promoted. We examined the relationship between liver regeneration an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.170
更新日期：1992-06-01 00:00:00
abstract：:BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) is an agent which stabilises oxyhaemoglobin and thus reduces oxygen delivery to tissues. It is of interest as a possible potentiator of bioreductive agents and/or hyperthermia. The increases in radiobiological hypoxic fraction of RIF-1 and KHT tumours 30 min after 7...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.387
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND:The Obermair nomogram was recently developed to predict the risk of relapse in patients with borderline ovarian tumours (BOTs) based on five readily available clinical, biological, and pathological characteristics. We set out to externally validate and assess its robustness using a multi-institutional BOT da...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2013.678
更新日期：2013-11-26 00:00:00
abstract：BACKGROUND:Stathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin's role on the metastatic process, we performed integrated mRNA-miRNA expression analysis to identify pathways regulated by stathmin. METHODS:MiRNA and gene arrays followed by miRNA-target-gene integration...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0669-1
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0933-4
更新日期：2020-09-01 00:00:00
abstract：:Oesopharyngeal brush (OPB) sampling with cytological analysis can yield exfoliated cells from asymptomatic tumours of the upper aero-digestive tract and the oesophagus. In this study, we compared cytological evaluation and molecular analysis for the detection of exfoliated cancer cells sampled with an OPB. A total of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600953
更新日期：2003-06-02 00:00:00
abstract：:Nineteen benign human breast tumours, from 19 premenopausal patients, were processed into slices and each tumour was individually cultured for 2 days in Medium 199. The effects of bovine insulin (5.0 microgram/ml) human placental lactogen (10.0 microgram/ml) and human growth hormone (10.0 microgram/ml) on 3H-thymidine...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.196
更新日期：1978-08-01 00:00:00
abstract：:Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.27
更新日期：1987-02-01 00:00:00
abstract：:Sera from breast cancer patients and from female controls were tested for inhibition of lysis of antibody-coated target cells by human leukocytes (K cells). Sera from 39% of breast cancer patients, but from only 8% of controls, inhibited lysis by more than 30%. This inhibition was unrelated to the stage of the disease...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.224
更新日期：1976-12-01 00:00:00
abstract：BACKGROUND:Childhood cancer survival estimates from developing nations are rare. METHODS:Using the US SEER and the Manila and Rizal Cancer Registry databases in the Philippines, 5-year survival for childhood leukaemia and lymphoma in 2001-2005 among Asian Americans were compared with both Filipinos and Caucasians in t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605703
更新日期：2010-06-29 00:00:00
abstract：:We conducted a case-control study to investigate the role of early infections in the aetiology of childhood acute leukaemias. The study included 280 incident cases (240 acute lymphoblastic leukaemia and 40 acute non-lymphoblastic leukaemia) and 288 hospital controls, frequency matched by age, gender, hospital, catchme...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600091
更新日期：2002-04-08 00:00:00
abstract：:In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.75
更新日期：1987-04-01 00:00:00
abstract：:Initial glycosylation of mucin-type O-linked protein is catalysed by one of the UDP-GalNAc: polypeptide N-acetyl-galactosaminyl transferase-3 (GalNAc-T3). O-glycosylation is important in the binding of cell adhesion molecules, cell differentiation, invasion, and metastasis in tumours. This study was designed to detect...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601531
更新日期：2004-01-26 00:00:00
abstract：:Multidrug resistance (MDR) is the major confounding factor in adjuvant solid tumour chemotherapy. Increasing intracellular amounts of chemotherapeutics to circumvent MDR may be achieved by a novel delivery method, photochemical internalisation (PCI). PCI consists of the co-administration of drug and photosensitiser; u...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603895
更新日期：2007-08-20 00:00:00
abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1301
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0892-9
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.129
更新日期：2012-05-08 00:00:00
abstract：:The expression of peroxisome proliferator-activated receptor (PPAR)gamma in thyroid neoplasias and in normal thyroid (NT) tissues has not been fully investigated. The objectives of the present work were: to study and compare the relative expression of PPARgamma in normal, benign and malignant thyroid tissues and to co...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601989
更新日期：2004-08-16 00:00:00
abstract：:It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic "nitrosamides" a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.169
更新日期：1973-11-01 00:00:00
abstract：:A set of monoclonal antibodies was constructed by immunising mice with peptide fragments of the c-myc oncogene product. One such antibody, Myc 1-6E10 was shown to bind to a 62,000 dalton protein identifiable with the c-myc product (p62c-myc). The antigen recognised was not destroyed by paraffin wax embedding. Myc 1-6E...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.174
更新日期：1985-08-01 00:00:00
