Abstract：
:The presence or absence of lymphocytic mucopolysaccharides (MPS) is studied in 223 subjects: 100 normals (controls); 8 cancer patients cured for more than 6 years; 30 cancer patients at the start of their treatment; and 85 relatives of first degree consanguinity of these last patients. The data are studied by statistical and genetic analysis. The results confirm the findings reported earlier and show that the difference in the probability of a high frequency of leucocytic MPS between the relatives of cancer patients and the controls is highly significant. Furthermore, this probability in a relative of first degree of consanguinity of a cancer patient is more than three times greater than in an individual of the general population. Genetic segregation analysis shows that the high leucocytic MPS trait segregates in the families of cancer patients after a classic pattern of dominant autosomal inheritance. Applying Falconer's nomogram it is concluded that the whole of this phenotypic variation is of genetic origin. Its interrelationships with cancer are discussed and it is postulated that this disturbance of the lymphocytic MPS represents a subclinical variant, not known until now, of the clinical mucopolysaccaridoses.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Riesco A,Cruz Coke Rdoi
10.1038/bjc.1973.147subject
Has Abstractpub_date
1973-09-01 00:00:00pages
269-74issue
3eissn
0007-0920issn
1532-1827journal_volume
28pub_type
杂志文章abstract：:We investigated the predictors of the risk of developing a second primary cancer after breast cancer, this occurring in about 12% of affected women. The analysis included 335 191 females, registered in the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) database, who had been diagnosed wit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603172
更新日期：2006-06-05 00:00:00
abstract：:NAD(P)H:quinone oxidoreductase (NQO1, EC 1.6.99.2) is an obligate two-electron reductase that can either bioactivate or detoxify quinones and has been proposed to play an important role in chemoprevention. We have previously characterized a homozygous point mutation in the BE human colon carcinoma cell line that leads...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.11
更新日期：1997-01-01 00:00:00
abstract：:New therapeutic strategies are now being developed against adenocarcinoma associated with erbB-2 amplification, particularly by inhibiting p185erbB-2 expression. Antisense oligodeoxynucleotides seem promising for this purpose as long as they are efficiently protected against degradation and targeted into the cells. We...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.238
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16INK4a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0964-x
更新日期：2020-09-01 00:00:00
abstract：:Intra-tumoural heterogeneity of proliferation has been assessed by taking multiple biopsies from 30 colorectal cancers. Following in vivo IUDR labelling, dual parameter flow cytometry was used to measure tumour DNA index (DI) and labelling index (LI) and to derive DNA synthesis time (Ts) and potential doubling time (T...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.376
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Previous studies have reported up to 50% of ductal carcinoma in situ (DCIS), is HER2 positive, but the frequency of HER2-positive invasive breast cancer (IBC) is lower. The aim of this study is to characterise HER2 status in DCIS and assess its prognostic value. METHODS:HER2 status was evaluated in a large ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0436-3
更新日期：2019-05-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) regulate colon cancer growth and metastasis. Previous studies utilizing antibodies against the VEGF receptor (DC101) or EGF receptor (C225) have demonstrated independently that these agents can inhibit tumour growth and induce apoptosis in col...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1936
更新日期：2001-08-17 00:00:00
abstract：BACKGROUND:Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CR...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.489
更新日期：2013-09-17 00:00:00
abstract：:Helix pomatia agglutinin (HPA)- and Concanavalin A (Con A)-binding carbohydrate expression were studied on 32 tumour samples from primary adenocarcinoma of the breast and 12 samples from lymph node metastases. Live cells were spilled from each of the fresh samples and the extent of fluorescent-labelled HPA and Con A-b...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.267
更新日期：1990-08-01 00:00:00
abstract：:To investigate possible relationships between genetic alterations and hormonal deregulation during breast cancer development and/or progression, we examined 616 primary breast cancers for loss of heterozygosity (LOH) at chromosomal regions 16q24, 17p13.3 and 17q21, and for amplifications of the ERBB2 and c-MYC loci. A...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.89
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:The National Comprehensive Cancer Network (NCCN) guidelines provide recommendations for staging of prostate cancer patients in the objective regarding presence of locoregional lymph node metastases (LNM) and bone metastases. We tested the performance characteristics of these recommendations in a community se...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0323-3
更新日期：2018-12-01 00:00:00
abstract：:Several diseases are known or suspected to be associated with altered levels of hormones and growth factors that may influence breast cancer risk. To elucidate this possibility, we studied the relationship between 23 medical conditions or procedures and breast cancer risk by means of data from a multicentric case-cont...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.289
更新日期：1997-01-01 00:00:00
abstract：:Regional chemotherapy is commonly used to treat patients with colorectal liver metastases. However, improvement in survival has still not been demonstrated. Cytotoxic loaded albumin microspheres for arterial administration have been described as a means of improving the the therapeutic index, but their distribution de...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.252
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment options. PDAC cells shift their metabolism towards glycolysis, which fuels the plasma membrane calcium pump (PMCA), thereby preventing Ca2+-dependent cell death. The ATP-generating pyruvate kinase-M2 (PKM2) is oncogenic and overexpressed...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0675-3
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0288-2
更新日期：2018-10-01 00:00:00
abstract：:MDM2 is an oncoprotein that inhibits p53 tumour-suppressor protein. Amplification of the MDM2 gene and overexpression of its protein have been observed in some human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To determine the clinicopathological and prognos...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.221
更新日期：1997-01-01 00:00:00
abstract：:High response rates have been reported in the treatment of advanced gastric cancer with epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF), including instances of unresectable disease being rendered operable by chemotherapy. We report our experience with ECF as neoadjuvant treatment in gastric and lowe...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1996.604
更新日期：1996-11-01 00:00:00
abstract：:Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resectio...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604177
更新日期：2008-02-12 00:00:00
abstract：:A substantial excess risk of lymphomas and nonmelanoma skin cancer has been demonstrated following organ transplantation. Large sample size and long follow-up time may, however, allow more accurate risk estimates and detailed understanding of long-term cancer risk. The objective of the study was to assess the risk of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601219
更新日期：2003-10-06 00:00:00
abstract：:The ultrastructure of two lymphoblastoid cell lines derived from Marek's disease lymphomata has been studied. The cells varied from 5 to 12 mum in diameter and had large round or oval nuclei. A nucleolus was occasionally present and about 3% of cells showed projections of the nuclear envelope. The cytoplasm contained ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.2
更新日期：1975-01-01 00:00:00
abstract：BACKGROUND:The role of tumour-infiltrating inflammation in the prognosis of patients with colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta-analysis was to determine the impact of tumour-infiltrating inflammation on survival outcomes. METHODS:Ovid MEDLINE and EMBASE were searched ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/bjc.2014.46
更新日期：2014-03-18 00:00:00
abstract：:A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters available at day 1 would be easier in daily practice. The objectives of this work were (1) to investigate a risk mod...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6600724
更新日期：2003-01-27 00:00:00
abstract：:For the first time in a clinical study oral Ifosfamide was used: 65 elderly or unfit patients with small cell lung cancer (SCLC) were treated as outpatients with fractionated oral Ifosfamide and Etoposide. Forty patients (62%) had extensive stage (ED) disease. The median age of the patients was 66 years. In the 60 pat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.265
更新日期：1989-08-01 00:00:00
abstract：:The antiapoptotic Livin/ML-IAP gene has recently gained much attention as a potential new target for cancer therapy. Reports indicating that livin is expressed almost exclusively in tumours, but not in the corresponding normal tissue, suggested that the targeted inhibition of livin may present a novel tumour-specific ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604028
更新日期：2007-11-05 00:00:00
abstract：:We examined the association between magnetic field (MF) exposure and survival among children with acute lymphoblastic leukaemia (ALL) treated at 51 Pediatric Oncology Group centres between 1996 and 2001. Of 1672 potentially eligible children under treatment, 482 (29%) participated and personal 24-h MF measurements wer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602916
更新日期：2006-01-16 00:00:00
abstract：:Cell viability following short (1 h) contact with paclitaxel or docetaxel was assayed using synchronised HeLa cells. Docetaxel proved almost totally lethal against S-phase cells. Its toxicity was only partial against cells in mitosis, and declined to a minimum with progression to G1. For paclitaxel, cytotoxicity incre...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.232
更新日期：1995-06-01 00:00:00
abstract：:We analysed 26 metastases from 25 patients with sporadic cutaneous malignant melanoma for alterations in the CDKN2 gene by a combined polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP)/nucleotide sequencing approach. Eleven alterations (one in exon 1, five in exon 2 and five in the 3' non-cod...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.59
更新日期：1996-02-01 00:00:00
abstract：:Metastatic variant sublines of the murine large-cell lymphoma cell line RAW117 were tested for their growth and migration properties in vitro in medium conditioned by soluble factors released from syngeneic mouse liver-, lung-, and brain-derived microvessel endothelial cells. Medium conditioned with hepatic sinusoidal...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.269
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:Patients with high-grade gliomas are treated with surgery followed by chemoradiation. The risk factors and implications of neurological side effects are not known. METHODS:Acute and late ≥ grade 3 neurological toxicities (NTs) were analysed among 2761 patients from 14 RTOG trials accrued from 1983 to 2003. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.123
更新日期：2011-04-26 00:00:00
abstract：:The reactivation of U.V.-irradiated adenovirus 2 in HeLa cells is enhanced 8-9 fold if the cells are given a brief hyperthermic shock before infection. Maximum reactivation is achieved by heating for 10 min at 45.5 degrees C and with a delay of 36 h between heating and infection. The induction process requires protein...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.32
更新日期：1984-02-01 00:00:00
