Abstract:
:The ultrastructure of two lymphoblastoid cell lines derived from Marek's disease lymphomata has been studied. The cells varied from 5 to 12 mum in diameter and had large round or oval nuclei. A nucleolus was occasionally present and about 3% of cells showed projections of the nuclear envelope. The cytoplasm contained many ribosomes and several mitochondria but endoplasmic reticulum was sparse. A small number of cells contained annulate lamellae and crystalline structures were occasionally seen. Cells with immature intranuclear herpesvirus particles were rarely present. The cells had many ultrastructural features in common with Burkitt's lymphoma-derived cell lines.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Frazier JA,Powell PCdoi
10.1038/bjc.1975.2subject
Has Abstractpub_date
1975-01-01 00:00:00pages
7-14issue
1eissn
0007-0920issn
1532-1827journal_volume
31pub_type
杂志文章abstract::Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690365
更新日期:1999-05-01 00:00:00
abstract::We present the cytogenetic investigations of five histiocytic tumour lesions from children. In four cases there was a confirmed diagnosis of Langerhans cell histiocytosis (LCH) and one case of histiocytosis that did not fulfil all the criteria for true LCH. All five cases showed cytogenetic abnormalities, including th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.89
更新日期:1998-02-01 00:00:00
abstract::Previous studies have reported inconsistent results regarding the modifying effect of hormone replacement therapy (HRT) on the association of body mass index (BMI) and the risk of colorectal cancer (CRC) among postmenopausal women. We assessed the use of HRT and BMI in 208 postmenopausal women with histologically conf...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604066
更新日期:2007-12-03 00:00:00
abstract:BACKGROUND:To date, there are few reports on gene products contributing to colon cancer progression. METHODS:We used a gene trap comprised of an enhanced retroviral mutagen (ERM) cassette that includes a tetracycline-responsive promoter upstream of a haemagglutinin (HA) tag and a splice donor site. Integration of the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605536
更新日期:2010-02-16 00:00:00
abstract::In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.293
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Childhood cancer survival estimates from developing nations are rare. METHODS:Using the US SEER and the Manila and Rizal Cancer Registry databases in the Philippines, 5-year survival for childhood leukaemia and lymphoma in 2001-2005 among Asian Americans were compared with both Filipinos and Caucasians in t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605703
更新日期:2010-06-29 00:00:00
abstract::Cultured cells maintained in very low oxygen levels alter their structure, metabolism and genetic expression. Culture conditions for cells were modified to minimise variation of nutrients and to allow normal survival levels after 24 h of hypoxic exposure. Under these hypoxic conditions, glucose consumption and lactate...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.264
更新日期:1990-08-01 00:00:00
abstract::The efficacy of high-dose chemotherapy (HDC) and circulating progenitor cell (CPC) transplantation in metastatic breast cancer (MBC) relies mainly on giving this treatment after a response to conventional induction chemotherapy has been achieved. For this reason an optimal mobilization regimen should be therapeuticall...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.231
更新日期:1997-01-01 00:00:00
abstract::An initial report suggested that patients homozygous for the arginine allele at codon 72 of P53 were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18-36% of head and neck cancers are HPV-related, we examined the genotypic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0993
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Four-and-a-half LIM domains protein 2 (FHL2) is a component of the focal adhesion structures and has been suggested to have a role in cancer progression. It has been shown to be overexpressed in the colorectal cancer (CRC). METHODS:Here, we examined a possible prognostic value of FHL2 in CRC. Immunohistoche...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.290
更新日期:2013-07-09 00:00:00
abstract::Screen-detected (SD) breast cancers are smaller and biologically more indolent than clinically presenting cancers. An often debated question is: if left undiagnosed during their preclinical phase, would they become more aggressive or would they only increase in size? This study considered a registry-based series (1988...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602289
更新日期:2005-01-17 00:00:00
abstract::The cell population kinetics of the transmissible venereal tumour of the dog was studied at two different stages of tumour growth using the labelled mitoses technique. At the first stage the tumours were growing with a doubling time of about 4 days; at the second stage their growth rate was limited, probably by an imm...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1972.54
更新日期:1972-10-01 00:00:00
abstract::Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its expression in pancreatic cancer has not yet been clinically reported. In this study, we investigated the relationship between CD133 expression and clinicopathological factors in pancreatic cancer. Pancreatic head carcinoma speci...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604307
更新日期:2008-04-22 00:00:00
abstract::With few exceptions, the major limit to high-dose chemotherapeutic treatments is the severity and duration of drug-induced myelosuppression. We have recently developed a monoclonal antibody, MAD11, which reacts with the potent anti-tumour antibiotic doxorubicin and other anthracyclines. To protect directly pluripotent...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.117
更新日期:1997-01-01 00:00:00
abstract::P-glycoprotein (P-gp) pumps multiple types of drugs out of the cell, using energy generated from ATP, and confers multidrug resistance (MDR) on cancer cells. ZD6474 is an orally active, selective inhibitor of the vascular endothelial growth factor receptor, epidermal growth factor receptor, and rearranged during trans...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603985
更新日期:2007-10-08 00:00:00
abstract:BACKGROUND:Non-epithelial gonadal tumours largely comprise sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Specific somatic mutations in DICER1, a microRNA maturation pathway gene, have been identified in these tumours. We conducted a study that aimed to confirm, refine and extend the previous observatio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.637
更新日期:2013-11-12 00:00:00
abstract:BACKGROUND:We evaluated the efficacy and safety of the modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients. METHODS:Seventy-three patients with T2-T4 or N+ were enroled. Preoperative chemotherapy consisted of three cycles of mFOLFOX6. The primary end points were the response ra...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.126
更新日期:2016-06-14 00:00:00
abstract:BACKGROUND:Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC who had...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/bjc.2012.545
更新日期:2013-02-19 00:00:00
abstract::Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many human cancers. Previously, to identify candidate epigenetically inactivated TSGs in renal cell carcinoma (RCC), we monitored changes in gene expression in four RCC cell lines after tr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604180
更新日期:2008-01-29 00:00:00
abstract::A serological assay for the quantitative determination of the novel tumour-associated epitope CA242 was developed and used for determination of sensitivity and specificity of CA242 in gastrointestinal cancer. The CA242 assay showed a better tumour specificity than CA50 (and CA 19-9). This was most noticeable in benign...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.44
更新日期:1992-02-01 00:00:00
abstract::Recently, we have found a high frequency of p53 gene mutations in human functional adrenal tumours. As the tumorigenesis is a multigene defect, we believe that other oncogenes may also be involved in the initiation or progression of adrenal tumours. Using the single-strand conformational polymorphism (SSCP) method, we...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.177
更新日期:1998-04-01 00:00:00
abstract::Administration of 5-aminolaevulinic acid (ALA) leads to porphyrin accumulation in malignant and premalignant tissues, and ALA is used as a prodrug in photodynamic therapy (PDT). To understand the mechanism of porphyrin accumulation after the administration of ALA and to investigate whether ALA-induced protoporphyrin I...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.559
更新日期:1998-09-01 00:00:00
abstract::Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.434
更新日期:1997-01-01 00:00:00
abstract::The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after injecting specimens with c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.333
更新日期:1997-01-01 00:00:00
abstract::Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes selected for resistance against doxorubicin, melphalan, teniposide and vincristine, were profiled for mRNA expre...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602699
更新日期:2005-08-22 00:00:00
abstract::The importance of tumour angiogenesis in the process of tumour growth and progression in solid tumours has been widely accepted. Among many angiogenic factors, vascular endothelial growth factor (VEGF) has been shown to play a major role in the development and dissemination of the malignant tumours. Nitric oxide (NO) ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690573
更新日期:1999-07-01 00:00:00
abstract::Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated by a complex network of factors produced by both stromal cells and neoplastic cells within solid tumours. The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.373
更新日期:1998-06-01 00:00:00
abstract::The micronucleus (MN) test has been carefully characterized in four human tumour cell lines of widely differing radiosensitivity. Two radioresistant bladder carcinoma cell lines (MGH-U1 and RT112), one sensitive medulloblastoma cell line (D283MED) and a sensitive neuroblastoma cell line (HX142) were used. The number o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.17
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Gold(III) porphyrin 1a is a new class of anticancer drug, which inhibits cell proliferation of wide range of human cancer cell lines and induces apoptosis in human nasopharyngeal carcinoma cells. However, the underlying signalling mechanism by which gold(III) porphyrin 1a modifies the intracellular apoptosis...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605147
更新日期:2009-07-21 00:00:00
abstract::Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 recepto...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2102
更新日期:2001-11-02 00:00:00