当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Sensitivity and specificity of CA242 in gastro-intestinal cancer. A comparison with CEA, CA50 and CA 19-9.

Sensitivity and specificity of CA242 in gastro-intestinal cancer. A comparison with CEA, CA50 and CA 19-9.

Abstract：

:A serological assay for the quantitative determination of the novel tumour-associated epitope CA242 was developed and used for determination of sensitivity and specificity of CA242 in gastrointestinal cancer. The CA242 assay showed a better tumour specificity than CA50 (and CA 19-9). This was most noticeable in benign hepatobiliary disease. The sensitivity at 90% specificity cut-off level was approximately three times higher for CA242 compared to CA50 in colo-rectal cancer Dukes A, B and C, while in pancreatic cancer the sensitivity of CA242 and CA50 was similar. CA242 was expressed independently of CEA, and the combination of CEA and CA242 gave in colo-rectal cancer considerably higher sensitivity than the use of only one of the markers. This was most pronounced in Dukes A and Dukes B patients. CA242 is a novel tumour marker of potential clinical use, particularly in colo-rectal cancer.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Nilsson O,Johansson C,Glimelius B,Persson B,Nørgaard-Pedersen B,Andrén-Sandberg A,Lindholm L

doi

10.1038/bjc.1992.44

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

215-21

issue

2

eissn

0007-0920

issn

1532-1827

journal_volume

65

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Assessment of bone response to systemic therapy in an EORTC trial: preliminary experience with the use of collagen cross-link excretion. European Organization for Research and Treatment of Cancer.

    abstract：:This study was designed to evaluate new bone resorption and tumour markers as possible alternatives to serial plain radiographs for the assessment of response to treatment. Thirty-seven patients with newly diagnosed bone metastases from breast cancer, randomized to receive oral pamidronate or placebo tablets in additi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690506

    authors： Vinholes J,Coleman R,Lacombe D,Rose C,Tubiana-Hulin M,Bastit P,Wildiers J,Michel J,Leonard R,Nortier J,Mignolet F,Ford J

    更新日期：1999-04-01 00:00:00

  • Benefit from preoperative radiotherapy in rectal cancer treatment: disease-free patients' and oncologists' preferences.

    abstract：:Preoperative radiotherapy (PRT) in resectable rectal cancer improves local control but increases probability of faecal incontinence and sexual dysfunction. Consensus was reached in 2001 in the Netherlands on a guideline advising PRT to new patients. Purpose was to assess at what benefit oncologists and rectal cancer p...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603954

    authors： Pieterse AH,Stiggelbout AM,Baas-Thijssen MC,van de Velde CJ,Marijnen CA

    更新日期：2007-09-17 00:00:00

  • Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis.

    abstract：BACKGROUND:Metastatic clear cell renal cell carcinoma (ccRCC) patients have <9% 5-year survival rate, do not respond well to targeted therapy and eventually develop resistance. A better understanding of molecular pathways of RCC metastasis is the basis for the discovery of novel prognostic markers and targeted therapie...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.828

    authors： White NM,Masui O,Newsted D,Scorilas A,Romaschin AD,Bjarnason GA,Siu KW,Yousef GM

    更新日期：2014-03-04 00:00:00

  • In vivo measurement of the association constant of a radio-labelled monoclonal antibody in experimental immunotargeting.

    abstract：:Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.219

    authors： Fjeld JG,Benestad HB,Stigbrand T,Nustad K

    更新日期：1992-07-01 00:00:00

  • Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.

    abstract：:Although most colorectal cancer develops based on the adenoma-adenocarcinoma sequence, morphologically, colorectal cancer is not a homogeneous disease entity. Generally, there are two distinct morphological types: polypoid and ulcerative colorectal tumours. Previous studies have demonstrated that K-ras codon 12 mutati...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600214

    authors： Chiang JM,Chou YH,Chen TC,Ng KF,Lin JL

    更新日期：2002-04-08 00:00:00

  • A phase II study of capecitabine and docetaxel combination chemotherapy in patients with advanced gastric cancer.

    abstract：:Capecitabine and docetaxel have considerable single-agent activity in gastric cancer with distinct mechanisms of action and no overlap of key toxicities. A synergistic interaction between these two drugs is mediated by taxane-induced upregulation of thymidine phosphorylase. We investigated the activity and the feasibi...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6601724

    authors： Park YH,Ryoo BY,Choi SJ,Kim HT

    更新日期：2004-04-05 00:00:00

  • Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines.

    abstract：:In addition to hypoxia, acidic extracellular pH (pH(e)) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601766

    authors： Kalliomäki T,Hill RP

    更新日期：2004-05-04 00:00:00

  • CTGF (IGFBP-rP2) is specifically expressed in malignant lymphoblasts of patients with acute lymphoblastic leukaemia (ALL).

    abstract：:Connective tissue growth factor (CTGF) is a major chemotactic and mitogenic factor for connective tissue cells. The amino acid sequence shares an overall 28-38% identity to IGFBPs and contains critical conserved sequences in the amino terminus. It has been demonstrated that human CTGF specifically binds IGFs with low ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1364

    authors： Vorwerk P,Wex H,Hohmann B,Oh Y,Rosenfeld RG,Mittler U

    更新日期：2000-09-01 00:00:00

  • Correlation between PIK3CA mutations in cell-free DNA and everolimus efficacy in HR+, HER2- advanced breast cancer: results from BOLERO-2.

    abstract：BACKGROUND:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation. METHODS:PIK3CA H1047R, E545K, and E542K mutations in plasma-derived cfDNA wer...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2017.25

    authors： Moynahan ME,Chen D,He W,Sung P,Samoila A,You D,Bhatt T,Patel P,Ringeisen F,Hortobagyi GN,Baselga J,Chandarlapaty S

    更新日期：2017-03-14 00:00:00

  • Oestrogen and progesterone receptor distribution in the cancerous breast.

    abstract：:To test the hypothesis that steroid hormone receptor expression is particularly pronounced in breast tumours when compared with non-neoplastic tissue, mastectomy samples were divided into 16 sectors. Multifocal tumours, of varying receptor phenotype were found in 4 patients and in addition different regions of large t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.90

    authors： Panahy C,Puddefoot JR,Anderson E,Vinson GP,Berry CL,Turner MJ,Brown CL,Goode AW

    更新日期：1987-04-01 00:00:00

  • Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer.

    abstract：BACKGROUND:Necdin (NDN) expression is downregulated in telomerase-immortalised normal human urothelial cells. Telomerase-immortalised normal human urothelial cells have no detected genetic alterations. Accordingly, many of the genes whose expression is altered following immortalisation are those for which epigenetic si...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.104

    authors： De Faveri LE,Hurst CD,Platt FM,Taylor CF,Roulson JA,Sanchez-Carbayo M,Knowles MA,Chapman EJ

    更新日期：2013-04-02 00:00:00

  • Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours.

    abstract：BACKGROUND:Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS:The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clonogenic survival assays. Expression of DNA repair genes and enzymes...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.403

    authors： von Bueren AO,Bacolod MD,Hagel C,Heinimann K,Fedier A,Kordes U,Pietsch T,Koster J,Grotzer MA,Friedman HS,Marra G,Kool M,Rutkowski S

    更新日期：2012-10-09 00:00:00

  • Frequent loss of expression or aberrant alternative splicing of P2XM, a p53-inducible gene, in soft-tissue tumours.

    abstract：:We investigated expression of a human p53-inducible gene, P2XM, a member of the P2X-receptor family of ATP-gated ion channels, in 56 human primary soft-tissue tumours including 47 sarcomas and nine benign tumors. Among the 47 sarcomas examined by reverse transcription polymerase chain reaction, 12 had lost expression ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690484

    authors： Nawa G,Miyoshi Y,Yoshikawa H,Ochi T,Nakamura Y

    更新日期：1999-06-01 00:00:00

  • Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: a crossectional and longitudinal evaluation.

    abstract：:Complex biological pathways including angiogenesis, invasion, osteoclastic activation and bone matrix degradation are involved in the formation of bone metastasis (BM). The aim of our study was to investigate the cross-sectional and longitudinal associations of a panel of 12 serum biochemical markers reflecting biolog...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603285

    authors： Voorzanger-Rousselot N,Juillet F,Mareau E,Zimmermann J,Kalebic T,Garnero P

    更新日期：2006-08-21 00:00:00

  • Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies.

    abstract：:Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1993.298

    authors： Banks RE,Gearing AJ,Hemingway IK,Norfolk DR,Perren TJ,Selby PJ

    更新日期：1993-07-01 00:00:00

  • Mammography screening in the Netherlands: delay in the diagnosis of breast cancer after breast cancer screening.

    abstract：:In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602158

    authors： Duijm LE,Groenewoud JH,Jansen FH,Fracheboud J,van Beek M,de Koning HJ

    更新日期：2004-11-15 00:00:00

  • Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis.

    abstract：BACKGROUND AND AIMS:The serum/plasma proteome was explored for biomarkers to improve the diagnostic ability of CA19-9 in pancreatic adenocarcinoma (PC). METHODS:A Training Set of serum samples from 20 resectable and 18 stage IV PC patients, 54 disease controls (DCs) and 68 healthy volunteers (HVs) were analysed by sur...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605764

    authors： Xue A,Scarlett CJ,Chung L,Butturini G,Scarpa A,Gandy R,Wilson SR,Baxter RC,Smith RC

    更新日期：2010-07-27 00:00:00

  • Predictors of complications in gynaecological oncological surgery: a prospective multicentre study (UKGOSOC-UK gynaecological oncology surgical outcomes and complications).

    abstract：BACKGROUND:There are limited data on surgical outcomes in gynaecological oncology. We report on predictors of complications in a multicentre prospective study. METHODS:Data on surgical procedures and resulting complications were contemporaneously recorded on consented patients in 10 participating UK gynaecological can...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2014.630

    authors： Iyer R,Gentry-Maharaj A,Nordin A,Burnell M,Liston R,Manchanda R,Das N,Desai R,Gornall R,Beardmore-Gray A,Nevin J,Hillaby K,Leeson S,Linder A,Lopes A,Meechan D,Mould T,Varkey S,Olaitan A,Rufford B,Ryan A,Shanbhag

    更新日期：2015-02-03 00:00:00

  • Do the British public recognise differences in survival between three common cancers?

    abstract：BACKGROUND:The recognition that cancer is not a single entity, rather that different cancers have different causes and trajectories, has been a key development in the scientific understanding of cancer. However, little is known about the British public's awareness of differences between cancers. This study examined dif...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.185

    authors： Whitaker KL,Simon AE,Beeken RJ,Wardle J

    更新日期：2012-06-05 00:00:00

  • Parental educational attainment as an indicator of socioeconomic status and risk of childhood cancers.

    abstract：BACKGROUND:Little has been reported on socioeconomic (SES) patterns of risk for most forms of childhood cancer. METHODS:Population-based case-control data from epidemiological studies of childhood cancer conducted in five US states were pooled and associations of maternal, paternal and household educational attainment...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605732

    authors： Carozza SE,Puumala SE,Chow EJ,Fox EE,Horel S,Johnson KJ,McLaughlin CC,Reynolds P,Von Behren J,Mueller BA,Spector LG

    更新日期：2010-06-29 00:00:00

  • A chelating derivative of alpha-melanocyte stimulating hormone as a potential imaging agent for malignant melanoma.

    abstract：:A chelating derivative of alpha-melanocyte stimulating hormone (MSH) has been synthesised, in which two molecules of the hormone are cross-linked by diethylenetriamine pentaacetic acid (DTPA). This compound, bisMSH-DTPA, was equipotent with MSH in an in vitro tyrosinase assay with Cloudman S91 melanoma cells. When DBA...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.409

    authors： Bard DR,Knight CG,Page-Thomas DP

    更新日期：1990-12-01 00:00:00

  • A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix.

    abstract：:A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1982.138

    authors： Thomas GM,Rauth AM,Black BE,Cummings BJ,Sorenti VL,Bush RS

    更新日期：1982-06-01 00:00:00

  • The in vitro genetic effects of fibrous erionite and crocidolite asbestos.

    abstract：:Epidemiologic evidence has recently identified an association between an endemic outbreak of pleural and peritoneal mesothelioma in the Urgup region of Turkey and exposure to zeolite fibres. This malignancy is usually associated with exposure to asbestos dusts whose mineralogical characteristics differ from those of z...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1986.158

    authors： Kelsey KT,Yano E,Liber HL,Little JB

    更新日期：1986-07-01 00:00:00

  • Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents.

    abstract：:The cellular pharmacology of a series of C8-linked pyrrolobenzodiazepine dimers with polymethylene linkers of n = 3-6 (compounds 1-4) has been studied in a range of human tumour cell lines. The four compounds showed the same pattern of relative activity in five ovarian carcinoma cell lines and one cervical carcinoma c...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.248

    authors： Smellie M,Kelland LR,Thurston DE,Souhami RL,Hartley JA

    更新日期：1994-07-01 00:00:00

  • Somatostatin receptor subtype mRNA expression in human colorectal cancer and normal colonic mucosae.

    abstract：:Somatostatin analogues may be useful novel agents in the systemic treatment of advanced colorectal cancer, as somatostatin inhibits proliferation in a wide variety of cell types. Here, we report the expression profiles of somatostatin receptor mRNAs in 32 pairs of malignant and normal colonic epithelia. Receptor subty...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.59

    authors： Laws SA,Gough AC,Evans AA,Bains MA,Primrose JN

    更新日期：1997-01-01 00:00:00

  • Intrathecal chemotherapy. Selection of cytostatic agents.

    abstract：:Selection of cytostatic agents for intrathecal administration is the subject of this paper.Both the toxic side effects-destruction of blood-brain barrier and change of body weight-and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of variou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1970.59

    authors： Hayakawa T,Yamada R,Kanai N,Kuroda R,Ushio Y,Higashi H,Mogami H

    更新日期：1970-09-01 00:00:00

  • Heterogeneity of DNA content in multiple synchronous hepatocellular carcinomas.

    abstract：:Heterogeneity of DNA content in multiple hepatocellular carcinomas (HCCs) was investigated by flow cytometry in 62 tumours from 26 patients who had undergone surgical treatment for multiple synchronous HCCs. Heterogeneity of DNA content was defined (a) when tumours had a different DNA ploidy pattern or (b) when the di...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.387

    authors： Hui AM,Kawasaki S,Imamura H,Miyagawa S,Ishii K,Katsuyama T,Makuuchi M

    更新日期：1997-01-01 00:00:00

  • Phorbol ester stimulates ethanolamine release from the metastatic basal prostate cancer cell line PC3 but not from prostate epithelial cell lines LNCaP and P4E6.

    abstract：BACKGROUND:Malignancy alters cellular complex lipid metabolism and membrane lipid composition and turnover. Here, we investigated whether tumorigenesis in cancer-derived prostate epithelial cell lines influences protein kinase C-linked turnover of ethanolamine phosphoglycerides (EtnPGs) and alters the pattern of ethano...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.457

    authors： Schmitt J,Noble A,Otsuka M,Berry P,Maitland NJ,Rumsby MG

    更新日期：2014-10-14 00:00:00

  • Estimated enterolignans, lignan-rich foods, and fibre in relation to survival after postmenopausal breast cancer.

    abstract：BACKGROUND:Lignans - oestrogenic substances present in various foods - are associated with postmenopausal breast cancer risk, but not much is known regarding their effects on survival. METHODS:In a follow-up study of 2653 postmenopausal breast cancer patients diagnosed between 2001 and 2005, vital status and causes of...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.374

    authors： Buck K,Zaineddin AK,Vrieling A,Heinz J,Linseisen J,Flesch-Janys D,Chang-Claude J

    更新日期：2011-10-11 00:00:00

  • Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKC eta with MDR1, MRP and LRP gene expression.

    abstract：:A possible link between protein kinase C (PKC) and P-glycoprotein (P-gp)-mediated-multidrug resistance (MDR) was assumed from studies on MDR cell lines selected in vitro. The functional relevance of PKC for the MDR phenotype remains unclear, and the involvement of a particular PKC isozyme in clinically occurring drug ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.13

    authors： Beck J,Bohnet B,Brügger D,Bader P,Dietl J,Scheper RJ,Kandolf R,Liu C,Niethammer D,Gekeler V

    更新日期：1998-01-01 00:00:00