Plasminogen activators in endoscopic biopsies as indicators of gastrointestinal cancer: comparison with resection specimens.

abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...

journal_title：British journal of cancer

authors： Ohradanova A,Gradin K,Barathova M,Zatovicova M,Holotnakova T,Kopacek J,Parkkila S,Poellinger L,Pastorekova S,Pastorek J

更新日期：2008-10-21 00:00:00

abstract：:The molecular events that drive the initiation and progression of ovarian adenocarcinoma are not well defined. We have investigated changes in gene expression in ovarian cancer cell lines compared to an immortalized human ovarian surface epithelial cell line (HOSE) using a cDNA array. We identified 17 genes that were ...

journal_title：British journal of cancer

authors： Arnold JM,Mok SC,Purdie D,Chenevix-Trench G

更新日期：2001-02-02 00:00:00

abstract：:Cells from V79 multicell spheroids must be exposed to approximately 50 times more etoposide than exponentially growing monolayers in order to produce the same amount of cell killing. A part of this difference in sensitivity is readily explained by the decrease in growth fraction of large spheroids, and by the protecti...

journal_title：British journal of cancer

authors： Olive PL,Banáth JP,Evans HH

更新日期：1993-03-01 00:00:00

abstract：:Lines of fibroblasts have been established from normal individuals and from patients diagnosed as suffering from one of the mucopolysaccharidoses or mucopolysaccharide-storage diseases. Transformation of these lines with SV40 virus has been found to reduce their capacity to secrete sulphated mucopolysaccharides into t...

journal_title：British journal of cancer

authors： Webb T

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

journal_title：British journal of cancer

authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

更新日期：2013-07-23 00:00:00

abstract：BACKGROUND:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. METHODS:We report the screening of an in-house drug library to id...

journal_title：British journal of cancer

authors： Khanim F,Davies N,Veliça P,Hayden R,Ride J,Pararasa C,Chong MG,Gunther U,Veerapen N,Winn P,Farmer R,Trivier E,Rigoreau L,Drayson M,Bunce C

更新日期：2014-03-18 00:00:00

abstract：:We cytogenetically investigated six osteoid osteomas, one osteoblastoma and one aggressive osteoblastoma, and observed clonal structural changes in one osteoid osteoma and in the aggressive osteoblastoma. Clonal chromosome changes had not been reported previously in osteoid osteoma, whereas the only reported chromosom...

journal_title：British journal of cancer

authors： Dal Cin P,Sciot R,Samson I,De Wever I,Van den Berghe H

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Patients with malignant pleural effusions (MPEs) generally have advanced disease with poor survival and few therapeutic options. Cells within MPEs may be used to stratify patients for targeted therapy. Targeted therapy with poly(ADP ribose) polymerase inhibitors (PARPi) depends on identifying homologous reco...

journal_title：British journal of cancer

authors： Patterson MJ,Sutton RE,Forrest I,Sharrock R,Lane M,Kaufmann A,O'Donnell R,Edmondson RJ,Wilson BT,Curtin NJ

更新日期：2014-07-08 00:00:00

abstract：:Chromosomal translocation t(11;22)(q24:q12) is detected in approximately 90% of tumours of the Ewing family (ET). This translocation results in EWS-Fli1 gene fusion which produces a EWS-Fli1 fusion protein acting as an aberrant transcriptional activator. We previously reported that the inhibition of EWS-Fli1 expressio...

journal_title：British journal of cancer

authors： Matsumoto Y,Tanaka K,Nakatani F,Matsunobu T,Matsuda S,Iwamoto Y

更新日期：2001-03-23 00:00:00

abstract：BACKGROUND:Stromal-tumour interactions facilitate pancreatic cancer (PC) progression. The hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the interaction between cancer cells and stromal pancreatic stellate cells (PSCs). This study assessed the effect of HGF/c-MET inhibition plus gemcitab...

journal_title：British journal of cancer

authors： Xu Z,Pang TCY,Liu AC,Pothula SP,Mekapogu AR,Perera CJ,Murakami T,Goldstein D,Pirola RC,Wilson JS,Apte MV

更新日期：2020-05-01 00:00:00

abstract：:Over a wide range of pH, the semiquinone free radicals formed by reduction of adriamycin exist as a form which is strongly stabilised by internal hydrogen bonding and resonance. They protonate with pKa = 2.9. Below this pH they exhibit absorption maxima at 430 nm (Emax = 13,200 dm3 mol-1 cm-1) and approximately 720 nm...

journal_title：British journal of cancer

authors： Land EJ,Mukherjee T,Swallow AJ,Bruce JM

更新日期：1985-04-01 00:00:00

abstract：:Tumour-associated prostaglandin-like material, assessed by bioassay, has been examined in 37 patients with primary and metastatic squamous carcinomas of the head and neck, previously treated by radiotherapy and chemotherapy followed by radical surgery. High amounts of prostaglandin-like material were extracted from tu...

journal_title：British journal of cancer

authors： Bennett A,Carter RL,Stamford IF,Tanner NS

更新日期：1980-02-01 00:00:00

abstract：:A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus ...

journal_title：British journal of cancer

authors： Higgins PJ,Tong C,Borenfreund E,Okin RS,Bendich A

更新日期：1979-08-01 00:00:00

abstract：:Based on the assumption that an accelerated proliferation process prevails in tumour cell residues after surgery, the possibility that treatment acceleration would offer a therapeutic advantage in postoperative radiotherapy of locally advanced head and neck cancer was investigated. The value of T(pot) in predicting th...

journal_title：British journal of cancer

authors： Awwad HK,Lotayef M,Shouman T,Begg AC,Wilson G,Bentzen SM,Abd El-Moneim H,Eissa S

更新日期：2002-02-12 00:00:00

abstract：BACKGROUND:Ovarian and endometrial high-grade serous carcinomas (HGSCs) have similar clinical and pathological characteristics; however, exhaustive protein expression profiling of these cancers has yet to be reported. METHODS:We performed protein expression profiling on 14 cases of HGSCs (7 ovarian and 7 endometrial) ...

journal_title：British journal of cancer

authors： Hiramatsu K,Yoshino K,Serada S,Yoshihara K,Hori Y,Fujimoto M,Matsuzaki S,Egawa-Takata T,Kobayashi E,Ueda Y,Morii E,Enomoto T,Naka T,Kimura T

更新日期：2016-03-01 00:00:00

abstract：:Treatment failure in AML is often attributed to P-glycoprotein-associated multidrug resistance. However, the importance of increased DNA repair in resistant cells is becoming more apparent. In order to investigate the ability of the DNA repair inhibitor aphidicolin to modulate drug resistance, we continually exposed b...

journal_title：British journal of cancer

authors： Sargent JM,Elgie AW,Williamson CJ,Lewandowicz GM,Taylor CG

更新日期：2001-03-02 00:00:00

abstract：:Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of...

journal_title：British journal of cancer

authors： Champion HR,Wallace IW,Prescott RJ

更新日期：1972-04-01 00:00:00

abstract：:The RNASEL gene on chromosome 1q25 has been identified as a prostate cancer susceptibility gene. We screened for RNASEL germline mutations in familial prostate cancer patients, and performed a case-control study to examine the association of specific variants with prostate cancer risk in the Japanese. Three variants w...

journal_title：British journal of cancer

authors： Nakazato H,Suzuki K,Matsui H,Ohtake N,Nakata S,Yamanaka H

更新日期：2003-08-18 00:00:00

abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...

journal_title：British journal of cancer

authors： Clarke CL,Sandle J,Jones AA,Sofronis A,Patani NR,Lakhani SR

更新日期：2006-08-21 00:00:00

abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...

journal_title：British journal of cancer

authors： Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge E

更新日期：2009-04-07 00:00:00

abstract：:The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...

journal_title：British journal of cancer

authors： Olsson H,Bladström A,Ingvar C,Möller TR

更新日期：2001-09-01 00:00:00

abstract：:Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation analysis to identi...

journal_title：British journal of cancer

authors： Ridge SA,Sludden J,Wei X,Sapone A,Brown O,Hardy S,Canney P,Fernandez-Salguero P,Gonzalez FJ,Cassidy J,McLeod HL

更新日期：1998-01-01 00:00:00

abstract：:The cell population kinetics of the transmissible venereal tumour of the dog was studied at two different stages of tumour growth using the labelled mitoses technique. At the first stage the tumours were growing with a doubling time of about 4 days; at the second stage their growth rate was limited, probably by an imm...

journal_title：British journal of cancer

authors： Cohen D,Steel GG

更新日期：1972-10-01 00:00:00

abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

journal_title：British journal of cancer

authors： Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

更新日期：2006-03-27 00:00:00

abstract：:The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...

journal_title：British journal of cancer

authors： García-Rocha M,García-Gravalos MD,Avila J

更新日期：1996-04-01 00:00:00

abstract：:Somatostatin receptor (sstr)-mediated radiation therapy is a new therapeutic modality for neuroendocrine (NE) tumours. High expression of sstr in NE tumours leads to tumour-specific uptake of radiolabelled somatostatin analogues and high absorbed doses. In this study, we present the first optimised radiation therapy v...

journal_title：British journal of cancer

authors： Kölby L,Bernhardt P,Johanson V,Schmitt A,Ahlman H,Forssell-Aronsson E,Mäcke H,Nilsson O

更新日期：2005-11-14 00:00:00

abstract：:Two soft-agar methods for assaying chemosensitivity of human cancers in vitro were compared with respect to colony morphology, plating efficiency (PE) and chemosensitivity of human melanomas. In 9 xenografts and 9 patients' biopsy specimens Method A (essentially that of Courtenay & Mills, 1978) gave considerably highe...

journal_title：British journal of cancer

authors： Tveit KM,Endresen L,Rugstad HE,Fodstad O,Pihl A

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Gestational trophoblastic diseases (GTDs) are related to trophoblasts, and human chorionic gonadotropin (hCG) is secreted by GTDs as well as normal placentas. However, the asparagine-linked sugar chains on hCG contain abnormal biantennary structures in invasive mole and choriocarcinoma, but not normal pregna...

journal_title：British journal of cancer

authors： Niimi K,Yamamoto E,Fujiwara S,Shinjo K,Kotani T,Umezu T,Kajiyama H,Shibata K,Ino K,Kikkawa F

更新日期：2012-12-04 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：:A retrospective analysis of 321 gastric cancer patients was made to assess the prognostic value of TNM classification, tumour differentiation, Laurén classification, proliferative rate, inflammatory reaction and tumour invasion in vascular or neural structures of the gastric wall. The TNM classification showed the str...

journal_title：British journal of cancer

authors： Setälä LP,Kosma VM,Marin S,Lipponen PK,Eskelinen MJ,Syrjänen KJ,Alhava EM

更新日期：1996-09-01 00:00:00