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A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer.

Abstract：

:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis found no significant interactions or main effect of group after controlling for age and intelligence. Using a calculation to examine performance at an individual level, reliable decline on multiple tasks was seen in 20% of chemotherapy patients, 26% of nonchemotherapy patients and 18% of controls at T2 (18%, 14 and 11%, respectively, at T3). Patients who had experienced a treatment-induced menopause were more likely to show reliable decline on multiple measures at T2 (OR=2.6, 95% confidence interval (CI) 0.823-8.266 P=0.086). Psychological distress, quality of life measures and self-reported cognitive failures did not impact on objective tests of cognitive function, but were significantly associated with each other. The results show that a few women experienced objective measurable change in their concentration and memory following standard adjuvant therapy, but the majority were either unaffected or even improve over time.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

doi

10.1038/sj.bjc.6603029

subject

Has Abstract

pub_date

2006-03-27 00:00:00

pages

828-34

issue

6

eissn

0007-0920

issn

1532-1827

pii

6603029

journal_volume

94

pub_type

杂志文章

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