当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Assessing the function of homologous recombination DNA repair in malignant pleural effusion (MPE) samples.

Assessing the function of homologous recombination DNA repair in malignant pleural effusion (MPE) samples.

Abstract：

BACKGROUND:Patients with malignant pleural effusions (MPEs) generally have advanced disease with poor survival and few therapeutic options. Cells within MPEs may be used to stratify patients for targeted therapy. Targeted therapy with poly(ADP ribose) polymerase inhibitors (PARPi) depends on identifying homologous recombination DNA repair (HRR)-defective cancer cells. We aimed to determine the feasibility of assaying HRR status in MPE cells. METHODS:A total of 15 MPE samples were collected from consenting patients with non-small-cell lung cancer (NSCLC), mesothelioma and ovarian and breast cancer. Primary cultures were confirmed as epithelial by pancytokeratin, and HRR status was determined by the detection of γH2AX and RAD51 foci following a 24-h exposure to rucaparib, by immunofluorescence microscopy. Massively parallel next-generation sequencing of DNA repair genes was performed on cultured MPE cells. RESULTS:From 15 MPE samples, 13 cultures were successfully established, with HRR function successfully determined in 12 cultures. Four samples - three NSCLC and one mesothelioma - were HRR defective and eight samples - one NSCLC, one mesothelioma, one sarcomatoid, one breast and four ovarian cancers - were HRR functional. No mutations in DNA repair genes were associated with HRR status, but there was probable loss of heterozygosity of FANCG, RPA1 and PARP1. CONCLUSIONS:HRR function can be successfully detected in MPE cells demonstrating the potential to stratify patients for targeted therapy with PARPi.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Patterson MJ,Sutton RE,Forrest I,Sharrock R,Lane M,Kaufmann A,O'Donnell R,Edmondson RJ,Wilson BT,Curtin NJ

doi

10.1038/bjc.2014.261

subject

Has Abstract

pub_date

2014-07-08 00:00:00

pages

94-100

issue

1

eissn

0007-0920

issn

1532-1827

pii

bjc2014261

journal_volume

111

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • A prospective study of urinary oestrogen excretion and breast cancer risk.

    abstract：:To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects we...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.304

    authors： Key TJ,Wang DY,Brown JB,Hermon C,Allen DS,Moore JW,Bulbrook RD,Fentiman IS,Pike MC

    更新日期：1996-06-01 00:00:00

  • Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer.

    abstract：:Bcl-2 expression in colorectal carcinomas was studied in a series of 224 patients and the relation to p53 expression, stage and survival assessed. Bcl-2 expression was down-regulated compared with normal mucosa in 67% (151) of the cases. In 144 cases staining was positive for p53 (MAB DO7), and 41 of these 144 p53-pos...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.310

    authors： Kaklamanis L,Savage A,Whitehouse R,Doussis-Anagnostopoulou I,Biddolph S,Tsiotos P,Mortensen N,Gatter KC,Harris AL

    更新日期：1998-06-01 00:00:00

  • Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis.

    abstract：:Stathmin is an intracellular phosphoprotein that is overexpressed in a number of human malignancies. Our previous study using proteomic profiling showed that significant upregulation of stathmin occurs in oral squamous-cell carcinoma (OSCC)-derived cell lines. In the current study, to determine the potential involveme...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602991

    authors： Kouzu Y,Uzawa K,Koike H,Saito K,Nakashima D,Higo M,Endo Y,Kasamatsu A,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

    更新日期：2006-03-13 00:00:00

  • Cellular pharmacology of a liposomal preparation of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine, a lipophilic derivative of 1-beta-D-arabinofuranosylcytosine.

    abstract：:The in vitro deamination, cytotoxicity, cellular drug uptake, distribution and cellular pharmacology in HL-60 cells of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC), a lipophilic derivative of arabinofuranosylcytosine (ara-C), were studied. Compared with ara-C, NHAC in liposomal formulations was highly resista...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.185

    authors： Horber DH,Schott H,Schwendener RA

    更新日期：1995-05-01 00:00:00

  • Patient-reporting improves estimates of postoperative complication rates: a prospective cohort study in gynaecological oncology.

    abstract：BACKGROUND:Most studies use hospital data to calculate postoperative complication rates (PCRs). We report on improving PCR estimates through use of patient-reporting. METHODS:A prospective cohort study of major surgery performed at 10 UK gynaecological cancer centres was undertaken. Hospitals entered the data contempo...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2013.366

    authors： Iyer R,Gentry-Maharaj A,Nordin A,Liston R,Burnell M,Das N,Desai R,Gornall R,Beardmore-Gray A,Hillaby K,Leeson S,Linder A,Lopes A,Meechan D,Mould T,Nevin J,Olaitan A,Rufford B,Ryan A,Shanbhag S,Thackeray A,Wood N

    更新日期：2013-08-06 00:00:00

  • Cancer of the testis and month of birth.

    abstract：:It has recently been reported that a series of testis cancers shows a temporal cycle in birth dates with a peak in certain months. This observation has been tested by an examination of a larger series covering all testis cancers diagnosed in the years 1971-84 in England and Wales, in men born in 1940 or later. Limited...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.117

    authors： Kinlen LJ,Willows AN

    更新日期：1987-05-01 00:00:00

  • Silibinin protects against cisplatin-induced nephrotoxicity without compromising cisplatin or ifosfamide anti-tumour activity.

    abstract：:Cisplatin is one of the most active cytotoxic agents in the treatment of testicular cancer, but its clinical use is associated with side-effects such as ototoxicity, neurotoxicity and nephrotoxicity. Long-term kidney damage from cisplatin particularly affects the proximal tubular apparatus and can be detected by incre...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.673

    authors： Bokemeyer C,Fels LM,Dunn T,Voigt W,Gaedeke J,Schmoll HJ,Stolte H,Lentzen H

    更新日期：1996-12-01 00:00:00

  • Sexual quality of life in Hodgkin Lymphoma: a longitudinal analysis by the German Hodgkin Study Group.

    abstract：BACKGROUND:Health-related quality of life (HRQoL) comprises different domains of physical, mental, and social well-being. In this analysis, we focus on sexual quality of life in Hodgkin Lymphoma (HL) patients. METHODS:Four-thousand one-hundred and sixty patients enroled in the HD10-HD12 trials underwent HRQoL assessme...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.550

    authors： Behringer K,Müller H,Görgen H,Flechtner HH,Brillant C,Halbsguth TV,Thielen I,Eichenauer DA,Schober T,Nisters-Backes H,Fuchs M,Engert A,Borchmann P

    更新日期：2013-01-15 00:00:00

  • Inhibition of the deubiquitinase USP10 induces degradation of SYK.

    abstract：BACKGROUND:There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine kinase 3 (FLT3), part...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0731-z

    authors： Yang J,Meng C,Weisberg E,Case A,Lamberto I,Magin RS,Adamia S,Wang J,Gray N,Liu S,Stone R,Sattler M,Buhrlage S,Griffin JD

    更新日期：2020-04-01 00:00:00

  • The use of expert surrogates to evaluate clinical trials in non-small cell lung cancer.

    abstract：:One hundred and eighteen doctors who treat pulmonary neoplasms in Ontario were asked how they would wish to be treated if they had non-small cell lung cancer. Four different scenarios were given. The physicians were then asked if they would consent to take part as subjects in one or more clinical trials for which they...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1986.224

    authors： Mackillop WJ,Ward GK,O'Sullivan B

    更新日期：1986-10-01 00:00:00

  • A phase I (tumour site-specific) study of carboplatin and temozolomide in patients with advanced melanoma.

    abstract：:Temozolomide is an oral alkylating agent that readily crosses the blood-brain barrier and has activity in patients with advanced melanoma. Carboplatin is a convenient outpatient treatment that also has activity in patients with melanoma. The purpose of this study was to assess the safety of a combination of temozolomi...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6601414

    authors： Strauss SJ,Marples M,Napier MP,Meyer T,Boxall J,Rustin GJ

    更新日期：2003-11-17 00:00:00

  • No association between P53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck.

    abstract：:An initial report suggested that patients homozygous for the arginine allele at codon 72 of P53 were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding. Since approximately 18-36% of head and neck cancers are HPV-related, we examined the genotypic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.0993

    authors： Hamel N,Black MJ,Ghadirian P,Foulkes WD

    更新日期：2000-02-01 00:00:00

  • Assessing the benefit-risk of new treatments using generalised pairwise comparisons: the case of erlotinib in pancreatic cancer.

    abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...

    journal_title：British journal of cancer

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/bjc.2015.55

    authors： Péron J,Roy P,Ding K,Parulekar WR,Roche L,Buyse M

    更新日期：2015-03-17 00:00:00

  • Cessation of smoking and drinking and the risk of laryngeal cancer.

    abstract：:A case-control study was conducted in Italy and Switzerland between 1992 and 2000 on 527 cases of laryngeal cancer and 1,297 hospital controls. The risk of laryngeal cancer steadily decreased from 3 years after stopping smoking. Some decline in risk was observed only 20 years or more after stopping drinking. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600638

    authors： Altieri A,Bosetti C,Talamini R,Gallus S,Franceschi S,Levi F,Dal Maso L,Negri E,La Vecchia C

    更新日期：2002-11-18 00:00:00

  • A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer.

    abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603029

    authors： Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

    更新日期：2006-03-27 00:00:00

  • Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis.

    abstract：:Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antige...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600507

    authors： Løvig T,Andersen SN,Thorstensen L,Diep CB,Meling GI,Lothe RA,Rognum TO

    更新日期：2002-09-23 00:00:00

  • Intake of wholegrain products and risk of colorectal cancers in the Diet, Cancer and Health cohort study.

    abstract：BACKGROUND:Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS:The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal can...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605806

    authors： Egeberg R,Olsen A,Loft S,Christensen J,Johnsen NF,Overvad K,Tjønneland A

    更新日期：2010-08-24 00:00:00

  • Low-dose anti-inflammatory combinatorial therapy reduced cancer stem cell formation in patient-derived preclinical models for tumour relapse prevention.

    abstract：BACKGROUND:Emergence of drug-resistant cancer phenotypes is a challenge for anti-cancer therapy. Cancer stem cells are identified as one of the ways by which chemoresistance develops. METHOD:We investigated the anti-inflammatory combinatorial treatment (DA) of doxorubicin and aspirin using a preclinical microfluidic m...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-018-0301-9

    authors： Khoo BL,Grenci G,Lim JSY,Lim YP,Fong J,Yeap WH,Bin Lim S,Chua SL,Wong SC,Yap YS,Lee SC,Lim CT,Han J

    更新日期：2019-02-01 00:00:00

  • Randomized double-blind phase II survival study comparing immunization with the anti-idiotypic monoclonal antibody 105AD7 against placebo in advanced colorectal cancer.

    abstract：:The cancer vaccine 105AD7 is an anti-idiotypic monoclonal antibody that mimics the tumour-associated antigen 791T/gp72 (CD55, Decay Accelerating Factor) on colorectal cancer cells. Phase I studies in patients with advanced disease confirmed that 105AD7 is non-toxic, and that T cell responses could be generated. A pros...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1054/bjoc.2001.1725

    authors： Maxwell-Armstrong CA,Durrant LG,Buckley TJ,Scholefield JH,Robins RA,Fielding K,Monson JR,Guillou P,Calvert H,Carmichael J,Hardcastle JD

    更新日期：2001-06-01 00:00:00

  • Interleukin-6, tumour necrosis factor alpha and interleukin-1beta in patients with renal cell carcinoma.

    abstract：:As regulators of malignant cell behaviour and communication with stroma, cytokines have proved useful in understanding cancer biology and developing novel therapies. In renal cell carcinoma, patients with inflammatory reactions are known to have poor prognosis. In order to elucidate the relation between renal cell car...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600257

    authors： Yoshida N,Ikemoto S,Narita K,Sugimura K,Wada S,Yasumoto R,Kishimoto T,Nakatani T

    更新日期：2002-05-06 00:00:00

  • Kaposi's sarcoma in Italy before and after the AIDS epidemic.

    abstract：:The incidence of Kaposi's sarcoma (KS) in 1976-90 was assessed in Italy, taking advantage of a network of nine population-based cancer registries covering, at its maximum, approximately 5.6 million subjects. The first examined period (1976-84) substantially reflects the epidemiology of KS prior to the AIDS epidemic in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.60

    authors： Geddes M,Franceschi S,Barchielli A,Falcini F,Carli S,Cocconi G,Conti E,Crosignani P,Gafà L,Giarelli L

    更新日期：1994-02-01 00:00:00

  • Variation in reported experience of involvement in cancer treatment decision making: evidence from the National Cancer Patient Experience Survey.

    abstract：BACKGROUND:Exploring variation in patients' experiences of involvement in treatment decision making can identify groups needing extra support, such as additional consultation time, when considering treatment options. METHODS:We analysed data from the 2010 English National Cancer Patient Experience Survey, a national s...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.316

    authors： El Turabi A,Abel GA,Roland M,Lyratzopoulos G

    更新日期：2013-08-06 00:00:00

  • Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D.

    abstract：:Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In the present work, we ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602722

    authors： Porojnicu AC,Robsahm TE,Ree AH,Moan J

    更新日期：2005-09-05 00:00:00

  • The cost-effectiveness of high dose chemotherapy in the treatment of relapsed Hodgkin's disease and non-Hodgkin's lymphoma.

    abstract：:As part of an NHS Executive Trent regional initiative we considered the role and cost-effectiveness of high dose chemotherapy in the treatment of relapsed Hodgkin's disease and non-Hodgkin's lymphoma. The key trials and case series show an additional patient benefit of 0.8-1.1 life years over standard chemotherapy. We...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1054/bjoc.1999.0880

    authors： Beard SM,Lorigan PC,Sampson FC

    更新日期：2000-01-01 00:00:00

  • Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies.

    abstract：:The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a murine mammary tumou...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601722

    authors： Perotti C,Fukuda H,DiVenosa G,MacRobert AJ,Batlle A,Casas A

    更新日期：2004-04-19 00:00:00

  • Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells.

    abstract：:Multidrug resistance (MDR) is the major confounding factor in adjuvant solid tumour chemotherapy. Increasing intracellular amounts of chemotherapeutics to circumvent MDR may be achieved by a novel delivery method, photochemical internalisation (PCI). PCI consists of the co-administration of drug and photosensitiser; u...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603895

    authors： Adigbli DK,Wilson DG,Farooqui N,Sousi E,Risley P,Taylor I,Macrobert AJ,Loizidou M

    更新日期：2007-08-20 00:00:00

  • The potential for oral combination chemotherapy of 5'-deoxy-5-fluorouridine, a 5-FU prodrug, and cyclophosphamide for metastatic breast cancer.

    abstract：:Preclinical studies have demonstrated the synergistic anti-tumour activity of combination therapy with the oral cytostatics, 5'-deoxy-5-fluorouridine (5'-DFUR) and cyclophosphamide (CPA), in human breast cancer xenograft models. This study was performed to evaluate the efficacy and safety of this oral combination chem...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6601350

    authors： Yoshimoto M,Tada K,Tokudome N,Kutomi G,Tanabe M,Goto T,Nishimura S,Makita M,Kasumi F

    更新日期：2003-11-03 00:00:00

  • The role of dendritic cell precursors in tumour vasculogenesis.

    abstract：:In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into func...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6602476

    authors： Coukos G,Benencia F,Buckanovich RJ,Conejo-Garcia JR

    更新日期：2005-04-11 00:00:00

  • Maternal vitamin and iron supplementation and risk of infant leukaemia: a report from the Children's Oncology Group.

    abstract：BACKGROUND:Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia. METHODS:Mothers of 443 cases of infant leukaemia diagnosed during 1996-2006 and 324 frequency-matched controls completed interviews. Associations were evaluated by unconditional logistic regression. RESUL...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605957

    authors： Linabery AM,Puumala SE,Hilden JM,Davies SM,Heerema NA,Roesler MA,Ross JA,Children's Oncology Group.

    更新日期：2010-11-23 00:00:00

  • High prevalence of Clostridium difficile diarrhoea during intensive chemotherapy for disseminated germ cell cancer.

    abstract：:A prospective, consecutive study of the aetiology of treatment-associated diarrhoea was conducted in 25 patients with disseminated germ cell cancer treated with intensive chemotherapy. Clostridium difficile was isolated in 45% of the diarrhoea episodes, which makes this species the most important bacterial pathogen in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.334

    authors： Nielsen H,Daugaard G,Tvede M,Bruun B

    更新日期：1992-10-01 00:00:00