The cost-effectiveness of high dose chemotherapy in the treatment of relapsed Hodgkin's disease and non-Hodgkin's lymphoma.

abstract：BACKGROUND:Testing for high-risk human papillomavirus (HPV) in primary screening for cervical cancer is considered more sensitive, but less specific, in comparison with Pap-smear cytology. Women with persistent HPV infections have a higher risk of developing cervical intraepithelial neoplasia 2+ (CIN2+) lesions. This s...

journal_title：British journal of cancer

authors： Gyllensten U,Sanner K,Gustavsson I,Lindell M,Wikström I,Wilander E

更新日期：2011-08-23 00:00:00

abstract：:This single-centre phase I trial was designed to determine the maximum tolerated dose of irinotecan and the recommended dose to use in combination with a fixed dose of 5-fluorouracil (5-FU) administered as a protracted venous infusion, for the first-line treatment of metastatic colorectal cancer (CRC). Tolerability an...

journal_title：British journal of cancer

authors： Saunders MP,Hogg M,Carrington B,Sjursen AM,Allen J,Beech J,Swindell R,Valle JW

更新日期：2004-10-18 00:00:00

abstract：:Angiopoietin-1 is an important regulator of endothelial cell survival. Angiopoietin-1 also reduces vascular permeability mediated by vascular endothelial growth factor. The effects of angiopoietin-1 on tumour growth and angiogenesis are controversial. We hypothesised that angiopoietin-1 would decrease tumour growth an...

journal_title：British journal of cancer

authors： Stoeltzing O,Ahmad SA,Liu W,McCarty MF,Parikh AA,Fan F,Reinmuth N,Bucana CD,Ellis LM

更新日期：2002-11-04 00:00:00

abstract：:Electron spin resonance (ESR) spectroscopy was used to examine changes in the concentration of paramagnetic metal ions in Yoshida tumours carried by female Wistar rats. Blood, spleen and lymph nodes from these animals were also examined by ESR. A decrease in the concentration of a paramagnetic species associated with ...

journal_title：British journal of cancer

authors： Dodd NJ,Silcock JM

更新日期：1976-11-01 00:00:00

abstract：:The important role of the p53 gene in tumour progression and cellular response to DNA damage has prompted investigation of the clinical significance of alterations to this gene. We examined both p53 overexpression and mutation of the gene in endometrial carcinoma in order to evaluate the prognostic significance of the...

journal_title：British journal of cancer

authors： Soong R,Knowles S,Williams KE,Hammond IG,Wysocki SJ,Iacopetta BJ

更新日期：1996-08-01 00:00:00

abstract：:The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic...

journal_title：British journal of cancer

authors： Richardson VJ,Ryman BE,Jewkes RF,Jeyasingh K,Tattersall MN,Newlands ES,Kaye SB

更新日期：1979-07-01 00:00:00

abstract：:Chemotherapy or radiotherapy often cause mucosal damage in the gut (gut mucositis) in cancer patients. As a step to investigate mechanisms underlying subsequent intestinal repair, we have examined the expression profiles of hepatocyte growth factor (HGF) and its receptor c-met, two molecules previously implicated in t...

journal_title：British journal of cancer

authors： Xian CJ,Couper R,Howarth GS,Read LC,Kallincos NC

更新日期：2000-02-01 00:00:00

abstract：:HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...

journal_title：British journal of cancer

authors： Hasegawa H,Kakuguchi W,Kuroshima T,Kitamura T,Tanaka S,Kitagawa Y,Totsuka Y,Shindoh M,Higashino F

更新日期：2009-06-16 00:00:00

abstract：:Combretastatin-A4 phosphate (cis-CA-4) is a tubulin-binding agent currently undergoing clinical trials as an anti-tumour drug. We have investigated whether CA-4 functions as a tumour-specific anti-vascular agent using the hyperplastic thyroid as a novel in vivo model of neovascularization. CA-4 elicited pathological c...

journal_title：British journal of cancer

authors： Griggs J,Hesketh R,Smith GA,Brindle KM,Metcalfe JC,Thomas GA,Williams ED

更新日期：2001-03-23 00:00:00

abstract：:Elderly patients are recommended to have a reduced starting dose (300 mg m(-2) once every 3 weeks) of irinotecan monotherapy. The aims of this analysis are to compare toxicity and survival according to age, performance status (PS), gender and prior radical pelvic radiotherapy (RT). The primary end points were overall ...

journal_title：British journal of cancer

authors： Chau I,Norman AR,Cunningham D,Waters JS,Topham C,Middleton G,Hill M,Ross PJ,Katopodis R,Stewart G,Oates JR

更新日期：2004-10-18 00:00:00

abstract：BACKGROUND:This multicentre, open-label study evaluated the efficacy and safety of SPI-1620, an analogue of endothelin-1, administered in combination with docetaxel as second-line treatment for patients with advanced biliary tract cancer (ABTC). METHODS:Eligible patients received continuous cycles of combination thera...

journal_title：British journal of cancer

authors： Kim R,Chiorean EG,Amin M,Rocha-Lima CMS,Gandhi J,Harris WP,Song T,Portnoy D

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Epidemiological studies evaluating the association of vitamin B6, vitamin B12 and methionine with breast cancer risk have produced inconsistent results. METHODS:Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose-response relationship was assessed...

journal_title：British journal of cancer

authors： Wu W,Kang S,Zhang D

更新日期：2013-10-01 00:00:00

abstract：:BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) is an agent which stabilises oxyhaemoglobin and thus reduces oxygen delivery to tissues. It is of interest as a possible potentiator of bioreductive agents and/or hyperthermia. The increases in radiobiological hypoxic fraction of RIF-1 and KHT tumours 30 min after 7...

journal_title：British journal of cancer

authors： Honess DJ,Hu DE,Bleehen NM

更新日期：1991-10-01 00:00:00

abstract：:To study the effect of oral supplemental calcium on colonic epithelial proliferation, 17 adenomatous polyp patients received 1.5 g Ca2+ as calcium carbonate daily during 12 weeks, while on a calcium constant diet, based on the patients' habitual diet. Seven subsequently continued calcium supplementation for 9 months w...

journal_title：British journal of cancer

authors： Kleibeuker JH,Welberg JW,Mulder NH,van der Meer R,Cats A,Limburg AJ,Kreumer WM,Hardonk MJ,de Vries EG

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:The PI3K/Akt signalling pathway, induced by epidermal growth factor receptor (EGFR) and Her-2, is involved in the constitutive activation of NF-kappaB in prostate cancer cell lines. In this study, we extended the in vitro observation using an ex vivo model of prostate cancer tissues and assessed the prognost...

journal_title：British journal of cancer

authors： Koumakpayi IH,Le Page C,Mes-Masson AM,Saad F

更新日期：2010-03-30 00:00:00

abstract：:We have shown that large numbers of haemopoietic progenitor cells are mobilised into the blood after filgrastim [granulocyte colony-stimulating factor (G-CSF)] alone and filgrastim following cyclophosphamide chemotherapy in previously untreated patients with ovarian cancer. These cells may be used to provide safe and ...

journal_title：British journal of cancer

authors： Weaver A,Wrigley E,Watson A,Chang J,Collins CD,Jenkins B,Gill C,Pettengell R,Dexter TM,Testa NG,Crowther D

更新日期：1996-12-01 00:00:00

abstract：:The pharmacological interest in lonidamine is related to its ability to enhance the cytotoxic effects of several DNA-damaging anti-tumour agents. This study was undertaken to better understand the in vivo interaction between lonidamine and cisplatin in the treatment of human tumour xenografts, including three carcinom...

journal_title：British journal of cancer

authors： De Cesare M,Pratesi G,Giusti A,Polizzi D,Zunino F

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...

journal_title：British journal of cancer

authors： Crespo M,van Dalum G,Ferraldeschi R,Zafeiriou Z,Sideris S,Lorente D,Bianchini D,Rodrigues DN,Riisnaes R,Miranda S,Figueiredo I,Flohr P,Nowakowska K,de Bono JS,Terstappen LW,Attard G

更新日期：2015-03-31 00:00:00

abstract：:The antiapoptotic Livin/ML-IAP gene has recently gained much attention as a potential new target for cancer therapy. Reports indicating that livin is expressed almost exclusively in tumours, but not in the corresponding normal tissue, suggested that the targeted inhibition of livin may present a novel tumour-specific ...

journal_title：British journal of cancer

authors： Wagener N,Crnković-Mertens I,Vetter C,Macher-Göppinger S,Bedke J,Gröne EF,Zentgraf H,Pritsch M,Hoppe-Seyler K,Buse S,Haferkamp A,Autschbach F,Hohenfellner M,Hoppe-Seyler F

更新日期：2007-11-05 00:00:00

abstract：:Squamous carcinoma of the oropharynx presents with symptoms common to many benign diseases, and this can cause delay in referral to secondary care. We investigate delay in referral, defining this as the time from symptom-onset to date of general practitioners referral letter to secondary care, and the effect of that d...

journal_title：British journal of cancer

authors： Pitchers M,Martin C

更新日期：2006-04-10 00:00:00

abstract：BACKGROUND:Several microRNA (miRNA) molecules have emerged as important post-transcriptional regulators of tumour suppressor and oncogene expression. Ras association domain family member 1 (RASSF1) is a critical tumour suppressor that controls multiple aspects of cell proliferation such as cell cycle, cell division and...

journal_title：British journal of cancer

authors： Pruikkonen S,Kallio MJ

更新日期：2017-05-23 00:00:00

abstract：:The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and ...

journal_title：British journal of cancer

authors： Kovacs CJ,Braunschweiger PG,Schenken LL,Burholt DR

更新日期：1982-02-01 00:00:00

abstract：:Recent investigations have increasingly focussed attention on the roles of intracellular vesicle trafficking in the regulation of epithelial polarity and transformation. Rab25, an epithelial-specific member of the Rab family of small GTPases, has been associated with several epithelial cancers. Whereas Rab25 overexpre...

journal_title：British journal of cancer

authors： Goldenring JR,Nam KT

更新日期：2011-01-04 00:00:00

abstract：:Melanoma is one of the most aggressive types of cancer and resection of the tumour prior to dissemination of tumour cells is still the most effective treatment. Therefore, early diagnosis of melanocytic lesions is important and identification of novel (molecular) markers would be helpful to improve diagnosis. Moreover...

journal_title：British journal of cancer

authors： de Wit NJ,Rijntjes J,Diepstra JH,van Kuppevelt TH,Weidle UH,Ruiter DJ,van Muijen GN

更新日期：2005-06-20 00:00:00

abstract：BACKGROUND:We evaluated the performance of primary high-risk human papillomavirus (hrHPV) testing by hybrid capture 2 (HC2) with different thresholds for positivity, in comparison with conventional cytology. METHODS:We used data of 25,871 women (aged 30-60 years) from the intervention group of the VUSA-Screen study (V...

journal_title：British journal of cancer

authors： Rijkaart DC,Coupe VM,van Kemenade FJ,Heideman DA,Hesselink AT,Verweij W,Rozendaal L,Verheijen RH,Snijders PJ,Berkhof J,Meijer CJ

更新日期：2010-09-28 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common complication of lung cancer. In this study, we assessed the feasibility of detection of EGFR mutations in samples of pleura...

journal_title：British journal of cancer

authors： Kimura H,Fujiwara Y,Sone T,Kunitoh H,Tamura T,Kasahara K,Nishio K

更新日期：2006-11-20 00:00:00

abstract：:Comorbid diseases can affect breast cancer prognosis. We conducted a population-based study of Danish women diagnosed with a first primary breast cancer from 1995 to 2005 (n=9300), using hospital discharge registry data to quantify comorbidities by Charlson score. We examined the influence of comorbidities on survival...

journal_title：British journal of cancer

authors： Cronin-Fenton DP,Nørgaard M,Jacobsen J,Garne JP,Ewertz M,Lash TL,Sørensen HT

更新日期：2007-05-07 00:00:00

abstract：:We studied 5555 seminoma patients and 3733 patients with nonseminomatous testicular cancers diagnosed in Southeast England between 1960 and 2004. For both groups survival improved over time: 10-year relative survival increased from 78% in 1960-1969 to 99% in 1990-2004 for seminomas, and from 55 to 95% for nonseminomas...

journal_title：British journal of cancer

authors： Robinson D,Møller H,Horwich A

更新日期：2007-02-12 00:00:00

abstract：:The vaso-active drug hydralazine causes a considerable increase in the cytotoxic effect of melphalan towards the KHT tumour in mice. The enhancement in response, measured as the concentration of melphalan required to achieve a given tumour response, is 3.0 and 2.35 when determined using the regrowth delay assay and th...

journal_title：British journal of cancer

authors： Stratford IJ,Adams GE,Godden J,Nolan J,Howells N,Timpson N

更新日期：1988-08-01 00:00:00

abstract：:Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In the present work, we ...

journal_title：British journal of cancer

authors： Porojnicu AC,Robsahm TE,Ree AH,Moan J

更新日期：2005-09-05 00:00:00